Drug delivery device
A syringe-like device having a drug dispensing tip connected to a motorized handpiece. The tip may be packaged pre-loaded with an amount of a liquid or phase transition drug or may be shipped empty and loaded with a liquid or phase transition drug by the user. The motorized handpiece contains suitable sensors and controllers for precisely actuating the tip for the controlled delivery of the liquid or phase transition drug in the tip. The handpiece by contain an internal power source, such as a battery, or may be connected to an external power source and/or control unit.
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The present invention generally pertains to the delivery of ophthalmically acceptable pharmaceutically active agents to the back of the eye and more particularly to an apparatus for delivery of precise amounts of a liquid or phase transition drug under controlled back pressure and flow conditions.
BACKGROUND OF THE INVENTIONAge related macular degeneration (ARMD) is the leading cause of blindness in the elderly. It attacks the center of vision and blurs it, making reading, driving, and other detailed tasks difficult or impossible. Current estimates reveal that approximately forty percent of the population over age 75, and approximately twenty percent of the population over age 60, suffer from some degree of macular degeneration. In “wet” ARMD, the type that most often causes blindness, newly formed choroidal blood vessels (CNV) leak fluid and cause progressive damage to the retina. Two main methods of treatment are currently being performed, (a) photocoagulation and (b) the use of angiogenesis inhibitors.
Photocoagulation can be harmful to the retina and is impractical when the CNV is in proximity of the fovea. Furthermore, photocoagulation often results in recurrent CNV over time.
Angiogenesis inhibitors may be administered orally, by intraocular injections, by extraocular sub-Tennon injections, or by local implants. In the sub-Tenon injection method, a physician disposes the tip of a curved needle externally around the eye near the macula, and releases a precise amount of the drug. However, a concern with sub-Tenon delivery is that the drug must be administered slowly and under relatively low pressure so as to be retained in the tissue rather than leaking back out, around the needle.
Therefore, a need exists in the field of ophthalmology for an improved apparatus for controlled delivery of a drug to the human eye.
BRIEF SUMMARY OF THE INVENTIONThe present invention improves upon the prior art by providing a syringe-like device having a drug dispensing tip connected to a motorized handpiece. The tip may be packaged pre-loaded with an amount of a liquid or phase transition drug or may be shipped empty and loaded with a liquid or phase transition drug by the user. The motorized handpiece contains suitable sensors and controllers for precisely actuating the tip for the controlled delivery of the liquid or phase transition drug in the tip. The handpiece may contain an internal power source, such as a battery, or may be connected to an external power source and/or control unit.
Accordingly, one objective of the present invention is to provide a syringe-like device having a drug dispensing tip.
Another objective of the present invention is to provide a device for the delivery of a drug to the human eye and having a drug dispensing tip actuated by a motorized handpiece.
Yet another objective of the present invention is to provide a drug delivery device wherein the flow rate of the drug being delivered can be controlled.
Yet another objective of the present invention is to provide a drug delivery device wherein the amount of the drug being delivered can be controlled.
These and other advantages and objectives of the present invention will become apparent from the detailed description and claims that follow.
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This description is given for purposes of illustration and explanation. It will be apparent to those skilled in the relevant art that changes and modifications may be made to the invention described above without departing from its scope or spirit.
Claims
1. A drug delivery device, comprising:
- a) a handpiece;
- b) a tip having a body, the body being removably attached to the handpiece;
- c) a cannula generally located on the body opposite the handpiece;
- d) a plunger located in the tip body; and
- e) a drive mechanism located in the handpiece, the drive mechanism providing movement of the plunger when the tip is connected to the handpiece.
2. The drug delivery device of claim 1 wherein the drive mechanism comprises a piezoelectric linear motor.
3. The drug delivery device of claim 1 wherein the handpiece further comprises an internal power source for the drive mechanism.
4. The drug delivery device of claim 1 wherein the handpiece further comprises internal control electronics for the drive mechanism.
5. The drug delivery device of claim 1 further comprising external control electronics for the drive mechanism.
6. The drug delivery device of claim 1 wherein the handpiece further comprises an external power source for the drive mechanism.
Type: Application
Filed: May 17, 2006
Publication Date: Nov 22, 2007
Applicant:
Inventors: Bruno Dacquay (Irvine, CA), Michael A. Zica (Costa Mesa, CA)
Application Number: 11/435,906
International Classification: A61M 1/00 (20060101); A61M 5/00 (20060101);