Publication number: 20040063704
Abstract: The present invention relates to novel compounds of formula (1) or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, a monocyclic heteroaromatic group or a bicyclic heteroaromatic group, said Ar group being optionally substituted by 1-4 substituents, which may be the same or different, and which are selected from the group consisting of: halogen, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-6alkyl, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-6alkoxy, arylC1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-6-alkyl, C3-7cycloalkylC1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, C1-6alkylsulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyloxy, C1-6alkylsulfonylC1-6alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6alkyl, C1-6alkylsulfonamido, C1-6alkylamido, C1-6alkylsulfonamidoC1-6alkyl, C1-6alkylamidoC1-6alkyl, arylsulfonamido, arylcarboxamido, arylsullonamidoC1-6alkyl, arylcarboxamidoC1-6alkyl, aroyl, arylC1-6alkyl, arylC1-6alkanoyl, a group R3OCO(CH2)s, R3CON(R4)(CH2)s, R3R4NCO(
Type:
Application
Filed:
October 16, 2003
Publication date:
April 1, 2004
Inventors:
Christopher Norbert Johnson, Harshad Kantilal Rami, Geoffrey Stemp, Kevin Thewlis, Mervyn Thompson, Antonio Keuok Keong Vong
Publication number: 20040063706
Abstract: A process for the preparation of a 4,4′-bistriazinylamino-stilbene-2,2′-disulphonic acid compound of formula (I) in which, independently, each R1 represents —NH2, —NH(C1-c10alkyl), —N(C1-C10alkyl)2, —NH(C2-C4hydroxyalkyl), —NH(C2-C4hydroxyalkyl)2, —N(C1-C10alkyl)(C2-C4hydroxyalalkyl), —NH(C1-C4alkoxy-C2-C4hydroxyalkyl), —N(C1-C4alkoxy-C2-C6hydroxyalkyl)2, —N(C1-C4alkoxy-C2-C4hydroxyalkyl)(C1-C10alkyl), —N(C1-C4alkoxy-C2C4hydroxyalkyl)(C2-C4hydroxyalkyl), —NH(C1-C4alkoxy-C1-C4alkoxy-C1-C4-alkyl), —N(C1-C4alkoxy-C1-C4alkoxy-C1-C4-alkyl)2, —N(C1-C4alkoxy-C1-C4alkoxy-C1-C4alkyl)(C1-C6alkyl), —N(C1-C6alkoxy-C1-C4alkoxy-C2-C4alkyl)(C2-C4hydroxyalkyl)-NH(C5-C7cycloalkyl), —N(C5-C7cycloalkyl)2, —NH(C6-C10aryl), NH(C7-C13aralkyl) or a morpholino, piperidino or pyrrolidino residue; M represents H, Na, Li, K, Ca, Mg, ammonium, or ammonium that is mono-, di-, tri- or tetrasubstituted by C1C4alkyl, C2-C4hydroxyalkyl
Type:
Application
Filed:
July 7, 2003
Publication date:
April 1, 2004
Inventors:
Georges Metzger, Dieter Reinehr, Hanspeter Sauter, Helena Dbaly