Abstract: A system and method are provided for fabricating an orifice plate for use in an ink jet printing system. Initially, a substrate base is provided, and a controlled-release layer is applied to a surface of the substrate base. A conductive metal layer is adherently coated on the controlled-release layer. At least one dielectric peg is created on a portion of the conductive metal layer, and a nozzle layer is applied on the conductive metal layer to partially cover the dielectric peg. Photolithography is used to define a trench that covers the nozzles prior to formation of a second reinforcing layer. The controlled-release layer is removed to separate the orifice plate from the substrate base. The conductive metal layer is selectively etched from the nozzle layer to produce a completed multi-layer orifice plate.

Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream.

Abstract: Pattern exposure is performed by selectively irradiating a resist film with extreme UV of a wavelength of a 1 nm through 30 nm band at exposure energy of 5 mJ/cm2 or less. After the pattern exposure, the resist film is developed so as to form a resist pattern.

Abstract: The object of the present invention is to provide, in the production of semiconductor circuit elements, a photoresist residue removing liquid composition which is excellent for removing photoresist residues after dry etching without attacking the wiring material or the interlayer insulating film etc.

Abstract: A device manufacturing method includes a first step for executing a multiple exposure to a first layer on a substrate, by use of a plurality of first masks, and a second step, to be executed after the first step, for executing a multiple exposure to a second layer on the substrate, by use of a plurality of second masks, wherein one of the second masks has a pattern portion of the same design rule as that of one of the first masks.

Abstract: A color developer solution capable of inhibiting precipitation or tar-staining occurring in the processing tank or the roller rack, even when being processed rapidly or at low replenishing rate and a concentrated composition thereof is disclosed, comprising at least one selected from specified N-disubstituted hydroxylamine derivatives and at least one selected from specified N-monosubstituted hydroxylamine derivatives in a molar ratio falling within the range of 1000:1 to 1:1.

Abstract: Disclosed is a photographic element comprising a support bearing a blue light sensitive record containing at least three layers having different levels of light sensitivity arranged in the order slowest to fastest with the slowest layer closest to the support and the fastest layer closest to the light exposure source, wherein (a) all of the blue-sensitive layers are closer to the light exposure source than the layers sensitive to any other color; (b) the slowest blue light sensitive layer is at least 1.0 logE slower than the next fastest blue light sensitive layer when measured at a density of 0.15 above Dmin, and contains a particular type of cyan dye-forming development inhibitor releasing (DIR) coupler; and (c) all of the blue light sensitive layers other than the slowest blue light sensitive layer independently contain a certain type of yellow dye-forming DIR coupler. Embodiments of the invention provide improved color rendition without sacrificing blue density.

Abstract: Spectral sensitizing dyes represented by the following formulas (1) to (4) are disclosed; silver halide photographic materials and thermally developable photosensitive materials containing the dyes are also disclosed.

Abstract: A heat-developable photosensitive material comprises: a support; a light-sensitive silver halide; a reducing agent for a silver ion; a binder; and a light-insensitive organic silver salt grain, wherein the light-insensitive organic silver salt grain contains a silver behenate in an specific amount.

Abstract: A method and apparatus for sulfur trioxide conditioning of flue gas, to assist in the removal of flyash from flue gas exhaust streams containing such flyash. More particularly, such a method and apparatus, which introduces an improvement in the transportation of dry sulfur and the melting and storage of resultant melted sulfur. The melted sulfur is subsequently burned and thereafter catalytically converted to sulfur trioxide for injection into a flue gas for such aforesaid assistance in the removal of flyash therefrom.

Abstract: A symmetric device for stabilization of a flame includes a primary oxidant pipe and a fuel pipe. The fuel pipe is internal to the primary oxidant pipe creating a primary oxidant conduit. A secondary oxidant pipe is internal to the fuel pipe creating a fuel conduit. A primary oxidant source supplies oxidant to the primary oxidant conduit. A fuel source supplies fuel to the fuel conduit. A secondary oxidant source supplies oxidant to the secondary oxidant pipe. The first oxidant velocity is greater than the second oxidant velocity and the fuel velocity is less than the second oxidant velocity. The primary oxidant pipe end extends past the fuel pipe forward end and the fuel pipe forward end extends past the secondary oxidant pipe end. A mismatch in velocity between fuel and oxidant generates a large scale vortex. An asymmetric embodiment is also provided.

Abstract: A communication and data interpreting system for detecting and converting and combining multiple analog signals from flame detectors into a single analog signal and RS 485 for transmission. This system also uses an analog clamping circuit to generate the analog signal from flame rod sensors and a load resistor and a high voltage generator for generating the signal in an UV sensing tube. The input signals are then multiplexed and sent to a microcomputer. The microcomputer uses a diode and a solid state relay circuit to generate a compatible signal output to a burner control.

Abstract: A piezoelectric lighter includes a flame-generating device (30) including a gas jet releasing mechanism (36) and spark-generating mechanism piezoelectric mechanism (50). The lighter includes two actuating elements (32, 34; 140, 150, 170, 180; 210, 220; 240, 250) capable of moving along a longitudinal axis (XX′) under the action of a force exerted by the user, at least one (32; 140; 170; 210; 240) of the actuating elements, called first actuating element, being capable of moving independently of the second actuating element (34; 150; 180; 220; 250) and to act on at least on one (50) of the mechanisms, called first mechanism, the second actuating element being adapted to act on the second mechanism (36).

Abstract: Of the type of lighters that have a gas tank (1) equipped with an exit valve (2) leading to a burner (6), where a push-button (15) simultaneously determines the opening of the valve (2) and the operation of a piezoelectric ignition generator (7), whose central characteristic is the incorporation of a track mechanism (16), operated by a second push-button (14) using the tension of a spring (20), so that said track mechanism can stop the functioning of the valve (2), in turn obstructing ignition, even though it acts on the push-button (15), which is necessary for the functioning of the lighter and simultaneously act on the push-buttons (14) and (15), thus producing ignition. The lighter has been designed to obstruct the manoeuvres necessary to produce ignition when in the hands of a child.

Abstract: The invention relates to a burner, in particular, for a motor vehicle supplementary or parking heater, for the burning of liquid fuel, in the presence of combustion air, comprising a combustion chamber (10), with a jet for the atomisation of liquid fuel, arranged before said chamber. According to the invention, the jet comprises a venturi tube (11) with the largest diameter end of the diffuser section thereof, opening into the combustion chamber (10), into the low pressure region of which, when compared with the upstream end of the diffuser section (12), the liquid fuel is introduced and through the inlet section (13) of which the air is pumped.

Abstract: A combustion apparatus (1) with a burner port assembly (3) comprises an elongated first array of main burner ports (53) for jetting and burning a fuel gas mixture of a concentration to make main flames. The combustion apparatus (1) comprises at least one second arrays of auxiliary burner ports (63) for jetting and burning a further fuel gas mixture of a different concentration to make auxiliary flames, wherein the second arrays of said auxiliary burner ports (63) extend along the first array of said main burner ports (53). The burner port assembly (3) is constructed using inner and outer wall segments (52) together with outermost wall segments (52a,52f) or bands (58). One of the bands (58) faces the corresponding one of said outermost segments (52a,52f) so as to define between them collateral burner ports (61a,61b).

Abstract: In order to provide a cement clinker production line with a calcinator connected to the rotary kiln and including a separate rotary drum-type reactor with the objective to safely burn even coarse secondary fuels in the drum-type reactor and also to evenly and effectively transfer the released heat energy to the cement raw meal, it is proposed in accordance with the invention to introduce into the rotary drum-type reactor on the inlet side for the solids a partial stream line of the tertiary air guided from the clinker cooler to the calcinator, a highly ignitable fuel, the low ignitable or low flammable secondary fuel and a partial stream line for the cement raw meal and to connect the exit side for the material on the rotary drum-type reactor via a line for carrying out the solid residues to the tertiary air channel and/or the rotary kiln exit gas channel of the calcinator and/or to the inlet chamber of the rotary kiln.

Abstract: A method and system for providing information for correct placement of one or more brackets on one or more corresponding teeth according to a predetermined treatment scheme. A virtual representation of a three-dimensional teeth arrangement of one or both jaws of the individual with brackets placed on said teeth is obtained, wherein the position and orientation of the brackets on said teeth being designed so as to achieve a desired treatment outcome. The virtual representation is processed to generate an output data, the output data driving a display, such as a computer monitor or a printed “hard-copy”, to display an image of at least one tooth with a bracket thereon, the displayed image having three-dimensional qualities indicative of said at least one tooth as viewed from a defined viewpoint. The invention can be applied to the placement of brackets onto the buccal side of the teeth as well as onto the lingual side of the teeth.

Abstract: A dental tartar detection system (10), especially for detection of subgingival tartar (S), comprises a probe (12) adapted to be displaced along a tooth (T) an illumination system (14) for illuminating with an incident light a region on the tooth (T), a detection system (16) for collecting the light reflected thereat, and an analysis system (34) for providing a signal to an operator of the probe (12) when measurements on the reflected light in one or more predetermined range of wavelengths fall within any predetermined range of values that are characteristic of tartar (S). Typically, the detection of tartar (S) is achieved on the basis of the possible colours that tartar (S) can have such that the aforementioned one or more predetermined range of values cover wavelengths associated with colours of tartar (S).

Abstract: A dental tray and mixing tip assembly with a material delivery system is provided, the tray comprises at least one material retention surface and a channel having an inlet and at least one outlet, the channel being designed to deliver material from the inlet through the outlet and onto the retention surface and a mixing tip comprising a mixing tube having an entrance, an exit, an internal cavity and a mixing device situated within the internal cavity of the tube, the tube further comprising two rotatable discs, and the exit of the tip being connected to the inlet of the tray.

Abstract: The present invention involves an intraoral illumination device and method for illuminating the interior cavity of a patient's mouth during a medical procedure. The illumination device includes a bite block adapted to be engaged by a patient's teeth for resting the patient's jaw during the medical procedure and fixing the bite block within the patient's mouth. An arcuate light dispersion piece is connected to the bite block so that, in use, the light dispersion piece is orientated in a rear, central part of the oral cavity of the patient's mouth so that dispersed light can be transmitted outward from the rear, central part of the oral cavity. A tongue and cheek retractor is adapted to retract and protect the patient's tongue and adjacent cheek tissue during the medical procedure. Multiple fluid evacuation channels are carried by the device and are adapted to communicate with the interior cavity of the patient's mouth for removing fluids from the oral cavity during the medical procedure.

Abstract: A bone spreader for preparing a site for dental prosthesis implantation consists of a relatively flat, wide, blade component and a longitudinal ridge component centrally disposed on one side of the blade component. Penetration of the instrument effects spreading of cortical bone tissue and produces a recess that includes a groove portion within which the root element of a dental implant can be accommodated.

Abstract: Screw-in dental implant comprising an implant body (made of titanium, zirconium or ceramic) intended to be implanted in the mandible bone or in the maxilla bone: a so-called post or abutment piece (2) (made of titanium, zirconium or ceramic) which is to take the tooth, which can be fixed upright or pre-inclined by 5°, in steps of 5°, to as much as 20°, by a transfixing screw (3). The post is centered and prevented from rotating with respect to the implant body by 24 to 36 teeth made on each face of the implant and of the post (2), these teeth being clamped down one set onto the other by a transfixing screw (3). Each face of each piece has 24 to 36 teeth (4) with an angle in cross section from 45° to 90° maximum.

Abstract: An industry specific plant model is developed by describing a physical description of each physical and logical object in the industry specific plant model. The industry specific objects are selected from an industry suite library that describes a behavior of each industry specific object in a workflow. The industry suite library can be extended with new descriptions of physical and logical objects. The industry suite library contains additionally also the rules which describe the behavior and the interaction of the objects.

Abstract: This teaching method uses this one-two-sided learning aid, called the ONE-PAGE-BOOK, a combination of two languages in which the syntax of the target language is set up to allow the student to learn how to speak, think, write, read and understand the target language. This portable, always accessible and easy-to-use learning aid will allow the student to spontaneously communicate within 120 hours of formal language training by just following the numerical sequence found in the learning aid. This new teaching method does not require memorization, repetition or the use of grammar as the main way to teach the target language. With the use of the learning aid no additional textbooks would be needed.

Abstract: An interactive educational system simultaneously provides educational materials to multiple users. The educational system tests and records each user's demonstrated comprehension of the materials provided. The server-based system can provide materials that are data, video data, or audio data. The user may input video, audio or other data. Each user can randomly access the precise location of the educational materials or portion thereof to be presented to the user.

Abstract: The invention relates to a method of drying blood plasma, blood plasma fractions or blood plasma products (material for treatment) obtained therefrom, the product being sprayed in a liquid or dissolved condition into an evacuable container, drying to the granular form being carried out by means of a fluidizing gas in the fluidized layer.

Abstract: An apparatus and method that allows the visualization of leakage of cell culture media through a conduit wall of a tissue-engineered biological construct such as a semilunar heart valve or valve graft under controlled physiologic conditions. The apparatus and method also allows for the assessment of valve function and intraluminal flow using conventional imaging modalities such as ultrasonic and magnetic resonance imaging. The apparatus allows the qualitative and quantitative evaluation of structural and functional characteristics of a condition tissue engineered construct prior to implantation using a valve housing and chamber and a flow-pressure simulator.

Abstract: The invention provides a method for assigning a cellular function to a component of a biochemical system. The method involves (a) determining a multidimensional shape space for one or more components of a biochemical system in a reference state; (b) perturbing a component within said biochemical system; (c) determining a perturbed multidimensional shape space for one or more components of a pathway in said perturbed biochemical system, and (d) identifying a multidimensional coordinate point corresponding to a component of said perturbed pathway altered between reference and perturbed multidimensional shape spaces, said identified component being assigned a cellular function of said perturbed pathway.

Abstract: Provided are Physalia fluorescent proteins (PFPs) and, more particularly, to PFPs of a Physalia species, and methods of detecting and isolating PFPs. Also provided are methods and compositions for using PFPs, including recombinant PFPs, as reporter molecules in in vitro and in vivo biological assays, including screening assays and cellular assays.

Abstract: In accordance with the present invention, there are provided selection systems and methods for screening for agents that control splicing of inteins in their native host protein (extein) or in homologous exteins. Specifically, there are provided positive genetic selection systems for the screening of agents which inhibit or activate protein splicing which comprise: a host cell containing a chromosomal gene encoding either a drug-resistant form of a target enzyme or a wild-type target enzyme, and a plasmid-borne gene encoding either a drug-sensitive form of the target enzyme, which is dominantly cytotoxic upon interaction with the drug, or a dominantly cytotoxic form of the target enzyme. In these systems the plasmid-borne gene contains an intein, and the inhibition or activation of splicing of the dominant cytotoxic form of the target enzyme by a given reagent results in the survival or death of the host cell. More specifically, positive genetic selection systems which utilize the M. xenopi GyrA intein or M.

Abstract: A continuous substrate and a continuous absorptive sheet are fed to a press station, and pressed continuously or intermittently. Part of the continuous absorptive sheet is charged in plural holes formed in the continuous substrate to form a biochemical analysis sheet. The biochemical analysis sheet is cut into predetermined tips to obtain a biochemical analysis unit.

Abstract: A method and system for genetic analysis of cells or nuclei. For each of one or more DNA sequences in the cells or nuclei, the DNA sequence is labeled with a probe producing a detectable optical signal. A two-dimensional image of the cell or nucleus is obtained that is focused in each of a plurality of parallel planes passing through the cell or nucleus. The number of optical signals from the DNA sequence in each image having one or more predetermined characteristics is determined, and the total number of optical signals in the images having the one or more predetermined characteristics is then determined.

Abstract: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.

Abstract: The present invention relates to recombinant HHV8 DNA as well as to methods for the preparation thereof.

Abstract: Hepatitis B virus capture oligonucleotides, primers and probes derived from conserved regions of the hepatitis B virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.

Abstract: The object of the present invention is to reproduce conditions where viral proteins can function along with the original life cycle of the viruses and to establish an expression system which can evaluate the function of viral proteins by a reporter gene without generating infectious viruses. The present invention provides an assay system comprising a vector containing DNA coding for RNA virus-derived RNA-dependent RNA polymerase and a vector containing a reporter gene expressed in the anti-sense direction.

Abstract: The invention provides materials and methods for detection and typing of HPV infection using PNA probes. More specifically, methods are provided for detecting high-risk types of HPV infection with minimal numbers of PNA probes or using PNA probes to selectively amplify only high-risk types of HPV. Novel primer sequences are also provided.

Abstract: The invention concerns a method for the detection of an infection with influenza A and/or influenza B virus comprising the steps: i) obtaining a saliva sample, ii) preparing the saliva sample for a detection reaction and iii) detecting the influenza A and/or influenza B virus in the saliva sample. The invention in addition concerns a test kit for the detection of an infection by the influenza A and/or influenza B virus containing: i) a device for the collection of a saliva sample and ii) reagents and auxiliary agents for the detection of influenza A and/or influenza B viruses. Furthermore the invention concerns the use of saliva as a sample material for the detection of an infection with the influenza A and/or influenza B virus.

Abstract: In livestock, a number of pathological conditions and/or syndromes have been noticed that do not seem to be attributable to, for example, an infection with a single microorganism. These syndromes however do seem to have an effect on the equilibrium which normally exists within the different bacteria constituting the bacterial flora. A number of these syndromes are referred to as dysbacteriosis and bacterial overgrowth. To enable at least in part the evaluation of the “general” health of the livestock the invention provides means and methods for analyzing the composition of a microbiological flora. In one aspect a method of the invention comprises providing a sample of the flora, selectively amplifying nucleic acid present in the sample, subjecting the amplificate to restriction digestion and analyzing the resulting pattern of restriction fragments.

Abstract: A method for producing biochemical analysis data includes the steps of selectively binding a substance derived from a living organism and labeled with a labeling substance which generates chemiluminescence emission when it contacts a chemiluminescent substrate with specific binding substances contained in a plurality of absorptive regions formed in a biochemical analysis unit, bringing the labeling substance into contact with a chemiluminescent substrate, thereby causing it to release chemiluminescence emission, producing a first digital signal for each of the plurality of absorptive regions of the biochemical analysis unit based on an analog data obtained by detecting the chemiluminescence emission for a first exposure time using a solid state area sensor, storing the first digital signals in a memory, producing a second digital signal for each of the plurality of absorptive regions of the biochemical analysis unit based on an analog data obtained by detecting the chemiluminescence emission for a second expo

Abstract: In accordance with the objects outlined above, the present invention provides methods of diagnosing individuals at risk for a disease state which results in aberrant Rad51 loci. The methods comprise determining the distribution of Rad51 foci in a first tissue type of a first individual, and then comparing the distribution to the distribution of Rad51 foci from a second normal tissue type from the first individual or a second unaffected individual. A difference in the distributions indicates that the first individual is at risk for a disease state which results in aberrant Rad51 loci. Preferred disease states include cancer and disease states associated with apoptosis.

Abstract: The DNA probes produced by molecular cloning and the characterization of specific gene region sequences is provided, these can be used as genetic markers for the genes such as Cytochrome b (cyt b); Mitochondrial control region (D-Loop); Inter Transcribed Spacers (ITS2) and Rhodopsin (ROD), 12S rRNA and 16S rRNA in mesopelagic lantern fishes which are found in the mesopelagic zones of the oceans where the photic regime is of dim light and associate themselves with the oxygen minimum layer, it also includes the recombinant DNA techniques for the preparation of specific gene probes and sequences of species specific primers of lantern fishes, novel gene probes and novel oligonucleotides for amplification of myctophid genes are disclosed.

Abstract: The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure.

Abstract: Disclosed are compositions and a method for amplification of nucleic acid sequences of interest. The method is based on stand displacement replication of the nucleic acid sequences of interest by multiple primers. In one preferred form of the method, referred to as multiple strand displacement amplification, two sets of primers are used, a right set and a left set. The primers in the right set are complementary to one strand of the nucleic acid molecule to be amplified and the primers in the left set are complementary to the opposite strand. The 5′ end of primers in both sets are distal to the nucleic acid sequence of interest when the primers have hybridized to the nucleic acid sequence molecule to be amplified. Amplification proceeds by replication initiated at each primer and continuing through the nucleic acid sequence of interest. A key feature of this method is the displacement of intervening primers during replication by the polymerase.

Abstract: Genetic polymorphisms responsible or associated with altered expression of cytochrome P450 CYP3A5 enzyme are described. Single nucleotide polymorphisms are provided. Methods for identifying subjects having a low or high drug metabolizing phenotype associated with CYP3A5 expression are provided. Assays, kits and methods for determining and assaying the CYP3A5 genotype and phenotype of individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's metabolism of drugs and therapeutic agents, the potential for drug interactions, and thereby toxicity and effectiveness of certain drugs and treatment modalities, are provided.

Abstract: The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

Abstract: A polynucleotide library useful in the molecular characterization of a carcinoma, the library including a pool of polynucleotide sequences or subsequences thereof wherein the sequences or subsequences are overexpressed in tumor cells, further wherein the sequences or subsequences correspond substantially to any of the polynucleotide sequences set forth in any of SEQ ID NOS: 1-468 or the complement thereof.

Abstract: Provided are proteins having NF-kB activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-kB. Using plasmid pNFkB-Luc, cDNA encoding a protein capable of activating NF-kB has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-kB activation.

Abstract: The present invention relates to mammalian receptors, particularly human pheromone receptors and the expression of these receptors in selected cells and tissues. More specifically, the invention encompasses novel human vomeronasal organ (VNO) receptors. The invention contemplates nucleic acid molecules and fragments thereof encoding human pheromone receptors and agents that specifically bind to the polypeptides comprising human pheromone receptors. The invention also encompasses vectors and cells for producing the nucleic acid molecules encoding human pheromone receptors as well as vectors and cells for expressing receptor polypeptides. The invention further relates to methods for isolation, characterization and detection of the nucleic acid molecules, polypeptides, and agents that bind to the receptors. The invention also encompasses diagnosis and treatment of diseases or disorders related to the aberrant expression of the human pheromone receptors hV3R1 and hV3R8.