Biological Cellular Material Tested Patents (Class 436/63)
  • Patent number: 11927509
    Abstract: Provided herein are systems and methods allowing for automated sampling and/or analysis of controlled environments, for example, to determine the presence, quantity, size, concentration, viability, species or characteristics of particles within the environment. The described systems and methods may utilize robotics or automation or remove some or all of the collection or analysis steps that are traditionally performed by human operators. The methods and systems described herein are versatile and may be used with known particle sampling and analysis techniques and particle detection devices including, for example, optical particle counters, impingers and impactors.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: March 12, 2024
    Assignee: PARTICLE MEASURING SYSTEMS, INC.
    Inventors: Giovanni Scialo, Davide Recchia
  • Patent number: 11898961
    Abstract: A system, device and method for measuring markers for a periprosthetic joint infection in a sample of synovial fluid. A sensor reader device includes a vial receptacle for receiving a vial containing synovial fluid. A light source illuminates the vial and an optical sensor detects light scattered and/or absorbed by white blood cells in the fluid sample. An electrical signal corresponding to the intensity of the light received at the optical sensor is detected. A white blood cell concentration is determined from the electrical signal value. The sensor reader device also includes one or more immunoassay strip receptacles. Immunoassay strips for other marker are inserted into the receptacles. Immunoassay optical sensors detect light generated by the immunoassay reaction on the immunoassay strip to determine the concentration of the marker. In example implementations, the device includes an immunoassay strip reader for leukocyte esterase and c-reactive protein.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: February 13, 2024
    Assignee: Alio, Inc.
    Inventors: Forrest Miller, Samit Kumar Gupta, David John Kuraguntla, Elsa Swanson
  • Patent number: 11890614
    Abstract: Apparatus is provided including a tube and a plunger sized and shaped to be inserted into the tube. A distal end of the plunger is shaped to define one or more first passageways therethrough, and the plunger is shaped to define one or more compartments in fluid communication with the first passageways. A filter is coupled to the distal end of the plunger. The plunger is shaped to define a second passageway that passes through the plunger from a proximal end of the plunger to the distal end of the plunger, and is positioned to facilitate testing of the filter. The apparatus is configured such that while the plunger is advanced within the tube while fluid is within the tube, the fluid in the tube is pushed through the filter, through the first passageways, and into the one or more compartments. Other embodiments are also described.
    Type: Grant
    Filed: December 12, 2022
    Date of Patent: February 6, 2024
    Assignee: HERO SCIENTIFIC LTD.
    Inventors: Lazar Fruchter, Arie Oscar Holtz, Robert Eric Levitz
  • Patent number: 11852639
    Abstract: A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface.
    Type: Grant
    Filed: February 2, 2022
    Date of Patent: December 26, 2023
    Assignee: Perosphere Technologies Inc.
    Inventors: Sasha Bakhru, Bryan Laulicht, Stefan Zappe, Solomon Steiner
  • Patent number: 11841314
    Abstract: The invention relates to a method and system for characterizing particles using a flow cytometer comprising detecting radiated light from the particles using two or more detectors positioned to allow for the detection in two or more angular directions and generating a waveform, as a digital representation for the detected radiated light for each of said angulation direction. The waveforms are transformed using one or more basis functions to obtain one or more coefficients characterizing the waveform. The one or more coefficients characterizing the waveform preferably correspond to properties of the particle(s), thereby enabling analysis of physical properties of the particles (such as size, shape, refractive index) or biological properties of the particles (such as cell type, cell cycle state or localization or distribution of molecules within the cell and/or on the cell surface). In preferred embodiments the method and system are used for a label-free sorting of particles, in particular biological cells.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: December 12, 2023
    Assignees: Deutsches Rheuma-Forschungszentrum Berlin, A.P.E Angewandte Physik & Elektronik GmbH
    Inventors: Toralf Kaiser, Daniel Kage, Claudia Giesecke-Thiel, Konrad von Volkmann
  • Patent number: 11835505
    Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.
    Type: Grant
    Filed: August 23, 2022
    Date of Patent: December 5, 2023
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventor: Nigel Clarke
  • Patent number: 11833506
    Abstract: A fluid dispenser having a reservoir (R) containing fluid (P) and air (A), the reservoir (R) forming an assembly opening (11); a fluid dispenser cannula (12) in communication with the reservoir (R); and an actuator member (2) engaged in the assembly opening (11), for supplying the dispenser cannula (13) with fluid (P). The actuator member (2) has a deformable membrane (23) that defines an outside face (231) forming a pusher (24), and an inside face (232) that is in contact with the air (A) of the reservoir (R), when the dispenser cannula (12) is in contact with the fluid (P) of the reservoir (R).
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: December 5, 2023
    Assignee: APTAR FRANCE SAS
    Inventors: Laurent Decottignies, Alain Lafosse, Jacky Bernard
  • Patent number: 11806929
    Abstract: A method of three-dimensional (3D) printing includes applying a solution to a channel. The solution includes a plurality of anisotropic particles suspending in the solution. Acoustic waves are applied to the channel. The frequency of the acoustic waves is configured to organize the plurality of anisotropic particles into one or more columns of organized anisotropic particles. The channel is connected to a printhead and a waste outlet. The solution comprising the one or more columns of organized anisotropic particles is deposited on a substrate via the printhead outlet.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: November 7, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rachel Collino, Tyler Ray, Matthew Begley
  • Patent number: 11802839
    Abstract: Color quantification of chemical test pads and titration of analytes can be performed under different lighting conditions. In one embodiment, the lighting condition is estimated under which a digital image is captured and utilized to select a set of reference colors from which the quantified color is compared to determine the titration. In another embodiment, a plurality of comparisons are made with different lighting conditions with the result having the highest confidence level being selected to determine the titration.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: October 31, 2023
    Assignee: HEALTHY.IO LTD.
    Inventors: Bernard Burg, Martin Zizi, Aaron Alexander Rowe, Anthony Smart, Walter De Brouwer
  • Patent number: 11796538
    Abstract: The present invention provides devices, systems, and methods, for performing biological and chemical assays.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: October 24, 2023
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
  • Patent number: 11796544
    Abstract: The present disclosure generally relates to systems and methods for partitioning species. In some embodiments, such systems can be used for determining one or more types of cancer. For example, certain aspects are generally directed to aqueous multiphase partitioning systems that can be used, for example, for distinguishing between different types of cancers, diagnosing subjects with cancer, or the like. In some cases, such systems can be identified using solvent properties such as the solvent dipolarity/polarizability difference (??*), the solvent hydrogen bond donor acidity difference (??), the solvent hydrogen bond acceptor basicity difference (??), and the electrostatic property difference (c) between two phases of the partitioning system. These may be within certain ranges in accordance with various embodiments.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: October 24, 2023
    Assignee: Analiza, Inc.
    Inventors: Arnon Chait, Boris Y. Zaslavsky
  • Patent number: 11781984
    Abstract: Methods of detecting platinum and copper in a test sample are provided. Kits for use in detecting platinum and copper in a test sample also are provided.
    Type: Grant
    Filed: May 9, 2022
    Date of Patent: October 10, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kazunori Koide, Melissa L. Campbell, Dianne Pham
  • Patent number: 11759781
    Abstract: Various embodiments of fluidic devices and methods of the present teaching can provide precision on-device loading of fluidic samples, and merging, mixing, and splitting of the fluidic samples, in illustrative embodiments as droplets, using pressures that can be provided by standard laboratory liquid handling equipment. Various embodiments of fluidic devices of the present teachings can provide on-device manipulation of accurate and precise fluidic volumes at the picoliter to nanoliter scale for each steps from fluidic sample loading to fluidic sample splitting. Various embodiments of fluidic elements of the present teachings, for example, but not limited by, various embodiments of fluidic traps of the present teachings, can have a constrained and measurable geometry, allowing for accurate and precise tuning of each fluidic sample volume throughout the on-device liquid handling process.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: September 19, 2023
    Assignee: UNCHAINED LABS
    Inventor: Deepak Solomon
  • Patent number: 11747276
    Abstract: A point of use analyte detection and quantification system for agricultural applications is provided. Related methods are also provided.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: September 5, 2023
    Assignee: SALVUS, LLC
    Inventors: Ron Levin, Clinton Beeland, James LeFiles, Joseph Egan, Timothy Zollers, Jacob Thompson
  • Patent number: 11744725
    Abstract: An ostomy appliance having a signal generator adapted to give a user or a health care professional a warning in time to change the appliance before leakage occurs by predetermining leakage or potential leakage of stomal fluids.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: September 5, 2023
    Assignee: Coloplast A/S
    Inventor: Kristoffer Hansen
  • Patent number: 11740241
    Abstract: The disclosed technology relates to chemical entities for the detection of wounds, e.g., chronic wounds or infected wounds, including compositions, substrates, kits, dressing materials, and articles, and systems containing such compounds. The disclosed technology further relates to methods of using these compositions, kits and systems in diagnostic assays, and in the diagnosis and/or detection of chronic or infected wounds based on enzymatic action on specific moieties and/or reaction sites. The disclosed technology additionally relates to detection of pathogenic, e.g., bacterial and/or viral substances, such as enzymes and substrates, at the wound situs. Additional disclosure relates to methods of characterizing wounds based on expression of a plurality of markers and using such information to treat, manage, and follow-up patients suffering from chronic or infected wounds.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 29, 2023
    Assignee: Synovo GmbH
    Inventors: Jan Hinrich Guse, Martin Reisser, Nikolas Pietrzik, Christiane Baeuerlein, Kornelia Eitel
  • Patent number: 11740177
    Abstract: A point of use analyte detection and quantification system for aquatic applications is provided. Related methods are also provided.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: August 29, 2023
    Assignee: SALVUS, LLC
    Inventors: Ron Levin, Clinton Beeland, James LeFiles, Joseph Egan, Timothy Zollers, Jacob Thompson
  • Patent number: 11733131
    Abstract: The present invention is to provide a tissue slice selection method and an embedded block-preparing cassette which are capable of suppressing occurrence of errors in inspection results. The present invention makes it possible to suppress the occurrence of errors in inspection results by including: an embedded block-preparing process of preparing an embedded block by embedding both a biological tissue fragment and a standard substance in the same embedding agent; an embedded tissue slice preparing step of slicing the embedded block to prepare a sheet-like embedded tissue slice having a tissue slice and standard substance slices appearing on a surface thereof; and a tissue slice selecting step of selecting the tissue slice to be inspected, based on a light signal from the standard substance slice.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: August 22, 2023
    Assignees: NIHON UNIVERSITY, NICHIREI BIOSCIENCES INC.
    Inventors: Shinobu Masuda, Ryohei Suzuki, Yuriko Kitano
  • Patent number: 11719617
    Abstract: A flow-cytometer has an excitation light source generating an excitation light that excites one or more bio-cells in a bio-sample carried by a flow path to luminesce. The flow-cytometer includes a spectrum dispersive element that disperses the luminescent light generated by the bio-sample into a photo-detector array. The flow-cytometer further includes a digital signal processor (DSP) that receives signals from the photo-detector array and generates a self-triggering signal based on the luminescent light generated by the bio-cells in bio-sample. The self-triggering signal triggers data capture in the DSP to improve synchronization with the data generated from signals received from the photo-detector array.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: August 8, 2023
    Assignee: Cytek Biosciences, Inc.
    Inventor: Wenbin Jiang
  • Patent number: 11719703
    Abstract: The present invention generally provides, in various embodiments, methods of analyzing samples having a low abundance of proteins, e.g., single cells, utilizing liquid chromatography and tandem mass spectroscopy (LC-MS/MS).
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: August 8, 2023
    Assignees: NORTHEASTERN UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Bogdan Budnik, Nikolai Slavov, Harrison Specht, Ezra Levy
  • Patent number: 11718826
    Abstract: A multi-channel system for classifying particles in a mixture of particles according to one or more characteristics including a common source of electromagnetic radiation for producing a beam of electromagnetic radiation and a beam splitter for producing multiple beams of electromagnetic radiation for directing multiple beams of electromagnetic radiation to each interrogation location associated with each flow channel of the multi-channel system.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: August 8, 2023
    Assignee: Inguran, LLC
    Inventors: Gary Durack, Jeffrey D. Wallace, Gary P. Vandre, Lon A. Westfall, Jeremy T. Hatcher, Niraj V. Nayak
  • Patent number: 11703441
    Abstract: Disclosed is a method for assisting prediction of onset of cerebral infarction, based on the number of red blood cells contained in a blood sample collected from a subject, comprising the steps of: calculating an exponent value for the prediction from a first measured value indicating red blood cell count measured by electrical resistance measurement method and a second measured value indicating red blood cell count measured by optical measurement method, comparing the exponent value with a reference range, and suggesting that the subject develops cerebral infarction when the exponent value is outside the reference range.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: July 18, 2023
    Assignees: KAWASAKI GAKUEN Educational Foundation, THE UNIVERSITY OF TOKYO, SYSMEX CORPORATION
    Inventors: Hiromi Kataoka, Yutaka Yatomi, Akiko Masuda, Hironori Shimosaka, Hajimu Kawakami
  • Patent number: 11702684
    Abstract: The present invention pertains to an enzymatic measurement method using an antibody-enzyme complex or a nucleic acid probe measurement method using an enzyme-labeled nucleic acid probe, in both of which the quantification of a product of a reaction by an enzyme in the antibody-enzyme complex or the enzyme-labeled nucleic acid probe is performed by generating thio-NAD(P)H by an enzymatic cycling reaction using NAD(P)H, thio-NAD(P), and a dehydrogenase (DH), and measuring the amount of the generated thio-NAD(P)H or measuring a change in color caused by the generated thio-NAD(P)H. An enzymatic reaction system in which NAD(P) generated from NAD(P)H by the enzymatic cycling reaction is selectively reduced, is caused to coexist with the enzymatic cycling reaction. The present invention also pertains to a kit for enzyme immunoassay, and a kit for nucleic acid probe measurement.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: July 18, 2023
    Assignee: BioPhenoMA Inc.
    Inventors: Etsuro Ito, Toshiaki Miura, Teruki Yoshimura, Satoshi Watabe
  • Patent number: 11680876
    Abstract: Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: June 20, 2023
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Wenpeng Zhang
  • Patent number: 11660226
    Abstract: An ostomy appliance has an adhesive wafer with a backing layer and an adhesive layer attached to the backing layer. The adhesive wafer has sensing means capable of recording application of pressure to the adhesive wafer during application of the ostomy appliance to the skin.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: May 30, 2023
    Assignee: Coloplast A/S
    Inventors: Anders Grove Sund, Lasse Hylleberg Mølleskov, Esben Strøbech
  • Patent number: 11651945
    Abstract: A system for the mass spectrometry analysis of an analyte includes a droplet ejection device, a spray head comprising a spray tip for ejecting the solvent as a spray, and a solvent delivery conduit for delivering solvent to the spray tip. The spray head includes a droplet inlet opening communicating with the surrounding atmosphere for receiving liquid droplets comprising the analyte. The droplet ejection device selectively ejects a liquid analyte droplet comprising the analyte through a surrounding atmosphere and the droplet inlet opening into a solvent flowing through the solvent delivery conduit. A method for the mass spectrometry analysis of an analyte is also disclosed.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: May 16, 2023
    Assignee: UT-BATTELLE, LLC
    Inventors: Vilmos Kertesz, John F. Cahill
  • Patent number: 11639495
    Abstract: Methods are described herein for isolating clonal populations of T cells having a defined genetic modification. The methods are performed, at least in part, in a microfluidic device comprising one or more sequestration pens. The methods include the steps of: maintaining individual T cells (or precursors thereof) that have undergone a genomic editing process in corresponding sequestration pens of a microfluidic device; expanding the T cells into respective clonal populations of T cells; detecting, in one or more T cells of each clonal population, the absence of a cell surface marker that was present in the individual T cells (or precursors thereof); and detecting, in one or more T cells of each clonal population, the presence of a first nucleic acid sequence that is indicative of the presence of an on-target genome edit in the clonal population of T cells. Also described are compositions comprising one or more clonal populations of T cells isolated according to the methods disclosed herein.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: May 2, 2023
    Assignees: The Regents of the University of California, Berkeley Lights, Inc.
    Inventors: Alexander Marson, Gregory G. Lavieu, Annamaria Mocciaro, Theodore L. Roth, Magali Soumillon, Hayley M. Bennett
  • Patent number: 11628452
    Abstract: Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. An apparatus may include a first layer being substantially transparent. A second layer may be coupled to the first layer. The second layer may be substantially absorbent to infrared radiation. The second layer and the first layer may collectively define a set of wells. The first layer may define a base for each well of the set of wells. The second layer may define an opening for each well of the set of wells. At least one of the first layer and the second layer may define a sidewall for each well of the set of wells.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: April 18, 2023
    Assignee: Zoetis Services LLC
    Inventors: Robert Justice Shartle, Gregory Trigub
  • Patent number: 11612888
    Abstract: The disclosure is directed to a device that includes an upper container configured to receive a fluid sample collected from a mammal into a first opening, the first opening opposite a second opening and a membrane covering at least a portion of the second opening, the membrane configured to allow transmission of a portion of the fluid sample through the membrane.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: March 28, 2023
    Assignee: The Research Foundation for The State University of New York
    Inventors: Srinivas Pentyala, Sahana Pentyala
  • Patent number: 11609175
    Abstract: The present invention falls within the field of medical apparatuses. Disclosed are a method and a device for identifying platelet aggregation, and a flow cytometer, which are used for accurately giving an alarm about a platelet aggregation during blood cell analysis.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: March 21, 2023
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Guanzhen Wang, Bo Ye, Jiantao Di
  • Patent number: 11604177
    Abstract: Devices, systems, and methods are provided for monitoring or analyzing excreta of a subject using a toilet. In one embodiment, the device includes a housing mounted adjacent a toilet bowl, a urinalysis module for deploying urinalysis strips into the toilet bowl to collect a urine sample from a subject's urine stream delivered into the toilet bowl and a urinalysis sensor to acquire data from the urinalysis strip related to the urine sample, and a stool analysis module including a camera oriented into the toilet bowl to provide images of contents of the toilet bowl. In addition, the device may include a uroflowmetry module and/or a biometric identification module. One or more sensors are provided for identifying when a subject uses the toilet, and a processor activates one or more of the modules when the sensors indicate a subject is using the toilet.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: March 14, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Seung-Min Park, Daeyoun Won, Brian J. Lee, Sunil Bodapati, Alexander Lozano, Diego Escobedo, Sanjiv Sam Gambhir
  • Patent number: 11590501
    Abstract: A microfluidic device can include an upstream passage, a sample passage, a bifurcating passage, and a combining passage. The upstream passage can be configured to provide a focusing stream. The sample passage can be configured to provide a sample stream. The bifurcating passage can include a specified bifurcating flow resistance. The combining passage can be configured to create a combined stream from the focusing stream and the sample stream, where the focusing stream can direct the sample stream away from the upstream passage and toward the bifurcating passage. A first portion of the combined stream can be discharged through the bifurcating passage. The main discharge can be configured to discharge a second portion of the combined stream. The main discharge can include a main discharge resistance that is selectable to vary the main discharge resistance relative to the bifurcating flow resistance.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: February 28, 2023
    Assignee: University of Virginia Patent Foundation
    Inventors: Nathan Swami, Walter Varhue, Linda W. Langman, Kenneth Brayman, Shayn Peirce-Cottler
  • Patent number: 11586025
    Abstract: A method for the microscopy scanning of a specimen. An immersion medium is used between a slide and a microscope objective, said immersion medium wetting a surface of the slide, and the microscope objective being relatively displaced over the surface of the slide for imaging. The surface is provided with a coating which repels the immersion medium.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: February 21, 2023
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Thomas Ohrt, Michael Goegler, Thorsten Kues
  • Patent number: 11584909
    Abstract: The present disclosure relates to a cell potential detection device, a method of manufacturing the cell potential detection device, and an information processing system that enable prevention of culture solution for a cell from leaking. The cell potential detection device includes: a cell potential detection chip including an electrode unit that detects potential of a cell; a substrate on which the cell potential detection chip is implemented; a first member sealing a connection electrically connecting the cell potential detection chip and the substrate; and a second member layered on the first member, the second member forming a liquid-storage portion that stores culture solution for the cell, together with the first member. The present technology can be applied to, for example, a semiconductor module in which packaged is a chip that detects the potential at an action-potential source point due to a chemical change of a cell.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: February 21, 2023
    Assignee: SONY SEMICONDUCTOR SOLUTIONS CORPORATION
    Inventor: Masataka Maehara
  • Patent number: 11577238
    Abstract: A method is provided for testing for presence of a particulate selected from the group consisting of: a microorganism, a fungus, a bacteria, a spore, a virus, a mite, a biological cell, a biological antigen, a protein, a protein antigen, and a carbohydrate antigen. The method includes (a) collecting, in a tube (22), fluid that potentially contains the particulate, (b) using a plunger (24) to push the fluid through a filter (26) disposed at a distal portion of the tube or at a distal end of the plunger, and subsequently, (c) while the filter is inside the tube, ascertaining if any of the particulate was trapped by the filter by applying a particulate-presence-testing-facilitation solution to the filter. Other embodiments are also described.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: February 14, 2023
    Assignee: HERO SCIENTIFIC LTD.
    Inventors: Lazar Fruchter, Arie Oscar Holtz, Robert Eric Levitz
  • Patent number: 11579154
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: February 14, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Patent number: 11573185
    Abstract: A method and device for detecting pyrethroid pesticide residues in crops. Reaction membrane is arranged on a bottom plate and provided with a check-up line and a quality control line; a first mounting block and a second mounting block are arranged on the bottom plate; a first slide is arranged in the first mounting block, a second slide is arranged in the second mounting block; a sample pad and a bonding pad are arranged in the first slide; a water absorption pad is arranged in the second slide; a liquid inlet provided with a pipe is formed in the first mounting block, a pressing hole provided with a press block is formed in the second mounting block; protrusions are respectively formed on the pipe and the press block; sliding grooves are formed in the liquid inlet and the pressing hole; and first springs are arranged between the protrusions and the sliding grooves.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: February 7, 2023
    Assignee: Tobacco Rsrch Inst. of Chinese Acad. of Ag. Sci.
    Inventors: Xiuguo Wang, Tong Liu, Dan Chen, Xiao Zheng, Guangjun Xu
  • Patent number: 11565253
    Abstract: A nano-fluidic device includes: a first substrate that has a nanoscale groove on one surface; and a second substrate that is integrally provided with the first substrate by bonding one surface of the second substrate to the one surface of the first substrate and forms a nanochannel with the groove of the first substrate, in which either the first substrate or the second substrate includes at least a thin portion in a part of a position overlapping the nanochannel in plan view, and the thin portion is deformed by pressing to open and close the nanochannel.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: January 31, 2023
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Yutaka Kazoe, Yuriy Pihosh, Takehiko Kitamori
  • Patent number: 11559357
    Abstract: The systems and methods of the present disclosure are used for guiding a medical instrument towards a target, the method positioning a medical instrument at a first location within a patient anatomy, wherein the medical instrument comprises at least one sensor, determining a first biomarker measurement using the at least one sensor, determining a second biomarker measurement using the at least one sensor, comparing the first biomarker measurement with the second biomarker measurement to determine a proximity to the target to provide a first comparison, and providing guidance for moving the medical instrument based on results of the first comparison.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: January 24, 2023
    Assignee: INTUITIVE SURGICAL OPERATIONS, INC.
    Inventors: Federico Barbagli, Simon P. DiMaio, Gary S. Guthart
  • Patent number: 11554368
    Abstract: The present invention provides a pipette tip, which can be used in in-vitro diagnostics, in particular in the diagnostic testing of body fluids, such as in coagulation testing. The Pipette tip contains two constituents in a spatially separated manner. The present invention furthermore provides a method of performing such diagnostics, e.g. coagulation analysis, and to the use of the pipette tip in such diagnostic testing.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: January 17, 2023
    Inventor: James Lynn Hill
  • Patent number: 11549969
    Abstract: A low-noise current sensor enables large dynamic range current measurements of alternating and direct current flows. The current sensor includes a first substrate, a first conductor, a magnetic flux conductor comprising a first portion orthogonal to the first conductor and a second portion, the second portion penetrating the first substrate, an inductive sensor comprising a first plurality of loops around the second portion of the magnetic flux conductor on the first substrate, wherein the first plurality of loops is orthogonal to the second portion of the magnetic flux conductor, and a Faraday cage that encloses the first plurality of loops and separates the first plurality of loops from the first conductor.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: January 10, 2023
    Inventor: James William Masten, Jr.
  • Patent number: 11549878
    Abstract: The invention relates to an in vitro method for determining the adsorbing capacity of an adsorbent having limited solubility, such as a bile acid sequestrant, under conditions simulating the mammalian gastrointestinal tract. The method is particularly useful for studying the release profiles of controlled release formulations comprising adsorbents having limited solubility.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: January 10, 2023
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Anna-Maria Tivert, Mike Frodsham, Jamie Farrar
  • Patent number: 11543399
    Abstract: The use of volatilization reagents is disclosed for improved detection of inorganic oxidizers such as, but not limited to, chlorates and perchlorates. Detection methods are disclosed whereby a reagent can transfer a proton to the anion (i.e., chlorate, perchlorate, etc.) of an inorganic salt analyte, forming an acid (i.e., chloric acid, perchloric acid) that is easier to detect by a mechanism whereby the acidified reagent is more easily vaporized, and hence, more easily detected. Concurrently, the anion of the acid forms a new salt with the cation released from the salt that was acidified. The reagents can also include acidic salts or cation-donators, more generally. In some embodiments, hydrated reagents or co-reagents that can release water can be employed.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: January 3, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Jude A. Kelley, Roderick Russell Kunz, Alla Ostrinskaya, Richard Paul Kingsborough
  • Patent number: 11536643
    Abstract: A method of automated measurement of motility and morphology parameters of the same single motile sperm. Automated motility and morphology measurements of the same single sperm are performed under different microscope magnifications. The same single motile sperm is automatically positioned and kept inside microscope field of view and in focus after magnification switch. A method of automated non-invasive measurement of sperm morphology parameters under high magnification of imaging. Sperm morphology parameters including subcellular structures are automatically measured without invasive sample staining. A method of automatically selecting sperms with normal motility and morphology and DNA integrity for infertility treatment.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: December 27, 2022
    Assignee: The Governing Council of the University of Toronto
    Inventors: Yu Sun, Changsheng Dai, Zhuoran Zhang
  • Patent number: 11524288
    Abstract: A device for analysing a sample comprising a nucleic acid to be captured and detected using a test strip are described. The device comprises a resilient biasing member disposed in an analysis chamber containing the test strip. The resilient biasing member exerts a force against the test strip sufficient to urge it into the sample chamber when it is in communication with the analysis chamber. This ensures that the test strip is reliably introduced into the sample chamber when it is in communication with the analysis chamber. In one embodiment, the sample chamber comprises guide members for guiding the test strip into the sample chamber. A free end of each guide member is shaped to prevent significant rotation of the test strip, so that the test strip is in correct alignment in the sample chamber for automatic reading of the test result, for example by a camera or optical reader.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: December 13, 2022
    Assignee: Diagnostics for the Real World, LTD.
    Inventors: Philip Stankus, Ivan Hin-Kwan Chew
  • Patent number: 11517236
    Abstract: The present invention provides a bio-electrode composition including a silsesquioxane bonded to an N-carbonyl sulfonamide salt, wherein the N-carbonyl sulfonamide salt is shown by the following general formula (1): wherein R1 represents a linear, branched, or cyclic alkylene group having 1 to 20 carbon atoms that may have an aromatic group, an ether group, or an ester group, or an arylene group having 6 to 10 carbon atoms; Rf represents a linear, branched, or cyclic alkyl group having 1 to 4 carbon atoms containing at least one fluorine atom; M+ is an ion selected from a lithium ion, a sodium ion, a potassium ion, and a silver ion. This can form a living body contact layer for a bio-electrode that is excellent in electric conductivity and biocompatibility, light-weight, manufacturable at low cost, and free from large lowering of the electric conductivity even though it is wetted with water or dried.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: December 6, 2022
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Motoaki Iwabuchi, Yasuyoshi Kuroda
  • Patent number: 11513054
    Abstract: Disclosed herein include systems, devices, and methods for determining a gating strategy. An acquisition system can cause a particle analyzer to collect parameter measurements of some particles of a sample. An analysis system can receive the parameter measurements and determine a gating strategy from the parameter measurements. The acquisition can collect measurements of some or all of the remaining particles of the sample using the gating strategy determined by the analysis system.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: November 29, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Joseph T. Trotter, Allison Irvine, Nikolay Samusik
  • Patent number: 11513130
    Abstract: Methods are described for measuring the amount of one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: November 29, 2022
    Assignee: Quest Diagnostics Investment Incoporated
    Inventors: Sum Chan, Qibo Jiang
  • Patent number: 11506591
    Abstract: A system for the differentiation of plastic and non-plastic particles in suspension in a liquid, and the method of use thereof. The system having a channel for constraining and presenting the liquid to a detector, the detector having at least one transmit electrode for emitting electrical current to at least one receive electrode. Circuitry provides the current input and received electrical signals measurement capacities. Particles passing the receive electrodes alter the received electrical current according to the particle's dielectric properties, the circuitry records the received signals and discerns a particle's nature, most often plastic from non-plastic, from the differential signal of these received signals as a function of frequency.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: November 22, 2022
    Assignee: Woods Hole Oceanographic Institution
    Inventors: Anna Pauline Miranda Michel, Beckett Colson
  • Patent number: 11506587
    Abstract: A liquid droplet and solid particle sensing device is provided that can measure the average droplet size in a spray. The present device uses a swirling flow to draw a particulate or a spry into the device for sizing and counting. The swirling flow is configured to keep all the particles away from the walls of the device and to concentrate them at the center of a flow channel to pass through the center of a light beam for high sensitivity and repeatability of the measurement.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: November 22, 2022
    Inventors: Alireza Hashemi, Mehrnoosh Houshmand, Anis Mirzaei, Hamid Reza Layegh Pour