Abstract: The present invention is for an oral osmotic controlled drug delivery system for a sparingly soluble drug comprising:

Abstract: A pharmaceutical construct is disclosed. The construct comprises at least a first region comprising a first superporous hydrogel having a selected medicament associated therewith to form an associated region. A second region of the construct comprising a second superporous hydrogel is attached to at least a portion of the associated region to seal the medicament therebetween.

Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films are effective at killing the plaque-producing germs that cause dental plaque, gingivitis and bad breath. The film can also contain pharmaceutically active agents. Methods for producing the films are also disclosed.

Abstract: A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.

Abstract: The aqueous suspension can be prepared by incorporating, in an aqueous suspension of a hardly soluble drug, a water-soluble polymer within the concentration range from the concentration at which the surface tension of the aqueous suspension of the drug begins to decrease up to the concentration at which the reduction in surface tension ceases. The resulting aqueous suspension shows ready redispersibility and will not undergo aggregation of dispersed particles or caking. Because of its good redispersibility, the suspension is useful as a parenteral preparation, eye drops, nasal drops, a preparation for oral administration, a lotion or the like.

Abstract: The invention described herein relates to methods for reducing and/or stopping bleeding or fluid loss from open wound, denuded tissue, or burned skin, comprising the step of applying to the open wound, denuded tissue or burned skin a gel-forming composition comprising at least one of the following compositions: a polyacrylic acid having the structural formula [CH2═CHCO2H]n, where n is between 10,000 and 70,000; a polyacrylic acid and a desiccated water soluble organic or inorganic base; polyacrylic acid and a desiccated poorly soluble basic salt, and a polyvinyl alcohol having the structural formula of [CH2═CHOH]n, where n is between 15,000 and 150,000.

Abstract: There is provided a pharmaceutical composition suitable for rectal administration, the composition comprising at least one oxazolidinone antibacterial drug, for example linezolid, in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection, the at least one oxazolidinone being in particulate form having a particle size of about 0.5 &mgr;m to about 150 &mgr;m, dispersed in a carrier in which the oxazolidinone is poorly soluble. The composition is, for example, a suppository, an enema, a microenema or a rectal capsule.

Abstract: Microparticles, obtainable by spray-drying a substantially pure solution of a therapeutic agent, consist essentially of the agent having its therapeutic activity when administered to the lung. In a preferred embodiment the agent is insulin.

Abstract: A lipoprotein compound delivery particle comprises: (a) a lipophilic or amphipathic compound to be delivered (e.g. paclitaxel); (b) at least one polar lipid (this ingredient being optional when the lipophilic or amphipathic compound serves itself as a polar lipid); (c) optionally, at least one neutral lipid; and (d) a truncated apolipoprotein B (apoB) protein having a deleted LDL receptor binding region. Conjugates useful for making such particles, pharmaceutical formulations containing such particles, and methods of using such particles are also described.

Abstract: Featured are highly useful pharmaceutical compositions that include a microparticle having a polymeric support material preferably adapted to disperse therapeutic agent. In a particular invention embodiment, the support material comprises at least 50% w/w of a homopolymer as described herein. Also featured are methods of making the compositions as well as using same to treat diseases such as bladder cancer.

Abstract: The present invention relates to nutritive compositions containing whey, FOS, and bovine or caprine colostrum for the creation and maintenance of a healthy intestinal flora and for the enhancement of the immune system.

Abstract: The invention relates to a method for treating organic material before decay or freeze drying. In the method, organic material, preferably refrigerated or frozen is subjected to a splitting treatment. Subsequently, the material is freeze dried. Next, the material is deposited for decay. The invention also relates to a decayable container, as well as an apparatus for performing the disclosed method.

Abstract: The subject of the present invention is acrochordon removal and prevention utilizing safe dependable effective biocompatable treatments with no scarring, bleeding, twisting, yanking, choking, burning, freezing, shocking, screaming and hypo pigmentation or hyper pigmentation. In one aspect of the invention, methods are provided for acrochordon removal comprising application of high concentrations of hydrogen peroxide.

Abstract: The present invention provides a pharmaceutical composition for application to the mucosa to be used in drug therapy comprising a water-insoluble and/or water-low soluble substance, a medicament, and an aqueous medium, and having an osmotic pressure of less than 290 mOsm. This composition is superior over conventional pharmaceutical compositions for application to the mucosa, due to efficient and high permeability to the blood at the mucosa. The present invention further provides a pharmaceutical composition for application to the mucosa comprising a hemostatic agent and a medicament. This composition is superior over conventional pharmaceutical compositions for application to the mucosa, due to permeability and retentivity at the mucosa.

Abstract: The present invention provides a method of administration of an agent which acts to remodel neuronal or vascular pathways for the long term management of sexual dysfunction in both males and females. In a preferred embodiment, the invention provides a method of ameliorating or reversing pathogenic vascular degradative modeling in the ilio-hypogastric-pudendal arterial bed and genitalia comprising administering to a human patient in need of such treatment a therapeutically effective amount of an anti-pressor agent. The anti-pressor agent comprises one or more compounds selected from the therapeutic classes of direct vasodilators such as hydralazine and NO donors, ACE inhibitors, angiotensin-II receptor antagonists, &agr;1-adrenergic receptor antagonists, &bgr;-adrenergic receptor antagonists, calcium channel blockers, and phosphodiesterase inhibitors.

Abstract: A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammatory response in animals. The formulation comprises comprising an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.

Abstract: In accordance with the present invention Jojoba Oil may be used in accordance with the treatment of and preventative measures associated with Gynecology of Obstetrics and general surgery, as well as in the treatment of eye diseases, inflammation of the internal, middle or external ear, rheumatic pain and arthritis, gingivostomatitis, toothache and dermal diseases. Jojoba oil is a natural product and is characterized by being non-irritant and non-allergic to skin and mucous membrane. This oil has lubricant, moisturizing and soothing properties, as well as having anti-bacterial, anti-inflammatory and anti-oxidant properties. It has a very high healing power and improves blood circulation, and also has high penetration into stratum corneum.

Abstract: The present invention relates to the preparation of therapeutic compositions comprising of fermented soy extracts made with lactic acid bacteria and the optional addition of at least a yeast. The invention also relates to therapeutic uses of such extracts in promoting general health, improving the health of subjects, preventing and/or treating cancer, preventing infections, reducing the incidence of infections, treating infections, treating asthma, treating inflammation, modulating the immune system and treating immune disorders.

Abstract: A novel therapeutic composition comprises three novel herbal extracts: Herba epimedium Extract, Rhizoma Drynaria fortunei (kze.) J. Sm Extract and Radix Tripterygium hypoglaucum (L'evl.) Hutch Extract, which are prepared through standardized manufacturing processes, respectively. A new formulation AHT-323 contains these three herbal extracts. The novel therapeutic composition described in the present application can be used for treating autoimmune diseases such as rheumatoid arthritis, inflammatory disorders and pain.

Abstract: A composition for inhibiting an increase in, or lowering, a blood sugar level, which comprises, as a main component, a concentrate of a hot water or alcohol extract of leaves of Lagerstroemia speciosa, Linn. or Pers. and has an corosolic acid content of 0.01 to 15 mg per 100 mg of the concentrate, and a method of inhibiting an increase in, or lowering, a blood sugar level by oral administration of the composition.

Abstract: A pelletizing die includes a pelletizing die member with a die exit side exposed to cooling fluid and a die entry side for receiving polymer fed thereto. The die member has a plurality of polymer channels and a plurality of extrusion orifices connected to a respective one of the channels to form a extrusion orifice section. A heating medium system has additional heating medium conduits between channels and a supply and intermediate header for heating the channels (radially from each side) and providing once in and once out heating medium flow. The die member may be formed by high temperature brazing of components using coordinated solder (Ni based or gold-nickel) and component heat treatment temperature. A thin hard face coating may be provided on raised extrusion orifice ring faces around each extrusion orifice section.

Abstract: Mold cleaning apparatus (1) includes a manifold (5) adapted to be coupled to a suction device. A first conduit (6) extends from the manifold (5) and has a first opening (8) remote from the manifold. A second conduit (7) extends from the manifold (5) and has a second opening (11) remote from the manifold (5). The first and the second openings (8, 11) being directed in opposite directions, and the first conduit (6) having a section (10) with a cross-sectional area which is less than cross-sectional area at any point along the length of the second conduit (7).

Abstract: Device for monitoring force and pressure in injection moulding machines, with at least one sensor for measuring the deformation of a machine part that is deformed by the closing or injection pressure, wherein a supporting body (2) is provided that relieves the machine part (3) monitored by the sensor (1) as soon as the closing or injection pressure exceeds a certain value that is less than half its maximum value.

Abstract: A device (1) for conveying and checking containers, in particular preforms, comprises an infeed and accumulation section (2) for containers arriving from a forming station and a carrousel (3) located downstream of the infeed and accumulation section (2) in the direction of feed of the containers, to feed the containers thorugh a sequence of checking stations (4) disposed in the periphery of carrousel (3). The infeed section is intermittently supplied with containers by the forming station while the carrousel (3) turns continuously. An endless chain (5) extends along a path defined by driving gear-wheels (6) which partially overlaps the infeed and accumulation section (2) and the circular trajectory of the carrousel (3). A first and second driving gearwheels (9a, 9b) positioned along the path followed by the endless chain (5) are mobile to compensate the variations in the length of a delivery section and a return section of the chain (5).

Abstract: A mold mounting plate for an injection molding machine for processing material, in particular plastic material, includes a main body having a plate-shaped central portion. Received in the main body are plural sleeves which define openings for support of column-like holding and/or guiding elements of the injection molding machine, and are secured to the central portion such as to establish a flexible bending/torsion joint. In this way, a transmission of moments onto the column-like holding and/or guiding elements as a result of a deformation of the mold mounting plate is minimized.

Abstract: A system for the convenient discharge of a non-liquid comestible from a container includes a substantially unitary cylindrical sleeve formed of a substantially rigid material, the sleeve defined about a longitudinal axis and having first and second ends. A first base of the system is formed of a substantially rigid material and is defined by a radial cross-section of the sleeve. A periphery of the base is secured in integral communication with the sleeve proximally to the first end of the axis thereof. A quantity of the comestible is disposed within the sleeve and against the first base. A wafer-like piston is disposed co-axially with the sleeve, an interior surface of which is in contact with the comestible, the piston disposed in press-slidable complemental relationship to an interior surface of the sleeve. The piston defines a second base at a second end of the sleeve axis, and is secured in fluid tight relationship to the sleeve between the sleeve proximally to the second end of the axis.

Abstract: A multilane extruder system is provided for forming a pliable mass such as a food dough into a plurality of substantially identical elongated extruded strips, and for depositing these strips onto a conveyor for further processing such as cutting into individual strips of selected length. The extruder system comprises an extruder manifold defining a plurality of flow channels having a substantially identical cross sectional size, shape, and length. Each flow channel includes a first segment extending radially outwardly from a central plenum chamber, and connecting with a second segment extending generally radially inwardly and terminating in an extrusion die port of selected shape. The second channel segments are oriented each at a selected individual angle relative to the radial direction for delivering the extruded strips onto the underlying conveyor in a substantially uniformly and closely spaced relation.

Abstract: The spring plunger of the present invention comprises: a body; a stopping portion for stopping the body; a pin whose projection height from the surface of a plate is to be precisely decided; a spring connected with the pin, and spring stopper for fig the end of the spring. When the stopping portion contacts a pit surface provided on the surface of the plate, the body of the spring plunger does not proceed any more in the female screw in the plate. Thus, the pin projection height from the surface of the plate is kept constant. According to the present invention, the pin projection height from a surface of an object body such as a mold surface can be controlled easily and precisely.

Abstract: An injection molding system having an improved valve gate arrangement that provides molded articles with improved vestige and or surface quality.

Abstract: An injection moulding machine with a closing unit with a stationary and a moveable die platen (1, 2) and a closing mechanism for the moveable die platen (2). The closing mechanism includes a pair of toggle levers opposite one another in mirror image, with two levers of unequal length (4, 5, 6, 7), wherein one lever (7) is pivotally connected to the stationary die platen (1) and the second lever (6) to the moveable die platen (2) respectively. Further, a drive mechanism is provided for the pairs of toggle levers (4, 5, 6, 7).

Abstract: A process is disclosed whereby wood chips are used in the brewing process to produce a beer which is more pleasing and mellow than conventional beers. The wood chips are preferably toasted oak chips.

Abstract: A frozen sandwich for commercial sales comprising a first portion of bread cut from a first slice of crusted bread. This first portion has an outer surface, a given periphery and a center area surrounded by a marginal area. A layer of unmelted solid cheese is deposited on the center area and is spaced inwardly from the marginal area. A second portion of bread cut from a second slice of crusted bread and overlying the first portion and the layer of cheese has an outer surface, a periphery generally matching the periphery of the first portion and a marginal area generally matching and coextensive with the marginal area of the first portion. The marginal areas are smashed together sufficiently to form a seal generally matching the peripheries of the bread portions. The surfaces of the bread portions are heat scorched to transform a thin skin of the portions into toasted bread.

Abstract: A frozen sandwich for commercial sales comprising a first portion of bread cut from a first slice of crusted bread and having an outer surface, a given periphery and a center area surrounded by a marginal area. A layer of masticated, plasticized cheese deposited on the center area of the first slice and spaced inwardly from the marginal area. A second portion of bread cut from a second slice of crusted bread and overlying the first portion and the center layer of cheese. The second portion also having an outer surface, a periphery generally matching the periphery of the first portion and a marginal area generally matching and coextensive with the marginal area of the first portion where the marginal areas are compressed together to form a seal generally matching the peripheries of the bread portions and the outer surfaces of the bread portions are heat scorched to transform a thin skin of the cut bread portions into a toasted bread condition.

Abstract: The invention relates to a polyhydric alcohol-free flavored filling for baked flour based products. These fillings include an aqueous phase, a mixture of sugars dissolved in the aqueous phase wherein the mixture comprises fructose, glucose and sucrose in relative proportions which prevents crystallization and set water activity value from 0.38 to 0.47, and an amount of flavoring and acidifying component. The filling of the invention provides an extended shelf life and preserves the crispness of baked flour based products in which it is included during the extended shelf life.

Abstract: An edible microcapsule comprising a core and a capsule wall, wherein the core is an edible hydrophobic substance, the capsule wall is formed by salting-out of a combination of a protein and an edible salt, and transglutaminase is used as a crosslinking agent for hardening (solidifying) the capsule wall, and a food containing the edible microcapsule.

Abstract: The invention relates to a “push-up” package and delivery system for a fat-based confectionery, as well as a method of forming the package by in situ molding of the confectionery therein. The confectionery may be dispensed by pushing up on a plunger member through a chamber in the package. The chamber cross-section may be any shape including a circle, oval, polygon, such as a square, rectangle, trapezoid, or triangle, a star or cross, or a character shape.

Abstract: Disclosed is a combination food and nutraceutical package which provides convenient and easy access to a food product and at least one nutraceutical. The packaging comprises two segments which secure the food product and the nutraceutical so as to provide a shelf-stable environment that prevents contamination between the various contents. In one embodiment, a single nutraceutical is packaged with a food product. In other embodiments, multiple nutraceuticals with a food product are secured. In yet another embodiment, the food product and nutraceuticals are placed within a tray and then sealed with the two segments. The food product is preferably a fruit based substance, but it may take other forms. The nutraceuticals may be a solid mass, in pill or capsule form, or they may be liquid housed within a container.

Abstract: A method of processing mature chickens comprises deboning the chicken into individual pieces and exposing the muscle fibers of the individual pieces to the ambient environment. A water binding agent is introduced to the muscle fibers and the muscle fibers are vacuum tumbled for dispersing the water binding agent throughout the muscle fibers in an uniform manner.

Abstract: A process for packaging a beverage into polyethylene terephthalate containers, the process includes the steps of: a) pasteurizing the beverage; b) cooling the pasteurized beverage to a temperature between about 25° C. and 50° C.; c) providing an unmodified PET container and a cap for the container and sterilizing the container and container cap; d) filling the sterilized container with the cooled pasteurized beverage; e) capping the filled sterilized container with the sterilized cap; and f) further pasteurizing the filled capped container at a temperature between about 55° C. and 65° C. for a period between approximately 15 to 60 minutes.

Abstract: A process for internally cooking food includes the steps of injecting a condensable cooking fluid into the interior of the food at a plurality of spaced-apart locations, dispersing the cooking fluid within the interior, and condensing the cooking fluid while in direct contact with the interior. The heat of condensation of the cooking fluid releases considerable heat energy useful for either pre-cooking the food to a desired intermediate cooking level, or thoroughly cooking the food. The heat of condensation of the fluid is high enough that only a small amount of condensable cooking fluid is required, per quantity unit of food being cooked. As a result, the food does not become excessively loaded with cooking fluid, and flavorants such as marinade substantially remain within the food. Where the condensable fluid is used for pre-cooking, the cooking may be thoroughly completed by placing the pre-cooked food in a conventional hot air oven.

Abstract: This invention relates to the use of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, or neotame, as a flavor (taste and/or aroma) modifier, and compositions containing the same.

Abstract: Compositions comprising the sweetener N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester sweetener (“neotame”), or L-aspartyl-L-phenylalanine sweetener (“aspartame”), and at least one divalent cation, trivalent cation or mixture thereof are disclosed. Divalent and trivalent cations enhance the stability of neotame and aspartame in edible compositions, including cola-type soft drinks and syrups.

Abstract: A dietary nutritional supplement for helping the body resist the effects of the aging process. The composition is designed to help a user feel healthier, look his or her best, and increase the ability to maintain a full, more active life as the person ages. The composition is a two-part composition, comprising a lipid-soluble portion in soft gel cap form and a water-soluble portion in hard shell capsule or tablet form.

Abstract: This invention relates to a storage stable buoyant waxy grain wherein the waxy grain is waxy triticale and waxy wheat. The starch in the waxy grain is gelatinized throughout and the cooked waxy grains of this invention can be stored for prolonged times in air tight or conventional cereal containers having a liner without acquiring rancid odors or tastes even in the absence of preservatives that inhibit the development of rancidity. Preferably, the waxy wholegrain is a waxy wheat having a protein content of no more than 14% by dry weight. The processes for preparing the waxy wholegrain food products of this invention are also described.

Abstract: The invention is directed to a complete cookie dough composition which is shelf stable at room temperature. The dough includes preselected amounts of flour, shortening, emulsifier, eggs, encapsulated leavening, salt, flavoring, a mold inhibitor and a source of sugar in an amount of about 20 to 40 weight percent, including a fluid corn syrup/sugar blend, the sugar effective to provide an Aw of less than about 0.75 for the dough product. The dough product has a pH above 7.0 and is stable at ambient temperatures for extended periods without degradation. The dough product produces a baked food product that is acceptable to consumers.

Abstract: A method for preparing a pastry-Vienna bakery product requiring whole eggs, wherein part of the eggs required for obtaining a specific quality for the pastry-Vienna bakery product are replaced by the addition of a preparation based on a solid composition containing egg white in powder form or one of the equivalent products well-known in the agri-food field. The invention also concerns powder compositions and their use for using fewer whole eggs (yolk and white) required for preparing a pastry-Vienna bakery product.

Abstract: The subject of the invention is a process for manufacturing aerated and grained sugar-free boiled sweets, wherein it comprises the steps consisting in:

Abstract: A process for preparing a consumable beverage containing a natural dairy beverage additive in the form of agglomerated natural milk powder. The powder is combined with other ingredients, either prior to being placed in the vending machine or upon demand within the vending machine, for the subsequent creation of a consumable beverage which includes the natural dairy beverage additive.

Abstract: Disclosed are improved, intermediate moisture sweetened gelled food compositions fortified with calcium supplied by calcium phosphate that is dispersed in an oil and/or fat. The gelled compositions comprise: A) about 55 to 85% by weight nutritive carbohydrate sweeteners; B) sufficient amounts of a gelling agent(s) to provide a gel strength of about 2-8 kg/cm2; C) about 50 to 1500 mg/oz total calcium; and D) about 9 to 20% moisture, and E) about to 0.1% to 5% of an edible fatty triglyceride. Also disclosed are methods for the preparation of such fruit products involving forming a concentrated slurry of calcium phosphate having a particle size such that at least 90% are less than 150 &mgr;m dispersed in at least a portion of the oil and/or fat, forming a gellable blend and admixing the gellable composition with the slurry to form a gellable calcium fortified composition and forming into desired shaped and sized pieces.

Abstract: A drink component thermally sterilized and flavors which has been removed of microorganism by filtration are formulated under aseptic conditions, and a mixture obtained is filled into containers. Milk-containing soft drinks are produced by a process comprising obtaining a first drink component containing milk and an emulsifier, sterilizing the first drink component at a high temperature and cooling the same, obtaining a second drink component not containing milk, sterilizing the second drink component at a high temperature and cooling the same, obtaining a flavor component removed of microorganism by filtration, and blending the cooled first drink component and the cooled second drink component under aseptic conditions.