Abstract: A blood vessel catheter with a non-planar tip that prevents or inhibits the catheter from adhering to the blood vessel wall or a blood clot when negative pressure is applied to the catheter to withdraw blood. The non-planar tip maintains its shape while in the blood vessel, while allowing blood to flow into the catheter.

Abstract: Multilumen catheters are provided. The subject multilumen catheters include a proximal end and a distal end separated by a non-coaxial multilumen tube. The subject catheters are further characterized in that they include a multiport manifold at their proximal ends, where at least two of the ports of the multiport manifold may comprise luer valves. Also provided are systems for use in flushing a vascular site with fluid, usually at least two different fluids, where the subject systems are made up of two multilumen catheters according to the subject invention, where one of the catheters is inserted inside of the other. In addition, kits comprising various components of the subject systems, e.g., at least two different multilumen catheters, are provided.

Abstract: A thoracic drainage system for removing liquid from the thoracic cavity of a patient. The system includes a reusable thoracic vacuum regulator and a standard disposable collection container. A disposable water seal chamber is also provided that can be disposed of after each patient and is a separable, independent component. There is also a combination thoracic vacuum regulator having a water seal chamber removable affixed thereto to enable the water seal chamber to be readily removed from the thoracic vacuum chamber in order to carry the water seal chamber along with the patient as that patient is transported.

Abstract: The present invention provides a body waste collector which allows the discharge of the gases in the ostomy bag over a long time and is, in addition, highly economical. The body waste collector comprises an ostomy bag 2 formed by sealing together the peripheral edge portions 16 of two films 7, 8 for collecting the body wastes, a faceplate 1 coupled to one film 7 of the ostomy bag, a gas-discharging vent 11 provided in the other film 8 of the ostomy bag so as to connect the inside of the ostomy bag to the outside thereof, and a deodorizing filter 12 disposed so as to communicate with the gas-discharging vent 11, wherein, between the two films 7, 8 of the ostomy bag, there is disposed an intermediate wall 13 which is comprised of a fluid-impermeable material and divides the space 10 in the ostomy bag into two regions, i.e.

Abstract: A diaper including a pocket patch for containing a substance such as powder wherein the pocket patch is connected with and adapted to dispense the substance to a surface of the diaper for receiving bodily waste and method of dispensing the substance to the diaper surface including folding the diaper about a crotch area thereof and patting the diaper to facilitate dispensing of the substance.

Abstract: A method of treating metabolic derangement is provided. Specifically, the method comprises the steps of administering an amount of an agent to alter cellular oxidative function while monitoring cellular oxidative function. The administration of the agent may be varied as a function of the monitored cellular oxidative function and will preferably be ceased when cellular oxidative function is restored.

Abstract: A drug dispensing system for substantially preventing addictive use of drugs. The system has multiple dispensers each containing a drug such as nasal spray. The drug in at least one of the dispensers is diluted to a first pre-selected concentration level with a diluent and the drug in at least a second one of the dispensers is diluted to a second lower pre-selected concentration level with a diluent.

Abstract: Disclosed is a closure catheter, for closing a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a plurality of tissue anchors, which may be deployed into tissue surrounding the opening, and used to draw the opening closed. Methods are also disclosed.

Abstract: An apparatus for sonoporation for transdermal delivery of a microparticles suspension containing microencapsulated drugs includes a container having an end covered with a porous membrane and containing said microparticles suspension and an ultrasound horn having a tip submerged in said microparticles suspension containing microencapsulated drugs. The ultrasound horn applies ultrasound radiation to the microparticles suspension containing microencapsulated drugs.

Abstract: A method for increasing cerebral blood flow is described. A catheter is inserted into the descending aorta, the catheter having a proximal region, a distal region, and at least one expandable member mounted on the distal region. The expandable member is positioned downstream from the takeoff of the brachiocephalic artery. The expandable member is expanded to at least partially obstruct blood flow in the aorta. The expandable member is then cycled between greater and lesser obstruction of blood flow. In this manner, renal ischemia and lower limb ischemia is avoided.

Abstract: Catheters having improved flexibility control, which can be provided by a slidable core wire disposed within the catheter and by shafts formed from segmented spine wires disposed within polymeric tubes. One catheter is an angioplasty catheter including an axially slidable core wire disposed within an inflation lumen, and having a pressure seal disposed about the core wire extending proximally from the catheter proximal end. The slidable core wire can provide a varying degree of stiffness to the catheter. The catheter can have greater stiffness when the core wire is axially distally extended and less stiffness when the core wire is retracted. One catheter has a shaft including a spine wire or stiffening element within an outer polymeric tube. The spine wire can include multiple segments having alternating wide and narrow segments, with the wide segments contacting the outer tube and contributing stiffness to the shaft and with the narrow segments contributing flexibility to the shaft.

Abstract: A laser surgery apparatus is provided to minimize a burden on a patient and to obtain a good result of a surgical operation. The laser surgery apparatus for performing surgery on a patient's eye by irradiating a laser beam thereonto comprises an irradiation device provided with an irradiation optical system for irradiating the laser beam onto the patient's eye, a control device for controlling the irradiation device, and an informing device for informing the patient of at least either a first period of a laser irradiation period or a second period of the laser irradiation period or both.

Abstract: A system for positioning an eye for laser surgery includes a first and a second radiation generator positioned, respectively, to emit a first line and a second line orthogonal to the first line, the line generators positioned in a predetermined relation to a laser surgical system. A position of the eye is adjustable along an axis that is substantially perpendicular to the lines to achieve a positioning wherein the lines form a cross. The location of the cross is a preferred position for the eye relative to the laser surgical system for the laser surgery. Another embodiment comprises a first and a second spot generator positioned to project a first and a second spot onto an eye adjacent the clear cornea, between the clear cornea and the scleral rim. The eye position is adjustable for achieving a positioning wherein the spots are substantially vertically aligned.

Abstract: Methods and devices for occlusion of the fallopian tubes of a woman. The method involves thermally damaging the lining of the utero-tubal junction with relatively low power, followed by placement of a reticulated foam plug. In one embodiment, vascularized tissue grows into the plug and prevents or discourages formation of scar tissue around the plug. Another embodiment with a relatively small foam pore size encourages formation of a vascularized capsule around the plug. The presence of this vascularized capsule limits the patient's foreign body response, so that the capsule does not constrict around the plug. Also presented is a catheter designed for wounding the epithelial layer of the utero-tubal junction, and a method of using the catheter to form a long yet shallow lesion in the utero-tubal junction.

Abstract: The present invention provides systems and methods for selectively applying electrical energy to a target location within of a patient's body, particularly including tissue in the spine. The present invention applies high frequency (RF) electrical energy to one or more electrode terminals in the presence of electrically conductive fluid to remove, contract or otherwise modify the structure of tissue structures. In one aspect of the invention, a method is provided for treating herniated discs within a patient's spine by applying sufficient electrical energy to the disc tissue to reduce a volume of the disc, thereby relieving pressure on a spinal nerve. In one embodiment, the high frequency voltage is sufficient to ablate a portion of the nucleus pulposis, either the extruded portion outside of the annulus or a portion or all of the pulposis within the annulus.

Abstract: The devices disclosed herein are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having Chronic Obstructive Pulmonary Disease. More particularly, these devices produce collateral openings or channels through the airway wall so that oxygen depleted/carbon dioxide rich air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs.

Abstract: An electrosurgical handpiece having a removable section permanently incorporating an electrode adapted for a particular procedure. The handpiece may be labeled for that procedure or otherwise visually distinguished from other handpieces, as, for example, by shape or color-coding, and the optimum electrode for that procedure is already pre-attached to the handpiece. The handpiece comprises a common connector attached at one end to a cable terminating in an end connector for attachment to an electrosurgical instrument, and at its other end adapted to receive and hold and electrically connect to the handpiece proper itself, i.e., a handle for the surgeon to hold and the attached electrode. A family of handpieces are preferably configured to removably attach to the common connector and thus could use the same common connector and cable and end connector for connecting to the instrument as a source of RF electrosurgical currents.

Abstract: A method of treating a sphincter that provides an expandable basket structure with a first energy delivery device. The basket structure is introduced in a sphincter. The first energy delivery device is advanced from the basket structure into an interior of the sphincter. Sufficient energy is delivered from the first energy delivery device to create a desired tissue effect in the sphincter. Thereafter, the basket structure is removed from the sphincter.

Abstract: Disclosed is an ablation method and apparatus used to close veins for treatment of venous insufficiency disease. The apparatus includes a catheter proportioned for insertion into a vein, a pair of inflatable balloons spaced apart on the catheter body, and an ablation electrode array disposed between the balloons. According to the disclosed method, the catheter is introduced into the vein to be treated and the balloons are distended. Blood is flushed and aspirated from the site between the balloons. RF power is applied to the electrode array, causing scarring of the vessel walls and eventual sealing of the vein.

Abstract: Methods, systems, and kits for treating breast tissue rely on transferring energy to or from cells lining an individual breast duct. Energy can be introduced into the breast duct, e.g., by filling the duct with an electrically conductive medium and applying radiofrequency energy to the medium. Other energy forms could also be used, such as light, ultrasound, radiation, microwave energy, heat, cold, direct current, and the like. By treating individual breast ducts, cancerous and pre-cancerous conditions originating in the duct can be effectively treated.

Abstract: A treatment instrument for an endoscope includes a main body, a cutting wire and an insertion portion. The cutting wire has an insertion portion inserted in the main body and an exposed portion situated at a distal side of the insertion portion and exposed out of the main body. The cutting wire is supplied with high-frequency current, and the insulating member electrically insulates a peripheral surface of the cutting wire. The insulating member insulates that part of the exposed portion, which is other than a non-insulated portion extending in a range of 5 mm to 15 mm from a distal end of the exposed portion. The excision portion is formed of the non-insulated portion of the cutting wire.

Abstract: Anatomically contoured anterior cervical plates with bone ingrowth surfaces, providing for intersegmental compressive preloading, and a rigid and locked interface to all of the bone, screws, with those engaging the vertebrae deployed in highly convergent pairs. The bone screws have a tapered self-tapping leading end, an increasing root diameter with a generally constant outer diameter with a thread that is narrow and sharp throughout and an enlarged head portion capable of an interference fit to the receiving holes of the plate. Instrumentation consists of plate holders, a compression apparatus and a pilot hole forming device that interlocks with. the plate. Methods for spinal compression and bone hole preparation are provided.

Abstract: Insertion instruments and a main body assembly and a universal wing to be inserted are provided, along with methods of using these instruments for the insertion of the spinal implants in patients to relieve the symptoms of, for example, spinal stenosis, injuries, and degenerative diseases of the spine. The instruments are simply designed and can be disassembled, making cleaning and sterilization easy and convenient. The instruments are designed to engage with and disengage from spinal implants easily, and use of the instrument in spinal implant surgery can be carried out with minimal surgical intervention and does not require general anesthesia. The main body assembly and the universal wing are designed to conveniently be secured to the insertion instruments. In an alternative embodiment the instrument can be nested and at least one instrument can include a handle provided at an angle.

Abstract: A dorsal fracture is treated from the volar side by using a T-shaped plate opposite the fracture. The plate is positioned against the volar side of the radial bone, a plurality of bone screws secure the plate along a non-fractured portion of the radial bone, and a plurality of bone pegs extend from the plate and into the bone fragments of the fracture. A support portion of the plate is provided distal of the bone pegs and supports comminuted bone fragments. One or more channels are optionally provided in the plate to receive wires which are adapted to anchor distal bone fragments to the plate. The plate is adapted in strength and materials to withstand the large bending forces thereon.

Abstract: An apparatus (10) maintains a desired distance between two parts (5, 6) of a severed sternum of a patient. The apparatus (10) includes an elongate member (20), such as a plastic or surgical steel plate, and an element (60) for securing the elongate member (20) to each of the two parts (5, 6) of the severed sternum. The elongate member (20) has longitudinal edges (32, 34) dimensioned and configured to space apart the two parts (5, 6) of the severed sternum the desired distance. When implanted, the two parts (5, 6) of the severed sternum engage the longitudinal edges (32, 34) of the elongate member (20) to maintain the desired distance between such parts.

Abstract: An encapsulation device for repair of articular cartilage defects includes a body for disposition adjacent a bone in an area of the cartilage defect, and elongated leg structure extending from the body and for disposition in the bone in the area of the cartilage defect. The leg structure is provided with a length which is a plurality of magnitudes greater than a thickness of the body, and is of a generally conical configuration.

Abstract: An apparatus for guiding the resection of the head of a humerus is provided. The apparatus includes a base, a cut block, and a stylus. The guide is used in connection with a reamer or other tool that is inserted into the intramedullary mayal of the humerus with the shank of the reamer extending superiorally above the head of the humerus to establish the axis of the humerus. The base is in rotatable connection with the reamer. The cut block is removably attached to the guide and has a component for receiving a saw blade. The stylus attaches to the cut block, preferably by engaging the component for receiving the saw blade, and extends around the articular margin of the humeral head to aid in setting height and version.

Abstract: An apparatus for positioning the cutting angle of a bone cutting guide, wherein the bone is preferably a tibia and/or a femur, which includes a first fastener to fasten the positioning apparatus to the bone such that the whole of the apparatus and the fastener of the cutting guide can rotate relative to the fastening axis, and a second fastener to fasten the positioning apparatus at a second fastening location onto the bone different from the first fastening location, so as to fix apparatus at a required position within the rotation relative to the first fastening axis.

Abstract: A distractor for separating adjacent elements, such as vertebrae. The distractor preferably has a scissors-type distracting mechanism, either in a simple scissors or double-acting scissors configuration. The distractor includes blades that are removable from the jaws of the distractor such that different blades may be used depending on the patient and situation with which the distractor is to be used. The jaws include a mating fixture and the blades include a mating portion for removable association with the mating fixture.

Abstract: Disclosed is a heart lead removal apparatus for removing an range of different sized implanted cardiac pacemaker or defibrillator leads from the heart, typically through a blood vessel leading to the heart. The lead removal apparatus comprises a stylet, an expandable portion, and an actuator portion which is manually advanced by the operator to cause the expandable portion to engage the coils within a pacemaker coil lumen. In one preferred embodiment, the expandable portion comprises a multifilar wire bundle that is helically wound around the stylet and attached about the tip thereof. The actuator portion, which comprises an elongate metal cannula attached to a first handle, is urged forward to contact the proximal end of the expandable portion, thereby causing the individual wires of the multifilar wire bundle to deform outward in a random fashion.

Abstract: A stent delivery system to facilitate introduction and placement of a stent, including a catheter having an expandable distal portion constructed and arranged for expanding the outer diameter of the catheter from a contracted state to an expanded state: a stent positioned around the distal portion of the catheter having a contracted condition and being expandable to an expanded condition, and being sized in the contracted condition to closely surround the catheter in the contracted state, the expandable distal portion of the catheter including a balloon within which there is included on the catheter shaft at least one body of a diameter larger than the catheter shaft to which the stent and balloon are fitted, as by crimping, for holding the stent in place until it is released therefrom by expansion of the balloon.

Abstract: The invention relates to a device for joining hollow organs with an elongated holder and a needle carrier which is positioned at one end of the holder, where the needle seat extends radially, forming an overhang projecting beyond the periphery of the holder, as well as with a plurality of needles which are disposed standing vertically on the projecting overhang of the needle seat, surrounding the holder.

Abstract: An instrument for exerting an end of a vessel over an end of a tubular workpiece. The instrument has a body having an axial bore, and a mandrel mounted within the axial bore and partially extending from the distal end of the axial bore. The mandrel is made from a sheet of spring-like material rolled into a conical shape. The distal end of the mandrel is insertable into the lumen of the vessel. A plunger substantially contained within the axial bore and axially moveable, extends into the proximal end of the mandrel and presses against an inner surface of the mandrel when the plunger is moved from a retracted position to an extended position, thereby causing the distal end of the mandrel to expand radially and the proximal end of the mandrel to contract radially. An optional spring mounted to the body provides a biasing force to move the plunger to the retracted position and to allow the mandrel to return to the conical shape.

Abstract: An apparatus and method for repairing severed or unattached soft tissue of the body, such as tendons, typically includes an anchor for engaging the soft tissue and a securement mechanism designed to securely attach the anchor to the soft tissue and to abut the soft tissue against a surface. The surface may be second soft tissue, a bone, or the like. The anchor may be formed as a plate and may include a plurality of apertures formed therein. Selected apertures of the plurality of apertures formed in the anchor may be configured to receive sutures therethrough. Other apertures of the plurality of apertures formed in the anchor may be configured to permit synovial fluid to contact the soft tissue below the anchor. The anchor may also include a plurality of teeth extending generally away from one surface of the anchor in a transverse direction and configured to penetrate soft tissue. Such teeth are typically configured to substantially restrict longitudinal movement between the anchor and the soft tissue.

Abstract: Apparatus and methods are provided for forming a working space on the interior wall of a blood vessel, such as the aorta. The working space is isolated from blood flow and permits creation of an anastomotic hole and subsequent suturing of the hole to form an end-to-side anastomosis, even while the heart is beating. The apparatus comprises tools including inflatable barriers, such as cup-shaped balloons, which engage the inner wall of the blood vessel with minimum trauma and maximum sealing. In a first embodiment, the inflatable barrier is introduced through a penetration at the site of the anastomotic attachment. In a second embodiment, the inflatable barrier is introduced through a second penetration axially spaced-apart from the site of the anastomotic attachment.

Abstract: A low-pressure balloon, and method of forming same by the steps of: preheat a thin film of thermoplastic polymeric material to a sufficient temperature; forming two halves of the balloon on said thin film of thermoplastic polymeric material by vacuum suction; isolating the two halves of the balloon from said thin film of thermoplastic polymeric material; bonding the two halves together on their edges to form the low-pressure balloon by radio-frequency welding method; and inverting the low-pressure balloon from inside out to turn the rough bonded edge of the two halves into the interior side of the balloon.

Abstract: A method of forming a catheter component, such as a balloon, in which the component has a thinned skirt section formed by expanding tubing to a radially enlarged outer diameter and then decreasing the inner diameter and the outer diameter of the radially enlarged skirt section before or during bonding of the skirt section to the catheter shaft. The method generally includes blow molding tubing in a balloon mold having a skirt portion with an inner diameter which is larger than an outer diameter of the thinned skirt section of the balloon, so that the balloon mold produces a balloon having a radially enlarged skirt section with a larger outer diameter than is desired for the finished balloon. By then decreasing the diameter of the radially enlarged skirt section, the resulting skirt section is thinned, to provide a balloon catheter having improved flexibility and low profile.

Abstract: An implantable filtering device for implanting within an artery supplying blood to the brain, the device being made of bio-compatible material and comprising a filtering unit for entrapping plaque debris, and an anchoring member engageable with the walls of the carotid artery for anchoring said filtering unit at a fixed location with the artery. The filtering unit has a tapering shape extending between a wide inlet portion and a narrower outlet portion extending downstream, and a tap element fitted at the outlet portion for entrapping plaque debris.

Abstract: Medical devices for filtering fluids flowing through a lumen and a method of forming medical devices. The devices can be used in vascular channels, urinary tracts, biliary ducts and the like, and filter emboli and other debris generated at a treatment site.

Abstract: Plugs and methods for plugging septal defects and blood vessels are provided. Plugs are delivered via catheter to a septal defect or a location where it is desired to occlude blood flow in a blood vessel. The plugs are positioned and expanded at the treatment site. The expansion of the plugs can be accomplished passively by using a heat-treated elastic frame or actively by using a balloon to deform a plastically-deforming frame. Plugging structures mounted to the frame span the defect or lumen and prevent blood flow. The plugs described herein have small profiles, and are more reliable than preceding intraluminal transcatheter methods.

Abstract: A guiding tool for controllable and reversible folding or deformation of a wound closure element before insertion into a percutaneous incision or puncture in the wall of e.g. a blood vessel, said incision or puncture being smaller than said wound closure element in an unfolded or undeformed state. It comprises a tubular member having a lumen. The lumen has inner walls provided with wound closure element guiding surfaces, adapted to reversibly reduce the spatial extension of a wound closure element during its passage through the guiding tool. A system for the introduction and securing of a wound closure element into a percutaneous incision or puncture in the wall of a vessel comprises such a guiding tool.

Abstract: The present invention discloses a process for producing a braided suture having an improved knot strength comprising heating a braided suture coated with a low molecular weight biocompatible polymer to a temperature sufficient to melt the low molecular weight biocompatible polymer for a time sufficient to allow the low molecular polymer to be redistributed into the interstices of the braided suture thereby providing a coated braided suture with an improved knot tensile strength. Also disclosed is the coated braided suture having a low molecular weight polymer optimally dispersed throughout the braided suture's cross-section.

Abstract: A frame (1) and a method for suturing a wound (22). The frame (1) is placed on each side of the wound (22) and reaches across it. The frame (1) has a first and second foundation part (2, 3) for placing on the skin (20) on each side and along the wound/wound edges respectively. A joining device extends (10) between the first and second foundation parts (2, 3). The first and second foundation parts (2, 3) are arranged with an adhesive (4, 5) for securing to the skin (20), and the joining device (10) is a flexible, jointed device of mainly constant length.

Abstract: A cancer electrochemical-therapeutic device using electrothermal needles, comprising two groups of electrothermal needles and three D.C. power supplies, each group having at least one electrothermal needle, two of the three D.C. power supplies—serving as heating power supply—being connected to the groups of electrothermal needles to heating them to realize electrothermal therapy, and the other D.C. power supply—serving as electrochemical power supply—being connected to the corresponding electrodes of the D.C. power supplies to realize electrochemical therapy between two electrothermal needles. The device is simple, easy to use and reliable, its cost is low and its therapy effect is good.

Abstract: Methods and apparatus for treating hemorrhoids and similar ailments are disclosed in which one or more piece of material are used to separate swollen, inflamed tissue from non-swollen tissue, material may be included within an undergarment that may be worn for the treatment of ailments such as hemorrhoids or an episiotomy. The material incorporated into the undergarment has elastic properties that, in the case of hemorrhoids, acts to separate the buttocks. The undergarment may also include one or more pocket enclosures to hold cold compresses, ice packs, pain ointment, etc. directly upon, or in close proximity to, the affected area. Alternately, the material may be one or more single-use strips that include adhesive such that the strips act to separate the affected area from the non-affected area.

Abstract: A liner is advanced through a narrowed region in a vessel such as the internal carotid artery. The liner is advanced through the narrowed region in a collapsed position. A stent is then advanced through the liner and expanded to open the narrowed region. The liner may also have an anchor which expands an end of the liner before the stent is introduced.

Abstract: A stent includes a first portion which does not substantially lengthen axially upon radial contraction of the first portion and a second portion which lengthens axially upon radial contraction of the second portion. The second portion extends from the first portion and constitutes a free end portion of the stent.

Abstract: An expandable metallic stent has discontinuities of non-conducting material. These eliminate electrically conducting paths in the stent rings and cells. This makes the stent easier to image with magnetic resonance imaging (MRI). The non-conducting material can include adhesives, polymers, ceramics, composites, nitrides, oxides, silicides, and carbides. The discontinuity is preferably shaped so that during expansion the discontinuity is placed in primarily a compressive stress.

Abstract: A coating for a stent and methods for coating a stent are provided. The coating may be used for the sustained delivery of an active ingredient or a combination of active ingredients.

Abstract: The invention relates to polymer-coated stents, processes for their production and their use for restenosis prevention.