Patents by Inventor Zhiyuan Zhang

Zhiyuan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dipeptidyl peptidase inhibitors
    Patent number: 8288539
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: October 16, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Dipeptidyl peptidase inhibitors
    Patent number: 8222411
    Abstract: Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: July 17, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Paul R. Brodfuahrer, Bruce Elder, Paul Isbester, Richard S. Fornicola, Philip B. Kisanga, Bingidimi I. Mobele, Grant J. Palmer, Maxwell M. Reeve, Jonathon S. Salsbury, Luckner Ulysse, Sripathy Venkatraman
  • Dipeptidyl peptidase inhibitors
    Patent number: 8188275
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 29, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • cMET inhibitors
    Patent number: 8178534
    Abstract: Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: May 15, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jerome C. Bressi, Shaosong Chu, Philip Erickson, Mallareddy Komandla, Lily Kwok, John D Lawson, Jeffrey A Stafford, Michael B. Wallace, Zhiyuan Zhang, Sanjib Das
  • Dipeptidyl peptidase inhibitors
    Patent number: 8173663
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 8, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Renin inhibitors
    Patent number: 8148367
    Abstract: Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: wherein the variables are as defined herein. The disclosed compounds are inhibitors of Renin.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: April 3, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Lily Kwok, Betty Lam, Zhe Li, Zhiyuan Zhang
  • Renin inhibitors
    Patent number: 8133898
    Abstract: The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:—wherein the variables are as defined herein.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: March 13, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Stephen L. Gwaltney, Zhiyuan Zhang, Betty Lam
  • Dipeptidyl peptidase inhibitors
    Patent number: 8093382
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: January 10, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Michael B. Wallace, Jeffrey A. Stafford, Zhiyuan Zhang
  • Method, system and device for increasing multimedia messaging service system capacity
    Patent number: 8019823
    Abstract: A method for increasing multimedia messaging service system capacity is provided, it comprises: a message distributing device determining a first multimedia messaging service center (MMSC) node for receiving multimedia message, and forwarding the multimedia message to a relay of the first MMSC node, after it having received multimedia message; the multimedia message being transmitted to a server of the first MMSC node by the relay of the first MMSC node, and stored in the server of the first MMSC node; the server of the first MMSC node corresponding to the relay of the first MMSC relay uniquely; the server of the first MMSC node sending the multimedia message to the receipt party via the relay of the first MMSC node and the message distributing device. A system and a device for increasing multimedia messaging service system capacity are provided, too. It can increase the capacity of multimedia messaging service system handling multimedia message service with the invention.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: September 13, 2011
    Assignee: Huawei Technologies Co., Ltd.
    Inventors: Guangchang Bai, Dawei Li, Zhiyuan Zhang, Weiming Cheng, Yang Wang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7960384
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: June 14, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Michael B. Wallace, Zhiyuan Zhang
  • Suture Fixation Arthroscope Apparatus of the Temporomandibular Joint Disk
    Publication number: 20110106111
    Abstract: A suture fixation arthroscope apparatus of the temporomandibular joint (TMJ) disk comprises a first suture needle and a first inner core, a second suture needle and a second inner core, and a third suture needle. The tail ends of the first and second suture needles are connected with a big handle via a valve panel, a vertical groove is opened towards the center of a circle of the surface of the big handle, a horizontal groove which is the same size as the vertical groove is vertically set at the place of the big handle connecting the valve panel. The first inner core includes a seamless tube and a top welded with wire snares, the second inner core includes a seamless tube and a top welded with a crochet hook, the radian near the tails of the first and second inner cores is 90 degrees, a small handle is connected at the tails.
    Type: Application
    Filed: February 5, 2010
    Publication date: May 5, 2011
    Applicant: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Inventors: Chi Yang, Shanyong Zhang, Zhiyuan Zhang, Minjie Chen, Xieyi Cai, Jinning Zhang, Xiuming Liu
  • Dipeptidyl Peptidase Inhibitors
    Publication number: 20110087022
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Application
    Filed: December 9, 2010
    Publication date: April 14, 2011
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7906523
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: March 15, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Jonathon S. Salsbury, Luckner G. Ulysse
  • Dipeptidyl peptidase inhibitors
    Patent number: 7872124
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C?NR4, and L, X, Z, R2 and R3 are as defined herein.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: January 18, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7825242
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein R2 is amino (C1-6)alkyl, hetero(C3-12)cycloakyl, hetero(C4-12)bicycloaryl, heteroaryl, or cyano; and W, X, Y, Z, R1, R5 and R7 are as defined herein.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: November 2, 2010
    Assignee: Takeda Pharmaceutical Company Limted
    Inventors: Jun Feng, Stephen L. Gwaltney, Betty Lam, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7807689
    Abstract: The present invention provides a compound of the formula: or stereoisomers or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, articles of manufacture comprising the same, and methods of using the same.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: October 5, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Zhiyuan Zhang, Bruce J. Elder, Paul K. Isbester, Grant J. Palmer, Luckner G. Ulysse
  • Dipeptidyl peptidase inhibitors
    Patent number: 7795428
    Abstract: Compounds are provided for use with DPP-IV of the formula: Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: September 14, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey Alan Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathan S. Salsbury, Luckner Ulysse
  • Dipeptidyl peptidase inhibitors
    Patent number: 7790736
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: September 7, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7790734
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: September 7, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Sheldon X. Cao, Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Xiao-Yi Xiao, Zhiyuan Zhang
  • KINASE INHIBITORS
    Publication number: 20100216765
    Abstract: Compounds, pharmaceutical compositions and kits are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
    Type: Application
    Filed: April 6, 2010
    Publication date: August 26, 2010
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Qing Dong, David J. Hosfield, Bheema R. Paraselli, Nicholas Scorah, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang