Patents Issued in September 15, 1987
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Patent number: 4693932Abstract: An oriented polyester film comprising ethylene terephthalate as the major repeating units, which comprises 0.01 to 1.0% by weight of silica particles and/or titanium dioxide particles having each an average particle size of 0.01 to 0.5.mu. and 0.005 to 1.0% by weight of calcium carbonate having an average particle size of 0.01 to 0.5.mu., which provides an oriented polyester film for the base film of video tape which has a flatness on the surface and has excellent slipperiness, abrasion resistance and running characteristics as well as excellent magnetic transducer characteristics.Type: GrantFiled: May 2, 1986Date of Patent: September 15, 1987Assignee: Toyo Boseki Kabushiki KaishaInventors: Katsuaki Kuze, Yasuhiro Nishino, Yujiro Matsuyama, Kozo Maeda, Masahiro Kobayashi, Tadashi Okudaira, Tsuyoshi Hongo, Osamu Makimura
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Patent number: 4693933Abstract: X-ray dispersive and reflective structures and materials are provided which exhibit improved resolution and reflectivity in specific ranges of interest without substantial fluorescence or absorption edges. The structures are formed of metallic and non-metallic layer pairs and can include a buffer layer between each layer to prevent interdiffusion to stabilize the structures. The materials can be thermally activated to control the desired properties, during or post deposition. The structures can be deposited by ion beam absorption techniques to form the structures in a precise manner. The index of the refraction of the structures can be continuously varying throughout the structures.Type: GrantFiled: October 31, 1983Date of Patent: September 15, 1987Assignee: Ovonic Synthetic Materials Company, Inc.Inventors: John E. Keem, Stanford R. Ovshinsky, Steven A. Flessa, James L. Wood, Keith L. Hart, Lennard Sztaba
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Patent number: 4693934Abstract: Magnetic recording tape comprising a ferromagnetic thin film on a non-magnetic base and having good running stability and low output fluctuation, clogging, and dropout can be obtained by making the stiffness of the overall tape0.149.times.wa.sup.3 /dxb=0.02 to 0.12 g mmwhereinw: load (g)a: radius of tape ring (mm)b: tape width (mm)d: deformation of tape ring (mm)The stiffness in the above formula can be determined by the method described in the specification.Type: GrantFiled: May 29, 1985Date of Patent: September 15, 1987Assignee: TDK CorporationInventors: Masaharu Nishimatsu, Hiroyuki Arioka, Hideki Ishizaki
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Patent number: 4693935Abstract: This invention provides pressure sensitive adhesive (PSA) compositions comprising a copolymer having a vinyl polymeric backbone having grafted thereto polysiloxane moieties. The compositions may contain other ingredients such as tackifier and/or plasticizer. An exposed surface of the PSA composition is initially positionable on a substrate to which it will be adhered but, once adhered, builds adhesion to form a strong bond. The PSA compositions may be used alone or in blends with unsiliconized PSA compositions. The invention also provides sheet materials coated with the PSA composition such as tape, labels, etc.Type: GrantFiled: May 19, 1986Date of Patent: September 15, 1987Assignee: Minnesota Mining and Manufacturing CompanyInventor: Mieczyslaw H. Mazurek
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Patent number: 4693936Abstract: An improved thermally stable, lubricious magnet wire enamel is disclosed which is particularly suitable for use as an outermost insulating, lubricating layer on a magnet wire substrate. The enamel comprises the reaction product of a tri-basic acid anhydride, a diisocyanate and a polyfunctional organosiloxane. The coating has a coefficient of friction, after application to magnet wire, of less than 0.10. It is also substantially all polyfunctional organosiloxane reacted, i.e. substantially no polyfunctional organosiloxane is capable of being extracted from the cured coating with organic solvents.Type: GrantFiled: June 9, 1986Date of Patent: September 15, 1987Assignee: Essex Group, Inc.Inventors: Charles W. McGregor, Melody L. Sutto
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Patent number: 4693937Abstract: Very high levels of insulation resistance and of insulation resistance stability of insulating compositions having polyolefin bases and having polar organic additives are achieved in this invention. The polar organic additives can be organic halogenated flame retardants, such as decabromodiphenyl oxide. The surprising increase in insulation resistance and in insulation resistance stability is achieved by addition of certain antioxidants in combination and, particularly, the addition of a zinc salt of mercaptoimidazole and a sterically hindered di-tertiary butyl phenol. The composition may be crosslinked by radiation or even by chemical means as through use of organic peroxides without loss of the surprisingly increased insulation resistance and insulation resistance stability.Type: GrantFiled: July 22, 1985Date of Patent: September 15, 1987Assignee: General Electric CompanyInventors: Alexander F. Wu, Robert B. Walters
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Patent number: 4693938Abstract: A uniform cryogenic layer of DT fuel is maintained in a fusion target having a low density, small pore size, low Z rigid foam shell saturated with liquid DT fuel. Capillary action prevents gravitational slumping of the fuel layer. The saturated shell may be cooled to produce a solid fuel layer.Type: GrantFiled: November 7, 1986Date of Patent: September 15, 1987Assignee: The United States of America as represented by the United States Department of EnergyInventor: Dale H. Darling
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Patent number: 4693939Abstract: Novel, non-crosslinked copolymers of vinyl trifluoroacetate (VTA) and up to 5 weight percent of the VTA of certain comonomers, such as vinyl esters, vinyl ethers, or disubstituted ethylene monomers, are disclosed. Solvolysis of these copolymers provides novel water-insoluble, non-crosslinked, poly(vinyl alcohol) copolymers which can be hydrated to copolymers having controllably variable hydrogel properties and high strength. Such poly(vinyl alcohol) copolymers are particularly desirable as ophthalmic devices such as contact lenses, corneal implants and transplants, and intraocular lenses.Type: GrantFiled: September 3, 1986Date of Patent: September 15, 1987Assignee: Minnesota Mining and Manufacturing CompanyInventor: Ronald F. Ofstead
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Patent number: 4693940Abstract: In a laminate comprising adjacent layers composed of incompatible polymers, the adhesion between the layers is enhanced by irradiation of the laminate, and can be further enhanced by high temperature annealing of the irradiated laminate.Type: GrantFiled: March 30, 1984Date of Patent: September 15, 1987Assignee: Raychem CorporationInventors: Christine E. Vogdes, Yutaka Kawazoye
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Patent number: 4693941Abstract: Poly(ethylene terephthalate) compositions containing a small amount of a terpolymer of ethylene containing carboxyl groups, which may be partly or completely converted to a divalent metal salt form, and reinforced with a mineral material having an aspect ratio of at least 10 can be formed into sheets which are readily thermoformable at moderate pressures and have very good thermoforming radius ratios.Type: GrantFiled: August 6, 1985Date of Patent: September 15, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: George J. Ostapchenko
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Patent number: 4693942Abstract: A method for manufacturing an apex seal for rotary piston engines, comprising steps of providing a substrate made of an iron based material and having a portion wherein a sliding surface is provided, spraying the portion of the substrate with a molten-state Co-Mo-Si type intermetallic compound to form a coating of the compound, heating the coating of the compound by applying electron beams or laser beams to thereby make the intermetal compound dispersed in the substrate, heating the substrate to 580.degree. to 780.degree. C. to anneal it and machining the substrate into a configuration of the apex seal. The apex seal made in accordance with this method is also disclosed.Type: GrantFiled: January 7, 1986Date of Patent: September 15, 1987Assignee: Mazda Motor CorporationInventors: Tsutomu Shimizu, Jun Miyata, Koji Yagii
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Patent number: 4693943Abstract: A magnetooptical recording medium of an amorphous magnetic alloy film of a composition which as an axis of easy magnetization in a direction perpendicular to the film surface represented by I, II or III:[(GdTb).sub.1-y (FeCo).sub.y ].sub.1-p Cr.sub.p (I)wherein 0.5.ltoreq.y.ltoreq.0.9 and 0.001.ltoreq.p.ltoreq.0.3;(GdTbFe).sub.1-(p+q) Cr.sub.p X.sub.q (II)wherein X can be either silicon or aluminum; p.gtoreq.0.001, q.gtoreq.0.001 and (p+q).ltoreq.0.3; or[(GdTb).sub.1-y (FeCo).sub.y ].sub.1-(p+q) Cr.sub.p X.sub.q (III)wherein X can be either silicon or aluminum, 0.5.ltoreq.y.ltoreq.0.9, p>0.001, q.gtoreq.0.001 and (p+q).ltoreq.0.3.Type: GrantFiled: November 16, 1984Date of Patent: September 15, 1987Assignee: Canon Kabushiki KaishaInventors: Hiroyoshi Kishi, Masaaki Matsushima
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Patent number: 4693944Abstract: A surface-coated wear-resistant member of cermet which includes a substrate of cermet and a hard coating vapor-deposited on a surface of the substrate. The coating is composed of at least one titanium compound selected from the group consisting of titanium carbide, titanium nitride, carbonitride of titanium, oxy-carbide of titanium, oxy-nitride of titanium and oxy-carbo-nitride of titanium. An atomic ratio of one of carbon, nitrogen, carbon plus nitrogen, carbon plus oxygen, nitrogen plus oxygen and carbon plus nitrogen plus oxygen to titanium(Ti) in the coating is in the range of between 0.3 and 0.8. The coating contains a compound of TiX and a compound of Ti.sub.2 X wherein X is one of carbon and nitrogen or at least two of carbon, nitrogen and oxygen. The coating may further includes titanium metal. The coating having an average thickness of 1 to 10 .mu.m. There is also disclosed a process for producing such a surface-coated wear-resistant member.Type: GrantFiled: September 23, 1986Date of Patent: September 15, 1987Assignee: Mitsubishi Kinzoku Kabushiki KaishaInventors: Taijiro Sugisawa, Akio Nishiyama
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Patent number: 4693945Abstract: A power generator containing a fuel cell (or cells) characterized by a fuel supply means designed to supply hydrogen gas and oxygen gas to the hydrogen and oxygen feed lines leading to the cell in response to a rapid rise of power load connected to the cell. This power generator suffers from no shortage of output power due to a delay of action and is excellent in responsiveness to sharp rise of load. In a preferred embodiment of this invention, the electrolyte is electrolyzed to produce hydrogen gas and oxygen gas by DC power generated by the fuel cell, and the produced gases are led to the hydrogen and oxygen feed lines leading to the fuel cell.Type: GrantFiled: April 22, 1986Date of Patent: September 15, 1987Assignee: Hitachi, Ltd.Inventors: Hideo Ohyauchi, Yoshiaki Amano, Eiji Yokoyama
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Patent number: 4693946Abstract: A battery assembly of the consumable metal anode type has now been constructed for ready assembly as well as disassembly. In a non-conductive and at least substantially inert cell body, space is provided for receiving an open-structured, non-consumable anode cage. The cage has an open top for facilitating insertion of an anode. A modular cathode is used, comprising a peripheral current conductor frame clamped about a grid reinforced air cathode in sheet form. The air cathode may be double gridded. The cathode frame can be sealed, during assembly, with electrolyte-resistant-sealant as well as with adhesive. The resulting cathode module can be assembled outside the cell body and readily inserted therein, or can later be easily removed therefrom.Type: GrantFiled: March 11, 1986Date of Patent: September 15, 1987Assignee: ELTECH Systems CorporationInventors: Marilyn J. Niksa, Gerald R. Pohto, Leslie K. Lakatos, Douglas J. Wheeler, Andrew J. Niksa, Thomas J. Schue
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Patent number: 4693947Abstract: A system and method for agitating the acid in a large lead-sulfuric acid storage battery of the calcium type. An air-lift is utilized to provide the agitation. The air fed to the air-lift is humidified prior to being delivered to the air-lift.Type: GrantFiled: April 21, 1986Date of Patent: September 15, 1987Assignee: The United States of America as represented by the United States Department of EnergyInventors: Alvin Weintraub, Robert S. MacCormack
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Patent number: 4693948Abstract: An electric storage battery has terminals (T1, T2) each having a wall (W1, W2) thereabout shaped to inhibit connection of an incorrect connectors (C1, C2) which are of mutually different shape and/or size. Each terminal (T1, T2) is laterally spaced from the electrode post (P1, P2) of the battery to which it is connected, and each post (P1, P2) is joined by a cast lead linking member (E) to the terminals.Type: GrantFiled: December 20, 1985Date of Patent: September 15, 1987Assignee: Lucas Industries Public Limited CompanyInventor: Keith J. B. McEwan
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Patent number: 4693949Abstract: The container or casing of a storage battery for automobiles and the like is so constructed as to be universally compatible for use with various types of securing mechanisms. Positive and negative terminals are provided on both the top and on one of the side walls. The battery may be secured by a peripheral frame which engages the periphery of the top wall, a central bail which overlies the medial portion of the top wall, or lower opposed clips which engage and clamp onto ledges on opposed side walls or opposed end walls. The top wall and bottom wall are so constructed as to nest to the adjacent housing in a stack when stored or displayed, and a space between adjacent housings allows visual inspection of a color coded handle. In addition, a unique vent cover construction elevates the wells surrounding the vent openings to maximize the vertical dimension of the plates therebeneath.Type: GrantFiled: August 12, 1985Date of Patent: September 15, 1987Assignee: Douglas Battery Manufacturing Co.Inventors: James H. Kellett, Raymond W. Gaddis, Robert W. Fritts, David L. Schoenecker
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Patent number: 4693950Abstract: A rechargeable current-generating cell is disclosed, composed of(a) an anode made of lithium or its alloys;(b) a non-aqueous electrolyte solution with a solid electrolyte or a molten electrolyte; and(c) a cathode of a vanadium-substituted alkali thiochromite having the general formula Na.sub.y Cr.sub.l-x V.sub.x S.sub.2, wherein x lies between 0.05 and 0.3 and y is 1 for the stoichiometric compound and from 0.1 to 0.4 for the non-stoichiometric one. The non-stoichiometric compound is obtained from the stoichiometric compound, by electrochemical oxidation thereof, either in the cell, after its assembly, or in a non-aqueous electrolyte solution in a separate vessel, prior to assembly of the cell. The non-stoichiometric compound can also be obtained by chemical oxidation of the stoichiometric one in a nonaqueous solution of iodine.Type: GrantFiled: October 30, 1985Date of Patent: September 15, 1987Assignee: Zlehit pri BanInventors: Rafail V. Moshtev, Vesselin G. Manev, Bogdana L. Puresheva
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Patent number: 4693951Abstract: An image bearing member for forming a toner image on the surface thereof characterized in that said surface has a maximum surface roughness of 20 .mu.m or less, and an average surface roughness satisfying the relation of r.ltoreq.2d between the average surface roughness and a toner particle size, wherein r is the average surface roughness; and d is a mean particle size of the toner particles; a contact angle with water at least 70 degrees; or a pencil hardness of F or harder as measured according to the JIS test method K-5400; a process for forming image with said member, and an utility thereof.Type: GrantFiled: June 1, 1984Date of Patent: September 15, 1987Assignee: Canon Kabushiki KaishaInventors: Yoshio Takasu, Yoshihiro Oguchi, Kazuharu Katagiri
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Patent number: 4693952Abstract: Toner for developing an electrostatic latent image comprising (a) a polyester resin obtained by polymerizing a composition containing an alcohol and a carboxylic acid, at least one of said alcohol and carboxylic acid containing multifunctional component of not less than tri-valents and (b) an epoxy resin.Type: GrantFiled: May 22, 1985Date of Patent: September 15, 1987Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Fumio Koizumi, Takahira Kasuya, Jiro Takahashi
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Patent number: 4693953Abstract: A moisture-sensitive element is produced by applying an ultraviolet-setting alkali-elution type resist ink on a prescribed part of a cation-exchange membrane, curing and drying the applied layer of the resist ink, chemically plating the cation-exchange membrane thereby forming electrode layers thereon, and thereafter removing the resist ink from the cation-exchange membrane.Type: GrantFiled: March 28, 1986Date of Patent: September 15, 1987Assignee: Agency of Industrial Science & Technology, Ministry of International Trade & IndustryInventor: Eiichi Torikai
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Patent number: 4693954Abstract: A heat developable light-sensitive material having both (a) a light-sensitive element which contains at least one light-sensitive silver halide emulsion layer and at least one image forming substance capable of forming a diffusible dye and (b) a dye fixing element capable of fixing the formed diffusible dye on the same side of one support, in such relation that a diffusible dye may permeate the dye fixing element (b) by diffusing from the light-sensitive element (a).The light-sensitive material of the present invention has a simple structure and does not require complicated procedures for its use or excess structural elements. Photographic images can be formed using the light-sensitive material in a short period of time by means of a simple photographic treatment.Type: GrantFiled: September 27, 1985Date of Patent: September 15, 1987Assignee: Fuji Photo Film Co., Ltd.Inventor: Hideki Naito
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Patent number: 4693955Abstract: Disclosed is a light-sensitive photographic element for negative type lithographic printing plates high in sensitivity and contrast which comprises a support having thereon a light-sensitive silver halide, a metal salt particle having substantially no light-sensitivity, a compound which reacts with an oxidized developing agent produced by development to release a compond which acts as a solvent or a solution physical development accelerator for said metal salt particle and physical development nuclei.Type: GrantFiled: March 18, 1985Date of Patent: September 15, 1987Assignee: Mitsubishi Paper Mills, Ltd.Inventors: Koichi Torizuka, Kiyoshi Futaki
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Patent number: 4693956Abstract: A process is disclosed for forming a high-contrast photographic image by developing a silver halide photographic element, including at least a silver halide emulsion layer, with an aqueous alkaline developing solution containing a dihydroxybenzene developing agent, a superadditive developing agent and an antioxidant at a pH of less than 12 in the presence of a hydrazine compound, an organic antifogging and contrast promoting agent selected within the class including a benzotriazole compound and a benzimidazole compound and a non polymeric hydroxymethylidyne group containing compound of formula: ##STR1## wherein R.sub.1 and R.sub.2 each independently represent a hydrogen atom, an aliphatic group, an aromatic group, a heterocyclic group, or R.sub.1 and R.sub.2 together complete a non aromatic cyclic group.Type: GrantFiled: November 15, 1985Date of Patent: September 15, 1987Assignee: Minnesota Mining and Manufacturing CompanyInventor: Carlo Marchesano
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Patent number: 4693957Abstract: New transition and inner transition metal chelate polymers and method for nthesizing thereof. Such polymers are used as positive or negative resists of high sensitivity for lithographic purposes in integrated circuit chip fabrication requiring submicron resolution. The polymers when irradiated undergo scission or crosslinking events which affects their solubility in developer solvents. They are synthesized either in non-aqueous solution with subsequent removal of excess solvent or interfacially with almost instantaneous precipitation of the polymer at the interface.Type: GrantFiled: March 14, 1985Date of Patent: September 15, 1987Assignee: The United States of America as represented by the Secretary of the NavyInventors: Ronald D. Archer, Christopher J. Hardiman, Ryszard Grybos, James C. W. Chien
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Patent number: 4693958Abstract: Lithographic plate, and method for making same, comprises a plate substrate with a selectively ink-receptive coating in the image area of the plate, rendered ink receptive by heat conversion of an initially water-soluble polymer coating of specifically defined polymer classes.Type: GrantFiled: January 28, 1985Date of Patent: September 15, 1987Assignee: Lehigh UniversityInventors: Anthony M. Schwartz, Norimichi Kawashima, Albert C. Zettlemoyer
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Patent number: 4693959Abstract: Use of a photoresist is improved due to increased adhesive to a substrate through an additive in the resist of a condensation polymer of formaldehyde, toluene sulfonamide and either a triazine such as melamine or hydantoin.Type: GrantFiled: March 7, 1986Date of Patent: September 15, 1987Assignee: E.I. Du Pont de Nemours and CompanyInventor: Robert W. Ashcraft
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Patent number: 4693960Abstract: A composition containing a polysiloxane having a polymerizable ethylenically unsaturated group, and 2,2-dimethoxy-2-phenyl acetophenone as an ultraviolet light sensitizer; and use thereof in lithography.Type: GrantFiled: November 7, 1986Date of Patent: September 15, 1987Assignee: International Business Machines CorporationInventors: Edward D. Babich, Michael Hatzakis, John J. Liutkis, Juri R. Parasczak, Jane M. Shaw
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Patent number: 4693961Abstract: A photopolymerizable coating agent made of (a) a low molecular weight epoxy-containing epoxy resin, (b) a high-molecular weight epoxy resin based on aromatic polyols and epichlorohydrin, (c) a light-sensitive ethylenically unsaturated monomer having terminal ethylene groups and (d) a photoinitiator and/or sensitizer, and, if desired, hardeners for epoxy resins. It is used for preparing temporary or permanent protective coatings and photographic relief images.Type: GrantFiled: April 10, 1986Date of Patent: September 15, 1987Assignee: Ciba-Geigy CorporationInventor: Sigrid Bauer
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Patent number: 4693962Abstract: A photochromic photosensitive composition comprising a indolinobenzothipyran-based spiropyran compound, a transparent, high molecular weight film forming resin, and a compound represented by the general formula (I): ##STR1## wherein R.sub.1, R.sub.3, R.sub.4 and R.sub.6 each represents a hydrogen atom, a halogen atom or a hydroxyl group, R.sub.2 and R.sub.5 each represents a hydrogen atom or a hydroxyl group, and X represents --NH--, --S--, ##STR2## (where R.sub.7 and R.sub.8 each represents a hydrogen atom, --CH.sub.3, --C.sub.2 H.sub.5, --CH.sub.2 CH.sub.Type: GrantFiled: December 9, 1985Date of Patent: September 15, 1987Assignee: Sony CorporationInventors: Shinichiro Tamura, Junetsu Seto
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Patent number: 4693963Abstract: This application discloses novel self-developing film units of the integral type. The film units have spacers or rails positioned between the superposed sheets for controlling the thickness of the applied layer of processing fluid. The rupturable pod is attached to the remainder of the film unit at only one edge, so that it may "float" after the processing fluid has been applied. A spacer is bonded to the mask in the area overlying the pod. The mask may be folded over and around only the leading and trailing ends of the film unit.Type: GrantFiled: April 1, 1986Date of Patent: September 15, 1987Assignee: Polaroid CorporationInventor: Thomas P. McCole
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Patent number: 4693964Abstract: Moderate camera speed photographic elements for producing subtractive primary dye images are disclosed, including one emulsion layer comprised of silver bromide or bromoiodide grains having a mean diameter in the range of from 0.4 to 0.55 .mu.m including tubular grains having an aspect ratio of greater than 8:1 accounting for at least 50 percent of the total projected area of the grains in the emulsion layer and being positioned to receive imaging radiation prior to one or more emulsion layers sensitized to the red or green portion of the spectrum. Enhancement of speed-granularity relationships, blue to minus blue speed separation, silver utilization, and image sharpness can all be realized.Type: GrantFiled: August 1, 1986Date of Patent: September 15, 1987Assignee: Eastman Kodak CompanyInventors: Richard L. Daubendiek, Gary L. House, Timothy R. Gersey
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Patent number: 4693965Abstract: A method for manufacturing a chemically and spectrally sensitized silver halide emulsion is described, which comprises carrying out chemical ripening of the emulsion in the presence of an iridium salt and a photographic spectral sensitizing dye.Type: GrantFiled: November 27, 1985Date of Patent: September 15, 1987Assignee: Fuji Photo Film Co., Ltd.Inventors: Mikio Ihama, Tadaaki Tani
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Patent number: 4693966Abstract: Human monoclonal antibodies which specifically bind to antigens found on cell surfaces of renal, lung, and breast cancer cells, intracellular cytoskeletal antigens, nuclear antigens, and cytoplasmic reticular antigens are disclosed. The antibodies are the product of hybridoma cell lines, where the immortal cell line may be, e.g., a human cell line, or a murine cell line.Type: GrantFiled: March 11, 1983Date of Patent: September 15, 1987Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Alan N. Houghton, Hannah Brooks, Richard J. Cote, Herbert F. Oettgen, Lloyd J. Old
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Patent number: 4693967Abstract: A diagnostic method and reagents for monitoring the efficacy of therapeutic treatment using the phenomenon of capping of cell membrane receptors, and is useful for relating receptor capping to clinical responses to therapy in patients with diseases, disorders, or malignancies involving cells that possess receptors. Therapeutic efficacy is determined by detecting receptors for activated substances, e.g., the third component of complement (C3), on cells having receptors therefor on the cell membrane surface, e.g., human lymphocytes, by the binding of an activated receptor substance, preferably labeled with a fluorescent or radioactive marker.Type: GrantFiled: February 18, 1981Date of Patent: September 15, 1987Assignee: Research CorporationInventor: Bobby J. Gormus
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Patent number: 4693968Abstract: An agent for quantitative determination of microorganisms, which comprises(a) an antibody prepared from a strain of the same species as the species of microorganisms to be determined,(b) an insolubilized cell component of a strain which can sufficiently bind to the antibody (a) but does not release and replace to other strains which have been bound with the antibody (a), and(c) a labelled second antibody, and a method for the quantitative determination of microorganisms. The agent and method of the present invention are useful for determinating simultaneously not only a strain from which the antibody is prepared but also other strains of the same species which are contained in the test sample.Type: GrantFiled: August 22, 1984Date of Patent: September 15, 1987Assignee: Dainippon Pharmaceutical Co., Ltd.Inventor: Tsunehiro Kitagawa
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Patent number: 4693969Abstract: A reagent for use in a "sandwich" enzyme-immunoassay comprising a polymer of a bioactive substance-specific antibody:enzyme conjugate, wherein said antibody is conjugated to said enzyme by means of heterobifunctional cross-linking agent and a "sandwich" enzyme-immunoassay employing the polymer.Type: GrantFiled: May 4, 1984Date of Patent: September 15, 1987Assignee: Cornell Research Foundation, Inc.Inventors: Brij B. Saxena, Premila Rathnam
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Patent number: 4693970Abstract: A method for immunoassay of an analyte in a fluid includes contacting the analyte with an antianalyte to give a bound fraction. The bound fraction activates the first component of complement whereby a substrate present in the fluid is modulated to provide a detectable signal. The signal may be detected to establish the presence or absence of the analyte in the fluid, or it may be quantitatively measured to determine the concentration of the analyte in the fluid. The invention includes a kit of materials useful in performing the method of the invention.Type: GrantFiled: June 21, 1985Date of Patent: September 15, 1987Assignee: Becton, Dickinson and CompanyInventors: James P. O'Connell, Randal A. Hoke, Patrick D. Mize
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Patent number: 4693971Abstract: A highly sensitive quantitative assay method for any one component which is L-glycero-3-phosphate (G3P), dihydroxyacetone-3-phosphate (DHAP), nicotinamide adenine dinucleotide (NAD) or reduced NAD, in a specimen to be assayed, comprising causing this component in the specimen to take part in the cycling reaction ##STR1## wherein GPO is glycerophosphate oxidase and GPDH is glycerophosphate dehydrogenase, and measuring a detectable change in the reaction system. There is thus provided a novel G3P-GHAP cycling reaction using GPO, which consumes O.sub.2 and generates H.sub.2 O.sub.2 and DHAP, with a substrate of G3P, and furthermore GPDH which consumes reduced NAD and generates NAD and G3P, with a substrate of DHAP. Examples of specimens are specimens which contain any one of G3P, DHAP, NAD or reduced NAD, or which liberate or generate such a component.Type: GrantFiled: January 30, 1984Date of Patent: September 15, 1987Assignee: Toyo Jozo Kabushiki KaishaInventor: Hideo Misaki
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Patent number: 4693972Abstract: A method for rapid detection of microorganisms in a body fluid sample includes detecting the microorganisms after treatment of the sample with a lysing agent in order to dissolve sample components other than microorganisms, and staining with a fluorescent dye. The lysing agent may be part of a composition which includes a culture medium thereby providing simultaneous lysis and growth before staining. Detection is preferably accomplished by reliance on the fluorescence emitted by the dye having been properly excited by light energy.A composition suitable for use in the above-described method includes a growth medium and a lysing agent.Type: GrantFiled: January 16, 1984Date of Patent: September 15, 1987Assignee: Becton, Dickinson and CompanyInventors: James D. Mansour, Thomas H. Schulte, Vernon R. Neece
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Patent number: 4693973Abstract: DNA sequences, recombinant DNA molecules and processes for producing bovine growth hormone-like polypeptides in high yield and the novel polypeptides produced thereby. These polypeptides are useful in improving the rate of growth of and meat production and quality in cattle.Type: GrantFiled: August 11, 1983Date of Patent: September 15, 1987Assignee: Biogen N.V.Inventor: Gary N. Buell
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Patent number: 4693974Abstract: Sweetening agents for human and animal foods in the solid or liquid states contain at least 50% by weight of leucrose. They may additionally contain one or more sweetening agents selected from the group consisting of artificial sweeteners and sugar surrogates. The leucrose is produced by reaction of saccharose with .alpha.-(1-6)-glucosyl transferase in the presence of at least 100 mmoles of fructose per 1,000 I.U. of enzyme, and at least a partial separation of the dextrans and iso-malto-oligosaccharides. Leucrose may be prepared by this method having a purity of at least 98% and may be used as a non-cariogenic, metabolically fully utilizable sweetening agent with good compatibility which is also suitable for diabetics.Type: GrantFiled: September 29, 1986Date of Patent: September 15, 1987Assignee: Pfeifer & LangenInventors: Dieter Schwengers, Herta Benecke
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Patent number: 4693975Abstract: Somatic cell hybrids of purely human origin are described that are suitable fusion partners for producing hybridomas by fusion with antibody producing cells, which hybridomas are stable and continuous.Type: GrantFiled: November 20, 1984Date of Patent: September 15, 1987Assignee: The Wistar InstituteInventors: Danuta Kozbor, Carlo M. Croce
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Patent number: 4693976Abstract: The invention relates to a process for the incorporation of foreign DNA into the genome of dicotyledonous plants by infecting the plants or incubating plant protoplasts with Agrobacterium tumefaciens bacteria, which contain one or more Ti (tumour inducing) plasmids, wherein as Ti plasmid a stable cointegrate plasmid composed of the plasmid R772 and the plasmid pTiB6 with foreign DNA incorporated in the T-region of the Ti component of the cointegrate plasmid is applied as well as to a cointegrate plasmid pAL969 and cointegrate plasmids derived from the cointegrate plasmid by the incorporation of foreign DNA into the T-region of the Ti component.Type: GrantFiled: February 23, 1984Date of Patent: September 15, 1987Inventors: Robbert A. Schilperoort, Jacques Hille
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Patent number: 4693977Abstract: Enzymes extracted from a prokaryotic .beta.-lactam producing microorganism are immobilized on a support for producing desacetoxycephalosporin and analogs thereof from L-.alpha.-aminoadipyl-L-cysteinyl-D-valine and analogs thereof. The enzymes are an epimerase, a cyclase and a ring expansion enzyme extracted preferably from S. clavuligerus, S. cattleya or S. lipmanii. The support is preferably a diethylaminoethyl ion exchange resin.Type: GrantFiled: January 23, 1986Date of Patent: September 15, 1987Assignee: Queen's University at KingstonInventors: Saul Wolfe, Donald Westlake, Susan Jensen
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Patent number: 4693978Abstract: The present invention provides a restriction endonuclease, characterized by the palindromic recognition sequence: ##STR1## and the cleavage position defined by the arrows. The present invention also provides a process for obtaining this new restriction endonuclease.Type: GrantFiled: September 28, 1984Date of Patent: September 15, 1987Assignee: Boehringer Mannheim GmbHInventors: Karl O. Stetter, Rudiger Schmitt
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Patent number: 4693979Abstract: The present invention provides a restriction endonuclease, characterized by the palindromic recognition sequence: ##STR1## and the cleavage position defined by the arrows. The present invention also provides a process for obtaining the new restriction endonuclease.Type: GrantFiled: September 28, 1984Date of Patent: September 15, 1987Assignee: Boehringer Mannheim GmbHInventors: Karl O. Stetter, Rudiger Schmitt
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Patent number: 4693980Abstract: The present invention provides a restriction endonuclease, characterized by the palindromic recognition sequence: ##STR1## and the cleavage position defined by the arrows. The present invention also provides a process for obtaining this new restriction endonuclease.Type: GrantFiled: September 28, 1984Date of Patent: September 15, 1987Assignee: Boehringer Mannheim GmbHInventors: Karl O. Stetter, Rudiger Schmitt, Frank Laue
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Patent number: 4693981Abstract: Vaccines employing inactivated viruses having improved retention of antigenic characteristics are prepared by psoralen-inactivation of the live virus in a non-oxidizing atmosphere. By excluding oxygen and other oxidizing species from the inactivation medium, degradation of the antigen characteristics resulting from irradiation with ultraviolet light is largely prevented. The resulting inactivated viruses are employed in vaccine preparations for the inoculation of susceptible hosts to inhibit viral infection.Type: GrantFiled: October 7, 1985Date of Patent: September 15, 1987Assignee: Advanced Genetics Research InstituteInventors: Gary P. Wiesehahn, Richard P. Creagan, David R. Stevens, Richard Giles