Patents by Inventor Zhiyuan Zhang

Zhiyuan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20090012059
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 8, 2009
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Dipeptidyl peptidase inhibitors
    Patent number: 7470700
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: December 30, 2008
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080188501
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: August 7, 2008
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080177064
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 24, 2008
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080161562
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 3, 2008
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080108807
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080108808
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080003283
    Abstract: Compounds are provided for use with DPP-IV of the formula: Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: August 7, 2007
    Publication date: January 3, 2008
    Applicant: TAKEDA PHARMACEUTICAL COMPANY, INC.
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathan Salsbury, Luckner Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20070249611
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Application
    Filed: March 27, 2007
    Publication date: October 25, 2007
    Inventors: Jun Feng, Stephen Gwaltney, Michael Wallace, Zhiyuan Zhang
  • One dimensional all-metal slab waveguide gas laser
    Patent number: 7126973
    Abstract: A one dimension all-metal slab waveguide gas laser comprises a slab waveguide gas discharge area and an optical resonator disposed in a metal vacuum chamber. The gas discharge area is formed by a top and a bottom metal electrodes and metal supporting blocks insolated with the electrodes. A metal liner plate and a metal press plate are sequentially disposed on upside of the metal electrodes. A metal supporting plate is disposed at underside of the metal electrodes. The metal top electrodes are connected with a supply power through link pins of the metal electrodes. An output mirror and a feedback mirror are respectively arranged at two sides of the optical resonator. An output window of the laser is disposed in the vacuum chamber.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: October 24, 2006
    Assignee: Beijing BDHlaser Science & Technology Inc. Ltd.
    Inventors: Jianguo Xin, Jiangxing Wu, Zhiyuan Zhang, Weiping Wang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20060135767
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Kinase inhibitors
    Publication number: 20060084650
    Abstract: Compounds, pharmaceutical compositions and kits are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
    Type: Application
    Filed: October 14, 2005
    Publication date: April 20, 2006
    Inventors: Qing Dong, David Hosfield, Bheema Paraselli, Nicholas Scorah, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Programmable one-pot oligosaccharide synthesis
    Patent number: 7019131
    Abstract: The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile one-pot synthesis of oligosaccharides. The influence on reactivity of the structural effects of different monosaccharide cores and different protecting groups on each glycoside donor is characterized and quantified. In addition, a correlation between glycosyl donor reactivity and the chemical shift of the anomeric proton by 1 H NMR has been established. A database of thioglycosides as glycosyl donors has been created using this reactivity data. The utility is demonstrated by the easy and rapid one-pot assembly of various linear and branched oligosaccharide structures.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: March 28, 2006
    Assignee: The Scripps Research Institute
    Inventors: Chi-Huey Wong, Zhiyuan Zhang, Ian Ollmann, Timor Baasov, Xin-Shan Ye
  • Dipeptidyl peptidase inhibitors
    Publication number: 20060014764
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein R2 is amino (C1-6)alkyl, hetero(C3-12)cycloakyl, hetero(C4-12)bicycloaryl, heteroaryl, or cyano; and W, X, Y, Z, R1, R5 and R7 are as defined herein.
    Type: Application
    Filed: July 15, 2005
    Publication date: January 19, 2006
    Inventors: Jun Feng, Stephen Gwaltney, Betty Lam, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050272765
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 8, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050261271
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: March 15, 2005
    Publication date: November 24, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050075330
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: April 7, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050070706
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 31, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050070530
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 31, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050070531
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 31, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Stephen Kaldor, Jeffrey Stafford, Michael Wallace, Zhiyuan Zhang