Abstract: Apparatus (18) for sensing electrical activity of a pancreas (20) of a patient is provided. The apparatus includes a set of one or more electrodes (100), adapted to be coupled to the pancreas, and a control unit (90), adapted to receive electrical signals from the electrodes indicative of electrical activity of pancreatic cells which are in a plurality of islets of the pancreas, and to generate an output responsive thereto.

Abstract: A therapeutic process, called inflectional therapy, is essentially a single-person process for diminishing the mental ailments of depression and anxiety. As the sufferer, being said single person, experiences such an ailment, [she]/he commences to record his thoughts and feelings by verbal expression onto a recording medium, such as an audio tape recorder. This is called a session, and the ensuing recording is called a recorded session. Typically, multiple sessions comprise adequate therapy for depression, but a single session usually diminishes a bout of anxiety. In circumstances where the sufferer does not have ready access to his recorder at the time of the ailment, he may commence recording his thoughts and feelings of the “prior” ailment when he eventually has access. Also, the sufferer may include positive, verbal expressions of encouragement during a session.

Abstract: Apparatus and method provide flexibility in generating a stimulation waveform to an electrode of an implantable medical device. The stimulation waveform comprises at least one stimulation pulse. The embodiment of the invention supports a generation of a stimulation pulse in which an amplitude and an electrical polarity of the stimulation pulse can be dynamically changed. The embodiment comprises a capacitor arrangement, a regulator and a switching array. The capacitor arrangement can be reconfigured with respect to an electrical reference through the switching array in order for the regulator to deliver the stimulation pulse to a pair of electrodes. In another embodiment, a plurality of stimulation waveforms are generated in which different stimulation waveforms are associated with different electrodes. With the embodiment, a plurality of regulators are connected and reconfigured to the capacitor arrangement in order that the different stimulation waveforms are generated by different regulators.

Abstract: The present invention provides methods of directly stimulating neural tissue with optical energy. By stimulating neural tissue at wavelengths, laser pulses, and spot sizes disclosed herein, nerve stimulation may be used to uniquely stimulate neural tissue in way not afforded by other means of stimulation. It can allow basic scientists to study the properties of individual neurons or populations of neurons without piercing tissue with fragile microelectrodes. Furthermore, responses of neural tissue can be studied in a pure fashion without contamination by electrical artifact commonly seen with electrical stimulation. With respect to clinical uses, optical stimulation can be used to map function in subsections of peripheral nerves as an aid to operative repair. Finally, stimulation with optical energy does not require physical contact with the nerve which may be an advantage clinically when physical manipulation of neural tissue is not desired.

Abstract: The device of the present invention provided an electrostimulation system with electromyographic and visual biofeed-back for sensing electromyographic impulses and facilitating muscular activity. The electrostimulation system comprises stimulator that is adapted to generate an electric impulse and at least one pair of electrodes adapted to transmit the electric impulse or to receive electromyographic impulses. The system further comprises an amplifier electrically communicating with the pair of electrodes, the amplifier is adapted to amplify the received electromyographic impulses and a filtering unit electrically communicating with the amplifier and is adapted to remove artifacts from the received electromyographic impulse. A commutation block is electrically communicating with the pair of electrodes and is adapted to alternately transfer the electromyographic impulses to the amplifier or to transfer the generated electric impulse from the stimulator.

Abstract: An implantable neurological stimulation system has an in-growth anchor coupleable to an implantable stimulation lead that configured for anchoring the stimulation lead to tissue. The stimulation lead is coupled to an implantable neurostimulator, and the in-growth anchor is positioned proximal to at least one electrode. Many embodiments of the implantable neurological stimulation system with in-growth anchor and its methods of operation are possible.

Abstract: A percutaneous electrode array is disclosed for applying therapeutic electrical energy to a treatment site in the body of a patient. The array comprises a plurality of electrode microstructures which are inserted into the epidermis, thereby overcoming the inherent electrical impedance of the outer skin layers and obviating the need to prepare the skin surface prior to an electro-therapy treatment. The array preferably includes an adhesion layer to help keep the electrode microstructures inserted into the epidermis during the duration of the therapeutic treatment, and temperature and condition monitoring devices to ensure proper treatment and enhance patient safety.

Abstract: The present invention is drawn to energy activated targeted delivery systems for administering a therapy to a target tissue or target composition in a mammalian subject, using an energy source that preferably transmits energy to a treatment site transcutaneously. The systems provide for administering to the subject a therapeutically effective amount of a targeted substance, which preferably selectively binds to the target tissue. Energy at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The energy intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted energy-activated agent or targeted prodrug product.

Abstract: An atrioventricular valve tissue ablation catheter (2), especially suited for treating Mahaim fibers, includes a shaft (4) with a deflectable tip (20) at the distal end (6) and a handle (10) at the proximal end (8). The tip includes a distal segment (66) curving in one direction and a proximal segment (44) curving in the opposite direction so the distal segment causes the distal segment can engage tissue on either side of the annulus (92) of the tricuspid (or mitral) valve (90). Ablation energy can be supplied through the ablation electrodes (46, 70) simultaneously or one at a time to ablate tissue at the annulus without the need for moving the catheter. Mapping electrodes (38) are provided proximal of the ablation electrodes.

Abstract: A blanket system (1) is provided for maintaining or controlling a patient's body temperature before, during, or after surgical and non-surgical procedures. The system includes a non-obtrusive cover blanket (3), a blower (28) to blow the air beneath the blanket (3) and a vacuum source (30) to suction the air from beneath the blanket (3) and away from the patient.

Abstract: An ablation catheter which is compatible with MRI systems, including a shaft and a distal tip assembly, each being made of MRI compatible material, at least one electrode supported on the tip assembly, the electrode being made of MRI compatible material, and at least one MRI compatible wire connected to the electrode and extending from the electrode to the proximal end of the shaft, the wire being made of MRI compatible material.

Abstract: The filter is composed of two portions. A first portion is a set of zig-zag struts arranged in a cylindrical fashion which fit against the wall of the vascular lumen and provide a base for positioning a filter portion. A filter portion is a set of struts. Each filtering strut has its upstream end connected to the positioning portion at the vascular wall and its downstream end held at a central position in the vascular lumen by a frangible connector or cord.

Abstract: The present invention provides a method and apparatus for mounting a stent onto a balloon on a stent delivery system. A stent is then loaded onto the delivery system and the resulting stent/balloon assembly is positioned in a first section of a mould and a second section of the mould is closed onto the first section and locked in place. Pressure is applied to the delivery system through a luer and the mould is heated. The pressure and heat are discontinued and the mould is cooled; this combination of heat and pressure secures the stent to the balloon. The method may include a cooling cycle to help retain the profile of the final stent delivery assembly.

Abstract: A stent balloon assembly wherein the balloon has been blow molded inside the stent. Segments of the balloon at least partially fill gaps in the stent, even after the assembly is compressed, to retain the stent on the balloon during delivery. The stent balloon assembly may also be mounted on a catheter.

Abstract: A self-expanding endoluminal device comprising at least one tubular filamentary member having a hollow core for receiving a guidewire, the tubular member having a straightened configuration with the guidewire in the hollow core and a shape memory configuration without the guidewire in the hollow core. A delivery system includes the guidewire. The hollow core may contain a substance that is adapted to be eluted from the tubular member or permanently contained inside. The device may further comprise a graft. The device may also comprise a plurality of filamentary members, more than one of which may comprise tubular members. The device may also have a severable extension that extends outside of the body through which the substance may be periodically injected.

Abstract: Percutaneous treatment of aortic aneurysms and like vascular anomalies by an apparatus and method wherein the apparatus is delivered via catheter and comprises a sleeve with at least one peripheral conduit which is caused to assume an expanded, rigid configuration by the introduction of a chemical or mechanical hardening means, whereby the sleeve is caused to assume an open cylindrical configuration for fluid flow therethrough.

Abstract: The present invention is directed to a vascular graft surrounding an expanded stent for transplantation into a patient.

Abstract: A biocompatible non-memory expandable polymeric article selected from stents, implantable prostheses, catheters, other surgical articles and sealants for implantable prostheses, and which is at least in part biodegradable and includes a combination where hollow cylindrical element (2) is depicted in cutaway form to reveal helical element (4), terminated schematically at (6) and where a combination of at least one thermoplastic elastomeric component and at least one thermoplastic non-elastomeric component, the article being either porous articles or having the potential to become porous by action of body fluids in situ), the thermoplastic non-elastomeric component being present in such an amount as will provide mechanical strength and rigidity to the article when in an expanded mode.

Abstract: This invention is a medical device and a method of using it. The device is a foldable stent or stent-graft which may be percutaneously delivered with (or on) a catheter, typically an endovascular catheter, to a body cavity or lumen and then expanded. It may also be delivered or via surgical (or other) techniques. The expandable stent structure utilizes torsional members which distribute bending and folding loads in such a way that the stent is not plastically deformed. The stent's configuration allows it to be folded or otherwise compressed to a very small diameter prior to deployment without changing the length of the stent. The graft component cooperating with the stent is tubular and preferably is blood-compatible material which may, if desired, be reinforced with fibers. The stent is able to provide collapsible support for otherwise frangible graft material.

Abstract: A stent and valve device (43) assembly for manufacture using suitable biocompatible materials and for placement, preferably percutaneously, into a vascular lumen.

Abstract: A stent including a plurality of loops, each of the loops includes an arcuately formed wire with a first end and a second end, the first end being attached to an inner elongate member and the second end being attached to an outer elongate member, the inner and the outer elongate members being arranged to slide with respect to each other along a common longitudinal axis, wherein sliding of the inner and the outer elongate members with respect to each other changes a cross-sectional area of each of the loops, characterized in that the inner and outer elongate members are attached to inner and outer coupler tubes, and are selectively releasable from the inner and outer coupler tubes, the inner coupler tube being nested inside the outer coupler tube.

Abstract: A new multiple component stent arrangement which allows for initial self-expansion and subsequent deformation to a final enlarged size.

Abstract: An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A deliver template having a mounting ring with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle. The deliver template may include a plurality of cutting guides for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area of the ring.

Abstract: The present invention is directed to a supplemental endo capsular lens (SECL) and the method of inserting and embedding the SECL within either a gel or polymer, inside the capsule of the crystalline lens, during phaco-ersatz or similar surgical procedures in order to supplement the refractive power of the eye with a view to (1) correcting ametropia while (2) maintaining a useable amplitude of accommodation.

Abstract: Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself provide simple and effective means to reconstruct damaged tissue, a preferred example being corneal tissue. The source of the epithelial stem cells can be a very small explant from healthy autologous and allogeneic tissue biopsy. The amniotic membrane is treated such that its extracellular matrix is maintained, but its cells are killed.

Abstract: A unique anterior chamber phakic lens and methods for implantation are provided. The foldable optical zone portion of the lens is secured to a pair of diametrically opposed haptic members extending outwardly from the optical zone periphery to the angle of the eye. Each of the haptic members comprises an elongated arm portion and a distal arcuate portion with an inward curvature having an abraded surface. The inventive phakic lens is angle fixated by inducing a slight amount of scar tissue where the distal ends of lens haptics rest in the angle. Accordingly, the unique phakic lens and implantation methods minimize lens related etiology such as iris chafing, glaucoma, uveitis, distortion of the iris, and/or corneal decompensation.

Abstract: Methods of producing an intraocular lens in vivo comprise preparing a composition of discrete water soluble macromolecular particles, mixing the composition with a water soluble photoinitiator and forming an opthalmically acceptable aqueous solution having a refractive index of at least 1.39, injecting the resulting aqueous solution into the capsular bag of an eye, and initiating crosslinking between the macromolecular particles by irradiation of a wavelength in the range of about 380 to 700 nm to create a lens in the capsular bag.

Abstract: A breast prosthesis may be formed by forming an outer layer on a mold, and filling the mold with a polymerizable foaming composition. The mold may be formed by forming a computer model of the prosthesis based on scanning a patient. The computer model may be used to form a solid model. A prosthesis may be coupled to the patient by coupling at least one metallic insert to the prosthesis and at least one magnet to the patient. Alternately, the prosthesis may be formed with a retaining harness integral to the prosthesis. In still another method, the prosthesis may be coupled to a retaining device surgically implanted in the patient.

Abstract: A push-in interbody spinal fusion implant having an expandable height.

Abstract: An artificial disc (10) to replace a damaged spinal disc in a spinal column (16) includes a resilient core (60) having an upper surface (62) and a lower surface(64). An upper retaining member (20) has an outer surface (22) engageable with a first vertebra (12) of the spinal column (16) and an inner surface (24) affixed to the upper surface (62) of the resilient core (60). A lower retaining member (40) has an outer surface (42) engageable with a second vertebra (14) of the spinal column (16) and an inner surface (44) affixed to the lower surface (64) of the resilient core (60). One of the upper and lower retaining members (20, 40) has an opening (30, 50) extending through the outer and inner surfaces into which the resilient core (60) deflects upon relative movement of the upper and lower retaining members (20, 40).

Abstract: The invention concerns an implant for replacing a vertebra at least partially, consisting of two parts adapted to be mutually connecting while enabling the adjustment of the implant total dimension, each part having an invariable dimension homologous with the implant dimensions. The parts form a screw-nut connection with each other.

Abstract: An intervertebral prosthetic joint including a first articular component adapted to engage a first vertebra and a second articular component adapted to engage a second vertebra. The articular components include abutting convex and concave articular surfaces that cooperate to permit articulating motion between the articular components. At least one of the convex and concave articular surfaces includes at least one surface depression that is configured to facilitate removal of matter disposed between abutting portions of the articular surfaces. In one embodiment of the prosthetic joint, each of the articular components has a vertebral bearing surface and a flange extending therefrom that is configured to penetrate a corresponding one of the first and second vertebrae, with the flange defining at least one opening extending therethrough to permit bone through-growth.

Abstract: A pseudo arthrosis device disposed in a patient between two adjacent vertebrae. The device has an enclosure with a plurality of compressible flexible members packed longitudinally therein. The enclosure is attached to at least one of the adjacent vertebrae. A method of use is disclosed.

Abstract: A push-in interbody spinal fusion (100) implant having an expandable height. The implant (100) comprises upper and lower members (102 and 106) with an expander in between (122). When the expander (122) is changed from one position to another, for example as in the first embodiment where it is rotated in a plane perpendicular to the axis of the upper and lower members (102 and 106), the height of the implant (100) is increased.

Abstract: A prosthetic joint kit that is particularly well suited for an elbow. In each of the various embodiments, the prosthetic joint kit transmits load through the prosthetic joint through a pair of spherically shaped bearing surfaces so as to transmit load over a relatively large area rather than at a point or over a line of contact. The prosthetic joint kit may be configured in a modular manner wherein a plurality of interchangeable stem structures, being structures and/or bearing inserts of various types are available. Construction in this manner enables a surgeon to configure the prosthetic joint to best suit the needs of the patient. For example, the surgeon may employ a modular flange for compressing a bone graft, a tissue fastener for securing soft tissue to a portion of the prosthetic joint, a cam for limiting the amount by which the prosthetic joint articulates or a bearing insert for tailoring the degree of varus/valgus constraint.

Abstract: A modular elbow prothesis includes a humeral component, an ulnar component and three bearing components. The ulnar component includes a stem for implantation in the intramedullary canal of an ulna and a body including a slot. Two of the three bearing components include flanges that mate with the slot of the ulnar component. The humeral component includes a stem for implantation in the intramedullary canal of the humerus and two arms extending from one end of the stem. An opening is formed in each arm and in two of the three bearing components. The modular elbow may be used in an unconstrained mode by attaching one bearing component to the ulnar component and the other to the humeral component by inserting a pin through the openings in the arms and the bearing component. The two bearing components are then placed adjacent each other such that they articulate about their bearing surfaces.

Abstract: A process for forming an orthopaedic implant prosthesis bearing (10) includes the step of quenching a residual free radical population present in an irradiated polyethylene preform or bearing with a supercritical fluid.

Abstract: This invention is directed to a tissue-engineered stent comprising a substantially cylindrical construct (10) having a first end (12) and a second end (14); a walled surface (16) disposed between the first end and the second end; the walled surface (16) comprising a biodegradable polymer scaffold seeded with disassociated chondrocytes. In one embodiment, the seeded scaffold is cultured in vitro prior to implantation in a host for a time period sufficient for cartilaginous tissue to form.

Abstract: Artificial joints wherein the mating surfaces are both non-metallic, preferably plastic, even more preferably polyethylene and even more preferably ultra-high molecular weight polyethylene. Because neither of the bearing surfaces of the artificial joint are made of metal, there is a potential for greatly reduced wear, and consequently, a potential for reducing the number of joint replacement surgeries.

Abstract: An improved method and composition for preventing damage to tissue and/or organs during surgery and during harvesting, implanting, manufacture and manipulation of bio-prostheses therefrom. Tissue surfaces and surgical articles involved in the surgery and bioprostheses are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue and/or organs during surgery. The composition comprises a solution of a polymeric material having a molecular weight of about 50,000 D or above having a concentration of from about 0.01% to about 15% by weight.

Abstract: A graphical user interface system for a thermal comfort controller. The user interface system has a central processing unit coupled to a memory and a touch sensitive display unit. The memory stores a temperature schedule data structure and perhaps a temperature history data structure. The temperature schedule data structure is made up of at least one set-point. The temperature history data structure is made up of at least one Actual-Temperature-Point. The display presents the set-points and/or the Actual-Temperature-Points. One representation of the display is a graphical step-function. The user uses a finger or stylus to program the set-points by pointing and dragging a portion of the step-function.

Abstract: Safety level error detection comparable to that provided by redundant wired safety relays is obtained on a backplane of a programmable logic controller or the like by a combination of error detection methods that in sum provide the requisite level of error detection required without necessitating a particular hardware requirement or duplicative message transmissions.

Abstract: An optimizer optimizes the configuration of a computer system, such as a web farm. The optimizer makes use of a performance simulator that simulates a cluster of machines running a given workload. A modular architecture allows different optimization modules to be plugged into the optimization system. In addition, the modular architecture also interfaces with different simulators through a simulator interface module. The simulator is decoupled from the optimization module. Simulation data may be filtered to provide and store only relevant objective and parameter values. A unique comparison module also guides the optimization module towards the optimum solution, even if no solutions have yet satisfied the objective completely. By caching simulation and/or optimization results (i.e. as opposed to raw simulation output data from the simulator), the simulations from previous simulation runs and different designers may be reused to reduce the time required for each optimization.

Abstract: A method for determining a similarity of a first solid model to a second solid model is disclosed. The method includes the steps of: selecting a set of features for representing the first solid model; extracting features corresponding to the selected set of features from the first solid model; constructing an undirected model dependency graph of the first solid model based on the selected set of features; extracting features corresponding to the selected set of features from the second solid model; constructing an undirected model dependency graph of the second solid model based on the selected set of features; comparing the undirected model dependency graph of the first solid model with the undirected model dependency graph of the second solid model; and outputting a numerical measure indicative of the similarity of the first solid model to the second solid model.

Abstract: A method of manufacturing, e.g., integrated circuits, and of managing a manufacturing process. Product unit (circuit) variation data is collected from clustered product units (wafer sites). Collected data is grouped according to a selected manufacturing parameter. Each group is normalized for the selected manufacturing parameter. Normalized groups are combined. Normalized process data is checked for variances and the data is regrouped and renormalized until variances are no longer found. Each identified variance is correlated with a likely source. Then, each said likely source is addressed, e.g., a tool is adjusted or replaced, to minimize variances.

Abstract: A method and a device are provided for calculating in advance the process variables of an industrial process. The method, which consists of at least one empirical model and a core model, is subsequently adapted and optimized using a model that has a partial inverse structure in relation to the core model. The empirical models are optimized by means of adaption or training algorithms, which, in addition to known process parameters, have the empirical variables calculated by the partial inverse core model as basic input variables.

Abstract: A computerized method and system for testing a function of an information-processing system. This includes providing an architecture having a set of test commands, the test commands including a set of one or more stimulation commands and a set of one or more result-testing commands, and defining a set of test verbs out of combinations of the test commands. This allows the test programmer to define an overall test program that uses the test verbs in writing a test program that specifies an overall function that will extensively test a system-under-test. The methods further includes executing a program that includes a plurality of test verb instructions and outputting a result of the program. In some embodiments, the present invention provides a computer-readable media that includes instructions coded thereon that when executed on a suitably programmed computer executes one or more of the above methods.

Abstract: A method for recognition of an input human motion as being the most similar to one model human motion out of a collection of stored model human motions. In the preferred method, both the input and the model human motions are represented by vector sequences that are derived from samples of angular poses of body parts. The input and model motions are sampled at substantially different rates. A special optimization algorithm that employs sequencing constraints and dynamic programming, is used for finding the optimal input-model matching scores. When only partial body pose information is available, candidate matching vector pairs for the optimization are found by indexing into a set of hash tables, where each table pertains to a sub-set of body parts. The invention also includes methods for recognition of vector sequences and for speech recognition.

Abstract: A programmable field measuring instrument includes a control unit, and a connector terminal, and a software protection device. The control unit executes a control program. The connector terminal is connected to the software protection device such that the software protection device may be released from the connector terminal. The software protection device includes a connector mating element with an integrated electronic component which allow authorization examination by the control unit.

Abstract: A typical light fixture is an integral unit that has a lamp assembly and a communications node to control the lamp assembly. Lighting systems contain many such light fixtures. One type of lighting system has at least two communications systems that interconnect the light fixtures. A digital controller is connected to one of the communications systems, at least one of the light fixtures of that communications system is a designated gateway for sending control signals to the other communications system. Another type of lighting system has two digital controllers connected to respective communications systems. Each of the communications systems interconnects many light fixtures, at least one of which has two communications nodes respectively connected to the communications systems. A third type of lighting system mixes combines the first and second types.