Oxidation resistant treatment for metallic medical devices
A method of treating a metallic medical device is disclosed and includes providing a metallic medical device, ionizing the media surrounding at least one electrode to produce an energized plasma proximate to the electrode, and exposing the metallic device to the plasma prior to use of the metallic device. In one embodiment a vascular stent is the medical device.
The present application claims priority to U.S. provisional patent application Ser. No. 60/460,365 filed Apr. 3, 2003 the entire contents of which are incorporated herein by reference.
FIELD OF THE INVENTIONThe present invention relates to a process for passivating a metallic surface. Specifically, an oxidation treatment is described herein is capable of efficiently passivating a metallic medical device thereby improving the corrosion resistance of the treated device. In one embodiment of the present invention the medical device is a vascular stent.
BACKGROUND OF THE INVENTIONDevices manufactured from at least one metallic material are commonly implanted within the body of patient to treat a variety of conditions. For example, stents, shunts, or other mechanical scaffoldings may be inserted into an occluded region of a lumen or luminal structure to provide and maintain patency therethrough. In an alternate embodiment, metallic screws, braces, or plates may be positioned within or attached to skeletonal structures throughout the patient's body to provide support thereto. Recently, total joint replacement devices such as replacement hip prosthetics and replacement knee prosthetics have been used to replace incompetent natural joint systems.
Presently, implantable metallic devices are manufactured from a variety of materials, including, stainless steel, tantalum, titanium, Nickel-Titanium alloys, shape memory alloys, super elastic alloys, low-modulus Ti—Nb—Zr alloys, and colbalt-nickel alloy steel (MP-35N). While implantable metallic devices manufactured these materials have proven useful in treating a variety of physiological conditions, a number of shortcomings associated with implantable metallic devices have been identified. For example, the extended exposure of the implanted metallic devices to bodily fluids and biological materials may result in device corrosion. As a result, the performance of the implanted device may be compromised.
In response, the materials used in the manufacture of implantable metallic devices generally undergo a chemical passivation process during the manufacture of the implantable device. Typically, the device is coated with, submerged in, or otherwise exposed to an oxidizing agent or compound. For example, nitric acid is frequently used as an oxidizing agent when passivating stainless steel. As a result, free metals on the surface of the implantable device may be removed and a non-reactive protective oxide layer capable of reducing or preventing material corrosion may be formed thereon. While the chemical passivating process has been effective in passivating implantable metallic devices, a number of shortcomings have been identified. For example, the chemical passivating processes tend to be time intensive procedures typically requiring the implantable device be exposed to an oxidizing agent for 15 minutes or more. In addition, oxidizing agents are hazardous materials and pose a health risk to exposed workers and may result in the unwanted deposition of chemical residues on the treated device.
Thus, in light of the foregoing, there is a need oxidation treatment for metallic medical devices capable of quickly passivating a metallic device without leaving chemical residues thereon.
BRIEF SUMMARY OF THE INVENTIONThe oxidation treatment described herein is capable of efficiently passivating a metallic medical device thereby improving the corrosion resistance of the treated device. In addition, the oxidation treatment disclosed herein reduces or eliminates the possibility of residual chemical impurities remaining on the treated device as a result of the passivating procedure.
In one embodiment, a method of treating a metallic medical device is disclosed and includes providing a metallic medical device, ionizing the media surrounding at least one electrode to produce an energized plasma proximate to the electrode, and exposing the metallic device to the plasma prior to use of the metallic device.
In an alternate embodiment, a method of passivating a medical device is described herein and includes providing a metallic medical device, positioning at least one electrode within an atmosphere containing at least oxygen, applying energy to the electrode, forming a plasma by ionizing the atmosphere proximate to the electrode, and exposing the metallic medical device to the plasma to produce an corrosion resistant oxidation layer thereon.
In another embodiment, an oxidation treatment for a metallic stent is disclosed and includes providing a metallic stent, forming a plasma within an atmosphere containing at least oxygen, and positioning the stent within the plasma.
In addition, a corrosion resistant medical device is described and comprises a metallic body and at least a corrosion resistant oxidation layer formed on the metallic body.
BRIEF DESCRIPTION OF THE DRAWINGS
The oxidation treatment disclosed herein may be used to passivate metallic medical devices to be used within the body of a patient, thereby improving the ability of the device to resist corrosion once implanted. Generally, passivation may be described as the removal of exogenous contaminants or compounds from the surface of a metallic device. When passivating a stainless steel item, for example, exogenous iron or iron compounds may be removed from the surface of the item, thereby altering the surface chemistry thereof. In addition, the oxidation treatment disclosed herein results in formation of an oxidation layer on the surface of the item. In addition to passivating metallic devices, the oxidation treatment of the present invention provides a metallic device substantially free of organic residues, unlike conventional passivating procedures utilizing wet chemical techniques which may result in the deposition of an organic contaminants on the implantable device.
The oxidation treatment of the present invention may be used to passivate a variety of metallic devices used throughout the body of a patient. For example, a metallic vascular stent may be subjected to the oxidation treatment disclosed herein prior to implantation with the vasculature of a patient. In another embodiment, the metallic medical device may include components of a replacement joint such as a replacement ball and socket joint, a metallic heart valve, implantable screws, pins, bolts, plates, skeletonal fusion devices, spinal fusion devices, bone anchors, shunts, staples, fasteners, dental implants or devices including orthodontic braces and retainers, or other metallic devices capable of being implanted into the body of a patient. In an alternate embodiment, the oxidation treatment described herein may be used to passivate or otherwise treat a variety of medical devices used prior to, during, or following a surgical or therapeutic procedure. For example, the disclosed oxidation treatment may be used to improve the corrosion resistance of retractors, retainers, couplings, scalpels, needles, forceps, dental tools or devices, bone cutters, saws, and/or other surgical or dental tools or devices. In addition, the present oxidation treatment may be used to passive various metals, including, without limitation, stainless steel, tantalum, titanium, Nickel-Titanium alloys, shape memory alloys, super elastic alloys, low-modulus Ti-Nb-Zr alloys, and colbalt-nickel alloy steel (MP-35N).
The oxidation treatment of the present invention utilizes a commercially available corona discharge or corona treatment system to produce the electrochemical reaction resulting in the passivation of the metallic device. A voltage sufficient to ionize the surrounding environment is applied to at least one electrode. In one embodiment, approximately 18 kV of direct current (DC) may be applied to the electrode thereby generating a corona discharge proximate thereto, although any voltage or current capable of creating a corona discharge may be used. Similarly, any number of electrodes may be used in the present invention. For example, a first charged electrode may be positioned proximate to a second electrode. The first charged electrode may be separated from the second electrode by a separation gap. The electrodes may positioned within an air environment, although those skilled in the art will appreciate that the electrodes may be located within environments containing other materials or gases. For example, the electrodes may be positioned within a field containing argon, helium, neon, or xenon. The application of sufficient voltage to the first charged electrode ionizes the media surrounding the electrode, for example, oxygen, thereby forming ozone (O3) and producing a plasma between or proximate to the first and second electrodes. Further, the Applicants theorize the Ozone forming the plasma is capable of chemically reacting with various metals of the metallic device and resulting in the oxidation thereof.
The metallic device may be subjected to or positioned within the ionized environment formed proximate to the electrode. For example, a stainless steel device (for example stainless steel 316L) may be subjected to the high energy plasma generated between or proximate to at least one electrode. As a result, the atoms of ozone forming the plasma react with atoms of iron, nickel, and chromium within the stainless steel substrate material thereby forming or depositing a corrosive resistant oxidation layer thereon. Those skilled in the art will appreciate that the metallic device undergoing the oxidation treatment disclosed herein is maintained at an ambient or near ambient temperature during the treatment procedure. Unlike wet oxidation procedures which may result in the deposition of residual materials on the metallic device and may require additional cleaning processes, the metallic device treated with the method disclosed herein may be sterilized and packaged for shipment. In addition, those skilled in the art will appreciate that the oxidation treatment disclosed herein results in the deposition of a corrosion resistant layer to the metallic device in substantially less time than presently required using a wet oxidation process. In one embodiment, the metallic device may be passivated by subjecting the metallic device to the corona discharge for about 3 seconds to several minutes, although those skilled in the art will appreciate that the metallic device may be subject to the corona discharge for a considerably less or more time as desired by the manufacturer. In contrast, the present wet passivating procedures using nitric acid typically require the metallic device be exposed to the oxiding agent for a period of 15 minutes or more.
A further, non-limiting illustration of the oxidation treatment disclosed herein is illustrated in the following examples.
EXAMPLE 1Seven stainless steel S670 stents manufactured by Medtronic AVE were washed for three minutes within an ultrasound bath containing 99% isopropyl alcohol (IPA). Thereafter, the seven stents were removed from the IPA bath and dried within a gaseous flow of nitrogen.
Once dried, the scents were number 1 through 7. Sample number 1 was left untreated. Sample numbers 2 through 7 underwent passivation using the oxidation treatment disclosed herein. A corona discharge device included an electrode was positioned within an oxygen environment. Approximately 18 kV of direct current electrical energy was applied to the electrode, thereby ionizing the oxygen proximate to the electrode and resulting in the creation of a ionizing plasma. As Table 1 shows, sample numbers 2-7 were exposed to a plasma created from a corona discharge device for varying lengths of times.
Following the oxidation treatment, sample number 1 (the untreated control sample) and treated sample numbers 2-7 underwent Electron Spectroscopy for Chemical Analysis (hereinafter ESCA) to determine the effects of the oxidation treatment on the surface composition of the stents. During the ESCA process, a small diameter x-ray beam is focused across an area of each stent, thereby causing electrons to be emitted from the of each stent. The emitted electrons are collected and examined to determine the surface composition of the device under test.
As shown in
Eight stainless steel S670 stents manufactured by Medtronic AVE were washed for three minutes within an ultrasound bath containing 99% isopropyl alcohol (IPA). Thereafter, the eight stents were removed from the IPA bath and dried within a gaseous flow of Nitrogen.
Once dried, the stents were number 1 through 8. Sample numbers 6-8 were left untreated. Sample numbers 1 through 5 underwent passivation using the oxidation treatment disclosed within. A corona discharge device included an electrode was positioned within an oxygen environment. Approximately 18 kV of direct current electrical energy was applied to the electrode, thereby ionizing the oxygen proximate to the electrode and resulting in the creation of a ionizing plasma. As Table 1 shows, sample numbers 1-5 were exposed to the plasma created from a corona discharge device for varying lengths of times between 5 seconds and 10 seconds.
Thereafter, the stents were subjected to cyclic potentiodynamic corrosion testing to determine the corrosion resistance of each sample.
In light of the foregoing, cyclic potentiodynamic polarization test revealed a higher breakdown potential and an increased difference between the rest potential and the breakdown potential for the treated stents (sample numbers 1-5)than found in the untreated stents (sample number 6-8). As a result, the oxidation treatment disclosed herein reduced the treated stent's susceptibility to localized corrosion thereby improving the treated stent's resistance to corrosion.
In closing it is understood that the embodiments of the invention disclosed herein are illustrative of the principles of the invention. In addition, those skilled in the art will appreciate that the oxidation treatment described herein may be used to provide the user with a variety of corrosion resistant metallic medical device, including, for example, vascular stents, replacement joints, metallic heart valves, screws, pins, bolts, staples, fasteners, plates, skeletonal fusion devices, spinal fusion devices, bone anchors, shunts, staples, fasteners, dental implants, orthodontic braces, dental retainers, retractors, retainers, couplings, scalpels, needles, forceps, dental tools, surgical tools, bone cutters, and saws. Accordingly, the present invention is not limited to that precisely as shown and described in the present invention.
Claims
1. A method of treating a metallic medical device, comprising:
- providing a metallic medical device;
- ionizing the media surrounding at least one electrode to produce an energized plasma proximate to the electrode; and
- exposing the metallic device to the plasma prior to use of the metallic device.
2. The method of claim 1 further comprising positioning the electrode in an atmosphere containing at least one material selected from the group consisting of Oxygen, Argon, Helium, Neon, and Xenon.
3. The method of claim 1 further comprising forming an oxidation layer a surface of the metallic device.
4. The method of claim 1 wherein the metallic device is selected from the group consisting of vascular stents, replacement joints, metallic heart valves, screws, pins, bolts, staples, fasteners, plates, skeletonal fusion devices, spinal fusion devices, bone anchors, shunts, staples, fasteners, dental implants, orthodontic braces, dental retainers, retractors, retainers, couplings, scalpels, needles, forceps, dental tools, surgical tools, bone cutters, and saws.
5. The method of passivating a medical device, comprising:
- providing a metallic medical device;
- positioning at least one electrode within an atmosphere containing at least Oxygen;
- applying energy to the electrode;
- forming a plasma by ionizing the atmosphere proximate to the electrode and
- exposing the metallic medical device to the plasma to produce an corrosion resistant oxidation layer thereon.
6. The method of claim 5 wherein the metallic device is selected from the group consisting of vascular stents, replacement joints, metallic heart valves, screws, pins, bolts, staples, fasteners, plates, skeletonal fusion devices, spinal fusion devices bone anchors, shunts, staples, fasteners, dental implants, orthodontic braces, dental retainers, retractors, retainers, couplings, scalpels, needles, forceps, dental tools, surgical tools, bone cutters, and saws.
7. An oxidation treatment for a metallic stent, comprising:
- providing a metallic stent;
- forming a plasma within an atmosphere containing at least Oxygen; and
- positioning the stent within the plasma.
8. A corrosion resistant medical device, comprising:
- a metallic body; and
- at least a corrosion resistant oxidation layer formed on the metallic body.
9. The device of claim 8 wherein the metallic body is manufactured from stainless steel;
10. The device of claim 8 wherein the medical device is selected from the group consisting of vascular stents, replacement joints, metallic heart valves, screws, pins, bolts, staples, fasteners, plates, skeletonal fusion devices, spinal fusion devices, bone anchors, shunts, staples, fasteners, dental implants, orthodontic braces, dental retainers, retractors, retainers, couplings, scalpels, needles, forceps, dental tools, surgical tools, bone cutters, and saws.
Type: Application
Filed: Apr 5, 2004
Publication Date: Feb 3, 2005
Inventor: Cheng-Han Chen (Santa Rosa, CA)
Application Number: 10/818,757