Patents by Inventor Zhiqiang Guo

Zhiqiang Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 7081459
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: July 25, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 7071200
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: July 4, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Collin Regan, Jaimie K. Rueter, Zhiqiang Guo, Yongsheng Chen, Charles Q. Huang
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20060122202
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: October 14, 2005
    Publication date: June 8, 2006
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley Dwight, Charles Huang, Fabio Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20060122204
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: November 1, 2005
    Publication date: June 8, 2006
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Charles Huang, Chen Chen, Yongsheng Chen, Zhiqiang Guo, Warren Wade, Martin Rowbottom, Jaimie Rueter
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 7056927
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: June 6, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley J. Dwight, Charles Q. Huang, Fabio C. Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 7015226
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: March 21, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Charles Q. Huang, Chen Chen, Yongsheng Chen, Zhiqiang Guo, Warren Wade, Martin Rowbottom, Jaimie K. Rueter
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050272733
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: May 4, 2005
    Publication date: December 8, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050234082
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R1, R2, R3a, R3b, R4, R5, R6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: December 17, 2004
    Publication date: October 20, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Chen Chen, Fabio Tucci, Zhiqiang Guo, Timothy Gross, Martin Rowbottom, R. Struthers
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6951858
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: October 4, 2005
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6921761
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: July 26, 2005
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050075339
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: November 10, 2003
    Publication date: April 7, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Patent number: 6872728
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R1, R2, R3a, R3b, R4, R5, R6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: March 29, 2005
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Chen Chen, Fabio C. Tucci, Zhiqiang Guo, Timothy D. Gross, Martin Rowbottom, R. Scott Struthers
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050043338
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: July 6, 2004
    Publication date: February 24, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Collin Regan, Jaimie Rueter, Zhiqiang Guo, Yongsheng Chen, Charles Huang
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050038057
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: July 6, 2004
    Publication date: February 17, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Yongsheng Chen, Dongpei Wu, Chen Chen, Warren Wade, Wesley Dwight, Charles Huang, Fabio Tucci
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20050038056
    Abstract: GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Application
    Filed: July 6, 2004
    Publication date: February 17, 2005
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Charles Huang, Chen Chen, Yongsheng Chen, Zhiqiang Guo, Warren Wade, Martin Rowbottom, Jaimie Rueter
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20040266773
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: April 26, 2004
    Publication date: December 30, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Preparation of deoxynucleosides
    Patent number: 6822089
    Abstract: Methods for preparing deoxynucleosides from their corresponding ribonucleosides by forming 3-tert-butylphenoxythiocarbonylderivatives of the ribonucleosides and subsequently effecting radical deoxygenation reactions at the carbon atoms to be deoxygenated.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: November 23, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Zhiqiang Guo
  • CRF receptor antagonists and methods relating thereto
    Publication number: 20040229879
    Abstract: Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke.
    Type: Application
    Filed: February 23, 2004
    Publication date: November 18, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Zhiqiang Guo, James R. McCarthy
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20040162290
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: November 10, 2003
    Publication date: August 19, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
  • CRF receptor antagonists and methods relating thereto
    Publication number: 20040157851
    Abstract: CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke.
    Type: Application
    Filed: November 4, 2003
    Publication date: August 12, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Brian P. Dyck, Charles Q. Huang, Jodie Nelson, Zhiqiang Guo, James R. McCarthy