Patents by Inventor Zhijian Zhu

Zhijian Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrazole and oxadiazolone substituted beta-amino acid derivatives
    Publication number: 20050014804
    Abstract: This invention relates to novel tetrazole and oxadiazalone ?-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.
    Type: Application
    Filed: March 8, 2004
    Publication date: January 20, 2005
    Inventors: Nancy Barta, Norman Colbry, Raymond Hudack, Kristin Lin, Jacob Schwarz, Andrew Thorpe, David Wustrow, Zhijian Zhu
  • Preparation of N2-alkylated 1,2,3-triazoles
    Publication number: 20040266848
    Abstract: Methods and materials for preparing N2-alkylated triazoles, such as 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]-phenyl}-2-[1,2,3]triazol-2-yl-propionic acid, are disclosed. Such compounds are PPAR agonists that are useful for treating non-insulin dependent diabetes.
    Type: Application
    Filed: June 25, 2004
    Publication date: December 30, 2004
    Inventors: Mark Allen Hadd, Brian Joseph Nichelson, Zhijian Zhu
  • Prodrugs of benzofuranylethyl carbamate NK1 antagonists
    Patent number: 6258800
    Abstract: The instant invention provides aqueous soluble prodrugs of formula (I) or a pharmaceutically acceptable salt thereof wherein R is —CH2OZ, —C(═O)OCH2OZ or Z, wherein Z is formula (a), —P(═O)(OH)2 or —C(═O)Q: n is an integer of from 0 to 3; m is an integer of from 0 to 1, of certain tachykinin antagonists (NK1 antagonists) useful in the treatment of emesis.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: July 10, 2001
    Assignee: Warner-Lambert Company
    Inventors: Michael Huai Gu Chen, Om Prakash Goel, Fred M. Hershenson, Zhijian Zhu, Oilun Helen Chan