Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising administering a compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof. ##STR1##
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Claims
1. A compound which is trans-retinoyloxymethyl butyrate.
2. A pharmaceutical composition useful for the treatment of cancer and other proliferative diseases comprising a therapeutically-effective amount of a compound of claim 1 and a pharmaceutically-effective carrier of diluent.
3. The pharmaceutical composition of claim 2 wherein said disorder is a leukemia.
4. A pharmaceutical composition useful as a differentiating agent or an anti-proliferation agent comprising a therapeutically-effective amount of a compound of claim 1 and a pharmaceutically-effective carrier or diluent.
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Type: Grant
Filed: Sep 16, 1994
Date of Patent: Jan 20, 1998
Assignees: Bar-Ilan University , Kupat Holim Health Insurance Institution of the General Federation of Labor
Inventors: Ada Rephaeli (Palo Alto, CA), Abraham Nudelman (Rehovot)
Primary Examiner: Johann Richter
Assistant Examiner: Laura L. Stockton
Law Firm: Kenyon & Kenyon
Application Number: 8/306,422
International Classification: C07C40310; A61K 31225; G01N 3348;
