Patents by Inventor Zhiqiang Guo

Zhiqiang Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6750350
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1, R2, R3a, R3b, R4, R5, R6, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: June 15, 2004
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Publication number: 20040087589
    Abstract: CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke.
    Type: Application
    Filed: January 8, 2003
    Publication date: May 6, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Brian P. Dyck, Charles Q. Huang, Jodie Nelson, Zhiqiang Guo, James R. McCarthy
  • Patent number: 6723721
    Abstract: Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke. The compounds of this invention have the following structures: wherein n, m, R, R1, R2, X and Ar are as defined herein, including stereoisomes and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: April 20, 2004
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Zhiqiang Guo, James R. McCarthy
  • Publication number: 20040048884
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: February 6, 2003
    Publication date: March 11, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Chen Chen, Fabio C. Tucci, Zhiqiang Guo, Timothy D. Gross, Martin Rowbottom, R. Scott Struthers
  • Patent number: 6677340
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: January 13, 2004
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
  • Patent number: 6673796
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: January 6, 2004
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Publication number: 20030216411
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: January 28, 2003
    Publication date: November 20, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Timothy D. Gross, Ying Hing Gao, Patrick J. Connors, Zhiqiang Guo, Chen Chen
  • Patent number: 6608197
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R1, R2, R3a, R3b, R4, R5, R6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: August 19, 2003
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Chen Chen, Fabio C. Tucci, Zhiqiang Guo, Timothy D. Gross, Martin Rowbottom, R. Scott Struthers
  • Publication number: 20030130282
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: July 10, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
  • Publication number: 20030114455
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: June 19, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Joseph Pontillo, Zhiqiang Guo, Dongpei Wu
  • Publication number: 20030073693
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: April 17, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Chen Chen, Dongpei Wu, Zhiqiang Guo, Martin Rowbottom
  • Patent number: 6537998
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein Ar, A, B, Q, R1, R2, R3a, R3b, R6, R7 and m are as defined herein, including stereoisomers, prodrugs and pharmaceutical acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: March 25, 2003
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Timothy D. Gross, Yinghong Gao, Patrick J. Connors, Jr., Zhiqiang Guo, Chen Chen
  • Patent number: 6531475
    Abstract: CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers and pharmaceutically acceptable salts thereof, wherein n, m, A, B, C, R, R1, R2 and Ar are as defined herein.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: March 11, 2003
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Brian P. Dyck, Charles Q. Huang, Jodie Nelson, Zhiqiang Guo, James R. McCarthy
  • Patent number: 6514982
    Abstract: CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers and pharmaceutically acceptable salts thereof, wherein n, m, A, B, C, R, R1, R2 and Ar are as defined herein.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: February 4, 2003
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Brian P. Dyck, Charles Q. Huang, Jodie Nelson, Zhiqiang Guo, James R. McCarthy
  • Publication number: 20020143008
    Abstract: Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke.
    Type: Application
    Filed: December 20, 2001
    Publication date: October 3, 2002
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Zhiqiang Guo, James R. McCarthy
  • Publication number: 20020132820
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: January 25, 2001
    Publication date: September 19, 2002
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Yun-Fei Zhu, Chen Chen, Fabio C. Tucci, Zhiqiang Guo, Timothy D. Gross, Martin Rowbottom, R. Scott Struthers
  • Patent number: 6348466
    Abstract: Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke. The compounds of this invention have the following structures: wherein n, m, R, R1, R2, X and Ar are as defined herein, including stereoisomes and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: February 19, 2002
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Mustapha Haddach, Zhiqiang Guo, James R. McCarthy
  • Patent number: 6239220
    Abstract: The present invent n provides a method for the preparation of triarylmethyl protecting group reagents. The reagents are prepared from reaction effluent from the cleavage step of oligonucleotide synthetic regimes.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: May 29, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Zhiqiang Guo
  • Patent number: 6124484
    Abstract: The present invention provides a method for the preparation of triarylmethyl protecting group reagents. The reagents are prepared from reaction effluent from the cleavage step of oligonucleotide synthetic regimes.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: September 26, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Zhiqiang Guo