Patents by Inventor Zhongying Chen

Zhongying Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INFLUENZA B VIRUSES HAVING ALTERATIONS IN THE HEMAGLUTININ POLYPEPTIDE
    Publication number: 20100322969
    Abstract: The present invention encompasses methods of producing influenza B viruses in cell culture. The influenza B viruses may have desirable characteristics, such as enhanced replication in eggs and may be used, for example, in vaccines and in methods of treatment to protect against influenza B virus infection.
    Type: Application
    Filed: June 18, 2008
    Publication date: December 23, 2010
    Applicant: Medimmune, LLC
    Inventors: Hong Jin, Zhongying Chen
  • Methods of Producing Influenza Vaccine Compositions
    Publication number: 20090246225
    Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
    Type: Application
    Filed: December 8, 2008
    Publication date: October 1, 2009
    Applicant: MedImmune, LLC
    Inventors: George Robert Trager, George Kemble, Richard M. Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred A. Pan, Eric Tsao, Chiaoyin Kathy Wang, Luisa Yee, Palani Balu
  • Multi Plasmid System For The Production Of Influenza Virus
    Publication number: 20090175907
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Application
    Filed: October 20, 2008
    Publication date: July 9, 2009
    Applicant: MedImmune, LLC
    Inventors: Erich Hoffman, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen
  • Multi plasmid system for the production of influenza virus
    Patent number: 7465456
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: December 16, 2008
    Assignee: MedImmune, LLC
    Inventors: Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen
  • Methods of Producing Influenza Vaccine Compositions
    Publication number: 20070161085
    Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
    Type: Application
    Filed: January 30, 2007
    Publication date: July 12, 2007
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Trager, George Kemble, Richard Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred Pan, Eric Tsao, Chiaoyin Wang, Luisa Yee, Palani Balu
  • Multi plasmid system for the production of influenza virus
    Publication number: 20050266026
    Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 1, 2005
    Inventors: Erich Hoffmann, Hong Jin, Bin Lu, Gregory Duke, George Kemble, Zhongying Chen
  • Methods of producing influenza vaccine compositions
    Publication number: 20040265987
    Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
    Type: Application
    Filed: February 25, 2004
    Publication date: December 30, 2004
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Robert Trager, George Kemble, Richard M. Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred A. Pan, Eric Tsao, Chiaoyin Kathy Wang, Luisa Yee, Palani Balu