ULTRASONIC TRANSDUCER ARRAY PROBE FOR SHEAR WAVE IMAGING
An ultrasonic transducer array probe (10) for shear wave imaging has a number of transducer elements which exceeds the number of transmit channels of a shear wave diagnostic imaging system. The probe includes a switch matrix or multiplexer (60) which selectively couples channels of the transmit beamformer (18) to the transducer elements of multiple shear wave apertures of the array. When the transmit beamformer is actuated, a plurality of push pulses are transmitted simultaneously to initiate shear waves in a subject.
The present application claims priority to U.S. Prov. Appl. No. 62/174,091, filed on Jun. 11, 2015, which is incorporated by reference in its entirety.
This invention relates to medical diagnostic ultrasound systems and, in particular, to an ultrasonic transducer array probe for ultrasound systems which perform measurements of tissue stiffness or elasticity using shear waves.
One of the uses of diagnostic ultrasound is to diagnose lesions in the body by tissue elasticity or stiffness. For example, breast tumors or masses with high stiffness might be malignant, whereas softer and more compliant masses are likely to be benign. Since the stiffness of a mass is known to correlate with malignancy or benignity, the ultrasonic technique known as elastography can be used to provide the clinician with evidence to aid in diagnosis and determination of a treatment regimen.
Another approach to elasticity measurement is shear wave measurement. When a point on the body is compressed, then released, the underlying tissue is compressed downward, then rebounds back up when the compressive force is released. But since the tissue under the compressive force is continuously joined to surrounding tissue, the uncompressed tissue lateral of the force vector will respond to the up-and-down movement of the compressed tissue. A rippling effect in this lateral direction, referred to as a shear wave, is the response in the surrounding tissue to the downward compressive force. Furthermore, it has been determined that the force needed to push the tissue downward can be produced by the radiation pressure from an ultrasound pulse, commonly called a “push pulse.” After the compressive force of the push pulse has ended and the tissue springs back, initiating the orthogonal shear wave, ultrasound reception can be used to sense and measure the tissue motion induced by the shear waves. Shear wave velocity is determined by local tissue mechanical properties. The shear wave will travel at one velocity through soft tissue, and at another, higher velocity through hard tissue. By measuring the velocity of the shear wave at a point in the body, information is obtained as to characteristics of the tissue such as its shear elasticity modulus, Young's modulus, and dynamic shear viscosity. The laterally propagating shear wave travels slowly, usually a few meters per second or less, making the shear wave susceptible to detection, although it attenuates rapidly over a few centimeters or less. See, for example, U.S. Pat. No. 5,606,971 (Sarvazyan) and U.S. Pat. No. 5,810,731 (Sarvazyan et al.) Since the same “push pulse” can be repeated for each measurement, the shear wave technique lends itself to objective quantification of tissue characteristics with ultrasound. Furthermore, the shear wave velocity is independent of the push pulse intensity, making the measurement less dependent upon the user.
But it requires time to acquire a series of data sets for shear wave analysis. As previously mentioned, the shear waves rapidly attenuate in the tissue. Furthermore, the tissue displacement caused by an ultrasonic push pulse is tiny, generally on the order of 30 micrometers or less. Consequently, it is usually necessary to repeat the shear wave measurement every few millimeters throughout the tissue being diagnosed. It would thus be desirable to be able to shorten the time required to make the necessary shear wave measurements throughout the tissue or organ being diagnosed, as by making several measurements simultaneously or generating shear waves of greater amplitude which can still be detected after passage through a greater tissue distance.
In some aspects, the present invention includes ultrasound systems. For example, the present invention includes an ultrasound system performing shear wave analysis. The ultrasound system can include a probe and a transmit beamformer with a given number of transmit channels. The system can also include an ultrasonic transducer array, located in the probe, and having a number of transducer elements that exceeds the given number. The system can include a switch multiplexer coupled between the transmit channels of the beamformer and the elements of the transducer array and can be configured to selectively couple each of the given number of transmit channels to transducer elements of a plurality of transmit apertures of a push pulse. The system can be configured to transmit a plurality of push pulses simultaneously when transmit channels of the beamformer are coupled to transducer elements of the plurality of transmit apertures.
In certain aspects, each transmit channel further includes a transmit signal source and an amplifier. The transmit signal source can include one of a pulser or a digital memory storing a transmit waveform in digital form. The switch matrix or multiplexer can include a plurality of single pole, single throw switches. The system can be configured to selectively connect each transmit channel by the closure of one or more of the plurality of switches to the at least one transducer element.
In some embodiments, a size of one of the transmit apertures is equal to a given number of transducer elements. The number of channels of the transmit beamformer can be 128 and a size of one of the transmit apertures is equal to 128 transducer elements. The system can also include a probe cable having signal lines coupling the transmit channels of the transmit beamformer to the switch multiplexer. The probe can include a probe handle and a distal end, wherein the switch multiplexer is located in the probe handle and the transducer array is located in the distal end. Alternatively, the probe can include a probe handle and a distal end, wherein the switch multiplexer and the transducer array are located in the distal end. In some aspects, the system can include a probe connector and a probe cable having signal lines coupling the probe connector to the transducer array, wherein the switch multiplexer is located in the probe connector.
In some aspects, the present invention can include methods for operating an ultrasound system. For example, the present invention can include a method for operating an ultrasound system to measure shear waves, the ultrasound system having a given number of transmit channels each having a signal source, and an ultrasonic array transducer having a number of transducer elements which is greater than the given number and a switch multiplexer of switches coupling the transmit channels to the transducer elements. The method can include closing switches of the switch multiplexer to couple transmit channels to transducer elements of more than one push pulse transmit aperture, wherein each of a plurality of individual channels is coupled to the transducer elements of a plurality of push pulse transmit apertures, and actuating the signal sources of the transmit channels to simultaneously transmit a plurality of push pulses from the array transducer. In certain aspects, the actuating can include actuating the signal sources of the transmit channels to simultaneously transmit a plurality of identical push pulses in parallel from the ultrasonic array transducer. The number of transducer elements of two apertures of the plurality of push pulse transmit apertures can be greater than the given number of transmit channels. The methods can also include repeating the closing and actuating steps with the closed switches changed to couple the transmit channels to transducer elements of different push pulse transmit apertures in the plurality.
In the drawings:
In some embodiments, the present invention includes an ultrasonic array transducer probe is described which is capable of transmitting multiple simultaneous push pulses for shear wave imaging. The probe is operated by switches of a switch matrix or multiplexer which can be set to couple individual channels of an ultrasound system transmit beamformer to multiple elements of different transmit apertures of the array transducer. The transmit beamformer can thereby transmit multiple, laterally separate push pulses from different probe apertures at the same time, causing multiple shear waves to be generated for interrogation at the same time or the development of constructive interference in the form of a stronger shear wave amplitude in the body.
The subject of the present invention is an ultrasound probe suitable for use in shear wave imaging procedures to transmit multiple simultaneous push pulses for the stimulation of shear waves. A preferred probe is designed for use with a standard ultrasound system beamformer which may have fewer transmit channels than the number of elements of the probe's transducer array. For instance, this permits a probe with a transducer array of more than 128 elements to be used with a standard transmit beamformer of 128 channels. This is accomplished by a switch matrix or switch multiplexer that selectively connects channels of the transmit beamformer to transducer elements of multiple apertures so that the transmission will result in multiple push pulses being transmitted from the multiple transducer apertures. Probes have been used with multiplexers in the past to selectively connect beamformer channels to elements of the array transducer. A familiar example is the switching of the active aperture along the array of a linear array probe, an operation commonly referred to as “tractor-treading.” For instance, eight channels of a beamformer may be translated from one end of a 128-element array to the other to transmit and receive a beam at each position along the array. Both the transmit and receive apertures are switched along the array, and the switching is conventionally done in the system beamformer, not the probe itself. Only one beam is sent and received at a time. U.S. Pat. No. 8,161,817 (Robinson et al.) illustrates tractor-treading of received signals to the receive beamformer by a probe microbeamformer in a two-dimensional array transducer. Another well-known use of switching a probe is known as synthetic aperture, commonly done when there are fewer receive beamformer channels than there are transducer elements. In this technique, transmission is done twice with the full transducer aperture, and reception is done of different halves of the aperture each time. The received half-apertures are then combined to form the full aperture, as described, for instance, in U.S. Pat. No. 6,050,942 (Rust et al.) There must be sufficient transmit channels to transmit over the full aperture each time, however. Another technique in which fewer beamformer channels than array elements are used is known as a folded aperture, which takes advantage of aperture symmetry to send and receive signals on pairs of transducer elements. For instance, consider a five-element aperture of elements 1-5, with element #3 being the center element. The elements can be paired so that elements #1 and #5 are connected to a single beamformer channel on receive, as are elements #2 and #4, with center element #3 connected to its own channel for beamforming. See, for example, U.S. Pat. No. 5,893,363 (Little et al.) The same pairing can be done on transmit. Folded apertures however can only be used to steer beams straight ahead; when beams are steered from side to side the symmetrically-located elements require different delays and pairing cannot be done.
The foregoing examples are mainly of element and channel switching during reception and all transmission and reception being of only one beam at a time. The reason for this is that ultrasound is used principally for imaging and the use of multiple transmit beams during imaging will cause image degradation known as clutter. On reception, the signals received for a receive beam from one transmit beam will be contaminated with echoes received from the other transmit beam which will appear in the reconstructed image as clutter. A number of proposals have been put forward for multiple beam transmission because it should decrease the time to scan the image field and hence increase the frame rate of display. U.S. Pat. No. 7,537,567 (Jago et al.) is one such proposal, which attempts to reduce the clutter by transmitting the multiple simultaneous imaging beams in sharply divergent directions. The inventors recognize the clutter problem as shown by the several precautions they recommend at the end of the patent to minimize the problem. The present inventors have taken advantage of the fact that shear wave imaging is not conventional pulse-echo imaging, but has as its purpose the measurement of a laterally propagating shear wave resulting from a push pulse. The echoes returned from the push pulse transmission itself are not used for anatomical imaging and consequently image clutter is not an issue.
The question arises in designing an implementation of the present invention of where to locate the switches of the matrix or multiplexer. In linear array imaging as described above, the switches for aperture switching are in the system mainframe, generally at the output of the beamformer. An implementation of the present invention can locate the switches in the system mainframe if desired, but this would create in most instances the need for a non-standard system beamformer and transducer socket. One desire of an implementation of the present invention is that it be used with a standard ultrasound system with standard probe sockets. This leads to a second possible location, the probe connector at the end of the probe cable which connects the probe to the system mainframe. It is known, for instance, to locate the amplifier for a therapy probe in the probe connector as shown in US Pat. pub. no. 2008/0228075 (Fraser et al.), and also to locate memory devices there which inform the ultrasound system of performance characteristics of the probe as described in U.S. Pat. No. 4,868,476 (Respaut). However, locating the switches in the probe connector will cause the cable to have a large number of signal conductors, one for each element of the array, undesirably increasing the size and weight of the probe cable. Hence the preferred location for the switches is in the probe case itself, which enables both a lightweight probe cable and use of the probe with a standard ultrasound system.
Referring now to
Following push pulse transmission, the switches of the matrix or multiplexer 60 are opened and the array 12 is operated to sample and measure the resultant shear wave. When the system of
It should be noted that the various embodiments described above and illustrated, e.g., by the exemplary ultrasound system of
As used herein, the term “computer” or “module” or “processor” may include any processor-based or microprocessor-based system including systems using microcontrollers, reduced instruction set computers (RISC), ASICs, logic circuits, and any other circuit or processor capable of executing the functions described herein. The above examples are exemplary only, and are thus not intended to limit in any way the definition and/or meaning of these terms.
The computer or processor executes a set of instructions that are stored in one or more storage elements, in order to process input data. The storage elements may also store data or other information as desired or needed. The storage element may be in the form of an information source or a physical memory element within a processing machine.
The set of instructions may include various commands that instruct the computer or processor as a processing machine to perform specific operations such as the methods and processes of the various embodiments of the invention. The set of instructions may be in the form of a software program. The software may be in various forms such as system software or application software and which may be embodied as a tangible and non-transitory computer readable medium. Further, the software may be in the form of a collection of separate programs or modules, a program module within a larger program or a portion of a program module. The software also may include modular programming in the form of object-oriented programming. The processing of input data by the processing machine may be in response to operator commands, or in response to results of previous processing, or in response to a request made by another processing machine.
Furthermore, the limitations of the following claims are not written in means-plus-function format and are not intended to be interpreted based on 35 U.S.C. 112, sixth paragraph, unless and until such claim limitations expressly use the phrase “means for” followed by a statement of function devoid of further structure.
Claims
1. An ultrasound system performing shear wave analysis, the ultrasound system comprising a probe and having a transmit beamformer with a given number of transmit channels, the system comprising:
- an ultrasonic transducer array, located in the probe, and having a number of transducer elements that exceeds the given number; and
- a switch multiplexer coupled between the transmit channels of the beamformer and the elements of the transducer array and configured to selectively couple each of the given number of transmit channels to transducer elements of a plurality of transmit apertures of a push pulse,
- wherein the system is configured to transmit a plurality of push pulses simultaneously when transmit channels of the beamformer are coupled to transducer elements of the plurality of transmit apertures.
2. The ultrasound system of claim 1, wherein each transmit channel further comprises a transmit signal source and an amplifier.
3. The ultrasound system of claim 2, wherein the transmit signal source comprises one of a pulser or a digital memory storing a transmit waveform in digital form.
4. The ultrasound system of claim 1, wherein the switch matrix or multiplexer comprises a plurality of single pole, single throw switches.
5. The ultrasound system of claim 4, wherein the system is configured to selectively connect each transmit channel by the closure of one or more of the plurality of switches to the at least one transducer element.
6. The ultrasound system of claim 1, wherein a size of one of the transmit apertures is equal to a given number of transducer elements.
7. The ultrasound system of claim 1, wherein the number of channels of the transmit beamformer is 128 and a size of one of the transmit apertures is equal to 128 transducer elements.
8. The ultrasound system of claim 1, further comprising a probe cable having signal lines coupling the transmit channels of the transmit beamformer to the switch multiplexer.
9. The ultrasound system of claim 8, wherein the probe further comprises a probe handle and a distal end,
- wherein the switch multiplexer is located in the probe handle and the transducer array is located in the distal end.
10. The ultrasound system of claim 8, wherein the probe further comprises a probe handle and a distal end,
- wherein the switch multiplexer and the transducer array are located in the distal end.
11. The ultrasound system of claim 1, further comprising a probe connector and a probe cable having signal lines coupling the probe connector to the transducer array,
- wherein the switch multiplexer is located in the probe connector.
12. A method for operating an ultrasound system to measure shear waves, the ultrasound system having a given number of transmit channels each having a signal source, and an ultrasonic array transducer having a number of transducer elements which is greater than the given number and a switch multiplexer of switches coupling the transmit channels to the transducer elements, the method comprising:
- closing switches of the switch multiplexer to couple transmit channels to transducer elements of more than one push pulse transmit aperture, wherein each of a plurality of individual channels is coupled to the transducer elements of a plurality of push pulse transmit apertures; and
- actuating the signal sources of the transmit channels to simultaneously transmit a plurality of push pulses from the array transducer.
13. The method of claim 12, wherein the actuating comprises actuating the signal sources of the transmit channels to simultaneously transmit a plurality of identical push pulses in parallel from the ultrasonic array transducer.
14. The method of claim 12, wherein the number of transducer elements of two apertures of the plurality of push pulse transmit apertures is greater than the given number of transmit channels.
15. The method of claim 12, further comprising repeating the closing and actuating steps with the closed switches changed to couple the transmit channels to transducer elements of different push pulse transmit apertures in the plurality.
Type: Application
Filed: May 31, 2016
Publication Date: Jun 14, 2018
Inventors: NEIL OWEN (EINDHOVEN), VIJAY THAKUR SHAMDASANI (EINDHOVEN), HARRY AMON KUNKEL (EINDHOVEN), SAMUEL RAYMOND PETERS (EINDHOVEN)
Application Number: 15/580,314