Patents by Inventor ZIJIAN ZHAO

ZIJIAN ZHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200357452
    Abstract: The present disclosure provides a data reading circuit and a storage unit. The data reading circuit includes a being read unit connected to a voltage stabilizing unit and configured to store data. The voltage stabilizing unit is configured to stabilize and output a current from the being read unit to a first amplifying unit. The first amplifying unit is configured to amplify and output the current from the being read unit to a comparing unit. A reference unit is connected to a second amplifying unit, to output a reference current to the second amplifying unit. The second amplifying unit is configured to amplify and output the reference current to the comparing unit. The comparing unit is configured to compare a comparing point voltage, that is based on the amplified current of the being read unit and the amplified reference current, with a reference voltage and to output comparison results.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 12, 2020
    Inventors: Tengye WANG, Jiaxu PENG, Tao WANG, Zijian ZHAO
  • Publication number: 20200023019
    Abstract: Provided is application of genetically engineered bacteria VNP20009-M in preparation of drugs for preventing and treating lung cancer.
    Type: Application
    Filed: March 29, 2018
    Publication date: January 23, 2020
    Inventors: Allan Zijian ZHAO, Yan LIN, Sujin ZHOU, Fanghong LI
  • Publication number: 20200023020
    Abstract: Provided is application of genetically engineered bacteria VNP20009-M in preparation of drugs for preventing and treating malignant sarcoma.
    Type: Application
    Filed: March 29, 2018
    Publication date: January 23, 2020
    Inventors: Allan Zijian ZHAO, Yan LIN, Sujin ZHOU, Fanghong LI
  • Publication number: 20190345198
    Abstract: The present disclosure relates to a peptoid compound, and a derivative, a salt, a preparation method and use thereof. The peptoid compound includes the following subunits: 4-phenylphenethylamine, monoprotected ethylenediamine, monoprotected tetramethylenediamine, 3,4-methylenedioxybenzylamine, isobutylamine, and R(+)-?-methylbenzylamine, in which molecular formulas of the subunits are as follows: in which P is independently an amino protecting group.
    Type: Application
    Filed: January 15, 2019
    Publication date: November 14, 2019
    Applicant: BOE Technology Group Co., Ltd.
    Inventor: Zijian Zhao
  • Publication number: 20190160036
    Abstract: The present invention discloses a novel phosphodiesterase 4 (PDE4) inhibitor ZL-n-91 for applications in preparing drugs for treating proliferation and metastasis of prostate cancer. The animal experiments and cytological experiments in mice showed that the PDE4 inhibitor ZL-n-91 of the present invention can significantly inhibit the proliferation and metastasis of prostate cancer cells, indicating that the PDE4 inhibitor ZL-n-91 is expected to be an important target for treating proliferation and metastasis of prostate cancer. It will lay a foundation for preparing drugs against proliferation and metastasis of prostate cancer, presenting good prospect for development and application.
    Type: Application
    Filed: August 8, 2017
    Publication date: May 30, 2019
    Applicant: GUANGZHOU SINOGEN BIOMEDICAL TECHNOLOGY, LTD
    Inventors: Allan Zijian ZHAO, Sijia GONG, Yan LIN, Fanghong LI, Xiaoxi LI, Sujin ZHOU, Zhenggang ZHENG
  • Publication number: 20180369188
    Abstract: The present invention discloses uses of a novel phosphodiesterase 4 (PDE4) inhibitor ZL-n-91 in preparing drugs against lung cancer proliferation and metastasis. The mouse survival curves and in vitro cell experiments show that the PDE4 inhibitor ZL-n-91 can significantly inhibit the proliferation and metastasis of lung cancer cells, indicating that this PDE4 inhibitor ZL-n-91 can become an important target for the studies on anti-lung cancer proliferation and metastasis, to provide a basis for preparing drugs against lung cancer proliferation and metastasis, with promising prospect of development and application.
    Type: Application
    Filed: March 30, 2017
    Publication date: December 27, 2018
    Inventors: Allan Zijian ZHAO, Sijia GONG, Yan LIN, Fanghong LI, Xiaoxi LI
  • Publication number: 20180339032
    Abstract: Provided is an application of a genetically engineered bacterium of attenuated Salmonella typhimurium in preparation of medicines for treating liver cancer. The bacterium is attenuated Salmonella typhimurium VNP20009 carrying a plasmid cloned with a methioninase gene. Also provided is a construction method of the bacterium.
    Type: Application
    Filed: August 17, 2016
    Publication date: November 29, 2018
    Inventors: Allan Zijian ZHAO, Sujin ZHOU, Yan LIN, Zhenggang ZHAO, Fanghong LI
  • Patent number: 10113184
    Abstract: It discloses a transformant for weight loss and lipid reduction, which is obtained by recombining and substituting human oxyntomodulin gene into thymidylate synthase gene of L.lactis genome. Wherein the recombinant substitution is homologous recombination by artificially synthesizing gene sequences, making the sequence flanking the human oxyntomodulin gene derived from the homologous sequences of thymidylate synthase gene in the L.lactis genome, then the gene fragments are electroporated into L. lactis, to carry out homologous recombination.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: October 30, 2018
    Assignee: NANJING SINOGEN BIOTECH & PHARMACEUTICAL INC.
    Inventors: Yan Lin, Rong Xiang, Allan Zijian Zhao, Fanghong Li
  • Patent number: 9990963
    Abstract: A word line voltage generator circuit, a semiconductor device, and an electronic device are provided. The word line voltage generator circuit includes a switch circuit connected to a high-level signal and a low-level signal and configured to output the high-level signal or the low-level signal as a word line voltage signal based on an input signal, and a drive signal control circuit configured to provide a drive signal connected to the switch circuit in response to the input signal. A voltage rising speed of the word line voltage signal is controlled by the drive signal.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: June 5, 2018
    Assignees: Semiconductor Manufacturing International (Shanghai) Corporation, Semiconductor Manufacturing International (Beijing) Corporation
    Inventors: Yijin Kwon, Hao Ni, Zijian Zhao, Yu Cheng
  • Publication number: 20180051303
    Abstract: It discloses a transformant for weight loss and lipid reduction, which is obtained by recombining and substituting human oxyntomodulin gene into thymidylate synthase gene of L. lactis genome. Wherein the recombinant substitution is homologous recombination by artificially synthesizing gene sequences, making the sequence flanking the human oxyntomodulin gene derived from the homologous sequences of thymidylate synthase gene in the L. lactis genome, then the gene fragments are electroporated into L. lactis, to carry out homologous recombination.
    Type: Application
    Filed: March 24, 2016
    Publication date: February 22, 2018
    Inventors: Yan LIN, Rong XIANG, Allan Zijian ZHAO, Fanghong LI
  • Publication number: 20180008682
    Abstract: The present disclosure provides uses of genetically engineered attenuated Salmonella typhimurium strain VNP20009-M in preventing and treating cancer metastasis. The genetically engineered strain VNP20009-M is targeted to cancer cells and has a significant effect of inhibiting metastasis and growth. VNP20009-M can be used to prepare medicaments for the prevention and treatment of tumor metastasis.
    Type: Application
    Filed: September 17, 2017
    Publication date: January 11, 2018
    Inventors: Allen Zijian Zhao, Sujin Zhou, Yan Lin, Zhenggang Zhao, Fanghong Li
  • Publication number: 20170352389
    Abstract: A word line voltage generator circuit, a semiconductor device, and an electronic device are provided. The word line voltage generator circuit includes a switch circuit connected to a high-level signal and a low-level signal and configured to output the high-level signal or the low-level signal as a word line voltage signal based on an input signal, and a drive signal control circuit configured to provide a drive signal connected to the switch circuit in response to the input signal. A voltage rising speed of the word line voltage signal is controlled by the drive signal.
    Type: Application
    Filed: March 29, 2017
    Publication date: December 7, 2017
    Inventors: YIJIN KWON, HAO NI, ZIJIAN ZHAO, YU CHENG
  • Patent number: 9439934
    Abstract: The current invention discloses an attenuated Salmonella typhimurium, a genetically engineered bacterium and applications thereof in preparing drugs for the treatment of prostate cancer. The attenuated Salmonella typhimurium has tumor targeting and significant inhibitory effects on prostate cancer cells. A genetically engineered bacterium bearing a L-methioninase gene plasmid also has tumor targeting ability. The attenuated Salmonella typhimurium with the plasmid can constitutively express L-methioninase in the tumor tissues, consume a significant amount of methionine and other nutrients, which in turn causes lack of nutrition and slow growth of tumor cells. Therefore, it can be used as drugs for treating prostate cancer.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 13, 2016
    Assignee: NANJING SINOGEN BIOTECH & PHARMACEUTICAL INC.
    Inventors: Allan Zijian Zhao, Sujin Zhou, Yan Lin, Zhenggang Zhao, Fanghong Li