Intracardiac pumping device

- ABIOMED EUROPE GMBH

The intracardiac pumping device has a pump (11) connected at its distal end (13) to a canula (15). At the distal end, the canula (15) has a suction head (16) for drawing blood. The suction head is extended by a non-sucking projection (20). The projection stabilizes the position of the pumping device in the heart. It extends the canula (15) mechanically without degrading the hydraulic conditions. It also serves as a spacer to prevent the suction head (16) from adhering to a wall of the heart.

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Description

The invention relates to an intracardiac pumping device adapted to be fully inserted into the heart via adjoining vessels to assist the natural cardiac pump function or to replace the same by a continuous pumping operation.

Intracardiac blood pumps inserted percutaneously into a patient's body are highly miniaturized. They comprise a cylindrical drive portion and a cylindrical pump portion. The intake end of the pump portion is provided with a flexible canula having a suction head with lateral inlet openings at the distal end. Such a pumping device is described in EP 0 916 359 A1 (Impella). Another pumping device conveying in the distal direction is described in WO 99/58170 (Impella). In this pumping device, the pumping portion is prolonged by a flexible canula adapted to be passed through a cardiac valve. A catheter projects from the distal end of the canula, at which catheter a balloon is provided which is to be entrained by the blood flow in the body when the pumping device is inserted.

A pumping device that takes in blood through a canula and then feeds it proximally can be placed such that it leads through the aortic valve, the suction head at the end of the canula being situated in the left ventricle, while the pump outlet lies in the aorta. The operation of the continually feeding pump is superposed on the pulsating activity of the heart so that the pump is subjected to heavily pulsating pressure variations. In this context it may happen that the pump, together with the associated proximal catheter is subjected to substantial changes in position. During a systole, the catheter is pressed against the outer side of the aortic arch, whereas it is pressed against the inner side thereof during a diastole. Further, the position of the pump varies continuously, which may result in displacements of the canula passing through the aortic valve and even in an ejection of the canula which then slips from the cardiac valve into the aorta.

It is another difficulty with such blood pumps that the suction head may adhere to tissue parts inside the heart by suction. This entails the danger of irritations of the heart and, further, the pumping capacity is reduced by the obstruction of inlet openings. Finally, it may happen that the canula adheres to the mitral valve by suction and an additional damage to the blood is induced by suction.

It is an object of the present invention to provide an intracardiac pumping device for percutaneous insertion that substantially avoids the risk of adhering by suction.

The present pumping device has the features of claim 1. According thereto, a flexible projection is provided at the canula distal of the inlet openings. The projection forms a mechanical spacer maintaining a distance to neighboring walls, yet does not change the pumping device hydraulically.

Beside the spacing function, the projection has other effects. It increases the mechanical length of the pumping device without increasing the hydraulic length. The increase in mechanical length has the consequence that the pumping device is less likely to slip out through the aortic valve. On the other hand, the hydraulic resistance of the canula is not increased so that the suction performance is not degraded. It is another effect that the projection essentially reduces the tendency of the pumping device to make pulsating motions caused by cardiac pulsation. The pumping device including the pump and the catheter lies much calmer within the heart, whereby also the danger of an ejection is reduced. In the event that a new insertion is to be allowed after an ejection, the distal projection is preferably configured such that a new retrograde passage of the aortic valve is possible easily and reproducibly.

In a preferred embodiment of the invention, the flexible projection is a hollow tube whose lumen is in communication with that of the canula. Such a pumping device is suited for use with a guide wire. When inserting the pumping device, the guide wire may be included as a stiffening means. It is also possible to first place the guide wire and to then slip the pumping device over the same. Eventually, an angled tip of the guide wire may also be pushed out from the projection to serve as a pathfinder through the vascular system. Although the lumen of the projection is in communication with the lumen of the canula, the pump does not suck through the projection. This is because the inlet openings at the suction head have a much larger cross section than the lumen of the projection so that due to the lower flow resistance the suction is affected for the much greater part through the inlet openings. A certain suction effect caused by the lumen of the projection is so small that it is negligible and is not sufficient to cause adherence by suction to other parts. Thus, other than the suction head, the projection is unable to adhere by suction. However, should the lumen of the projection be obstructed for some reason, this has no effects on the hydraulic function of the pump.

The flexible projection may comprise a pigtail tip as known from catheters and stents. The rounded pigtail tip allows for an atraumatical supporting at heart or vessel walls. Moreover, the tip is so soft and flexible that it adapts to any cavity topology by deforming. The pigtail tip also facilitates the insertion and the placing of the pumping device. Specifically, it can be used in combination with a guide wire, the pigtail tip being stretched by the guide wire during insertion. When the pigtail tip is advanced without the guide wire, a simple and reproducible retrograde passage through the aortic valve is still possible. This is of particular importance since the guide wire is removed for the pump to operate and can not be advanced again without having to remove the pump for that purpose. Should the pump be ejected from the left heart due to the systolic cardiac functions, it may be repositioned even without the wire because of the configuration of the flexible projection as a pigtail.

The following is a detailed description of embodiments of the invention with reference to the drawing. The features mentioned in the context of the embodiments do not limit the scope of the invention. The same is defined by the claims.

IN THE FIGURES

FIG. 1 illustrates the pumping device operating in the heart;

FIG. 2 illustrates the pumping device in an unused state;

FIG. 3 shows a section through the suction head with the projection attached thereto;

FIG. 4 illustrates an embodiment in which the suction head has a flow-shaping inflow funnel; and

FIG. 5 illustrates an embodiment in which the canula comprises a second set of inlet openings at the end of the projection.

FIG. 1 illustrates the heart H with the aorta AO branching therefrom. Via the aortic arch 10, the aorta passes into a vertical strand that branches into the femoral artery, among others. The pumping device is percutaneously inserted into the femoral artery in the region of the groin and is advanced to the heart.

The intracardiac pumping device comprises a pump 11 with a proximal end 12 and a distal end 13. The pump 11 has a housing with an outer diameter of 4 mm at most and a length of approximately 15 mm so that the pump can be inserted percutaneously and be operated inside the heart. Larger pumps that can only be inserted surgically must not exceed an outer diameter of 6 mm because of the peripheral vessel diameters.

The proximal end 12 of the pump 11 is connected with a catheter 14 including the electric wires for the operation and the control of the pump 11. The distal end 13 is connected with a canula 15 which is an elongate flexible hose forming at its distal end a suction head 16 with lateral inlet openings 17. The pump 11 draws blood through the inlet openings 17 of the canula 15 and pumps the same through the outlet openings 18 provided in the sides of the pump. The pump and the canula are generally designed as described in EP 0 916 369 A1 (Impella). The canula 15 is a hose with a length of about 40 to 70 mm, whose wall is formed by a coiled wire provided with a polyurethane coating. The canula 15 has a certain form stability, yet it is flexible.

According to the invention, the suction head 16 of the canula 15 is adjoined by a projection 20 that extends the canula 15 mechanically, but not hydraulically. The projection 20 has a length of 10 to 30 mm. In the present case, it is provided with a pigtail tip 21 to allow for atraumatic support at body tissue.

The solid lines in FIG. 1 represent the extension of the pumping device in the heart H and the aorta AO. The pumping device is placed such that the pump 11 is located in the aorta AO while the suction head 16 lies in the left ventricle LV. The canula 15 extends through the aortic valve AK. Thus, the pump draws blood from the left ventricle LV and feeds into the aorta AO. Moreover, FIG. 1 shows the left atrium LA and the mitral valve MK.

The pump 11 pumps continuously at a delivery rate of 2 to 3 l/min. The reaction force tends to pull the pump into the heart. This force is countered by the pumping force of the heart. During the systole, the heart has a fluctuating delivery rate of about 10 l/min. It has been found that the pump moves resulting in a systolic position 25 at the outer side of the aortic arch 10 during the ejection phase of the heart, while, during the filling phase, a diastolic position 26 on the inner side of the aortic arch 10 is obtained. With these movements, the position of the canula 15 and the suction head 16 also changes. When the suction head 16 comes close to the trabecula structures situated at the wall of the heart, there is a danger of these structures being caught by suction, of an occlusion of the suction head, of an increased damage to the blood and the risk of a hematoma being formed in the cardiac structure.

Adhering by suction is made more difficult by the projection 20 that is supported at the wall of the heart. Further, the projection 20 forms a mechanical extension of the canula to prevent ejection from the left ventricle and the aortic valve.

As is evident from FIG. 2, the pump 11 comprises a motor part 30 and a pump part 31 arranged axially one behind the other. The pump part 31 includes a housing ring and an impeller driven by the motor and feeding the blood flow in the axial direction, the blood flow being deflected outward radially and exiting laterally from the housing of the pump 11 through the outlet openings 18. The pump part 31 is axially adjoined by the canula 15 having about the same outer diameter (4 mm) as the pump 11. The suction head 16 with the inlet opening 17 has a length of about 10 to 15 mm. The outlet openings 18 have an area at least as large as the cross-section area of the canula lumen so that the suction head forms no constriction.

In FIG. 2, the projection 20 is designed as a hollow hose with a continuous lumen 32. The width of this lumen is much smaller than that of the canula lumen. The lumen 32 serves to pass a guide wire 33 therethrough to facilitate the insertion of the pumping device into the body. The guide wire 33 extends the projection 20 if the same has a preformed bend. The guide wire may also have a soft flexible bent tip protruding from the distal end of the projection 20 and serving as a pathfinder through the vascular system. The guide wire 33 leads into the pump 11, through the pump part 31 and out from an outlet opening 18. It is then guided along the outside of the catheter 14. After the pumping device has been placed, the guide wire is withdrawn.

As illustrated in FIG. 2, the canula 15 has a preformed bend 34 that also serves to better find the path.

FIG. 3 illustrates the distal end of the canula 15 with the suction head 16. The suction head 16 comprises the longitudinal inlet openings 17. At its end, a ball 36 is provided into which a hollow pin 37 is inserted and welded. This pin 37 serves as a connecting element for the projection 20, which in the present case is provided with a pigtail tip 21. The lumen 32 of the projection 20 extends through the pin 37 and the ball 36 into the suction head 16. Here, the outer diameter of the projection 20 is smaller than that of the canula 15.

FIG. 4 illustrates an embodiment in which the suction head 16 includes an inflow funnel 41 in an expansible suction basket 40. The suction basket 40 is made from a material able to restore itself, for example, or it is expanded by a balloon. In the expanded state, the suction basket 40 has an outer diameter larger than that of the canula 15. Thus, the suction basket 40 is expanded from its initial 4 mm to a diameter of about 6 mm. Here, the inflow funnel 41 is spanned from a flexible polymer screen that allows for a smooth inflow and substantially increases the hydraulic capacity of the pump by reducing the hydraulic losses.

In the embodiment of FIG. 5, the canula 15 has a two-stage design. It is provided with first inlet openings 17 forming the main inlet. Distal of the inlet openings 17, the projection 20 follows that, in the present case, has the same outer diameter and the same lumen diameter as the canula 15. In the distal end portion of the projection 20, further lateral auxiliary openings 44 are provided that serve as auxiliary openings. No suction head is provided here. The distal end of the canula is closed by a rounded end wall 45 with a passage for a guide wire 33.

The pumping device of FIG. 5 is slipped over the guide wire 33 that passes through the impeller part 33 of the pump 11 and exits laterally from an outlet opening 18. After the pumping device has been positioned, the guide wire 33 is withdrawn in the proximal direction. The operation of the pump 11 causes blood to be drawn through the inlet openings 17. Due to the higher flow resistance of the projection 20 and the auxiliary openings 44, only the inlet openings 17 exert a suction effect, while the projection 20 has practically no hydraulic effect. Only when the inlet openings 17 adhere by suction or are clogged in another way, will the auxiliary openings 44 become effective. The projection 20 has an angled part 46. Its lumen is in communication with that of the canula 15. The projection has a flexibility that is preferably higher than that of the canula 15.

Claims

1. An intracardiac pumping device for percutaneous insertion, comprising a pump connected at the proximal end with a catheter and at the suction-side distal end with a canula having inlet openings remote from the pump, characterized in that a flexible pigtail tip is provided at the canula distal of all of the inlet openings, wherein said flexible pigtail tip forms a spacer for keeping said inlet openings spaced apart from adjacent heart walls.

2. The pumping device of claim 1, wherein the pigtail tip comprises a non-sucking projection.

3. The pumping device of claim 1, wherein the pigtail tip comprises a hollow hose whose lumen is in communication with that of the canula.

4. The pumping device of claim 1, wherein the inlet openings are provided in an expansible suction basket including an inflow funnel.

5. The pumping device of claim 1, wherein the pigtail tip has an outer diameter that is smaller than that of the canula.

6. The pumping device of claim 1, wherein the canula has a preformed bend.

7. The pumping device of claim 1, wherein a guide wire is provided that leads through the pump and is adapted to be advanced from the canula into the pigtail tip.

8. The pumping device of claim 1, wherein the pigtail tip has lateral auxiliary openings.

Referenced Cited
U.S. Patent Documents
2350534 June 1944 Rosinger
3333127 July 1967 Congdon et al.
3354833 November 1967 Laing
3489145 January 1970 Judson et al.
3936683 February 3, 1976 Walker
4065234 December 27, 1977 Yoshiyuki et al.
4115040 September 19, 1978 Knorr
4135253 January 23, 1979 Reich et al.
4153048 May 8, 1979 Magrini
4420851 December 20, 1983 Wiener
4679558 July 14, 1987 Kensey et al.
4686982 August 18, 1987 Nash
4728319 March 1, 1988 Masch
4747821 May 31, 1988 Kensey et al.
4747840 May 31, 1988 Ladika
4749376 June 7, 1988 Kensey et al.
4753221 June 28, 1988 Kensey et al.
4777951 October 18, 1988 Cribier
4846152 July 11, 1989 Wampler et al.
4895557 January 23, 1990 Moise et al.
4919647 April 24, 1990 Nash
4984972 January 15, 1991 Clausen et al.
5011469 April 30, 1991 Buckberg et al.
5017103 May 21, 1991 Dahl
5037403 August 6, 1991 Garcia
5042984 August 27, 1991 Kensey et al.
5061256 October 29, 1991 Wampler
5097849 March 24, 1992 Kensey et al.
5147186 September 15, 1992 Buckholtz
5158279 October 27, 1992 Laffey et al.
5163431 November 17, 1992 Griep
5169378 December 8, 1992 Figuera
5250059 October 5, 1993 Andreas et al.
5275580 January 4, 1994 Yamazaki
5357963 October 25, 1994 Mayol et al.
5376114 December 27, 1994 Jarvik
5405383 April 11, 1995 Barr
5421338 June 6, 1995 Crowley et al.
5480392 January 2, 1996 Mous
5749855 May 12, 1998 Reitan
5827171 October 27, 1998 Dobak, III et al.
5863179 January 26, 1999 Westphal et al.
5888241 March 30, 1999 Jarvik
5938672 August 17, 1999 Nash
5954745 September 21, 1999 Gertler et al.
6001078 December 14, 1999 Reekers
6054788 April 25, 2000 Dombrovski et al.
6083260 July 4, 2000 Aboul-Hosn
6123725 September 26, 2000 Aboul-Hosn
6129704 October 10, 2000 Forman et al.
6183220 February 6, 2001 Ohara et al.
6245007 June 12, 2001 Bedingham et al.
6413222 July 2, 2002 Pantages et al.
6517528 February 11, 2003 Pantages et al.
6533716 March 18, 2003 Schmitz-Rode et al.
6537247 March 25, 2003 Shannon
6544216 April 8, 2003 Sammler et al.
6841910 January 11, 2005 Gery
6858001 February 22, 2005 Aboul-Hosn
6974436 December 13, 2005 Aboul-Hosn et al.
6976996 December 20, 2005 Aboul-Hosn
6981942 January 3, 2006 Khaw et al.
7022100 April 4, 2006 Aboul-Hosn et al.
7027875 April 11, 2006 Siess et al.
7393181 July 1, 2008 McBride et al.
7646376 January 12, 2010 Blersch
7731675 June 8, 2010 Aboul-Hosn et al.
7841976 November 30, 2010 McBride et al.
7927068 April 19, 2011 McBride et al.
8439859 May 14, 2013 Pfeffer et al.
8888728 November 18, 2014 Aboul-Hosn et al.
20010000528 April 26, 2001 Cho
20020151799 October 17, 2002 Pantages et al.
20030135086 July 17, 2003 Khaw et al.
20030135940 July 24, 2003 Lev et al.
20030208097 November 6, 2003 Aboul-Hosn et al.
20040022640 February 5, 2004 Siess et al.
20040044266 March 4, 2004 Siess et al.
20040113502 June 17, 2004 Li et al.
20040193046 September 30, 2004 Nash et al.
20040260237 December 23, 2004 Squadrito
20050135942 June 23, 2005 Wood et al.
20060008349 January 12, 2006 Khaw
20060062672 March 23, 2006 McBride et al.
20060195004 August 31, 2006 Jarvik
20070118072 May 24, 2007 Nash
20080103591 May 1, 2008 Siess
20080114339 May 15, 2008 McBride et al.
20080132747 June 5, 2008 Shifflette
20080183136 July 31, 2008 Lenker et al.
20090060743 March 5, 2009 McBride et al.
20090062597 March 5, 2009 Shifflette
20090088609 April 2, 2009 Schmitz-Rode et al.
20090093764 April 9, 2009 Pfeffer et al.
20090093796 April 9, 2009 Pfeffer et al.
20090218728 September 3, 2009 Moyer
20090227892 September 10, 2009 Krombach et al.
20100210895 August 19, 2010 Aboul-Hosn et al.
20100268017 October 21, 2010 Siess
20110071338 March 24, 2011 McBride et al.
20130066140 March 14, 2013 McBride et al.
20150073202 March 12, 2015 Aboul-Hosn et al.
Foreign Patent Documents
2613175 January 2007 CA
2632420 June 2007 CA
4414903 November 1995 DE
100 59 714 May 2002 DE
102005039950 March 2007 DE
0364293 April 1990 EP
0445782 September 1991 EP
0445782 November 1991 EP
0768900 April 1997 EP
0914171 May 1999 EP
0916359 May 1999 EP
0916359 May 1999 EP
1034808 September 2000 EP
1207934 May 2002 EP
2047872 April 2009 EP
2229965 September 2010 EP
2788223 July 2000 FR
H04126158 April 1992 JP
WO-9944651 September 1999 WO
WO-99/58170 November 1999 WO
WO-0019097 April 2000 WO
WO-0043053 July 2000 WO
WO-0043053 July 2000 WO
WO 01/83016 August 2001 WO
WO-0183016 November 2001 WO
WO-02/22200 March 2002 WO
WO/02/43791 June 2002 WO
WO-02/43791 June 2002 WO
WO-03103745 December 2003 WO
WO-2006020942 February 2006 WO
WO-2006034158 March 2006 WO
WO-2010063494 June 2010 WO
Other references
  • Brochure Impella Pumpsystem of Impella CardioSystems AG, “Turning Lives Around,” Aug. 2003 (4 pages).
  • Buecker et al., “Use of a Nonmetallic Guide Wire for Magnetic Resonance-Guided Coronary Artery Catheterization,” Investigative Radiology, 39:11, pp. 656-660 (2004).
  • Compendium of Technical and Scientific Information for the Hemopump Temporary Cardiac Assist System, 1988 (15 pages).
  • Dekker, Andre, et al, “Efficacy of a New Intraaortic Propeller Pump vs the Intraaortic Balloon Pump,” Chest Journal; Jun. 2003 (7 pages).
  • Frazier, O.H., et al, “First Human Use of the Hemopump, A Cather-Mounted Ventricular Assist Device,” Ann Thorac Surg., Feb. 1990; 49(2): pp. 299-304.
  • International Preliminary Report on Patentability, from PCT/EPOS/008858, issued Jun. 7, 2011.
  • JOMED Reitan Catheter Pump Brochure, www.jomed.com/rcp (undated) (6 pages).
  • Lueger, Lexikon der Technik, “Lexikon der Feinwerktechnik”, 1968, vol. 13, Deutsche Verlags-Anstalt GmbH, Stuttgart, seite 551.
  • Reitan, Oyvind et al, “Hydrodynamic Properties of a New Percutaneous Intra-aortic Axial Flow Pump,” ASAIO Journal; Jay-Jun. 2000; vol. 16; pp. 323-329.
  • Rothman, Martin T, “The Reitan Catheter Pump: A New Versatile Approach for Hemodynamic Support,” London Chest Hospital Barts & The Long NHS Trust, presented at TCT Conference, Oct. 24-26, 2006, (40 pages).
  • Schmitz-Rode, T et al. 2005. An Expandable Percutaneous Catheter Pump for Left Ventricular Support. Journal of the American College of Cardiology, 45:11, pp. 1856-1861.
  • Schmitz-Rode, T et al. 2006. Temporary Pulmonary Stent Placement as Emergency Treatment of Pulmonary Embolism. Journal of the American College of Cardiology, 48:4, pp. 812-816.
  • Siess, Thorsten, “Systemanalyse und Entwicklung intravasaler Rotationspumpen zur Herzunterstutzung,” Helmholtz-Institut, Jun. 24, 1998 (105 pages) and partial English translation (37 pages).
  • Verma, R et al. 2006. Evaluation of a Newly Developed Percutaneous Thrombectomy Basket Device m Sheep with Central Pulmonary Embolisms. Investigative Radiology, 41:10, pp. 729-734.
  • Wampler, Richard, K., “In Vivo Evaluation of a Peripheral Vascular Access Axial Flow Blood Pump,” ASAIO Trans., Jul.-Sep. 1988;34(3): pp. 450-454.
Patent History
Patent number: 9427507
Type: Grant
Filed: Jul 24, 2004
Date of Patent: Aug 30, 2016
Patent Publication Number: 20100268017
Assignee: ABIOMED EUROPE GMBH (Aachen)
Inventor: Thorsten Siess (Wuerselen)
Primary Examiner: Christopher D Koharski
Assistant Examiner: Roland Dinga
Application Number: 10/566,423
Classifications
Current U.S. Class: Sensing Means Inserted In Blood Vessel (600/505)
International Classification: A61M 1/10 (20060101); A61M 1/12 (20060101); A61M 25/00 (20060101);