Patents Issued in February 6, 2003
  • Publication number: 20030027128
    Abstract: The present invention relates to the finding that receptors for the neurotransmitter 5-HT of the 5-HT2B class are located on the human colon, and that their activation potentiates neuronally-mediated responses, and are thus causative in the abnormal motility and pain associated with IBS. The invention provides a method of treatment of IBS which comprises providing to a patient in need of treatment an effective amount of a 5HT2B receptor antagonist which acts on 5HT2B receptors located in the colon of said patient. Such antagonists may be administered in the form of compositions adapted to be delivered to the colon, such as depot formulations and suppositories. Assay methods for the development of compounds for the treatment of IBS are also provided.
    Type: Application
    Filed: May 29, 2002
    Publication date: February 6, 2003
    Inventors: Richard Anthony Borman, Nicholas S. Tilford, Gordon S. Baxter
  • Publication number: 20030027129
    Abstract: Method for detecting binding events using micro-X-ray fluorescence spectrometry. Receptors are exposed to at least one potential binder and arrayed on a substrate support. Each member of the array is exposed to X-ray radiation. The magnitude of a detectable X-ray fluorescence signal for at least one element can be used to determine whether a binding event between a binder and a receptor has occurred, and can provide information related to the extent of binding between the binder and receptor.
    Type: Application
    Filed: May 16, 2001
    Publication date: February 6, 2003
    Inventors: Benjamin P. Warner, George J. Havrilla, Grace Mann
  • Publication number: 20030027130
    Abstract: The invention relates to the discovery of a novel RNA sequence at the 3′ terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3′ sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
    Type: Application
    Filed: June 13, 2001
    Publication date: February 6, 2003
    Applicant: Washington University
    Inventors: Charles M. Rice, Alexander A. Kolykhalov
  • Publication number: 20030027131
    Abstract: The purpose of the present invention is to provide a method for efficiently expressing a protein in an active form by using baculovirus expression system wherein the protein is selected from a membrane-bound enzyme, a substrate of the membrane-bound enzyme, a membrane-bound enzyme activator, a membrane-bound transport protein, a channel protein, a membrane structural protein, a protein involved in adhesion, a protein involved in antigen presentation, or a protein involved in formation of high dimensional structure of a protein.
    Type: Application
    Filed: June 20, 2001
    Publication date: February 6, 2003
    Inventors: Takao Hamakubo, Tatsuhiko Kodama, Mineko Yamaguchi
  • Publication number: 20030027132
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: September 4, 1998
    Publication date: February 6, 2003
    Inventors: STEVEN M. RUBEN, CRAIG A. ROSEN, CARRIE L. FISCHER, DANIEL R. SOPPET, KENNETH C. CARTER, DANIEL R. BEDNARIK, GREGORY A. ENDRESS, GUO-LIANG YU, JIAN NI, PING FENG, PAUL E. YOUNG, JOHN M. GREENE, ANN M. FERRIE, ROXANNE DUAN, JING-SHAN HU, KIMBERLY A. FLORENCE, HENRIK S. OLSEN, REINHARD EBNER, LAURIE A. BREWER, YANGGU SHI
  • Publication number: 20030027133
    Abstract: An array of a mixture of at least two components is formed and an experiment is conducted on the array to produce results. At least one Six Sigma technique is applied to the steps to improve results of the experiment.
    Type: Application
    Filed: May 31, 2001
    Publication date: February 6, 2003
    Inventor: James Norman Cawse
  • Publication number: 20030027134
    Abstract: Risk factors for diabetic onset in a subject are detected by using a gene coding for CD38 protein, which is originally identified as a human lymphocyte surface marker, as a risk gene, and detecting mutations in the gene.
    Type: Application
    Filed: January 31, 2001
    Publication date: February 6, 2003
    Inventors: Toru Egashira, Makoto Nagano, Yukiko Sagehashi, Kana Matsui, Hiroaki Hattori, Azuma Kanatsuka, Shin Takasawa, Hiroshi Okamoto
  • Publication number: 20030027135
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Application
    Filed: March 2, 2001
    Publication date: February 6, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Publication number: 20030027136
    Abstract: The invention provides methods and materials for evaluating arthritis conditions. Specifically, the invention provides methods and materials for determining the severity of an arthritis condition in a mammal that involve determining whether or not a sample from that mammal contains an elevated level of a CD21L polypeptide, a lymphotoxin-&bgr; polypeptide, or a chemoattractant polypeptide. The invention also provides methods and materials for assisting medical or research professionals in determining the severity of an arthritis condition in a mammal. In addition, the invention provides methods and materials related to kits that can be used to determine the severity of an arthritis condition.
    Type: Application
    Filed: March 23, 2001
    Publication date: February 6, 2003
    Inventors: Jorg J. Goronzy, Cornelia M. Weyand
  • Publication number: 20030027137
    Abstract: The invention provides isolated nucleic acids molecules, designated SMRTe nucleic acid molecules, which encode proteins involved in nuclear receptor mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMRTe nucleic acid molecules, host cells into which the expression vectors have been introduced, methods for identifying compounds that modulate SMRTe activity, and nonhuman transgenic animals in which a SMRTe gene has been introduced or disrupted. The invention still further provides isolated SMRTe proteins, fusion proteins, antigenic peptides, and anti-SMRTe antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: March 27, 2001
    Publication date: February 6, 2003
    Inventor: J. Don Chen
  • Publication number: 20030027138
    Abstract: The invention relates to DNA markers specific to WA cytoplasmic male sterile lines of rice, for assessing seed purity and a method for ensuring the purity of cytoplasmic male sterile lines of rice using the said DNA based markers.
    Type: Application
    Filed: March 28, 2001
    Publication date: February 6, 2003
    Inventors: Yashitola Jamir, Ramesh V. Sonti
  • Publication number: 20030027139
    Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.
    Type: Application
    Filed: March 29, 2001
    Publication date: February 6, 2003
    Inventors: Kenneth Jacobs, John McCoy, Edward R. LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael J. Agostino, Michael R. Bowman, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Steven H. Howes, Richard J. Resnick, Kalmalakar Gulukota, James R. Graham
  • Publication number: 20030027140
    Abstract: This invention provides methods for sequencing DNA by detecting the identity of a nucleotide within a DNA sequencing fragment using mass spectrometry. The invention provides cleavable linkers for attaching a label to a dideoxynucleotide and provides labeled dideoxynucleotides. The invention also provides methods for increasing mass spectrometry resolution using linkers with different mass. The invention further provides systems for separating a labeled moiety from non-labeled components in one or more samples in solution.
    Type: Application
    Filed: March 30, 2001
    Publication date: February 6, 2003
    Inventors: Jingyue Ju, John Robert Edwards, Zengmin Li
  • Publication number: 20030027141
    Abstract: The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of monitoring gene expression, as well as for the analysis and quantitation of changes in gene expression for a defined set of genes and in response to a wide variety of events.” It is an important feature of the present invention that no single molecular species of cDNA gives rise to more than one fragment in the collection of products which are subsequently amplified and representative of each expressed gene. This achievement is facilitated by immobilizing the cDNA prior to digesting and then digesting with sequentially with two frequently cutting enzymes. Linker oligomers are ligated to each cut site following the respective digestion. Primers, complementary to the oligomer sequence with an additional 3′ variable sequence are used to amplify the fragments.
    Type: Application
    Filed: April 23, 2001
    Publication date: February 6, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Michael C. MacLeod, C. Marcelo Aldaz, Sara S. Gaddis
  • Publication number: 20030027142
    Abstract: A novel transcriptome analyzing method and to provide a gene found by this method and a protein encoded by the gene. A method for determining whether or not a continued arbitrary DNA sequence existing in the genome of an arbitrary biological species, in which the nucleotide sequence is already known but its possibility of being a gene expression region is unclear (specific region), is the specific region, which comprises detecting whether or not a nucleotide sequence that corresponds to the nucleotide sequence of the region is present in the RNA of the biological species, and a method for determining the gene expression region in an arbitrary region on a genome or the entire genome, which comprises repeatedly carrying out the above method.
    Type: Application
    Filed: July 16, 2001
    Publication date: February 6, 2003
    Applicant: TOSOH CORPORATION
    Inventors: Takahiko Ishiguro, Kiyoshi Yasukawa
  • Publication number: 20030027143
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 16, 2001
    Publication date: February 6, 2003
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Publication number: 20030027144
    Abstract: The present invention provides a DNA encoding a TADG-16 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-16 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-16 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-16 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Application
    Filed: July 17, 2001
    Publication date: February 6, 2003
    Applicant: The University of Arkansas for Medical Sciences
    Inventors: Lowell J. Underwood, Timothy J. O'Brien, Kazushi Shigemasa
  • Publication number: 20030027145
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 17, 2001
    Publication date: February 6, 2003
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Publication number: 20030027146
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 17, 2001
    Publication date: February 6, 2003
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey Williams, William I. Wood
  • Publication number: 20030027147
    Abstract: Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.
    Type: Application
    Filed: July 20, 2001
    Publication date: February 6, 2003
    Inventors: Paul F. Worley, Paul R. Brakeman
  • Publication number: 20030027148
    Abstract: A method and device of detecting a molecule, such as DNA or RNA, is provided. The device includes a substrate having an array of at least one biodetection site. The biodetection site is in contact with an electrical resonator. A biochemical probe is applied to the site and is subsequently interacted with the target biomolecule at the site. The magnetic properties of the biodetection site are measured and may be correlated with the presence and quantity of biomolecules at the site. Methods of using the device to detect the presence and determine the quantity of molecules at the site are also provided.
    Type: Application
    Filed: July 26, 2001
    Publication date: February 6, 2003
    Inventors: Allyson Beuhler, Irina Shmagin, Lawrence Lach
  • Publication number: 20030027149
    Abstract: Disclosed herein are methods of selecting probes to target nucleic acid sequences, methods of making oligonucleotide arrays comprising such probes, and methods of using such arrays. Also, described herein are oligonucleotide arrays comprising probes selected by a method of the invention.
    Type: Application
    Filed: August 2, 2001
    Publication date: February 6, 2003
    Inventors: David Dorris, Abhijit Mazumder, Richard D. Shippy
  • Publication number: 20030027150
    Abstract: A method of identifying the haplotype of an organism comprising the use of multiple duplexed amplifications of a single copy of an isogenic nucleotide sequence of interest coupled with detection of putative nucleotide sequence polymorphisms, as well as a kit and apparatus therefor.
    Type: Application
    Filed: August 3, 2001
    Publication date: February 6, 2003
    Inventor: David A. Katz
  • Publication number: 20030027151
    Abstract: A bone strength and mineralization regulatory (“BSMR”) protein is provided that can exist in multiple forms and that affects bone density. Polymorphic gene sequences of the protein are provided that are diagnostic of predipostion to osteoporosis. Other detection tools, compositions and methods of their use also are provided for predicting, evaluating and altering bone strength and mineralization status. The invention provides new natural and synthetic pharmaceuticals that effect the BSMR regulatory pathway and improve bone status. Tools also are provided for finding new pharmaceuticals that operate by binding to BSMR and that activate and/or deactivate this protein's biological function related to osteoporosis and blood vessel formation.
    Type: Application
    Filed: August 17, 2001
    Publication date: February 6, 2003
    Inventors: Matthew L. Warman, Yaoqin Gong, Bjorn R. Olsen, Georges Rawadi, Sergio Roman-Roman
  • Publication number: 20030027152
    Abstract: The present invention relates to mammalian Lhx3 nucleic acids and proteins encoded thereby. More specifically, the invention discloses novel porcine and human Lhx3 genes and isoforms thereof. The invention further relates to genomic mapping of the human Lhx3 coding region to the subtelomeric region of Chromosome 9. The invention also relates to methods and kits relating to the nucleic and amino acids encoding Lhx3 and uses therefor.
    Type: Application
    Filed: August 17, 2001
    Publication date: February 6, 2003
    Applicant: Indiana University Advanced Research and Technology Institute
    Inventors: Simon J. Rhodes, Jeanne L. Bridwell, Bradley C. Meier, Gretchen E. Parker, Jeffrey R. Price, Aaron D. Showalter, Kyle W. Sloop
  • Publication number: 20030027153
    Abstract: This invention relates to methods and compositions for diagnosing and treating neuropsychiatric disorders, such as schizophrenia, schizoaffective disorder, bipolar affective disorder, unipolar affective disorder and adolescent conduct disorder. In particular, the invention provides novel variants of CADPKL nucleic acid sequences, as well as novel CADPKL polypeptides encoded by these variant sequences. The variant CADPKL nucleic acid sequences provided by this invention, as well as the variant polypeptides they encode are ones that statistically correlate with the presence of a neuropsychiatric disorder in individuals. The invention therefore also provides methods and compositions for using these variant nucleic acids and polypeptides to diagnose and treat such neuropsychiatric disorders.
    Type: Application
    Filed: August 23, 2001
    Publication date: February 6, 2003
    Inventors: Joanne M. Meyer, Rory Barrington-Martin, Alexander Parker
  • Publication number: 20030027154
    Abstract: The present invention provides nucleic acid arrays with improved sensitivity for a nucleic acid. The array comprises various kinds of nucleic acid probes, which are capable of hybridizing to the nucleic acid, immobilized at different positions on a substrate. Single-stranded nucleic acid probes are immobilized on the substrate by covalent bond, and functional groups that can have negative charge by dissociating in an aqueous solution or by hydrolysis are introduced on the surface of regions of the substrate on which no nucleic acid probe is immobilized.
    Type: Application
    Filed: August 31, 2001
    Publication date: February 6, 2003
    Applicant: Hitachi, Ltd.
    Inventors: Masatoshi Narahara, Toshiro Saito, Hiroyuki Tomita, Hirokazu Kato
  • Publication number: 20030027155
    Abstract: A method for detecting human hepatocellular carcinoma (HCC), wherein the method comprises detecting a homozygous deletion in human chromosome 8p23.
    Type: Application
    Filed: September 13, 2001
    Publication date: February 6, 2003
    Inventors: Anne DeJean, Agnes Marchio, Pascal Pineau
  • Publication number: 20030027156
    Abstract: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
    Type: Application
    Filed: September 12, 2001
    Publication date: February 6, 2003
    Applicant: Maxygen, Inc.
    Inventors: Phillip A. Patten, Willem P. C. Stemmer
  • Publication number: 20030027157
    Abstract: Disclosed are methods for identifying nucleic acid sequences which are of different abundances in different nucleic acid source populations, e.g. differentially expressed genes or genomic variations among individuals or populations of individuals. In one embodiment, probes derived from the source nucleic acid populations are derivatized with a terminal sample ID (SID) sequence characteristic of that population. Upon competitive hybridization of the probes to a reference or index nucleic acid library containing all the sequences in the populations being compared, the SID tags remain single stranded, and those from the different sources are then annealed to one another. Unhybridized (remainder) SID sequences are then quantified. By labeling such remainder SID sequences with a fluorescent dye, FACS sorting of beads containing the hybridized probes can be carried out. The signal ratio upon which such sorting is based is enhanced compared to competitive hybridization using labeled probes without SID sequences.
    Type: Application
    Filed: September 27, 2001
    Publication date: February 6, 2003
    Inventors: Rongdian Fu, Sydney Brenner, Glenn Albrecht
  • Publication number: 20030027158
    Abstract: This application is drawn to novel nucleic acid sequences encoding mammalian polypeptides that have sequence similarity to human breast tumor-associated protein 47. The nucleic acid sequence is 1987 nucleotides long and contains an open reading frame from nucleotides 991 to 1447. The novel, encoded polypeptides comprise 152 amino acid residues.
    Type: Application
    Filed: October 15, 2001
    Publication date: February 6, 2003
    Applicant: CuraGen Corporation
    Inventors: Richard A. Shimkets, Elma Fernandes, John Herrman, Corine Vernet
  • Publication number: 20030027159
    Abstract: The invention relates to a set of combinatorially labeled oligonucleotide probes each member thereof: (i) having a predetermined label distinguishable from the label of any other member of said set, and (ii) being capable of specifically hybridizing with a predetermined chromosome or nucleic acid molecule, and to the use of such molecules, alone or in concert with nucleic acid amplification methods.
    Type: Application
    Filed: November 20, 2001
    Publication date: February 6, 2003
    Inventors: David C. Ward, Michael Speicher, Stephen Gwyn Ballard, John T. Wilson
  • Publication number: 20030027160
    Abstract: A probe array comprises a plurality of probes immobilized at a plurality of matrix sites on a substrate for capturing a target substance, wherein the probes are sequentially synthesized at the matrix sites on the substrate until a desired length, the probes are different from each other, and a labeling compound is coupled to each terminus of the probes in a final step of the synthesis. The probe array of the invention allows sensitive and reliable detection of the target substance. A method of evaluating the amount of the fully synthesized probes at respective matrix sites is also provided.
    Type: Application
    Filed: November 21, 2001
    Publication date: February 6, 2003
    Inventors: Tadashi Okamoto, Nobuko Yamamoto, Tomohiro Suzuki
  • Publication number: 20030027161
    Abstract: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.
    Type: Application
    Filed: November 13, 2001
    Publication date: February 6, 2003
    Applicant: GENSET, S.A.
    Inventors: Stephane Bejanin, Hiroaki Tanaka
  • Publication number: 20030027162
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: November 15, 2001
    Publication date: February 6, 2003
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Ivar J. Kljavin, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Strwart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Zemin Zhang
  • Publication number: 20030027163
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: November 15, 2001
    Publication date: February 6, 2003
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Kevin P. Baker, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Ivar J. Kljavin, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Zemin Zhang
  • Publication number: 20030027164
    Abstract: The present invention relates to novel human nucleic acid molecules encoding novel human cation channels, and proteins and polypeptides encoded by such nucleic acid molecules. More specifically, the nucleic acid molecules of the invention include novel human genes, e.g., hVR1d.1 and hVR1d.2, that encode proteins or polypeptides that are expressed in spinal cord and brain tissues and display sequence homology and structural homology to the vanilloid and TRP (transient receptor potential) families of cation channel proteins. The proteins and polypeptides of the invention directed to this novel human cation channel may be therapeutically valuable targets for drug delivery in the treatment of human diseases that involve calcium, sodium, potassium or other ionic homeostatic dysfunction, such as central nervous system (CNS) disorders, e.g.
    Type: Application
    Filed: November 30, 2001
    Publication date: February 6, 2003
    Inventors: Glen T. Gaughan, John N. Feder, Thomas C. Nelson, Gabe Mintier, Chandra S. Ramanathan
  • Publication number: 20030027165
    Abstract: The present invention provides isolated nucleic acid sequences and expression vectors encoding the pol &kgr;76, substantially purified pol &kgr;76, and methods for detecting pol &kgr;76.
    Type: Application
    Filed: December 7, 2001
    Publication date: February 6, 2003
    Inventor: Juan Saus
  • Publication number: 20030027166
    Abstract: The invention is directed to isolated coding sequences and to the protein sequences they code for. The coding sequence for BRCA1(omi4) gene is provided together with the protein sequence it codes for. The BRCA1(omi4) sequence is used for identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because the patient has an inherited causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with the isolated BRCA1(omi4) coding sequence and protein replacement therapy with the BRCA1(omi4) protein.
    Type: Application
    Filed: December 20, 2001
    Publication date: February 6, 2003
    Applicant: OncorMed Inc.
    Inventors: Antonette C.P. Allen, Tracy S. Angelly, Tammy Lawrence, Sheri J. Olson, Mark B. Rabin
  • Publication number: 20030027167
    Abstract: The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding MRE 11, which is a protein involved in modulation of cellular proliferation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate cellular proliferation via modulation of MRE 11; as well as to the use of expression profiles and compositions in diagnosis and therapy related to modulation of cellular proliferation.
    Type: Application
    Filed: December 21, 2001
    Publication date: February 6, 2003
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Yasumichi Hitoshi, Susan Demo, Yonchu Jenkins
  • Publication number: 20030027168
    Abstract: Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity and then validating the role of the candidate gene in establishment of such a cellular state or activity. Certain methods utilized RNA interference techniques in the validation process.
    Type: Application
    Filed: October 19, 2001
    Publication date: February 6, 2003
    Applicant: AGY Therapeutics, Inc.
    Inventors: Li Gan, Mirella Gonzalez-Zulueta, Kristin Anton, Richa Wilson, Thorsten Melcher, Daniel Chin
  • Publication number: 20030027169
    Abstract: The present invention relates to a novel one-well assay which couples a conventional polymerase chain reaction (PCR) amplification step to a single nucleotide primer extension step for the determination of nucleotide sequence variations in the genotyping of single nucleotide polymorphisms and other DNA variations detected by primer extension methods. A PCR amplification step, a phosphatase digestion step (or a molecular weight-selective filter step), and a primer extension step are consecutively performed in the same well plate followed by electrospray mass spectrometry detection of the single nucleotide polymorphism bases. Alternative one-well assays which utilize exonuclease I or &lgr;-exonuclease in addition to the phosphatase digestion step are also disclosed.
    Type: Application
    Filed: October 25, 2001
    Publication date: February 6, 2003
    Inventors: Sheng Zhang, Colleen K. Van Pelt, Gary A. Schultz
  • Publication number: 20030027170
    Abstract: Novel means and methods for their use are provided to determine the function of the product(s) of one or more sample nucleic acids. The sample nucleic acids are synthetic oligonucleotides, DNA, or cDNA and encode polypeptides, antisense nucleic acids, or GSEs. The sample nucleic acids are expressed in a host by a vehicle to alter at least one phenotype of the host. The altered phenotype(s) is/are identified as a means to assign a biological function to the product(s) encoded by the sample nucleic acid(s).
    Type: Application
    Filed: December 21, 2001
    Publication date: February 6, 2003
    Inventors: Ronald Vogels, Abraham Bout, Helmuth van Es, Govert Schouten
  • Publication number: 20030027171
    Abstract: This invention relates to new cell cycle regulatory proteins and nucleic acids encoding them.
    Type: Application
    Filed: January 18, 2002
    Publication date: February 6, 2003
    Inventors: Chu-Wen Yang, Ann-Ping Tsou, Chin-Wen Chi, Ming-Ji Fann, Chen-Kung Chou
  • Publication number: 20030027172
    Abstract: A central role for the gene encoding dopamine beta-hydroxylase in neuropsychiatric disorders is disclosed. Use of single nucleotide polymorphisms in the dopamine beta-hydroxylase gene for diagnosis, prediction of clinical course and treatment response, development of new treatments and development of cell-culture based and animal models for research and treatment are disclosed.
    Type: Application
    Filed: January 22, 2002
    Publication date: February 6, 2003
    Inventors: Pamela Sklar, Eric S. Lander, Melvin G. McInnis, J. Raymond DePaulo, Virginia Willour, James Potash
  • Publication number: 20030027173
    Abstract: The present invention provides methods for rapidly determining the function of nucleic acid sequences by transfecting the same into a host organism to effect expression. Phenotypic and biochemical changes produced thereby are then analyzed to ascertain the function of the nucleic acids which have been transfected into the host organism. The invention also provides methods for silencing endogenous genes by transfecting hosts with nucleic acid sequences to effect expression of the same. The present invention also provides methods for selecting desired functions of RNAs and proteins by the use of virus vectors to express libraries of nucleic acid sequence variants. Moreover, the present invention provides methods for inhibiting an endogenous protease of a plant host.
    Type: Application
    Filed: February 5, 2002
    Publication date: February 6, 2003
    Inventors: Guy Della-Cioppa, Robert L. Erwin, Wayne P. Fitzmaurice, Kathleen Hanley, Monto H. Kumagai, John A. Lindbo, David R. McGee, Hal S. Padgett, Gregory P. Pogue
  • Publication number: 20030027174
    Abstract: The present invention relates to methods and devices for detecting and differentiating between Mycobacterium strains in a sample based upon species-specific upstream p34 gene region (us-p34) sequences. New us-p34 sequences and probes and primers derived therefrom are provided as well as methods and diagnostic kits based on the same.
    Type: Application
    Filed: February 14, 2002
    Publication date: February 6, 2003
    Inventors: Jean-Luc Gala, Pascal Vannuffel
  • Publication number: 20030027175
    Abstract: The present invention relates to a methodology for discovering genes responsible for a particular phenotype. The subject method can be used with a variety of cell types, including eukaryotic and prokaryotic cells, and for determining the role of genes and gene programs in the various growth states of those cells and responses to drugs or other environmental cues.
    Type: Application
    Filed: February 13, 2002
    Publication date: February 6, 2003
    Inventors: Gregory Stephanopoulos, Ryan T. Gill, Stefan Wildt
  • Publication number: 20030027176
    Abstract: A method is provided for determining the type of an infectious pathogen in a patient who is suspected to be suffering from an infectious pathogen. The method involves first measuring the amounts of a plurality of markers in a body fluid sample of the patient. The markers of interest are produced by the patient as part of that patient's innate immune response to the presence of the infectious pathogen and are indicative of the type of the infectious pathogen in the patient. Next, a marker profile is identified based on the measured amounts of the plurality of markers. Finally, if the marker profile is indicative of an infection, then the type of infectious pathogen within the patient is determined from the marker profile. In preferred embodiments, any individual marker is either an mRNA or a protein. Methods for identifying suitable markers and kits are provided as well.
    Type: Application
    Filed: February 15, 2002
    Publication date: February 6, 2003
    Inventor: Peter J. Dailey
  • Publication number: 20030027177
    Abstract: The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a prodeudre for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
    Type: Application
    Filed: February 22, 2002
    Publication date: February 6, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventors: William A. Haseltine, Steven M. Ruben, Ying-Fei Wei, Mark D. Adams, Robert D. Fleischmann, Claire M. Fraser, Rebecca A. Fuldner, Ewen F. Kirkness, Craig A. Rosen