Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
A method of hormonally treating menopausal (including perimenopausal and post-menopausal) disorders in women, a composition, and a multi-preparation pack therefor. The administrative regimen to which the pack is particularly adapted comprises continuously and uninterruptedly administering a progestogen to a woman while cyclically administering an estrogen by using a repetitive dosage regimen. This regimen calls for administering the estrogen continuously for a period of time between about 20 and about 120 days, followed by terminating administering the estrogen for a period of time between about 3 and about 7 days. Alternatively, both the progestogen and estrogen may be administered for the full treatment period without interruption. The regimen avoids many of the problems associated with the administration of estrogen alone or with progestogen administered according to conventional regimens, and also avoids problems associated with such conventional regimens by maintaining the estrogen and progestogen at low daily dosage levels of between 0.005 mg and 2.5 mg estrogen and 0.25 mg and 30 mg progestogen.
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Claims
3639600 | February 1972 | Hendrix |
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Type: Grant
Filed: Oct 13, 1995
Date of Patent: Jul 6, 1999
Assignees: WOCO Investments, Ltd. , Pre JAY Holdings, Limited
Inventors: Earl E. Plunkett (London), Bernard M. J. Wolfe (London)
Primary Examiner: Raymond J. Henley, III
Law Firm: Pillsbury Madison & Sutro LLP
Application Number: 8/542,941
International Classification: A61K 3156;