Patents Issued in August 14, 2003
  • Methods for separating oligonucleotides
    Publication number: 20030153741
    Abstract: Methods for separating oligonucleotides are described. The oligonucleotides to be separated include separation tags attached to each end of the oligonucleotides.
    Type: Application
    Filed: February 8, 2002
    Publication date: August 14, 2003
    Inventor: Marek Kwiatkowski
  • Purification of oligonucleotides
    Publication number: 20030153742
    Abstract: Methods and compounds useful for the purification of oligonucleotides and their analogs are provided wherein the oligonucleotides are contaminated with at least one oligonucleotide having at least one abasic site by the formation of imines at the aldehyde moiety of the abasic site and subsequent separation based on extractions, precipitations or chromatography.
    Type: Application
    Filed: January 2, 2003
    Publication date: August 14, 2003
    Inventors: Achim H. Krotz, Vasulinga T. Ravikumar
  • Processes for the synthesis of oligomeric compounds
    Publication number: 20030153743
    Abstract: Methods for the preparation of oligonucleotides having bioreversible phosphate blocking groups are disclosed. The oligonucleotides are prepared utilizing amidite type chemistry wherein the bioreversible phosphorus protecting group is formed as an integral part of the amidite reagent.
    Type: Application
    Filed: January 3, 2003
    Publication date: August 14, 2003
    Inventors: Muthiah Manoharan, Andrei Guzaev
  • Anti-viral 7-deaza L-nucleosides
    Publication number: 20030153744
    Abstract: The present invention comprises 7-deaza L-nucleosides having unexpectedly high inhibitory activity against the hepatitis B virus. The invention further comprises pharmaceutical compositions comprising such compounds as well as methods of treating mammals, particularly humans, infected with HBV and other viral infections.
    Type: Application
    Filed: December 20, 2002
    Publication date: August 14, 2003
    Applicant: Micrologix Biotech Inc.
    Inventors: Khalid Mekouar, Robert Deziel, Samir Mounir, Radhakrishnan P. Iyer
  • Process for producing nucleic acid derivative
    Publication number: 20030153745
    Abstract: A process for efficiently producing a nucleic acid derivative by condensing a specific nitrogen-containing heterocyclic compound such as a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose using a less expensive and safe reagent. Namely, a process for producing a nucleic acid derivative by condensing a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose in the presence of an iron halide.
    Type: Application
    Filed: February 11, 2003
    Publication date: August 14, 2003
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Yuki Takuma, Kyoko Endo, Takeshi Murakami, Tomoko Maeda, Tomoko Sasaki, Youichi Matsumoto
  • Beta-glucan compositions and process therefore
    Publication number: 20030153746
    Abstract: An efficient method for producing high quality beta glucan enriched soluble dietary fiber products is described. An aqueous extraction slurry of beta glucan-containing grain material is homogenized, acidified and enzymatically digested to reduce viscosity and optimize separation of insolubles from the aqueous extract solution. The resulting extract is heat processed to precipitate denatured protein components and subsequently dried or otherwise processed to provide the products for use as food additives or dietary supplements.
    Type: Application
    Filed: February 4, 2002
    Publication date: August 14, 2003
    Inventors: Bernhard H. Van Lengerich, Olaf Gruess, Friedrich P. Meuser
  • Purification process
    Publication number: 20030153747
    Abstract: Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.
    Type: Application
    Filed: January 21, 2003
    Publication date: August 14, 2003
    Inventors: Johannes Ludescher, Werner Veit
  • Cephalosporin intermediates
    Publication number: 20030153748
    Abstract: A process and intermediates in the production of cefotiam (hexetil).
    Type: Application
    Filed: February 12, 2003
    Publication date: August 14, 2003
    Inventors: Peter Kremminger, Johannes Ludescher, Siegfried Wolf
  • Method for the production of caprolactam
    Publication number: 20030153749
    Abstract: A process is provided for the preparation of caprolactam from a compound of formula (I):
    Type: Application
    Filed: December 4, 2002
    Publication date: August 14, 2003
    Inventors: Frank Ohlbach, Andreas Ansmann, Rolf-Hartmuth Fischer, Johann-Peter Melder
  • Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
    Publication number: 20030153750
    Abstract: The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-&agr;) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
    Type: Application
    Filed: November 18, 2002
    Publication date: August 14, 2003
    Applicant: Pliva farmaceutska industrija, dionicko drustvo
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Zeljko Zupanovic, Boska Hrvacic
  • Inhibitors of phospholipase enzymes
    Publication number: 20030153751
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Application
    Filed: May 8, 2002
    Publication date: August 14, 2003
    Applicant: American Home Products Corporation
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Pyrrolopyrimidines as therapeutic agents
    Publication number: 20030153752
    Abstract: Chemical compounds having structural formula I 1
    Type: Application
    Filed: March 29, 2000
    Publication date: August 14, 2003
    Inventors: Gavin C. Hirst, David Calderwood, Rainer Munschauer, Lee D. Arnold, David N. Johnston, Paul Rafferty
  • Process for the preparation of a piperazine derivative
    Publication number: 20030153753
    Abstract: (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-4-[2-[(2S)-2-(methoxymethyl)morpholino]ethyl]-2-(3-hydroxy-4-methylbenzyl)piperazine dihydrochloride is obtained by debenzylating (2R)-4-benzyl-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(3-hydroxy-4-methylbenzyl)piperazine, then N-alkylating and converting to hydrochloride.
    Type: Application
    Filed: December 13, 2002
    Publication date: August 14, 2003
    Inventors: Keiichi Koga, Ryoki Orii, Yosuke Fujii, Shunsuke Goto, Satoshi Hirabayashi
  • Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
    Publication number: 20030153754
    Abstract: Disclosed are the compounds of the formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 14, 2003
    Applicant: Neurogen Corporation, A Corporation of the State of Delaware
    Inventors: Pamela Albaugh, Gang Liu, Kenneth Shaw, Alan Hutchison
  • Bicyclic amine derivatives as inhibitors of class 1 receptor tyrosine kinases
    Publication number: 20030153755
    Abstract: Fused bicyclic amines of formula (1) are described wherein Ar is an aryl or heteroaryl group; Y is a —S(O2)— or —C(O)— group; R1 is a hydrogen or halogen atom or an alkyl, haloalkyl, alkoxy, haloalkoxy or cyano group; X is a nitrogen atom or a C(R1a) group where R1a is as defined for R1 and may be the same or different; W and Z are each a carbon atom and together with U form an optionally substituted five- or six-membered monocyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the activity of Class I receptor tyrosine kinases and are of use in the prophylaxis and treatment of hyperproliferative disorders such as cancer, psoriasis, restenosis, atherosclerosis and fibrosis.
    Type: Application
    Filed: February 4, 2003
    Publication date: August 14, 2003
    Inventors: David Festus Charles Moffat, Peter David Davis
  • Pyrimido[5,4-e] [1,2,4]triazine-5, 7-diamine compounds as protein tyrosine phosphatase inhibitors
    Publication number: 20030153756
    Abstract: The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B.
    Type: Application
    Filed: December 10, 2002
    Publication date: August 14, 2003
    Inventors: Kevin Richard Guertin, Lina Quattrocchio Setti
  • Synthesis and purification of valacyclovir
    Publication number: 20030153757
    Abstract: The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.
    Type: Application
    Filed: November 13, 2002
    Publication date: August 14, 2003
    Inventors: Marina Yu Etinger, Lev M. Yudovich, Michael Yuzefovich, Gennady A. Nisnevich, Ben Zion Dolitzky, Boris Pertsikov, Boris Tishin, Dina Blasberger
  • 1,3,4-Oxadiazole derivatives and process for producing the same
    Publication number: 20030153758
    Abstract: Oxadiazole derivatives represented by formula (I): 1
    Type: Application
    Filed: January 17, 2003
    Publication date: August 14, 2003
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Tsutomu Kojima, Katsutoshi Hachiya, Kazuyuki Ohmoto
  • 1-Glyoxlylamide indolizines for treating cancer
    Publication number: 20030153759
    Abstract: Disclosed is a compound represented by Structural Formula (I): 1
    Type: Application
    Filed: September 13, 2002
    Publication date: August 14, 2003
    Applicant: SBR Pharmaceuticals Corp.
    Inventors: Keizo Koya, Lijun Sun, Mitsunori Ono, Weiwen Ying, Hao Li
  • Process for the synthesis of (R)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation
    Publication number: 20030153760
    Abstract: The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
    Type: Application
    Filed: December 20, 2002
    Publication date: August 14, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Paul Devine, Hansen Karl
  • Preparation of terpyridines
    Publication number: 20030153761
    Abstract: Process for preparing terpyridines of the formula I 1
    Type: Application
    Filed: April 30, 2002
    Publication date: August 14, 2003
    Applicant: BASF Aktiengesellschaft
    Inventors: Ralph Lunkwitz, Gunther Pabst, Guenter Scherr
  • Process for preparing imidazoquinolinamines
    Publication number: 20030153762
    Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.
    Type: Application
    Filed: February 6, 2003
    Publication date: August 14, 2003
    Applicant: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom
  • Pharmaceutically active compounds and methods of use
    Publication number: 20030153763
    Abstract: The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.
    Type: Application
    Filed: December 17, 2002
    Publication date: August 14, 2003
    Inventors: N. Laxma Reddy, Michael Maillard, David Berlove, Sharad Magar, Graham J. Durant
  • Process for preparing 4-substituted piperidines
    Publication number: 20030153764
    Abstract: The present invention provides a process for preparing N-protected-4-substituted piperidines of formula (I) wherein Pg represents a suitable nitrogen protecting group; X represents a heterocycle, substituted heterocycle, substituted alkenyl or substituted aryl wherein the substituted heterocycle, substituted alkenyl or substituted aryl are substituted with from 1 to 3 suitable activating groups; and R1, R2, R3, R4, R5, R6, R7, and R8 each independently represent an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II) wherein the substituents are defined as above, with triethylsilane and trifluoroacetic acid.
    Type: Application
    Filed: May 28, 2002
    Publication date: August 14, 2003
    Inventors: Alexander Glenn Godfrey, Steven Wayne Pedersen
  • Hydrogenation of precursors to thiazolidinedione antihyperglycemics
    Publication number: 20030153765
    Abstract: Provided is a method of hydrogenating the exocyclic double bond of a thiazolidinedione precursor in a method of making a thiazolidinedione antihyperglycemic, for example pioglitazone, including work-up steps to afford pure thiazolidinedione antihyperglycemic.
    Type: Application
    Filed: December 20, 2002
    Publication date: August 14, 2003
    Inventor: Ben-Zion Dolitzky
  • Process for producing crystal
    Publication number: 20030153766
    Abstract: The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.
    Type: Application
    Filed: November 7, 2002
    Publication date: August 14, 2003
    Inventors: Hideo Hashimoto, Hideaki Maruyama
  • Method for producing 2-chloro-5-chloromethyl-1,3-thiazole
    Publication number: 20030153767
    Abstract: A process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole, in which allyl isothiocyanate of formula CH2═CH—CH2-NCS is reacted at from −40° C. to +30° C., in a solvent that is inert under the reaction conditions, with from 1 to 2 mol of a chlorinating agent per mol of allyl isothiocyanate; to the reaction mixture so obtained there is added, at a reaction temperature of from 0° C. to the boiling temperature of the solvent used, from 1 to 5 mol of oxidising agent per mol of allyl isothiocyanate, and then 2-chloro-5-chloromethyl-1,3-thiazole is isolated from the reaction mixture and is optionally converted by crystallisation into high-purity 2-chloro-5-chloromethyl-1,3-thiazole.
    Type: Application
    Filed: March 27, 2003
    Publication date: August 14, 2003
    Inventors: Sylvia Krich, Christian Burger, Johann Altreiter, Birgit Zwolfer
  • Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Publication number: 20030153768
    Abstract: Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): 1
    Type: Application
    Filed: November 26, 2002
    Publication date: August 14, 2003
    Applicant: Genzyme Corporation
    Inventor: Bradford H. Hirth
  • Processes for preparing imidazole derivatives and salts thereof
    Publication number: 20030153769
    Abstract: The present invention provides a process for preparing an imidazole derivative or its salt which comprises reacting a tetrahydrofuran or tetrahydropyran derivative with formamidine or its salt in the presence of a base.
    Type: Application
    Filed: February 6, 2003
    Publication date: August 14, 2003
    Applicant: YUHAN CORPORATION
    Inventors: Jeong-Seok Chae, Tai-Au Lee, Sang-Seon Park, Doo-Byung Lee, Beom-Joo Maeng
  • Novel sPLA2 inhibitors
    Publication number: 20030153770
    Abstract: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Application
    Filed: September 27, 2002
    Publication date: August 14, 2003
    Inventors: Ho-Shen Lin, Michael Enrico Richett
  • Large scale synthesis of optically pure aziridines
    Publication number: 20030153771
    Abstract: Disclosed is an efficient, inexpensive method for the preparation of chiral aziridines on a large scale.
    Type: Application
    Filed: September 27, 2002
    Publication date: August 14, 2003
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson, Gaznabi Khan
  • Process for the preparation of vitamin E
    Publication number: 20030153772
    Abstract: The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of Arimethylhydroquinone and isophytol.
    Type: Application
    Filed: December 19, 2002
    Publication date: August 14, 2003
    Applicant: Aventis Animal Nutrition, S.A.,
    Inventors: Jildaz Dhainaut, Thierry Durand
  • Process for the production of dihydropyridines
    Publication number: 20030153773
    Abstract: The present invention relates to the production of a salt of a bis-condensation reaction.
    Type: Application
    Filed: February 14, 2002
    Publication date: August 14, 2003
    Inventors: Gregory S. Wayne, Wenke Li
  • Process for the preparation of citalopram
    Publication number: 20030153774
    Abstract: The present invention provides, inter alia, a novel process for the preparation of Citalopram, a known antidepressant.
    Type: Application
    Filed: September 11, 2002
    Publication date: August 14, 2003
    Applicant: Pharmachem Technologies Limited,
    Inventors: Aslam A. Malik, Hasan Palandoken, Joy A. Stringer, DerShing Huang, Antonio Romero, Olivier Dapremont
  • Process for producing oxirane compound
    Publication number: 20030153775
    Abstract: A process for producing an oxirane compound from ethylbenzene hydroperoxide and an olefin in the presence of an immobilized catalyst bed, wherein the process satisfies the following conditions (1) to (4):
    Type: Application
    Filed: December 4, 2002
    Publication date: August 14, 2003
    Inventors: Noriaki Oku, Tateo Seo
  • Process for obtaining betulin
    Publication number: 20030153776
    Abstract: The invention relates to an improved process for obtaining pure crystalline betulin which is substantially free from betulinic acid, from an extract of birch bark.
    Type: Application
    Filed: January 31, 2003
    Publication date: August 14, 2003
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Markus Sauter, Carsten Bender
  • Amine compounds and curable compositions derived therefrom
    Publication number: 20030153777
    Abstract: Disclosed are compounds produced by a process comprising the step of reacting an amine reactant with an epoxide reactant to form a hydrolytically stable carbon-nitrogen bond therebetween, wherein at least one of the amine or epoxide reactants comprises a terminal alkoxysiyl group. Also disclosed are curable compositions comprising the compounds of the present invention and the cured products derived therefrom.
    Type: Application
    Filed: November 19, 2002
    Publication date: August 14, 2003
    Inventors: Garth L. Wilkes, Chenghong Li
  • Magnesium mediated preparation of fluorinated alkyl silanes
    Publication number: 20030153778
    Abstract: An efficient method is disclosed for the preparation of trifluoromethyl- and difluoromethylsilanes using magnesium metal mediated reductive tri- and difluoromethylation of chlorosilanes with tri- and difluoromethyl sulfides, sulfoxides, and sulfones. One byproduct of the process is diphenyl disulfide. Since phenyl trifluoromethyl sulfone, sulfoxide and sulfide are readily prepared from readily available trifluoromethane and diphenyl disulfide, the method can be considered “pseudo-catalytic” for the preparation of (trifluoromethyl)trimethylsilane from environmentally benign trifluoromethane.
    Type: Application
    Filed: November 27, 2002
    Publication date: August 14, 2003
    Inventors: G.K. Surya Prakash, Jinbo Hu, George A. Olah
  • Process for separating reaction mixtures and recycling quaternary salts and bases
    Publication number: 20030153779
    Abstract: A process for the removal and recovery of quaternary salt (A) and base (D) from a reaction mixture is disclosed. The reaction mixture resulting from oxidative direct carbonylation contains in addition to (A) and (D), at least one hydroxyaromatic compound (B) and at least one reaction product (C) and optionally a solvent, and the process entails a) adding acid to the reaction mixture to cause conversion of (D) into a hydroxyaromatic compound (B2) b) separating the reaction mixture into b1.) that contains (C) and optionally (B) and/or (B2) and b2.) that contains (A) and optionally (B) and/or (B2), and c) reacting b1.) with a base (E) to re-form (D).
    Type: Application
    Filed: December 16, 2002
    Publication date: August 14, 2003
    Inventors: Peter Fischer, Sven Michael Hansen, Claus-Peter Reisinger
  • Perfluoroalkyl-substituted amines, acids, amino acids and thioether acids
    Publication number: 20030153780
    Abstract: Perfluoroalkyl-substituted amines, acids, amino acids and thioether acid compounds containing a perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkene group as well as derivatives thereof, are described. They are useful as surfactants in a variety of applications where low surface tensions are required, including coating formulations for glass, wood, metal, cement, paper, textiles, as foam control agents in polyurethane foams and especially in aqueous fire-fighting formulations.
    Type: Application
    Filed: July 24, 2002
    Publication date: August 14, 2003
    Inventors: Marlon Haniff, Ted Deisenroth, John Jennings, Karl Friedrich Mueller
  • AMINOTHIOL COMPOUNDS AND ACYLATED DERIVATIVES THEREOF
    Publication number: 20030153781
    Abstract: The present invention discloses aminothiol compounds and acylated derivatives thereof, which respectively have general formula I and formula II wherein R1-R6 are substitutable ligands. Such compounds can perform as superior catalysts in asymmetric addition reactions of organic zinc and aldehyde. According to the present invention, the compounds is needed only less than 0.02% of main reactants to obtain enantioselectivity higher than 99% enantiomeric excess, whereby the asymmetric reactions can become very economic.
    Type: Application
    Filed: January 8, 2002
    Publication date: August 14, 2003
    Inventors: Teng-Kuei Yang, Nan-Kuang Chen, To Liu
  • Method and apparatus for preparing a dialkyl carbonate, and its use in the preparation of diaryl carbonates and polycarbonates
    Publication number: 20030153782
    Abstract: Unexpected corrosion of downstream sections of a dialkyl carbonate manufacturing apparatus has been traced to alkyl chloroformate impurities, which slowly decompose to yield hydrochloric acid. An improved process and apparatus for dialkyl carbonate synthesis reduce corrosion by physically removing or chemically decomposing the alkyl chloroformate impurities within the corrosion-resistant upstream sections of the apparatus. The alkyl chloroformate may be decomposed by passing it through a passageway at a temperature of about 30° C. to about 130° C. for a time of about 0.5 hour to about 10 hours. The passageway may include one or more holding vessels or a tubular section that promotes plug flow.
    Type: Application
    Filed: August 23, 2002
    Publication date: August 14, 2003
    Inventors: Eugene Pauling Boden, Ganesh Kailasam, Larry Neil Lewis, Alberto Nisoli, John Yaw Ofori, Angel Sanchez Gonzalez, Ignacio Vic Fernandez
  • Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
    Publication number: 20030153783
    Abstract: A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1
    Type: Application
    Filed: January 8, 2003
    Publication date: August 14, 2003
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'Uomo, Maria Ornella Tinti, Francesco De Angelis
  • Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
    Publication number: 20030153784
    Abstract: A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1
    Type: Application
    Filed: February 25, 2003
    Publication date: August 14, 2003
    Inventors: Fabio Giannessi, Natalina Dell'uomo, Maria Ornella Tinti, Francesco De Angelis
  • Method for preserving quaternary ammonium salt
    Publication number: 20030153785
    Abstract: A method of improving the stability of a quaternary ammonium salt and a method of efficiently preparing the quaternary ammonium salt having improved stability.
    Type: Application
    Filed: November 5, 2001
    Publication date: August 14, 2003
    Inventors: Naoki Hirano, Masako Saijyo
  • Complex oxide catalyst and process for preparation of acrylic acid
    Publication number: 20030153786
    Abstract: A catalyst which is a complex oxide catalyst represented by the following general formula (1):
    Type: Application
    Filed: February 25, 2003
    Publication date: August 14, 2003
    Inventors: Michio Tanimoto, Daisuke Nakamura, Hiromi Yunoki
  • Surfactants
    Publication number: 20030153787
    Abstract: Compounds of the formula R2.[(AO)n.R3]m, where R2 is a residue of a group having at least m active hydrogen atoms derived from hydroxyl and/or amino and/or amido groups, AO is alkyleneoxy, n is 2 to 200; R3 includes residue(s) of alkenyl succinic acids and optionally other acids, and m is 2 to 10, but when m is 2 there are other restrictions in the definitions, are disclosed as useful thickeners and/or dispersants in aqueous systems. The use of such materials as thickeners is also disclosed.
    Type: Application
    Filed: December 10, 2002
    Publication date: August 14, 2003
    Applicant: Imperial Chemical Industries PLC
    Inventors: Neil Michael Carpenter, Steven John Anderson, Richard Robert Tenore, Peter Glynn Hibbert
  • Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing alpha-keto amide compound using them
    Publication number: 20030153788
    Abstract: The present invention is to provide manufacturing intermediates which can be led to useful &agr;-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: 1
    Type: Application
    Filed: December 30, 2002
    Publication date: August 14, 2003
    Applicant: Seikagaku Corporation
    Inventors: Nobuo Kobayashi, Tsuneo Koji, Takashi Fujita, Tomofumi Nishimura, Akihiko Hosoda
  • Synthesis of [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfides
    Publication number: 20030153789
    Abstract: The present invention is directed to labeled compounds, [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfides wherein the 13C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure 1
    Type: Application
    Filed: January 14, 2003
    Publication date: August 14, 2003
    Inventors: Rodolfo A. Martinez, Marc A. Alvarez, Louis A. Silks, Clifford J. Unkefer
  • Process for the preparation of 1-(2,6,6-trimethyl-2-cyclohexene-1-yl)-but-2-ene-1-one
    Publication number: 20030153790
    Abstract: The present invention relates to a novel process for the preparation of 1-(2,6,6-trimethyl-2-cyclohexene-1-yl)-2-but-2-ene-1-one commonly known as &agr;-Damascone, by acylation of unsaturated cyclic hydrocarbon 2,6,6-trimethyl-1-cyclohexene followed by work up and its purification by vacuum distillation.
    Type: Application
    Filed: February 13, 2002
    Publication date: August 14, 2003
    Inventors: Kudli Shrinivas Prashanth Kumar, Nagaraj Surekha