Abstract: Supported bis(phosphorus) ligands are disclosed for use in a variety of catalytic processes, including the isomerization, hydrogenation, hydroformylation, and hydrocyanation of unsaturated organic compounds. Catalysts are formed when the ligands are combined with a catalytically active metal, such as nickel.

Abstract: There is provided a process for producing a modified polymer rubber having modified both ends, which comprises the steps of:

Abstract: Compositions including one or more anionic polymerization initiators and one or more additives for improving functionalizing efficiency of living polymer anions are disclosed. The present invention also provides compositions including one or more electrophiles and one or more additives for improving functionalizing efficiency of living polymer anions. Novel electrophiles and processes for improving polymer anion functionalization efficiencies are also disclosed.

Abstract: Novel monofunctional polyethylene glycol aldehyde for pegylating therapeutically active proteins to produce pegylated protein conjugates which retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived and a new synthesis for preparing such aldehydes.

Abstract: A process for polymerizing monomers in the gas phase, in fluidized bed reactors is described, where unsaturated, gas phase monomers are fed into the reactors in the presence of a mixture of inert diluents having a composition that allows the dew point to be adjusted, this leading to high production rates under stable operation in a non condensed operation mode.

Abstract: A production process for a vinyl-based polymer is provided. The production process comprises a step for polymerizing a vinyl-based monomer by a radical reaction within an aqueous medium in a polymerization vessel, and a step for supplying a reaction inhibitor with a melting point of no more than 40° C. from a reaction inhibitor supply tank to the polymerization vessel via a reaction inhibitor supply pipe. The reaction inhibitor supply tank and the reaction inhibitor supply pipe are heated, and the reaction inhibitor is added to the polymerization vessel in a liquid state with a viscosity of no more than 200 mPa·s. The reaction inhibitor can be added to the polymerization mixture without the use of an organic solvent even at low temperatures, and problems such as the solidification of the reaction inhibitor inside the supply tank or piping, and subsequent blocking of the piping do not occur.

Abstract: New compositions, titanium-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with titanium metal centers have high performance characteristics, including high styrene incorporation into ethylene/styrene copolymers.

Abstract: The group IIa metal containing catalyst system of this invention can be utilized to synthesize rubbery polymers having a high trans microstructure by solution polymerization. Such rubbery polymers having a high trans microstructure content, such as polybutadiene rubber, styrene-isoprene-butadiene rubber, styrene-butadiene rubber, can be utilized in tire tread rubbers that exhibit improved wear and tear characteristics. This invention more specifically reveals a catalyst system which is comprised of (a) an organolithium compound, including organolithium functionalized compounds, (b) a group IIa metal salt selected from the group consisting of group IIa metal salts of di(alkylene glycol)alkylethers and group IIa metal salts of tri(alkylene glycol) alkylethers, and (c) an organoaluminum compound, and optionally an organomagnesium compound.

Abstract: The present invention describes the synthesis of new fluorinated elastomers with very low glass transition temperatures (Tg), a good resistance to bases, gasoline and other carburants and good workability properties, these elastomers contain hexafluoropropene (HFP), perfluoro(4-methyl-3,6-dioxaoct-7-ene) sulfonyl fluoride (PFSO2F), vinylidene fluoride (VDF) and/or at least one fluorinated alkene and/or one vinyl perfluorinated ether. In a precise case, they are prepared by radical polymerisation of HFP and PFSO2F or by radical terpolymerisation HFP, PFSO2F and VDF in the presence of different organic initiator, such as peroxides, peresters or diazo compounds.

Abstract: An ionomer and a process for forming the ionomer such that the ionomer has (1) low equivalent weight; below 950, preferably between 625 and 850, and most preferably between about 700 and about 800; and (2) high conductivity, (greater than 0.15 S/cm). In an alternative embodiment, the ionomer has (1) low equivalent weight; below 950, preferably between 625 and 850, and most preferably between about 700 and about 800; and (2) acceptably low hydration, (less than about 75 weight percent). These ionomers are adapted to be processed into thin films that have acceptable physical stability. They are thus extremely well-suited for low humidity or high temperature fuel cell applications.

Abstract: A fluorine-containing copolymer obtained by copolymerizing tetrafluoroethylene, hexafluoropropylene and perfluoro vinyl ether as component monomers, wherein a weight ratio of tetrafluoroethylene, hexafluoropropylene and perfluoro vinyl ether units constituting the fluorine-containing copolymer is 70 to 95:5 to 20:0 to 10, respectively; the fluorine-containing copolymer having: a melt flow rate of 30 (g/10 minutes) or more; a volatile content index of 0.2% by weight or less; and a stress relaxation modulus G(t) (unit: dyn/cm2) which satisfies the following formula at t=0.1 second when measured at a temperature of 310° C.

Abstract: The present invention describes synthesis of new fluorinated elastomers presenting very low glass transition temperatures, a good resistance to bases, petroleum and fuels and good properties for forming. These elastomers contain, by way of example, from 90 to 50 mole % of vinylidene fluoride (VDF) and from 10 to 50 molar % of perfluoromethyl vinyl ether (PMVE). In this precise case, they are prepared by radical copolymerisation of VDF and with PMVE in presence of various organic initiators such as for example the peroxides, the peresters or the diazo compounds.

Abstract: A fluorocopolymer which comprises (A) polymerized units based on tetrafluoroethylene, (B) polymerized units based on ethylene and (C) polymerized units based on a compound represented by CH2═CX(CF2)2Y (wherein each of X and Y which are independent of each other, is a hydrogen atom or a fluorine atom), wherein the molar ratio of (A)/(B) is from 20/80 to 80/20, and the molar ratio of (C)/((A)+(B)) is from 1/1000 to 15/100, and which has a volume flow rate of from 1 to 1000 mm3/sec. The fluorocopolymer has a low fuel permeability coefficient and is excellent in the fuel barrier properties.

Abstract: A composition and method is described for providing conformal protective or decorative polymer coatings on metals such as aluminum, copper, iron, steel, zinc, and their by dip autopolymerization. In accordance with the present invention, an acidic solution of organic monomer undergoes autopolymerization upon contact with a metal substrate, thereby forming a polymeric coating on the substrate. The method comprises providing the acidic monomer solution, dipping the metal substrate to be coated for a prescribed period of time depending on the thickness of the coating desired, and then removing the substrate from the solution. Importantly, the polymerization requires no application of external driving force, such as thermal or electrical energy. The coatings thus formed are up to 50 microns thick, and conform to the shape of the substrate. These coatings further have uniform thickness, and excellent thermal stability and protective properties.

Abstract: What is described herein is a pharmaceutical excipient which is a proliferous copolymer of vinyl pyrrolidone and vinyl acetate, having advantageous dissolution and disintegration properties.

Abstract: Acetal compounds in which a 5- or 6-membered ring acetal structure is connected to a norbornene structure through a linker represented by —(CH2)m— in which one hydrogen atom may be substituted with a hydroxyl or acetoxy group, and m is from 1 to 8 are novel. Using the acetal compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation and has excellent sensitivity, resolution, and etching resistance.

Abstract: The present invention is directed to a method of forming a polymer composition having quaternary alkane units and aromatic hydrocarbon units. The aromatic hydrocarbon units have substituents of the general formula R1SiR2R3R4, wherein R1 is optional and is a hydrocarbon or ether linking the silicon and the aromatic hydrocarbon, and R2, R3, and R4 are one or more of hydrogen, alkyl, and alkoxy, with the provision that no more than two may be hydrogen or alkyl.

Abstract: The present invention is directed to a single stage free radical precipitation polymerization process for producing a copolymer involving admixing a solvent, a free-radical-forming agent, (meth)acrylic acid, and at least one monomer selected from the group consisting of styrene, vinyl acetate, methylmethacrylate, butyl acrylate, methyl acrylate, acrylonitrile, and isopropylacrylamide; initiating a free-radical precipitation polymerization to form a plurality of polymer radicals; precipitating a polymer from said polymer radicals; maintaining the admixture of reactants at a temperature above the lower critical solution temperature of said admixture; and controlling the temperature of said admixture to control the rate of propagation of the polymer. The process is useful for producing random copolymers of vinyl acetate or styrene with more than 4 percent and up to greater than 20 percent by weight of (meth)acrylic acid.

Abstract: The process for the continuous preparation of homopolymers or copolymers by free-impinging-jet micromixing of fluids formed (1) of monomer(s) and (2) of an initiator system consists in micromixing the said fluids (1) and (2) and in recovering the mixture of these fluids in the form of a resultant jet Jr, originating from the point of impingement (I), the micromixture being obtained by:

Abstract: The present invention relates to a method for preparing a weatherable thermoplastic resin, and more particularly to a method for preparing a thermoplastic acrylate-styrene-acrylonitrile (ASA) resin having superior weatherability and colorability. In detail, the present invention provides a method comprising the steps of: a) preparing a seed by adding a water-soluble initiator to an aromatic vinyl compound, or to a (meth)acrylic acid alkyl ester, and polymerizing; b) preparing an alkyl acrylate rubber polymer by adding an alkyl acrylate monomer, an emulsifier of pH 3˜-9, and an oil-soluble initiator to the seed, and polymerizing; and c) preparing a thermoplastic resin by adding an aromatic vinyl compound, a vinyl cyanide compound, an emulsifier of pH 9˜-13, and an oil-soluble initiator to the alkyl acrylate rubber polymer, and graft polymerizing.

Abstract: For the preparation of organopolysiloxanes, water glass diluted with water to a concentration of 3 to 15 wt % is reacted with a triorganohalosilane in the presence of an acid and an oxygen-containing solvent such as isobutyl alcohol, methyl isobutyl ketone or 1-pentanol. The invention achieves a considerable reduction of the environmental load, an improved utilization of reactants, an improved yield, and a cost reduction, and enables production of low viscosity MQ resins.

Abstract: The present invention relates to polyurethane prepolymer having terminal alkoxysilane and OH groups which is the reaction product of

Abstract: Solid polyurethane powder coating compositions which contain uretdione groups and cure at low baking temperatures, to processes for preparing such compositions, and to their use for producing plastics, especially powder coatings, which crosslink to high-gloss or matt, light- and weather-stable coating films.

Abstract: The present invention relates to a catalyst and to a process for preparing color-reduced polyisocyanates containing isocyanurate groups.

Abstract: Novel diphenylmethane diisocyanate composition that comprises diphenylmethane diisocyanate, a diphenylmethane diisocyanate uretonimine group-containing derivative, a reaction product of diphenylmethane diisocyanate and a diol of number average molecular weight less than 250 and optionally methylene bridged polyphenyl polyisocyanates of isocyanate functionality higher than two, the composition having a content of 2,4 isomer between 2 and 50%. The novel composition is highly stable. The invention also provides a process for its preparation, process for making polyurethane articles using the composition of the invention, as well as the polyurethane articles thus obtained.

Abstract: A golf ball comprising a core and a cover, wherein the core or the cover is formed from a composition comprising at least one acid functional polyurethane, polyurea, or copolymer thereof.

Abstract: The invention concerns the use of stannylenes and germylenes of general formula (1) wherein: 1

Abstract: A low viscosity (and therefore low VOC) resin can be produced by limiting the molar ratio of the reactants, especially the dicarboxylic acid compound, used in the reaction. Specifically, reacting a reaction mixture comprising (i) one mole of a diepoxide having at least two glycidyl ether type epoxy groups; (ii) 0.5 to 2.0 moles of an unsaturated monocarboxylic acid; (iii) 0.1 to 0.5, preferably 0.1 to 0.3, moles of maleic anhydride; and, (iv) water, until substantially all of the epoxy groups disappear leads to the formation of a resin with a high shear (at least 500 s−1) viscosity of less than 1200 cP when measured in a 70% NVM (non-volatile matter) styrene solution. The resin may be used in barrier coatings, gel coatings, skin coatings and as a laminate resin.

Abstract: Provided are polyimide and a thin film thereof which have a three-dimensional structure and therefore are excellent in a mechanical strength and a heat resistance as compared with those of conventional linear polyimide.

Abstract: A polycarbonate composition excellent in both antistatic property and coloring matter coatability containing (a) a polycarbonate obtained by an ester exchange process, and (b) a compound having a molecular weight of from 300 to 8,000 and having any of ester bond, carbonate bond, amide bond and urethane bond in its molecule and an aromatic hydrocarbon group substituted by at least one alkyl group at the molecular end thereof, a write once read many optical disc substrate and a write once read many optical disc using the same and a process for the production of a write once read many optical disc are described.

Abstract: The invention relates to a process for preparing a liquid melamine urea formaldehyde resin that has long term stability. The invention also relates to a liquid MUF resin with a high formaldehyde and melamine content. The invention further relates to a liquid suspension hardener including a catalyst, a thickener, a filler, and water. The invention also relates to a adhesive composition for use in wood bonding that is made by adding a hardener to the resin.

Abstract: The present invention contemplates poly(aminoamide) pre-polymers, polyamide polymers, a multi-step process for the synthesis of these pre-polymers and polymers using acrylates and at least one monomer containing at least two primary amines, and the resins resulting from the reaction of the polymers with an epihalohydrin. These resins may be used as wet strength resins and creping aids in the papermaking industry as well as surface additives for wool.

Abstract: A photocurable and thermosetting resin composition comprises (A) an actinic energy ray-curable resin having at least one structure represented by the following general formula (1), (B) a polymerization initiator, (C) a diluent, and (D) a polyfunctional oxetane compound. The actinic energy ray-curable resin mentioned above can be produced by causing the reaction of (a) a polyfunctional oxetane compound with (b) an unsaturated monocarboxylic acid and the subsequent reaction of (c) a polybasic acid anhydride with a primary hydroxyl group of the resultant modified oxetane resin (a′).

Abstract: A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.

Abstract: An organic polymer comprising a conjugated backbone for transporting negative charge carriers and having a first band gap and at least one side unit pendent from the backbone for transporting positive charge carriers and having a second band gap, wherein the structure of the organic polymer is selected so that the first and second band gaps are distinct from one another in the polymer.

Abstract: The invention relates to catalyst components, containing:

Abstract: The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.

Abstract: Disclosed is a safe, efficient and environmentally friendly method for preparing imidoesters.

Abstract: A method and tools for the biochemical processing of protein samples towards their analysis and identification by, for example, mass spectrometry (MS). The method involves the reversible (non-covalent) immobilization, purification and concentration of proteins onto a solid surface and subsequent solid-phase enzyme-catalyzed proteolysis of the proteins. The constituent peptides are recovered in near-quantitative yields in a format ideally suited for identification by routine MS technologies. The process is easily adapted such that additional chemical and/or enzymatic transformation(s) of the immobilized proteins or peptides can be performed to facilitate the acquisition of and increase the information content obtained from the MS analysis.

Abstract: The present invention relates, in general, to autotaxin. In particular, the present invention relates to a DNA segment encoding autotaxin; recombinant DNA molecules containing the DNA segment; cells containing the recombinant DNA molecule; a method of producing autotaxin; antibodies to autotaxin; and identification of functional domains in autotaxin.

Abstract: DNA sequences encoding endothelial cell-leukocyte adhesion molecules ELAMs, methods for producing such molecules, and ELAMs (including the specific molecules ELAM1 and VCAM1 and 1b) essentially free of normally associated animal proteins are disclosed. Antibodies against ELAMs are also disclosed.

Abstract: A novel polypeptide, a polynucleotide encoding this polypeptide, a expression vector comprising this polynucleotide, a cell transfected with the expression vector, and a pharmaceutical composition for promoting type II collagen production, a pharmaceutical composition for promoting aggrecan production, and a pharmaceutical composition for treating and/or preventing osteoarthritis comprising the above polypeptide as an active ingredient are disclosed.

Abstract: The present invention relates to 11 novel genes from S. aureus and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of S. aureus polypeptide activity. The invention additionally relates to diagnostic methods for detecting Staphylococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Staphylococcus.

Abstract: A method of perlecan isolation (from the EHS tumor) which produces “clean” (i.e. substantially “pure”) perlecan is disclosed. Clean perlecan is thus produced in sufficient quantities for use in a number of different in vitro and in vivo assays. In addition, this isolation method exploits a newly discovered aggregating property of a ˜220 kDa heparan sulfate proteoglycan (HSPG) observed during gel filtration chromatography, which allows it to be effectively separated from non-aggregating perlecan. The method employs specific cation exchange, anion exchange, molecular sieve chromatography and immobilized GAG affinity chromatography. It is demonstrated that there are no other contaminating proteins in the perlecan and HSPG preparations, and that the perlecan core protein is intact. Improved, clean perlecan based, rodent models of fibrillar amyloid protein deposition, accumulation and/or persistence in tissues are disclosed.

Abstract: A method for purifying proteins by Protein A chromatography is described which comprises removing contaminants by washing the solid phase with various intermediate wash buffers.

Abstract: Compounds of formula (I) where: X1 is OH or SH or NH2 or -L-Z; X2 and X3 are the same or different and each is H, C1-4 alkyl, benzyl a protecting group or -L-Z, X4 is H or C1-4 alkyl, L is a linker comprising a chain of 0-10 atoms, Z is a group comprising a detectable moiety which comprise at least one detectable moiety are useful in the diagnosis and prognosis and radiotherapy of metastatic bone disease.

Abstract: Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.

Abstract: A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.

Abstract: The present invention relates to the acid sphingomyelinase gene and to methods of diagnosing Niemann-Pick disease. It is based, at least in part, on the cloning and expression of the full-length cDNA encoding acid sphingomyelinase and on the discovery of mutations in the acid sphingomyelinase gene of Ashkenazi Jewish Niemann-Pick disease patients.

Abstract: A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which has been named hap, is similar to that of the DNA-binding hormone receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5 kb hap mRNA species which is undetectable in normal adult and fetal livers, but present in all non-hepatic tissues analyzed. Low stringency hybridization experiments revealed the existence of hap related genes in the human genome. The cloned DNA sequence is useful in the preparation of pure hap protein and as a probe in the detection and isolation of complementary DNA and RNA sequences. The hap protein is a retinoic acid (RA) receptor identified as RAR-&bgr;.