Abstract: A transgenic animal with alterations in an H2-O gene is prepared by introduction of an altered H2-O gene into a host animal. The resulting transgenic animals produce a substantially greater frequency of high affinity antibodies compared to H2-O wild type animals. A method for the production of high affinity antibodies is disclosed.

Abstract: The invention features transgenically produced PDGF, e.g., transgenically produced PDGF which is expressed in the milk of a transgenic mammal, and is present in the milk in active form, e.g., as a dimer. The invention also features methods of producing transgenic PDGF, transgenic animals capable of expressing PDGF, and nucleic acid sequences encoding PDGF, e.g., nucleic acid sequences encoding PDGF under the control of a mammary gland specific promoter.

Abstract: The invention provides isolated nucleic acids that encode HTPL, including two isoforms, and fragments thereof, vectors for propagating and expressing HTPL nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel HTPL isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human HTPL nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human HTPL gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the HTPL nucleic acids, proteins, and antibodies of the present invention.

Abstract: Transgenic animals that do not express functional SR-BI and ApoE develop severe atherosclerosis, by age four weeks in transgenic mice. Moreover, these animals exhibit progressive heart dysfunction by as early as age four weeks, and die by age nine weeks. This animal model has now been demonstrated to be useful as a screen for compounds which alleviate the symptoms of atherosclerosis and heart disease. Animals (Apo E−/− SR-BI +/−) were fed PROBUCOL beginning at the time of mating. Offspring are weaned at three weeks and fed PROBUCOL. In contrast to animals (Apo E−/− SR-BI −/−) not fed PROBUCOL, 50% of whom are dead at six weeks, all animals (Apo E−/− SR-BI −/−) on PROBUCOL have a normal phenotype (MRI of heart function, ECG, echocardiogram, histology) at six weeks. At seven to eight months, there is evidence of atherosclerosis and some myocardial infarction. This demonstrates that the compound has a preventative action.

Abstract: The present invention relates to compositions, including transgenic and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a PPAR gene. The present invention also provides methods for identifying agents that modulate PPAR expression and function, useful models, and potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a USP3-like deubiquitinating enzyme gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a HSPC150-like gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells.

Abstract: Recombinant polynucleotides and methods for altering the regulation of gene expression in plants are provided to modify a plant's traits, in particular disease tolerance.

Abstract: Methods for plant transformation, for improving transformation efficiency, and for producing transgenic plants are provided. The methods comprise crossing a recipient plant from a genetic line of a plant species of interest with a donor plant selected from a transformation competent genetic line of the same plant species or of another closely related plant species to obtain a hybrid plant. Tissues obtained from the hybrid plant are transformation competent. These tissues can then be transformed with one or more nucleotide sequences of interest and selected for transgenic events having the nucleotide sequence of interest integrated within a chromosome derived from the recipient plant. Transformed cells can be selected and transgenic hybrid plants regenerated. The nucleotide sequence of interest can be introgressed into the genetic line from which the original recipient parent was derived, or into other genetic lines. Transformed plants and seeds are additionally provided.

Abstract: A method for organelle transformation is disclosed in which a transgene-carrying organelle is physically transferred from a donor to a recipient, wherein the donor and the recipient may be of similar or dissimilar species. The method disclosed comprises isolation and concentration of the organelle to be transferred from the tissue of the donor followed by injection of the organelle into the cytoplasm of a target organism, whereupon the transgene of the injected organelle is expressed.

Abstract: DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.

Abstract: The present invention discloses Arcelin promoters capable of transcribing a heterologous nucleic acid sequence at high levels in plants. The promoters are particularly suited for use in soybean plants and plant cells. Methods of modifying, producing, and using the promoters are also disclosed. The invention further discloses compositions, transformed host cells, transgenic plants, and seeds containing the high-expression Arcelin promoters, and methods for preparing and using the same.

Abstract: Novel isolated polynucleotides that encode polypeptides involved in plant cell signaling are provided, together with genetic constructs comprising such polynucleotides. Methods for using such constructs for the modulation of cell signaling in plants are also disclosed, together with transgenic plants comprising such constructs.

Abstract: The invention is isolated nucleic acid molecules encoding Na+/H+ exchanger polypeptides for extrusion of monovalent cations (preferably lithium ions and postassium ions, most preferably sodium ions) from the cytosol of cells to provide the cell with increased salt tolerance. In a preferred embodiment, the nucleic acid is obtained from Arabidopsis thaliana. Crop species transformed with the nucleic acid molecule are capable of surviving in soil with high salt levels that would normally inhibit growth of the crop species.

Abstract: The present invention relates to an amino acid sequence of second starch branching enzyme (SBE II) of potato and a fragment thereof as well as to the corresponding isolated DNA sequences. Furthermore, the invention relates to vectors comprising such an isolated DNA sequence, to processes for production of transgenic potatoes, and to the use of said potatoes for the production of starch. The starch obtained will show a changed pattern of branching of amylopectin as well as a changed amylose/amylopectin ratio.

Abstract: The present invention relates to promoters which permit a caryopsis-specific expression or suppression of genes in genetically modified plants, to methods for the tissue-specific gene expression or gene suppression in plants, expression cassettes, recombinant vectors and host cells containing such promoters, to transgenic plant cells and plants transformed with said promoters, and to methods for generating such plant cells and plants.

Abstract: The present invention relates to methods and compositions for regulating plant GABA production. More particularly, the invention relates to the use of polynucleotides that encode functional plant GAD enzymes for enhancing a plant's ability to produce. In various aspects, the invention provides methods of treating plants, vectors and other nucleic acid molecules useful for the treatments, and transformed plants better able to tolerate environmental or other plant stress.

Abstract: Soybean are transformed by inserting a functional gene into an explant of a soybean (particularly after being pre-treated with high doses of cytokinin (hormone)), transferring embryonic axes explants of the mature soybean seeds incubated on wet filter papers in the presence of at least one phenol compound naturally produced when plant cells have been wounded, to induce vir genes, and incubated in the dark in such presence at 20° C.-25° C. for at least 24 hr. After incubation, the explants are transferred to a media to develop shoots from explants, control Agrobaterium growth, and after shoot elongation, separated shoots, with or without roots, are either transferred to soil, or contacted with at least 1 mg/l IBA before transplant.

Abstract: A novel soybean cultivar, designated SGO911RR, is disclosed. The invention relates to the seeds of soybean cultivar SGO911RR, to the plants of soybean SGO911RR and to methods for producing a soybean plant produced by crossing the cultivar SGO911RR with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar SGO911RR with another soybean cultivar.

Abstract: Broadly this invention provides an inbred corn line G4901. The methods for producing a corn plant by crossing the inbred line G4901 are also encompassed by the invention. Additionally, the invention relates to the various parts of inbred G4901 including culturable cells. This invention relates to hybrid corn seeds and plants produced by crossing the inbred line G4901 with at least one other corn line.

Abstract: An inbred corn line, designated VMM1, is disclosed. The invention relates to the seeds of inbred corn line VMM1, to the plants of inbred corn line VMM1 and to methods for producing a corn plant, either inbred or hybrid, by crossing the inbred line VMM1 with itself or another corn line. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from the inbred VMM1.

Abstract: Shrub rose plant having short spreading growth; warm pink rosette-shaped flowers produced in quite large sprays; light fruity type fragrance; and soft green, highly polished foliage.

Abstract: A new and distinct variety of Hybrid tea rose plant which have attractive creme-pink colored flowers and attractive dark green and glossy foliage. The buds are large and well turbinated. This new variety is having high production of long stems with a long vase life, vigorous, upright growth, and good tolerance to powdery mildew. The variety successfully propagates from softwood cuttings and is well suitable for year round production of cut flowers in commercial glass houses as a flowering cut rose. This and distinct variety has shown to be uniform and stable in the resulting generations from asexual propagation.

Abstract: This invention relates to a new and distinct variety of strawberry (Fragaria xananassa) named ‘Sable’. The invention is an early season, short-day variety similar to ‘Veestar’. ‘Sable’ is distinguished from ‘Veestar’ by its higher productivity, larger fruit, broader fruit, and pattern of disease resistance.

Abstract: A Chrysanthemum plant named ‘MARVINE’ characterized by its large sized blooms with purple and white ray-florets and yellow-green disc florets.

Abstract: A Chrysanthemum plant named ‘White Elite Reagan’ characterized by its medium sized blooms with white ray-florets and yellow-green disc florets.

Abstract: A new cultivar of Euphorbia named ‘Charam’ that is distinguished by a compact clumping growth habit, terminal cymes that turn increasingly red in late winter, then open into yellow-green floral heads that completely cover the plant from March through May. In combination with its hardiness and a long period of garden interest, these traits set ‘Charam’ apart from all other existing varieties of Euphorbia known to the inventor.

Abstract: A Petunia cultivar particularly distinguished by its pale lavender pink flower color and creeping, mounding habit.

Abstract: A Petunia cultivar particularly distinguished by the dark purple flower color.

Abstract: A new and distinct Guzmania plant named ‘Deplakar’ characterized by compact plant shape; short leaves; compact flower shape; yellow inflorescences with red/orange tips.