Abstract: A method for immobilisation of nucleic acids onto glass and silicon surfaces is described, wherein said nucleic acids are immobilised onto unmodified glass and other silicon surfaces. A new class of modified nucleic acids, namely silanised nucleic acids, and methods of preparing such modified nucleic acids, as well as a method for producing DNA chips of various density with only end-attachment of DNA applied, are also described.

Abstract: This invention relates to methods for identifying regions of RNA molecules that are available for interaction with small molecules, particularly regions that can hybridize with oligonucleotides having complementary sequences. Identifying such regions is useful in the design of probes, anti-sense oligonucleotides and small molecule drugs.

Abstract: A method of preparing microchips having nucleic acid attached thereto is disclosed. In the method a surface of a first chip (master chip), to which surface nucleic acid is attached, and a surface of a second chip (print chip), are brought into contact with each other, whereby the nucleic acid attached to the first chip is partially transferred to the surface of the second chip, through detachment from the first chip, and immobilization onto the second chip.