Patents Issued in December 20, 2001
  • Process for manufacture of zeolites and zeolite mixtures having enhanced cation exchange properties, products produced thereby, and detergent compositions formulated therewith
    Publication number: 20010053741
    Abstract: A zeolite A or an A/X mixture having an LCC>70 g liquid/100 g zeolite (hydrated) and a cold water CER>200 mg CaCO3/gram anhydrous zeolite (hydrated). The zeolite product may have a crystal size of 0.1-0.7 microns, a bulk density of 0.19-0.37 g/ml, and a median particle size of 1-5 microns. A process for making zeolite A or A/X mixtures is also claimed, including mixing a sodium silicate solution, a sodium aluminate solution, and an amorphous aluminosilicate initiator gel in a mixing vessel to create an aluminosilicate synthesis gel, and crystallizing the aluminosilicate synthesis gel to form zeolite crystals. The sodium aluminate solution may be added gradually to at least the sodium silicate solution at a rate of about 1-5% of the total batch alumina per minute, and/or a percentage of the total batch alumina may be added as alumina trihydrate (ATH) powder.
    Type: Application
    Filed: March 16, 2001
    Publication date: December 20, 2001
    Inventors: Daniel J. Micco, Richard J. Hinchev
  • CATALYST AND PROCESSES FOR OLEFIN TRIMERIZATION
    Publication number: 20010053742
    Abstract: A process is provided to modify an olefin production catalyst system which comprises contacting an olefin production catalyst system with ethylene prior to use. A second embodiment of the invention comprises contacting an aluminum alkyl and a pyrrole-containing compound prior to contacting a chromium containing compound and prior to contacting an olefin. A process also is provided to trimerize and/or oligomerize olefins with the novel, modified olefin catalyst production systems. These modified olefin production catalyst systems can produce less solids, such as, for example, polymer, during a trimerization reaction.
    Type: Application
    Filed: December 18, 1998
    Publication date: December 20, 2001
    Inventors: RONALD D. KNUDSEN, JEFFREY W. FREEMAN
  • Negative active material for lithium secondary battery
    Publication number: 20010053743
    Abstract: Disclosed is a negative active material for a lithium secondary battery. The negative active material includes graphitized coke having a graphitization catalyst element and non-flat artificial graphite. The negative active material for a lithium secondary battery has good electrolyte-immersibility due to the gap between the graphite particles from graphitized coke having a graphitization catalyst element, and non-flat artificial graphite. Therefore, the present invention may provide a lithium secondary battery which has good high-rate capacity and initial efficiency.
    Type: Application
    Filed: May 9, 2001
    Publication date: December 20, 2001
    Inventors: Jae-Yul Ryu, Sang-Young Yoon, Wan-Uk Choi, Kyou-Yoon Sheem, Sang-Jin Kim
  • NEW SILICOALUMINOPHOSPHATES HAVING AN AEL STRUCTURE, AND THEIR PREPARATION
    Publication number: 20010053744
    Abstract: Disclosed are silicoaluminophosphates (SAPOs) having unique silicon distributions and their preparation. More particularly, the new SAPOs have a high silica:alumina ratio, and are prepared from single phase synthesis solutions, or from microemulsions containing surfactants.
    Type: Application
    Filed: May 20, 1999
    Publication date: December 20, 2001
    Inventors: KARL G. STROHMAIER, DAVID E. W. VAUGHAN
  • CATALYTIC CONVERTER HAVING CATALYST WITTH NOBLE METAL ON ALUMINA AND MOLECULAR SIEVE CRYSTAL SURFACE AND METHODS OF MAKING SAME
    Publication number: 20010053745
    Abstract: A catalytic converter for treating exhaust gas from an internal combustion engine containing a catalyst characterized by having platinum or a platinum alloy dispersed on alumina particles and predominantly on the exterior surface of molecular sieve crystals. Also provided is a catalyst for such a converter and processes for manufacture of such catalyst. In addition, methods for treating exhaust gas from an internal combustion engine to reduce the amounts of hydrocarbon, carbon monoxide and nitrogen oxides emitted to the atmosphere are included.
    Type: Application
    Filed: February 16, 1999
    Publication date: December 20, 2001
    Inventors: KARL C. KHARAS, HEINZ J. ROBOTA
  • Color-image-forming medium
    Publication number: 20010053746
    Abstract: In a color image-forming medium, a substrate is coated with a color-developing layer which is composed of at least one kind of heat-sensitive color-developing component, and a plurality of pressure-sensitive microcapsules. Each of the pressure-sensitive microcapsules is filled with a dye exhibiting a first single-color, and features a pressure/temperature characteristic to be broken when being subjected to a predetermined pressure within a first temperature range. The heat-sensitive color-developing component features a thermal color-developing characteristic to develop a second single color within a second temperature range defined by a first critical temperature and a second temperature. The first critical temperature is in the first temperature range, and the second critical temperature exceeds an upper limit temperature of the first temperature range.
    Type: Application
    Filed: April 24, 2001
    Publication date: December 20, 2001
    Applicant: ASAHI KOGAKU KOGYO KABUSHIKI KAISHA
    Inventors: Minoru Suzuki, Kazuyuki Shimbo, Yukio Kubota
  • THERMAL TRANSFER IMAGE-RECEIVING SHEET
    Publication number: 20010053747
    Abstract: A thermal transfer image-receiving sheet comprises a substrate sheet and a dye receptor layer disposed on at least one surface side of the substrate sheet, the dye receptor layer comprising a copolymer comprising styrene compound monomer and acrylic compound monomer and a plasticizer selected from the group consisting of phosphoric ester compounds, phthalic acid ester compounds, trimellitic acid ester compounds and dibasic aliphatic acid ester compounds. The thermal transfer image-receiving sheet is capable of forming an image excellent in density of coloring, sharpness/clearness and durability in various aspects, in particular light resistance.
    Type: Application
    Filed: November 4, 1998
    Publication date: December 20, 2001
    Inventor: YOSHIHIKO TAMURA
  • Large superconductor and its intermediate, and method for manufacturing the same
    Publication number: 20010053748
    Abstract: A large superconductor intermediate of REBa2Cu3Ox system (where RE is one kind or a combination of rare earth elements including Y), characterized by a structure that oxide superconductors having non-superconductive phases finely dispersed in REBa2Cu3Ox phases (123 phases) of different peritectic temperatures (Tp) are laminated three-dimensionally in the order of Tp's, seed crystals mounted on the oxide superconductor layer having a highest Tp, and excluded phases included in at least the oxide superconductor having the high Tp.
    Type: Application
    Filed: March 8, 2001
    Publication date: December 20, 2001
    Inventors: Mitsuru Sawamura, Mitsuru Morita
  • Method of and composition for reducing the loss of fluid during well drilling, completion or workover operations
    Publication number: 20010053749
    Abstract: Disclosed is a composition for and method of reducing the loss of fluid from well drilling, completion, or workover fluids during well drilling, completion, or workover operations, particularly for reducing or overcoming the lost circulation of drilling fluids. The composition comprises an aqueous liquid containing partially hydrated chitosan particles wherein the chitosan particles have been partially hydrated at a pH less than about 4.5, and wherein the aqueous liquid has a pH of at least about 6.5 such that any further solublizing of the chitosan is prevented. The aqueous liquid, preferably when mixed with a drilling, completion, or workover fluid, is effective in decreasing the loss of such fluids after introducing the partially hydrated chitosan-containing liquid or fluid into the flow passages in a well to which such fluids are being lost.
    Type: Application
    Filed: July 3, 2001
    Publication date: December 20, 2001
    Inventors: Jack C. Cowan, Michael J. Kilchrist
  • LUBRICANT OIL COMPOSITION FOR INTERNAL COMBUSTION ENGINES
    Publication number: 20010053750
    Abstract: The lubricating oil of the present invention exhibits an excellent effect of agglomerating solid impurity particles it contains to a sufficiently large size as to be captured and removed by an oil filter.
    Type: Application
    Filed: July 9, 1999
    Publication date: December 20, 2001
    Inventors: SATOHI OGANO, NOBUCHIKA KAWAGOISHI, MAKOTO YONEDA, TOSHIAKI KURIBAYASHI
  • Manufacture of lubricant additives
    Publication number: 20010053751
    Abstract: Oil-soluble or oil-dispersible trinuclear molybdenum-sulfur compounds are made by reacting, in a polar medium, a reactant molybdenum compound containing an anion that possesses a trinuclear molybdenum core, and a dithiocarbamate that is produced in situ.
    Type: Application
    Filed: March 23, 2001
    Publication date: December 20, 2001
    Inventors: Jonathan M. McConnachie, Ian A. W. Bell, Edward I. Stiefel, Stanley J. Brois, Ernestine W. Hill, Alisdair J. Brown
  • Rheology control agent
    Publication number: 20010053752
    Abstract: The present invention provides a rheology control agent of oil, which can impart a remarkably high elastic modulus with being sufficiently flowable as liquid by adding the same to the oil and it provides an oil composition having the greatly improved rheology characteristics.
    Type: Application
    Filed: March 14, 2001
    Publication date: December 20, 2001
    Applicant: Kao Corporation
    Inventors: Seiichi Miyanaga, Osamu Takiguchi
  • STABLE CLEANSING COMPOSITIONS CONTAINING ACTIVE AGENTS
    Publication number: 20010053753
    Abstract: Stable cleansing compositions containing an active agent and a surfactant and further containing ethoxylated solubilizing agents, and a process for stabilizing such compositions.
    Type: Application
    Filed: August 10, 1999
    Publication date: December 20, 2001
    Inventor: CAROLYN ENGEKHART
  • Water soluble package of liquid cleaning composition
    Publication number: 20010053754
    Abstract: A water soluble package in the form of a horizontal form-fill-seal envelope formed from a plastics film, the package containing a substantially non-aqueous liquid detergent composition having a viscosity of from 25 to 10,000 mPaS.
    Type: Application
    Filed: April 12, 2001
    Publication date: December 20, 2001
    Applicant: Unilever Home & Personal Care USA, Division of Conopco, Inc.
    Inventors: Malcolm Hewitt, Hannah Mansfield, Neeraj Gupta, James Dawson Cropper
  • Fabric care method
    Publication number: 20010053755
    Abstract: The present invention provides a process for inhibiting the re-absorption of migrating dyes in the wash liquor, comprising introducing into a wash liquor containing a peroxide-containing detergent, from 0.5 to 150, preferably from 1.5 to 75, especially from 7.
    Type: Application
    Filed: April 13, 2001
    Publication date: December 20, 2001
    Inventors: Frank Bachmann, Josef Dannacher, Martin Studer, Beat Freiermuth, Cornelia Makowka, Peter Weingartner, Grit Richter, Gunther Schlingloff
  • Solvent mixtures suited for use with wiping cloth on auto bodies
    Publication number: 20010053756
    Abstract: A solvent mixture comprising an alcohol, an aromatic hydrocarbon or an organic compound containing carboxyl but not hydroxyl moieties, and optionally and preferably a non-aromatic hydrocarbon or halohydrocarbon is particularly effective in removing incompletely cured residues of a variety of sealing compounds from the surfaces of automobile bodies, without damaging intermediate or final finish coatings for the automobile bodies. The solvent mixture may advantageously be absorbed in a wiping cloth for convenient use.
    Type: Application
    Filed: January 11, 2001
    Publication date: December 20, 2001
    Inventor: Chester P. Jarema
  • Speckled detergent composition
    Publication number: 20010053757
    Abstract: Speckled detergent compositions with colored glassy phosphates and conventional detergent ingredients.
    Type: Application
    Filed: March 20, 2001
    Publication date: December 20, 2001
    Applicant: The Procter & Gamble Company
    Inventors: Lucia Mendez Mata, Fabrizio Meli
  • Methods and compositions for the treatment and prevention of lung disease
    Publication number: 20010053758
    Abstract: Methods and compositions for the treatment of lung disease, such as emphysema and/or bronchopulmonary dysplasia, in a mammal. Also disclosed are methods promoting the formation of alveolar septa and increasing the gas-exchange surface area of a mammalian lung, and for the prevention and/or treatment of alveolar destruction.
    Type: Application
    Filed: July 31, 2001
    Publication date: December 20, 2001
    Inventors: Gloria DeCarlo Massaro, Donald Massaro, Roshantha A. Chandraratna
  • Skin cancer preventive agent
    Publication number: 20010053759
    Abstract: The present invention provides a skin cancer preventive agent that inhibits the promotion of carcinogenesis of skin cancer while having high levels of safety and stability as well as being free of adverse side effects. The present invention is characterized by containing sericin.
    Type: Application
    Filed: May 24, 2001
    Publication date: December 20, 2001
    Applicant: KABUSHIKI KAISHA AIOI HAKKO & SEIREN KABUSHIKI KAISHA
    Inventors: Zongxuan Jin, Koichiro Muramatsu, Hideyuki Yamada, Naozumi Fuwa, Hiroshige Hibasami
  • Treatment of infarcts
    Publication number: 20010053760
    Abstract: This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.
    Type: Application
    Filed: July 30, 2001
    Publication date: December 20, 2001
    Inventors: Stephen J. Brand, Alfred L. Goldberg, Louis Plamondon, Francois Soucy, Peter J. Elliott
  • METHOD FOR ADMINISTERING ASPB28-HUMAN INSULIN
    Publication number: 20010053761
    Abstract: The claimed invention relates to a method of administering AspB28-human insulin by inhalation, a method for treating diabetes by administering AspB28-human insulin by inhalation, and a method for treating hyperglycemia by administering AspB28-human insulin by inhalation.
    Type: Application
    Filed: January 6, 1999
    Publication date: December 20, 2001
    Inventors: RICHARD DENNIS DIMARCHI, ROGER GARRICK HARRISON, RONALD KEITH WOLFF
  • METHOD OF TREATING REPRODUCTIVE DISORDERS
    Publication number: 20010053762
    Abstract: This is a method for treating reproductive disorders associated with a failure of gamete maturation in subjects by administering a composition containing a complex of insulin-like growth factor (IGF) and insulin-like growth factor binding protein-3 (IGFBP-3).
    Type: Application
    Filed: March 18, 1999
    Publication date: December 20, 2001
    Inventor: CHRISTOPHER A. MAACK
  • Method and composition for modulating an immune response
    Publication number: 20010053763
    Abstract: Disclosed is a method of inhibiting or preventing a condition associated with undesired secretion of a macrophage inflammatory protein using inhibitors of ATP-sensitive K+-channels, inhibitors of the Na+/H+ antiporter, inosine, or inosine analogs.
    Type: Application
    Filed: March 26, 2001
    Publication date: December 20, 2001
    Inventors: Andrew Salzman, Csaba Szabo
  • Interleukin-1 inhibitors in the treatment of diseases
    Publication number: 20010053764
    Abstract: The invention pertains to methods for treating medical disorders characterized by elevated levels or abnormal expression of IL-1 by administering an IL-1 antagonist, such as soluble type II IL-1 receptor.
    Type: Application
    Filed: May 11, 2001
    Publication date: December 20, 2001
    Inventors: John E. Sims, Larry F. O'Neal
  • Methods and compositions for the selective regulation of chorionic prostanoids
    Publication number: 20010053765
    Abstract: Methods for inhibiting the production of specific vasoconstrictive prostanoids, such as thromboxane and prostaglandin F2&agr;, through the addition of insulin like growth factor, particularly IGF-I or IGF-II, to human placental cells are disclosed. IGF-I is demonstrated to avoid affecting material and placental production of prostaglandin E, human chorionic gonadotropin, PGFM, and 6 -keto-PGF1-alpha by placental cells. Improved methods for vasoregulation of vasoconstrictive diseases of pregnancy are also disclosed. Methods for treating hypertension with IGF-I are also described. Improved methods for inhibiting pre-term labor are also provided. Methods for inducing labor with agents that specifically inhibit insulin like growth factor are also disclosed. Such inhibitors of IGF-I include antibodies, antagonists of IGF-I, and metabolizing enzymes of IGF-I.
    Type: Application
    Filed: July 12, 2001
    Publication date: December 20, 2001
    Applicant: Board of Regents, The University of Texas System
    Inventor: Theresa M. Siler-Khodr
  • Method of treating disorders of the eye
    Publication number: 20010053766
    Abstract: The present invention relates, in general, to methods of treating disorders of the eye, and, in particular, to methods of preventing or treating elevated eye pressure and glaucoma. The invention further relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: February 12, 2001
    Publication date: December 20, 2001
    Inventors: Janardan Kumar, Vasanth Rao, David L. Epstein, Pratap Challa
  • Compounds and their uses
    Publication number: 20010053767
    Abstract: Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. Preferred compounds of the invention are based on the substituted cyclitols, such as the chiro-inositol derivative pinitol (3-O-methyl-chiro-inositol).
    Type: Application
    Filed: March 2, 2001
    Publication date: December 20, 2001
    Inventors: Manuel Martin-Lomas, Thomas William Rademacher, Hugo Norberto Caro, Irene Francois
  • GENE THERAPY USING REPLICATION COMPETENT TARGETED ADENOVIRAL VECTORS
    Publication number: 20010053768
    Abstract: This invention provides a method of treating cancer by administering a replication competent adenoviral vector comprising a therapeutic gene and a disease specific gene regulatory region operationally linked to at least one replication gene. The replication competent targeted adenoviral vector preferentially replicates in the tumor cells following activation of the tumor specific gene regulatory region thereby amplifying the effect of the therapeutic gene carried by the replication competent adenoviral vector. This invention enables for the first time the targeting of a therapeutic gene for treating cancer using small amounts of viral vectors which selectively replicate to deliver therapeutic dosages of the therapeutic gene.
    Type: Application
    Filed: December 16, 1998
    Publication date: December 20, 2001
    Inventors: RICHARD J. GREGORY, WHEI-MEI HUANG
  • Use of pro-apoptotic factors in treatment of atherosclerosis
    Publication number: 20010053769
    Abstract: The present invention features a novel method of treating vascular disease that involves modifying smooth muscle cells to express a gene encoding a protein having both anti-inflammatory and pro-apoptotic activity. Preferably, the protein of the invention also has an anti-proliferative effect in smooth muscle cells. In general, the method is useful in preparing vascularized organs and vessels for transplant into a patient. Alternatively, the present invention can be applied to treat atherosclerotic lesions in damaged vessels.
    Type: Application
    Filed: January 19, 2001
    Publication date: December 20, 2001
    Inventors: Christiane Ferran, Maria B. Arvelo
  • Bispecific molecules cross-linking ITIM and ITAM for therapy
    Publication number: 20010053770
    Abstract: The invention includes bispecific molecules capable of cross-linking ITAM and ITIM receptors on a cell in order to inhibit cell activation, as well as gene therapy approaches using nucleotides encoding such bispecific molecules for expression in vivo. One example of an ITAM/ITIM receptor pair is Fc&egr;RI and HM18, and another is Fc&egr;RI and Fc&ggr;RII. Cross-linking of these receptors with a bispecific molecule of the invention would lead to inhibition of the release of allergic mediators and amelioration of the symptoms of allergic diseases. Other diseases can be ameliorated by cross-linking ITIM/ITAM receptor pairs.
    Type: Application
    Filed: March 16, 2001
    Publication date: December 20, 2001
    Inventors: David Thomas, Sunny Tam
  • USE OF GLUCOSAMINE AND CLUCOSAMINE DERIVATIVES FOR QUICK ALLEVIATION OF ITCHING OR LOCALIZED PAIN
    Publication number: 20010053771
    Abstract: The present invention relates to the new use of glucosamine and/or its derivatives for the preparation of a therapeutical composition for treating and quick relief of itching and/or local pain which results from a variety of causes. The invention further relates to therapeutical compositions for use in this treatment.
    Type: Application
    Filed: October 1, 1999
    Publication date: December 20, 2001
    Inventor: DIRK ANDRE RICHARD VANDEN BERGHE
  • Aza analogues of alkyl lysophospholipids exert immunomodulatory effects
    Publication number: 20010053772
    Abstract: The present invention relates to alkyl lysophospholipid (ALP), and derivatives thereof, that are potent cytokine inducers and immunomodulatory agents. The immunomodulatory agents are administered to a subject having a condition characterized by an altered or aberrant cytokine activity such as, but not limited to, neoplasia, infectious diseases, chronic and acute immune diseases, autoimmunity, transplantation, diseases mediated by nitric oxide and cytokines, adverse drug reactions, obesity, septic shock, and adverse side effects due to cancer chemotherapy.
    Type: Application
    Filed: April 30, 2001
    Publication date: December 20, 2001
    Inventors: Benjamin Bonavida, Xiao-Hu Gan
  • Method for inhibiting the growth of cancers
    Publication number: 20010053773
    Abstract: A method for inhibiting the growth of tumors and cancers in mammals comprising administering a chemotherapeutic agent to significantly reduce the tumor in mass and then administering a benzimidazole derivative. Potentiators can also be included in the benzimidazole composition.
    Type: Application
    Filed: July 23, 2001
    Publication date: December 20, 2001
    Applicant: The Procter & Gamble Company
    Inventor: James Berger Camden
  • Non-steroidal ligands for the estrogen receptor
    Publication number: 20010053774
    Abstract: Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.
    Type: Application
    Filed: December 14, 2000
    Publication date: December 20, 2001
    Applicant: GLAXO WELLCOME INC..
    Inventor: Timothy Mark Willson
  • Nasal solutions
    Publication number: 20010053775
    Abstract: The invention relates to liquid pharmaceutical compositions adapted to nasal administration. The liquid nasal formulations of the invention are characterized inter alia by having excellent and prolonged moisturizing properties.
    Type: Application
    Filed: June 13, 2001
    Publication date: December 20, 2001
    Inventors: Matthias Seidel, Christopher Buckley
  • Tricyclic pyridin-2-one analogue as a GABA receptor ligand
    Publication number: 20010053776
    Abstract: 9-(4-Methylthiazol-2-yl)- 11-(pyridin-4-yl)-6,7-dihydro-5H-2, 7a-diazadibenzo[a,c]cyclohepten-8-one, and pharmaceutically acceptable salts thereof, are selective ligands for GABAA receptors, in particular having high affinity for the a2 and/or a3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
    Type: Application
    Filed: May 18, 2001
    Publication date: December 20, 2001
    Inventors: James Michael Crawforth, Karl Richard Gibson, Michael Rowley
  • Drug treatment for restless leg syndrome
    Publication number: 20010053777
    Abstract: A method for the treatment of Restless Leg Syndrome (RLS), which comprises administering an &agr;2-agonist and a second agent selected from the group consisting of the dopamine agonists, opioids, benzodiazepines and the combination of L-DOPA plus a decarboxylase inhibitor.
    Type: Application
    Filed: August 1, 2001
    Publication date: December 20, 2001
    Inventor: Hans Michael Brecht
  • Pharmaceutical compositions of glycogen phosphorylase inhibitors
    Publication number: 20010053778
    Abstract: Pharmaceutical compositions comprise a glycogen phosphorylase inhibitor and at least one concentration-enhancing polymer. The composition may be a simple physical mixture of glycogen phosphorylase inhibitor and concentration-enhancing polymer or a dispersion of glycogen phosphorylase inhibitor and polymer.
    Type: Application
    Filed: March 14, 2001
    Publication date: December 20, 2001
    Inventors: Dennis J. Hoover, Ravi M. Shanker, James A.S. Nightingale, Dwayne T. Friesen, Douglas A. Lorenz
  • Novel compounds and compositions for treating diseases asociated with protease activity
    Publication number: 20010053779
    Abstract: Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.
    Type: Application
    Filed: June 4, 2001
    Publication date: December 20, 2001
    Inventors: Timothy J. Church, Neil Scott Cutshall, Anthony R. Gangloff, Thomas E. Jenkins, Martin S. Linsell, Joane Litvak, Kenneth D. Rice, Jeffrey R. Spencer, Vivian R. Wang
  • Daily treatment for erectile dysfunction using a PDE5 inhibitor
    Publication number: 20010053780
    Abstract: The present invention relates to phosphodiesterase (PDE) enzyme inhibitors and to their use in pharmaceutical articles of manufacture. In particular, the present invention relates to potent inhibitors of cyclic quanosine 3′,5′-monophosphate specific phosphodiesterase type 5 (PDE5) that when incorporated into a pharmaceutical product at about 1 to about 10 mg unit dosage are useful for the treatment of sexual dysfunction by daily administration of the PDE5 inhibitor. The articles of manufacture described herein are characterized by PDE5 inhibition, and accordingly, provide a benefit in therapeutic areas where inhibition of PDE5 is desired, especially erectile dysfunction, with minimization or elimination of adverse side effects resulting from inhibition of other phosphodiesterase enzymes and with an improvement of -vascular conditioning.
    Type: Application
    Filed: April 13, 2001
    Publication date: December 20, 2001
    Inventors: John S. Whitaker, Inigo Saenz de Tejada, Kenneth M. Ferguson
  • Pharmaceutical composition for enhancing cognition
    Publication number: 20010053781
    Abstract: The invention discloses a pharmaceutical composition for enhancing cognition, preventing and/or treating cognition disorders, including 50-100 mg/kg ferulic acid or a pharmaceutically acceptable salt or derivative thereof, and a pharmaceutically acceptable carrier or excipient. The pharmaceutical composition is useful in the treatment of disorders of learning acquisition, memory consolidation, and retrieval.
    Type: Application
    Filed: February 22, 2001
    Publication date: December 20, 2001
    Applicant: National Science Council
    Inventors: Ming-Tsuen Hsieh, Ying-Tsung Lin
  • Pyrrolo[2,3-d]pyrimidine compounds
    Publication number: 20010053782
    Abstract: A compound of the formula 1
    Type: Application
    Filed: December 8, 2000
    Publication date: December 20, 2001
    Inventors: Todd A. Blumenkopf, Mark E. Flanagan, Michael J. Munchhof
  • PHARMACEUTICAL COMPOUNDS
    Publication number: 20010053783
    Abstract: A pharmaceutical compound of the formula 1
    Type: Application
    Filed: January 13, 1998
    Publication date: December 20, 2001
    Inventor: JOHN FAIRHURST
  • Imminoribitol PNP inhibitors, preparation thereof and use thereof
    Publication number: 20010053784
    Abstract: Compounds represented by the formula: 1
    Type: Application
    Filed: March 22, 2001
    Publication date: December 20, 2001
    Applicant: BIOCRYST PHARMACEUTICALS, INC
    Inventors: Philip E. Morris, John A. Montgomery, Yarlagadda S. Babu
  • Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
    Publication number: 20010053785
    Abstract: This invention provides substituted compounds of the general formulae: 1
    Type: Application
    Filed: March 2, 2001
    Publication date: December 20, 2001
    Inventors: Michael S. Malamas, Richard E. McDevitt, Folake O. Adebayo
  • Methods for treating addictive disorders
    Publication number: 20010053786
    Abstract: The present invention provides a method of reducing cravings to food or an addictive substance in a mammal comprising administering an effective amount of a D1/D5 antagonist or a D1/D5 partial agonist to a mammal in need thereof. These compounds are also useful in the treatment of addictive drug induced psychoses. Suitably the addictive substance is cocaine, amphetamine, nicotine, opiates, tobacco or alcohol. The addictive substance may be ecstasy. The preferred compound is (+)-1-[1-(2-chlorophenyl)cyclopropyl]-7-hydroxy-6-methoxy-2-methyl- 1,2,3,4 -tetrahydroisoquinoline and salts thereof.
    Type: Application
    Filed: June 28, 2001
    Publication date: December 20, 2001
    Inventors: David John Heal, Patricia Lesley Needham
  • COMPOSITIONS FOR TREATING ALERGIC AND OTHER DISORDERS USING NORASTEMIZOLE IN COMBINATION WITH OTHER ACTIVE INGREDIENTS
    Publication number: 20010053787
    Abstract: Methods and compositions are disclosed utilizing metabolic derivatives of astemizole for the treatment of allergic disorders while avoiding the concomitant liability of adverse effects associated with the astemizole. The metabolic derivatives of astemizole are also useful for the treatment of retinopathy and other small vessel disorders associated with diabetes mellitus and such other conditions as may be related to the antihistamine activity of astemizole. For example, the metabolic derivatives of astemizole are useful for the treatment of asthma, motion sickness, and vertigo, without the concomitant liability of adverse effects associated with astemizole.
    Type: Application
    Filed: April 16, 2001
    Publication date: December 20, 2001
    Applicant: Sepracor Inc.
    Inventors: Raymond L. Woosley, A. K. Gunnar Aberg
  • 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
    Publication number: 20010053788
    Abstract: The present invention relates, among many things, to novel 4,5-dihydro-1H-pyrazole compounds which can be potent antagonists of the cannabis CB1-receptor.
    Type: Application
    Filed: March 23, 2001
    Publication date: December 20, 2001
    Applicant: Solvay Pharmaceuticals B.V.
    Inventors: Josephus H. M. Lange, Cornelis G. Kruse, Jacobus Tipker, Martinus T. M. Tulp, Bernard J. Van Vliet
  • Novel compounds for use as antidepressants, aphrodisiacs and adjunctive therapies in humans
    Publication number: 20010053789
    Abstract: Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen- or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, animals that eat such plants, or chemical synthesis, have been found to act as an antidepressant or otherwise a treatment for bettering mood, a therapy for improving sexual desire or performance, an adjunctive therapy for achieving weight loss, and an adjunctive therapy for substance abuse and addiction. These compounds, at concentrations suitable for human therapeutic use, may be obtained from plants such as corn in their early growth stages and from parts of animals such as the velvet antler tips of deer and elk.
    Type: Application
    Filed: April 13, 2001
    Publication date: December 20, 2001
    Inventors: Mark J. Rosenfeld, Patricia J. Berger, Norman C. Negus
  • Mothod and composition for treatment of ischemic neuronal reperfusion injury
    Publication number: 20010053790
    Abstract: Methods and compositions for treatment of, or protection from, neuropathy resulting from reperfusion injury upon reversal of an ischemic condition, comprising treatment or prophylactic treatment of the patient with an antagonist of the type 3 ryanodine receptor, such that a rise in cytosolic Ca2+ concentration is prevented. Therapeutic compositions containing dantrolene or aminodantrolene are administered to the patient to prevent a rise in cytosolic Ca2+ that would otherwise result in Ca2+-mediated neuronal damage. Treatment of ischemic optic neuropathy by this method is shown, and the methods and compositions presented are also applicable to other ischemic reperfusion neuropathies, such as stroke, reperfusion injury after TPA treatment/carotid endarterectomy, seizures, and excitotoxic retinal damage in glaucoma.
    Type: Application
    Filed: December 4, 2000
    Publication date: December 20, 2001
    Inventors: Harpal S. Mangat, Gerry Bullough, Gary Brown