Biological Cellular Material Tested Patents (Class 436/63)
  • Patent number: 11449987
    Abstract: A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial thickness or gland lumen roundness of the tissue, wherein an increase in epithelial thickness or a decrease in gland lumen roundness indicates the presence of prostate cancer or a prostate cancer field defect.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: September 20, 2022
    Assignees: Wisconsin Alumni Research Foundation, The Medical College of Wisconsin, Inc.
    Inventors: David Frazier Jarrard, Bing Yang, Peter LaViolette
  • Patent number: 11442056
    Abstract: Embodiments herein include a method for detecting a brain condition in a subject. The method can include obtaining a breath sample from the subject and contacting it with a chemical sensor element, where the chemical sensor element includes a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set and classifying the sample data set into one or more preestablished brain condition classifications. Other embodiments are also included herein.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: September 13, 2022
    Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, Boston Scientific Scimed, Inc.
    Inventors: Gregory Kermit Peterson, Justin Theodore Nelson, Gregory J. Sherwood
  • Patent number: 11442055
    Abstract: The invention relates to a method for detecting an analyte present in a liquid specimen, including: injecting the liquid specimen into a detection chamber, the detection chamber having a non-zero volume enclosing polymeric beads covered with a reagent suitable for the analyte to be detected; capturing at least one image of at least one region of the detection chamber using a sensor; processing the image acquired by the sensor, which includes determining a texture level of the acquired image; and determining a concentration of the analyte depending on the texture level determined for the image.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: September 13, 2022
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Myriam-Laure Cubizolles, Thomas Bordy, Frederic Revol-Cavalier
  • Patent number: 11442073
    Abstract: Disclosed are methods and systems for measuring serotonin in a sample using liquid chromatography and mass spectrometry.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: September 13, 2022
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Matthew Lee Francis Crawford, Yvonne Zamorano Wright, Russell Philip Grant
  • Patent number: 11428682
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: August 30, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Nigel Clarke
  • Patent number: 11421270
    Abstract: Embodiments disclosed herein provide reagents and methods for high-throughput screening of nucleic acid sequence variations in nucleic acid containing specimens. Nucleic acid specimens to be screened are loaded into separate discrete volumes. Optically encoded particles are used to deliver primers to amplify one or more sequences comprising the nucleic acid sequence variation. The optically encoded particles may be delivered to the discrete volumes randomly resulting in a random combination of optically encoded particles in each well, or a unique combination of optically encoded particles may be specifically assigned to each discrete volume. The observable combination of optically encoded particles may then be used to identify each discrete volume.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 23, 2022
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: David Feldman, Daniel Sazer, Paul Blainey
  • Patent number: 11403861
    Abstract: Automated stain finding. In an embodiment, an image of a sample comprising one or more stains is received. For each of a plurality of pixels in the image, an optical density vector for the pixel is determined. The optical density vector comprises a value for each of the one or more stains, and represents a point in an optical density space that has a number of dimensions equal to a number of the one or more stains. The optical density vectors are transformed from the optical density space into a representation in a lower dimensional space. The lower dimensional space has a number of dimensions equal to one less than the number of dimensions of the optical density space. An optical density vector corresponding to each of the one or more stains is identified based on the representation.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 2, 2022
    Assignee: LEICA BIOSYSTEMS IMAGING, INC.
    Inventors: Walter Georgescu, Bharat Annaldas, Allen Olson, Kiran Saligrama
  • Patent number: 11391630
    Abstract: A spectrum measuring device according to the present disclosure includes an accommodation part having a space for accommodating a culture solution containing a medium and cells, a light source device for irradiating a first surface of the space with excitation light, a light receiving device for receiving fluorescence occurring from the first surface, and an arithmetic device for spectral analysis of the fluorescence received by the light receiving device. In the space, the depth from the first surface of a fluorescence region where fluorescence is produced by incident excitation light is a value giving an internal shield of a prescribed level of less in the fluorescence region. The arithmetic device calculates the fluorescence spectrum of the cells by subtracting the fluorescence spectrum of the medium from the spectrum of the fluorescence of the culture solution obtained by the light receiving device.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: July 19, 2022
    Assignee: AZBIL CORPORATION
    Inventor: Norio Hasegawa
  • Patent number: 11366101
    Abstract: Provided are ex vivo systems and methods of predicting the response of a drug or other agent on a tissue. In some embodiments, the systems and methods comprise cutting a tissue into tissue fragments, adding a drug or other agent to the tissue fragments based on an estimated tumor content, and performing an ex vivo measurement on the tissue fragments.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: June 21, 2022
    Assignee: Elephas Biosciences Corporation
    Inventors: Jonathan Daniel Oliner, Neil Anthony, Sean Caenepeel, Laura Catherine Funk Hrycyniak, John Rafter, Tomasz Zal
  • Patent number: 11365213
    Abstract: Disclosed are a composition for clearing spheroids, a method for clearing spheroids using same, and a kit comprising same. The composition for clearing spheroids can clear the spheroids in a convenient and rapid manner and thus may be usefully used for imaging of spheroids and in identifying the causes of various diseases, treating the diseases, and predicting the therapeutic effects and toxicity of drugs. In addition, the composition may be used in combination with various medical devices, and in particular, can be prepared as a kit and usefully used as an in vitro medical diagnostic device.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: June 21, 2022
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Ki-Suk Kim, Sun Hyun Park
  • Patent number: 11340240
    Abstract: A method for determining the fat processing activity and/or predicting the risk of obesity in a subject involves determining the level of pro-neurotensin or fragments thereof of at least 5 amino acids in a bodily fluid obtained from the subject, and correlating the level of pro-neurotensin or fragments thereof with fat processing activity and/or the risk of incidence of obesity in the subject. An elevated level is indicative of enhanced fat processing activity and/or predictive for an enhanced risk of getting obesity.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: May 24, 2022
    Assignee: SPHINGOTEC GMBH
    Inventors: Andreas Bergmann, Olle Melander
  • Patent number: 11253853
    Abstract: Fluidic devices and methods are provided.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: February 22, 2022
    Assignee: OPKO Diagnostics, LLC
    Inventors: Matthew Dirckx, Jason Taylor, Vincent Linder
  • Patent number: 11243201
    Abstract: The present invention provides devices, systems, and methods, for performing biological and chemical assays.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: February 8, 2022
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
  • Patent number: 11181537
    Abstract: The invention relates to the detection of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: November 23, 2021
    Assignee: Quest Diagnostics Investments Incoporated
    Inventors: Scott M. Goldman, Julie A. Neidich
  • Patent number: 11168108
    Abstract: The present invention provides a composition for adjusting biological tissue size and a method for adjusting the size of biological tissue using the said composition. The composition for adjusting the size of biological tissue according to the present invention can adjust the size of biological tissue according to the specifications of a microscope and the needs of a researcher, and can be used as a mounting solution to easily acquire an image of the biological tissue. Therefore, the composition can be usefully used to reveal the causes of and find treatment methods for various disorders.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: November 9, 2021
    Inventors: Ki-Suk Kim, Sun Hyun Park, Dae-hwan Nam
  • Patent number: 11110456
    Abstract: A microfluidic bead-packing method includes activating a first micropump to transfer active microbeads through an inlet microchannel from a bead suspension reservoir to an adsorbing channel; packing the microbeads in the adsorbing channel; and activating a second micropump to reverse flow through at least a portion of the inlet microchannel and to transfer a sample fluid through the inlet microchannel from a sample reservoir to the adsorbing channel such that the sample fluid interacts with the packed microbeads.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: September 7, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Pavel Kornilovich, Alexander Govyadinov, David P. Markel, Erik D. Torniainen
  • Patent number: 11104880
    Abstract: A system for sorting a mixture of sperm cells in a fluid flow path, including stained sperm cells from two distinguishable groups, namely X chromosome bearing sperm and Y chromosome bearing sperm. The system and method can include an electromagnetic radiation source for exciting fluorescence emissions from the stained particles, a photodetector for detecting the fluorescence emissions from the stained particles, a processor for classifying the stained particles; and a photo-damaging laser for damaging selected particles in the flow path.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: August 31, 2021
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Patent number: 11054411
    Abstract: A method of controlling a blood analyzer for measuring platelets is provided. The method comprises: determining a relationship between at least one first measurement value obtained by detecting platelets in at least one previous test by an electrical type detector of the blood analyzer and at least one second measurement value obtained by detecting the platelets in the at least one previous test by an optical type detector of the blood analyzer, and controlling the blood analyzer to prepare the first and/or second measurement sample for a current test according to the determined relationship.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: July 6, 2021
    Assignee: Sysmex Corporation
    Inventors: Jo Linssen, Pieter Steenhuis
  • Patent number: 11016062
    Abstract: A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: May 25, 2021
    Assignees: University of South Florida, TransGenex Nanobiotech, Inc.
    Inventors: Shyam S. Mohapatra, Subhra Mohapatra, Rasim Oytun Guldiken, Rajesh R. Nair, Tao Wang
  • Patent number: 10928401
    Abstract: The present disclosure provided methods and systems for diagnosing diseases and monitoring their progression and therapeutic responses by detecting a presence or absence, or an increase or decrease, of one or more substances in a sample.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: February 23, 2021
    Assignee: NEWOMICS INC.
    Inventors: Daojing Wang, Pan Mao
  • Patent number: 10859586
    Abstract: Disclosed are methods and systems for measuring serotonin in a sample using liquid chromatography and mass spectrometry.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: December 8, 2020
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Matthew Lee Francis Crawford, Yvonne Zamorano Wright, Russell Philip Grant
  • Patent number: 10830746
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: November 10, 2020
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Nigel Clarke
  • Patent number: 10821441
    Abstract: A microfluidic device includes a substrate and a cover. The substrate has an inlet port, a first microchannel, one or more parking loops, a second microchannel and an outlet port for each microchannel network. The first microchannel is connected to the inlet port, the second microchannel is connected to the outlet port, the parking loops are connected between the first and second microchannels. Each parking loop includes a parking loop inlet, a parking loop output, a fluidic trap connected between the parking loop inlet and the parking loop outlet, and a bypass microchannel connected to the parking loop inlet and the parking loop outlet. The cover is attached to a top of the substrate and has an inlet opening and an outlet opening through the cover for each microchannel network. The inlet and outlet openings of the cover are disposed above the inlet and outlet ports in the substrate.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 3, 2020
    Assignee: Texas Tech Univeristy System
    Inventors: Siva A. Vanapalli, Swastika S. Bithi
  • Patent number: 10683496
    Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: June 16, 2020
    Assignee: General Electric Company
    Inventors: Lin Chen, Bing Zhang, Klaus Hochleitner, Rong Hou, Yanju Wang
  • Patent number: 10585080
    Abstract: A pressure sensor and its use for visually determining whether a preselected pressure threshold has been achieved, for example during high pressure processing treatment of a foodstuff. The pressure sensor includes a contained color-changing system having a dye, a developer, and a solvent; upon achievement of the preselected pressure threshold, the dye and the developer interact, resulting in a visible color change. Further, the visible color change can be retained upon a decrease in pressure and upon an increase in temperature, thereby effectively recording the achievement of the preselected pressure threshold during the high pressure processing treatment.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: March 10, 2020
    Assignee: Chromatic Technologies, Inc.
    Inventors: Ruizheng Wang, Timothy J. Owen, Lyle D. Small
  • Patent number: 10569272
    Abstract: A sorting device (10) is disclosed comprising a channel (40) adapted to allow passage of a plurality of samples in a fluid to a first side of a sorting junction (50) and a plurality of Braille valves (105) connected by a plurality of connectors to the sorting junction (50). An analysis device (80), such as a camera, is used for analysing ones of the plurality of the samples and adapted to control ones of the plurality of Braille valves depending on properties of the analysed ones of the plurality of the samples.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: February 25, 2020
    Assignee: EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Christoph Merten, Qingzong Tseng, Ramesh Utharala, Lukas Frese
  • Patent number: 10534008
    Abstract: The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: January 14, 2020
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Scott M. Goldman, Julie A. Neidich
  • Patent number: 10458980
    Abstract: A method of preparing a cantilever sensor for measuring biochemical interactions and their associated stress wherein a cantilever having two sides is coated on one side with at least a gold layer and both sides of the cantilever are functionalized with a self-assembled monolayer (SAM) of a probe molecule by incubating the cantilever in a solution having a concentration of the probe molecule of between 1 to 1000 ?M. The unpassivated cantilever sensor comprising a layer coated on one side with a coating comprising gold and being unpassivated on the opposite side, wherein both surfaces comprises a self-assembled monolayer of a probe molecule in which the surface area occupied per probe molecule varies in the range 0.4-1.5 nm2, enabling the stress at the gold top surface that is not cancelled out by a counter stress from the bottom surface so that accurate quantitation of a target molecule is achieved.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 29, 2019
    Assignee: 3P SENSE LIMITED
    Inventors: Joseph Wafula Ndieyira, Samadhan Patil, Giuseppe Mazza, Massimo Pinzani
  • Patent number: 10338369
    Abstract: A method for setting an evaluation parameter for a fluorescence microscope includes exciting dye particles in a sample to fluoresce and detecting fluorescent light from the particles. A graphical representation of a distribution of the fluorescent light is determined and a signal is generated for use in displaying the graphical representation on a display unit. Each subregion of the graphical representation is associated with a comparison value that is representative of a light quantity in the subregion. A predefined threshold is used as an evaluation parameter and compared to the comparison values. The subregions having a comparison value that is greater than the threshold value are marked on the display unit with predefined markings. The threshold value is changed and the comparison values are compared to the changed threshold value. The marked regions are defined as events and a complete image of the sample is obtained based on the events.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: July 2, 2019
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Jonas Foelling
  • Patent number: 10279345
    Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may include an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In certain embodiments, the detection channel may be used to provide feedback on the extent of incubation and/or mixing. Based on the feedback, one or more component of the fluidic system may be regulated to allow the requisite degree of mixing and/or incubation to be achieved.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: May 7, 2019
    Assignee: OPKO Diagnostics, LLC
    Inventors: Matthew Dirckx, Jason Taylor, Vincent Linder
  • Patent number: 10234397
    Abstract: A reagent for detection of urine monophenolic metabolites and a method for preparing the reagent are disclosed, in which the monophenolic metabolites, for example, tyrosine, p-hydroxyphenyl alanine, tryptophan and 5-hydroxyindoleacetic acid can serve as tumor markers. The reagent for detection of urine monophenolic metabolites is an aqueous solution containing nitric acid, sulfuric acid, mercuric sulfate, mercurous nitrate, nickel nitrate, phosphomolybdic acid and cobalt sulfate. The preparation method includes preparation of solutions A, B, C, D and E, and mixing.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 19, 2019
    Assignee: JIANGSU DONGBO BIO-PHARMACEUTICAL CO. LTD.
    Inventors: Dong Liu, Lei Li, Mingbin Zheng
  • Patent number: 10190963
    Abstract: Methods and systems are disclosed for generating an entrainment factor in a flow cytometry sample. The methods comprise flowing a sample with a series of particles through the flow cytometer, detecting events and calculating an expected frequency of those events based on a distribution, such as a Poisson distribution, and measuring an observed frequency of particle events. An entrainment factor may be generated from a ratio of observed event frequency to expected event frequency. Further adjustment to the flow cytometer maybe performed based on the indicated entrainment factor such as adjusted sorting bias.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: January 29, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Joseph Trotter, Sujata Iyer
  • Patent number: 10126232
    Abstract: A sample test method, microfluidic device, and test device efficiently and accurately compensates for interference of an interfering substance present in a sample using optical measurement without addition of a separate reagent for detecting the interfering substance. The sample test method includes: measuring an optical characteristic value of a target substance present in a sample; measuring an optical characteristic value of an interfering substance present in the sample; and determining a concentration of the target substance for which interference of the interfering substance is compensated for based on the optical characteristic value of the interfering substance.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: November 13, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sung Ha Park, Sang Bum Park, Beom Seok Lee, Kui Hyun Kim, Joo Hee Park, Kyung Mi Song, Euy Hyun Cho, Ha Na Kim
  • Patent number: 10113774
    Abstract: Materials, components, and methods consistent with the present invention are directed to the fabrication and use of micro-scale channels with a fluid, where the temperature and flow of the fluid is controlled through the geometry of the micro-scale channel and the configuration of at least a portion of the wall of the micro-scale channel and the constituent particles that make up the fluid. Moreover, the wall of the micro-scale channel and the constituent particles are configured such that collisions between the constituent particles and the wall are substantially specular.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: October 30, 2018
    Assignee: Forced Physics, LLC
    Inventor: Scott Davis
  • Patent number: 10035848
    Abstract: An anti-C3d antibody or antibody fragment; method for use thereof to kill cancer cells; and related methods and compositions.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: July 31, 2018
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Virginia Patent Foundation
    Inventors: Adrian U. Wiestner, Martin W. Skarzynski, Margaret A. Lindorfer, Ronald P. Taylor, Christoph Rader, Berengere Vire
  • Patent number: 10006840
    Abstract: The present invention provides methods and compositions for separating cells from a sample containing erythrocytes. The method is for recovering desired cells from a sample containing the desired cells, erythrocytes and undesired cells comprising: a) contacting the sample with a composition, said composition comprising: i) an erythrocytes aggregation reagent ii) at least one antigen recognizing moiety coupled to a magnetic particle, wherein said particle with said at least one antigen recognizing moiety specifically binds to at least one antigen specific for one or more undesired cellular components; b) applying simultaneously i) gravity sedimentation for sedimentation of erythrocytes and ii) a magnetic field gradient to said sample for immobilizing said magnetic particle generating a pellet and a supernatant phase, and c) recovering the desired cells from the supernatant phase. Compositions for the use within the present method are also disclosed.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: June 26, 2018
    Assignee: Miltenyi Biotec GmbH
    Inventors: Burgund Kauling, Volker Huppert
  • Patent number: 9975913
    Abstract: The present invention relates to a method for in-gel visual detection and quantitative detection of proteins in activity based protein profiling (ABPP) using horseradish peroxidase mimic FeIII-TAML complex of ligand as a catalytic probe. The invention further relates to kit comprising compounds of formula (I) and method for the detection of bioanalytes using kit comprising compounds of formula (I).
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: May 22, 2018
    Assignee: Council of Scientific & Industrial Research
    Inventors: Sayam Sen Gupta, Sushma Kumari, Chakadola Panda
  • Patent number: 9966458
    Abstract: The present invention relates to a method and a device for providing a current of spin-polarized electrons. More particularly, the present invention is suited for use in spin electronics or detection of spin-polarized electrons.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: May 8, 2018
    Assignees: Westfälische Wilhelms Universität Münster, Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Benjamin Göhler, Volker Hamelbeck, G. Friedrich Hanne, Helmut Zacharias, Ron Naaman, Tal Zvi Markus
  • Patent number: 9897530
    Abstract: Apparatus and methods for detecting, characterizing, and compensating motion-related error of moving micro-entities are described. Motion-related error may occur in streams of moving micro-entities, and may represent a deviation in and expected arrival time or an uncertainty in position of a micro-entity within the stream. Motion-related error of micro-entities is observed in a flow cytometer, e.g., as pulse jitter, and is found to have a functional dependence on a parameter of the system. The pulse jitter can be compensated, according to one embodiment, by adjusting data acquisition observation windows. For the flow cytometer, a reduction of pulse jitter can improve measurement accuracy, resolution of doublets, system throughput, and enable an increase in an interrogation region for probing the micro-entities.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: February 20, 2018
    Assignees: Sony Corporation, Sony Corporation of America
    Inventors: Gary Durack, Stephen D. Fleischer, Jeremy Hatcher, David Roberts, Michael Zordan
  • Patent number: 9874537
    Abstract: The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: January 23, 2018
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventor: Masaki Fujiwara
  • Patent number: 9857361
    Abstract: The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: January 2, 2018
    Assignee: IRIS International, Inc.
    Inventors: Bart J. Wanders, Eric Chapoulaud, Brett Jordan
  • Patent number: 9835606
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: December 5, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Nigel Clarke
  • Patent number: 9829436
    Abstract: The present invention relates to enhancement of detectable emissions from carbon nanodots or variants thereof by using the techniques of MEF to further enhance carbon nanodot brightness, photostability, and thus, potentially detectability in biological imaging applications by using plasmon supporting materials, such as silver island films and positioning of the carbon nanodots an optimal distance from the plasmon supporting materials.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: November 28, 2017
    Inventor: Chris D. Geddes
  • Patent number: 9830553
    Abstract: A code book is generated for mapping source to target code words which allows encoding source data at reduced probability of incorrect decoding, e.g. for DNA storage. The target code words are grouped (102) into subsets and comprise identifying and remaining portions. The identifying portions of target code words corresponding to a same subset are identical. A first code symbol set of source code words is selected (103) for addressing the subsets. For the subsets, neighboring subsets are determined (104). The identifying portions of the target code words of neighboring subsets differ from those of the corresponding subset by up to a predetermined amount of symbols. Source code words are assigned (105) where the corresponding first code symbols address the same subset to said subset such that an amount of target code words of said subset having their remaining portions identical to their neighboring subsets corresponds to an optimization criterion.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: November 28, 2017
    Assignee: THOMSON LICENSING
    Inventors: Xiaoming Chen, Meinolf Blawat, Klaus Gaedke, Ingo Huetter
  • Patent number: 9817003
    Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort including centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using 9-oxo-ODE as biomarker.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: November 14, 2017
    Assignee: NESTEC S.A.
    Inventors: Sebastiano Collino, Ivan Montoliu Roura, Francois-Pierre Martin, Philippe Alexandre Guy, Serge Andre Dominique Rezzi
  • Patent number: 9802192
    Abstract: A sorting chamber (1) for sorting first particles (25) from second particles (26) comprising: an internal chamber (7), which is delimited by a base wall (2), a top wall (4), and a spacer (6), set between the base wall (2) and the top wall (4); an internal chamber (7), which is at least partially-delimited by the base wall (2) and top wall (4); two passages (8), which set in communication the internal chamber (7) with the external environment; and a plurality of cavities (9), which are designed to house the first particles (25), are made in the base wall (2) and have openings (10) towards the internal chamber (7) with widths of from 4 to 6 ?m.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 31, 2017
    Assignee: Menarini Silicon Biosystems S.p.A.
    Inventors: Giuseppe Giorgini, Gerardo Perozziello, Alex Calanca, Gianni Medoro, Nicolò Manaresi
  • Patent number: 9797909
    Abstract: A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: October 24, 2017
    Assignee: Lightship Medical Limited
    Inventors: William Paterson, Nick Barwell, Bruce Culbert, Barry Colin Crane
  • Patent number: 9737260
    Abstract: The present invention is based on the finding that enrichment of D3-creatinine in a urine sample following oral administration of a single defined dose of D3-creatine can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for detecting creatinine and D3-creatinine in a single sample. The methods of the invention find use, inter alia, in diagnosing disorders related to skeletal muscle mass, and in screening potential therapeutic agents to determine their effects on muscle mass.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: August 22, 2017
    Assignees: GLAXOSMITHKLINE LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Marc K. Hellerstein, William Evans
  • Patent number: 9739658
    Abstract: The present invention relates to a cell peeling recognizing device and a cell peeling recognizing method. When a moving part (robot 6) moves culture vessel 5, imaging device 14 images an interior of culture vessel 5 a plurality of times as the cells move inside the culture vessel due to the moment of inertia, and recognizing part 10a recognizes the peeled state of cells C by comparing various sets of the captured imaging data. The peeled state of cells in the culture vessel can be determined with high precision.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: August 22, 2017
    Assignee: SHIBUYA CORPORATION
    Inventor: Daisuke Watanabe
  • Patent number: 9694177
    Abstract: A device for electrically controlled of ions, comprises a first electrolyte; a first electrode, which is arranged in direct or indirect contact with the first electrolyte, an encapsulation; and an ion conductor, which is arranged to receive and/or deliver ions from/to the first electrolyte. The encapsulation is arranged to effectively enclose the first electrolyte, and the ion conductor is arranged to transport ions from/to an outside of the encapsulation.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: July 4, 2017
    Assignee: OBOE IPR AB
    Inventors: Magnus Berggren, Joakim Isaksson, Edwin Jager, Peter Kjall, David Nilsson, Agneta Richter-Dahlfors, Daniel T. Simon, Klas Tybrandt, Barbara Canlon