Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.

Abstract: A fluid sensor (15) is disclosed. The sensor comprises a frame (21), first and second electrodes (271, 272) supported by the frame and separated by space occupiable by a fluid, and a third electrode (273) lying in a path (29) on the frame between the first and second electrodes.

Abstract: The present invention discloses a pavement element annotation method for point cloud data with fusion of height, which comprises the following steps: constructing all single-frame point clouds into a joint point cloud in a global coordinate system based on the pose of each frame of single-frame point cloud; removing dynamic objects in the joint point cloud to obtain a static joint point cloud; transforming the static joint point cloud into an overhead image; pre-annotating the pavement elements in an overhead image by using the pavement element pre-annotation model; modifying the pre-annotated result to obtain an overhead image annotation; based on a ball query algorithm and a ground point algorithm, establishing a transformational relation between the pixels of the overhead image and the points of the static joint point cloud; transforming the overhead image annotation into a static joint point cloud annotation based on the transformational relation.

Abstract: A method and an apparatus for 4D road scene annotation based on time series data includes: obtaining point cloud data and multi-view 2D image data of a same road scene at a same time series, as well as a rotation matrix R and a translation vector t obtained through sensors; merging all the point cloud data into a combined point cloud using the rotation matrix R and the translation vector t; performing dynamic and static object annotation and lane line annotation on the combined point cloud in the 4D road scene; and mapping annotation information in the 4D road scene to all the 2D image data at the time series based on camera parameter information, to obtain annotation information on 2D images. The method fully utilizes time series information, avoiding the loss of important information.

Abstract: Embodiments disclosed herein provide a peptoid compound comprising a structure shown in Formula I and a detection chip having the peptoid compound coupled onto its surface. The peptoid compound has a strong binding ability with EpCAM protein on the surface of circulating tumor cells. The diagnostic technology of colorectal adenocarcinoma, gastric adenocarcinoma, breast cancer, ovarian cancer, lung adenocarcinoma, prostate cancer, pancreatic cancer, stem cell cancer, retinoblastoma, or primary esophageal squamous cell carcinoma based on the peptoid compound can realize rapid detection or diagnosis. In addition, the peptoid compound can be made by a simple synthesis method with high preparation efficiency and low production cost.

Abstract: The present disclosure provides reagents such as a hybridization solution and a pre-digestion treatment solution and kits for fluorescence in situ hybridization, and also provides a detection method for fluorescence in situ hybridization using the above reagents or kits. The fluorescence in situ hybridization can be achieved with ultrafast speed and high resolution.

Abstract: A preservation solution of magnetic beads includes a surfactant, a water-soluble salt and a bacteriostatic agent.

Abstract: A detection chip and a manufacturing method thereof, and a detection method are provided. The detection chip includes: a base substrate, and a detection layer, provided on the base substrate and including a plurality of detection holes. An inner wall of each of at least part of detection holes among the plurality of detection holes is hydrophilic, and a contact angle of the inner wall is within 30 degrees.

Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.

Abstract: A detection chip and a preparation method thereof, the detection chip may include a base substrate and a detection layer, the detection layer is provided on the base substrate and include a plurality of detection holes, each of at least a portion of the plurality of detection holes has a hole wall provided with a hydrophilic layer, and a contact angle of the hydrophilic layer is within 20 degrees. The detection chip can implement high-throughput, crosstalk does not easily occur between adjacent detection holes, which, thus, may improve detection accuracy.

Abstract: The present disclosure provides a magnetic bead suspension reagent, a method for purifying nucleic acid by using the magnetic bead suspension reagent, and a method for sorting nucleic acid by using the magnetic bead suspension reagent. The magnetic bead suspension reagent includes magnetic beads and a surfactant, the surfactant includes a nonionic surfactant and an anionic/cationic surfactant, and both the nonionic surfactant and the anionic/cationic surfactant are present in the magnetic bead suspension reagent.

Abstract: The embodiments disclosed herein provide a peptoid, which is a compound of Formula I or a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof. N—R4, N—R3, N—R2, and N—R1 in Formula I are respectively. The peptoid has a strong binding ability with an EpCAM protein. It can be used as molecular probes for diseases associated with an EpCAM protein, to achieve targeted therapy, in vivo imaging diagnosis and prognosis monitoring of the diseases associated with the EpCAM protein at low cost, high accuracy and high efficiency.

Abstract: A reaction device for a detection chip and a reaction system are provided. The reaction device includes a chip carrier and an electrical signal control unit. The chip carrier is configured to place and fix the detection chip; and the electrical signal control unit is configured to apply an electrical signal to the detection chip so as to drive a heating electrode of the detection chip.

Abstract: A data processing method for a biochip comprises: acquiring a biochip image to be detected; performing binarization processing on the biochip image to obtain a binary image; performing a morphological dilation operation on the binary image in a row direction to obtain a first image, and performing a morphological dilation operation on the binary image in a column direction to obtain a second image; performing connected domain detection on the first image in the row direction, and performing connected domain detection on the second image in the column direction, to determine the number of rows and the number of columns of a sample point array and center position information of each sample point.

Abstract: Provided is application of genetically engineered bacteria VNP20009-M in preparation of drugs for preventing and treating lung cancer.

Abstract: A device and method for degassing an on-load tap-changer (OLTC) of a transformer for convenient on-site operation. The degassing device includes an OLTC. The OLTC is respectively connected with an oil suction pipe and an oil injection pipe. One end of the oil suction pipe extends to the inside bottom of the OLTC, and the other end of the oil suction pipe extends to the outside of the OLTC to connect with an oil suction and degassing device. One end of the oil injection pipe extends to an upper part inside the OLTC, and the other end of the oil injection pipe extends to the outside of the OLTC to connect with a vacuum oil injection device. The present disclosure has the advantages of convenient on-site operation, excellent degassing effect, simple structure and convenient installation, reduces degassing time and manpower and investment in maintenance, and improves degassing quality.

Abstract: Disclosed is an application of methioninase gene therapy in the treatment of a malignant tumor. In the gene therapy, a virus is used as a vector to insert an exogenous methioninase gene to constitute a methioninase expression system inside a tumor, thus providing an endogenous mechanism for further consumption of methionine. In vitro cytology experiments indicate that the methioninase gene therapy significantly reduces the level of intracellular methionine, effectively inhibits the proliferation of tumor cells, and can be used in an application in preparing a drug for the targeted treatment of a malignant tumor.

Abstract: A phosphodiesterase type 5 inhibitor is used in the preparation of a medicament for resisting fibrotic diseases.

Abstract: A biological chip, a manufacturing method thereof, an operation method thereof, and a biological detection system are provided. The biological chip includes a base substrate and a plurality of working units. The plurality of the working units are arranged on the base substrate; each of the working units includes a working element configured to be in contact with a target substance; and the working element includes a metal electrode and an electric-field-controllable surface modification layer on a surface of the metal electrode.

Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.