Patents Issued in May 6, 2004
  • Polypeptide-human rna binding protein 19 and the polynucleotide encoding it
    Publication number: 20040087525
    Abstract: A novel polypeptide-human RNA binding protein 19, the polynucleotide encoding it and a method producing the polypeptide by DNA recombinant technology. The present invention further discloses a method using the peptide for treating various disorders, e.g., protein metabolism disorder, embryonic deformative, various tumors, and immunological diseases. The protein is also suitable for human antisenescence research. The present invention also discloses an antagonist of the polypeptide and its therapeutic application. The present invention further discloses the use of the polynucleotide encoding the novel human RNA binding protein 19.
    Type: Application
    Filed: December 18, 2002
    Publication date: May 6, 2004
    Inventors: Yumin Mao, Yi Xie
  • Therapeutically useful compositions of DNA-RNA hybrid duplex constructs
    Publication number: 20040087526
    Abstract: The present invention provides novel compositions and methods for suppressing the expression of a targeted gene using RNA-DNA hybrid constructs. The invention further provides novel methods and compositions for generating or producing RNA-DNA hybrids, whose quantity is high enough to be used for the invention's gene silencing transfection and possibly in therapeutics applications. This improved RNA-polymerase chain reaction method utilizes thermocycling steps of promoter-linked DNA or RNA template synthesis, in vitro transcription and then reverse transcription to bring up the amount of RNA-DNA hybrids up to two thousand folds within one round of the above procedure for specific gene silencing.
    Type: Application
    Filed: March 19, 2003
    Publication date: May 6, 2004
    Inventors: Shi-Lung Lin, Henry H. Ji
  • Methods for treatment of thiol-containing compound deficient conditions
    Publication number: 20040087527
    Abstract: Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.
    Type: Application
    Filed: March 27, 2003
    Publication date: May 6, 2004
    Inventors: Brian J. Day, Leonard W. Velsor
  • Compositions and methods for performing reverse gene therapy
    Publication number: 20040087528
    Abstract: The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an abnormal tissue is delivered to a cell of an animal afflicted with a disease or disorder to alleviate the disease or disorder. In one embodiment, a plasmid vector encoding HERG (A561V) protein is delivered to a cell of an animal afflicted with re-entrant atrial flutter-mediated cardiac arrhythmia.
    Type: Application
    Filed: July 31, 2003
    Publication date: May 6, 2004
    Inventors: Robert J. Levy, Denise Y. Burton
  • Delivery system for entrapping charged macromolecules and a method for preparing same
    Publication number: 20040087529
    Abstract: The present invention relates to a new delivery system and method for producing same. The delivery system is a biphasic system of delivering charged macromolecules and comprises of a negatively charged hydrophobic organic phase and a positively charged inorganic phase. The organic phase and the inorganic phase entrapping added macromolecules. The macromolecules are entrapped by electrostatic bonds between the organic phase, the inorganic phase and the macromolecules. The method for producing the delivery system comprises the steps of contacting together and mixing a negatively charged organic phase, a charged macro-molecule and a positively charged inorganic phase.
    Type: Application
    Filed: April 28, 2003
    Publication date: May 6, 2004
    Inventors: Youssef Elazhary, Boby Makabi-Panzu, John David Hurley, Sylvette Laurent
  • Methods and compositions for modulating leptin activity
    Publication number: 20040087530
    Abstract: Administration of leptin affects food intake and body weight in animals and humans by a mechanism involving actions on specific regions of the hypothalamus. CIS-1, SOCS-1, SOCS-2 and SOCS-3 genes were investigated for their ability to antagonize leptin action. In mammalian cell lines, SOCS-3 completely blocked leptin induced signal- transduction, whereas CIS, SOCS-1 and SOC-2 were without effect. SOCS-3 is a major target of leptin action in leptin responsive cells in the hypothalamus, and SOCS-3 is a potent inhibitor of leptin signaling. Increased SOCS-3 activity in leptin-responsive neurons is a potential mechanism for the leptin resistance observed in syndromes of obesity, affective mood disorders and reproductive disorders.
    Type: Application
    Filed: May 6, 2003
    Publication date: May 6, 2004
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Jeffrey S. Flier, Christian Bjorbaek
  • Compositions and methods for the treatment of cancer
    Publication number: 20040087531
    Abstract: Composition and methods of treating, preventing, and managing cancer by inhibiting the expression of the gene tpt1 are disclosed. In addition, a method of identifying genes that are involved in the tumor reversion of two or more types of cancers is also disclosed.
    Type: Application
    Filed: May 16, 2003
    Publication date: May 6, 2004
    Inventors: Adam Telerman, Robert Amson, Marius Tuijnder, Laurent Susini
  • Method of treating malignancies through induction of blood immune responses
    Publication number: 20040087532
    Abstract: A method of treating malignancies through induction of immune responses has been found. In one aspect, the present invention is a method for treating malignancy comprising administering an effective amount of a vaccine comprising antigen-presenting cells loaded with at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides. In another embodiment, the vaccine comprises at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides which target antigen-presenting cells in the patient. The vaccines can also further comprise antigen-presenting cells loaded with control antigens used to determine the patient's immune competence. The evaluation of vaccine-induced immune responses in blood provides a predictive factor for treatment efficacy.
    Type: Application
    Filed: November 26, 2003
    Publication date: May 6, 2004
    Inventors: Jacques F. Banchereau, Anna K. Palucka, Joseph Fay, Ralph Steinman, Madhay Dhodapkar, Knut M Wittkowski
  • Antisense compounds, methods and compositions for treating MMP-12 related inflammatory disorders
    Publication number: 20040087533
    Abstract: The present invention relates antisense oligonucleotide compounds for use in modulating the function of nucleic acid molecules encoding mammalian MMP-12. More specifically, the invention provides compounds of 8 to 50 nucleobases in length capable of specifically hybridising with nucleic acid molecules encoding MMP-12 and thereby inhibiting the expression of the MMP-12 protein product, as well as pharmaceutical compositions thereof and methods of its use.
    Type: Application
    Filed: July 16, 2003
    Publication date: May 6, 2004
    Inventors: Andreas Dieckmann, Robert Lofberg, Oliver Von Stein, Petra Von Stein, Liam Good
  • Immunomodulatory oligonucleotides
    Publication number: 20040087534
    Abstract: Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
    Type: Application
    Filed: July 30, 2003
    Publication date: May 6, 2004
    Applicants: University of Iowa Research Foundation, The United States of America, as Represented by the Secretary, Dept. of Health and Human Services, Coley Pharmaceutical Group, Inc., CPG Immunopharmaceuticals, Inc.
    Inventors: Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
  • Pharmaceutical composition for angiogenesis
    Publication number: 20040087535
    Abstract: The feasibility of gene therapy using NO synthase (NOS) to treat peripheral arterial disease was examined. According to the present invention, transfection of NOS vector resulted in a significant increase in blood flow and capillary density. Thus, the present invention provides a method for treating or preventing angiogenesis-dependent conditions by administering a NOS gene in the form of naked DNA.
    Type: Application
    Filed: August 6, 2003
    Publication date: May 6, 2004
    Applicant: AnGes MG, Inc.
    Inventors: Ryuichi Morishita, Tsunetatsu Namba, Toshio Ogihara
  • Antisense modulation of KOX 1 expression
    Publication number: 20040087536
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of KOX 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding KOX 1. Methods of using these compounds for modulation of KOX 1 expression and for treatment of diseases associated with expression of KOX 1 are provided.
    Type: Application
    Filed: August 19, 2003
    Publication date: May 6, 2004
    Inventors: Kenneth W. Dobie, Susan M. Freier
  • Compositions comprising fusion polypeptides HIV-Nef and NGF, and methods of using the same
    Publication number: 20040087537
    Abstract: A conjugate comprising a first and second sequence, wherein the first sequence comprises at least part of the human low affinity Nerve Growth Factor receptor (LNGFR) or a polynucleotide coding for LNGFR, and the second sequence comprises at least part of a mutant HIV Nef or a polynucleotide coding for F12Nef.
    Type: Application
    Filed: August 29, 2003
    Publication date: May 6, 2004
    Applicant: MOLMED SPA
    Inventor: Maurizio Federico
  • Methods of treating cancer using immunostimulatory oligonucleotides
    Publication number: 20040087538
    Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
    Type: Application
    Filed: November 21, 2003
    Publication date: May 6, 2004
    Applicant: University of Iowa Research Foundation
    Inventors: Arthur M. Krieg, George Weiner
  • Method of treating conditions related to platelet activity
    Publication number: 20040087539
    Abstract: Methods of treating thrombotic and hemostatic conditions related to platelet activity are described herein. The methods of treating thrombotic and hemostatic conditions use active agents that modulate production of guanosine 3′, 5′ cyclic monophosphate (cGMP) or the function of cGMP-dependent protein kinase (PKG), and its downstream effectors, the ERK and p38 pathways.
    Type: Application
    Filed: December 12, 2003
    Publication date: May 6, 2004
    Inventor: Xiaoping Du
  • Combinatorial library synthesis and pharmaceutically active compounds produced thereby
    Publication number: 20040087540
    Abstract: The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.
    Type: Application
    Filed: April 28, 2003
    Publication date: May 6, 2004
    Applicant: Micrologix Biotech Inc.
    Inventors: Wenqiang Zhou, Yi Jin, Arlene Roland, Radhakrishnan Parameswaran Iyer
  • Crystalline and amorphous forms of beta-L-2'-deoxythymidine
    Publication number: 20040087541
    Abstract: Physical forms of beta-L-2′-deoxythymidine are disclosed that can be characterized by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns, thermal properties, and methods of manufacture. These forms of beta-L-2′-deoxythymidine can be used in the manufacture of other forms of beta-L-2′-deoxythymidine, or in pharmaceutical compositions. Particularly preferred uses are in the treatment of hepatitis B.
    Type: Application
    Filed: August 6, 2003
    Publication date: May 6, 2004
    Inventors: David Jonaitis, Richard Storer
  • Disaccharide and trisaccharide C6-C12 fatty acid esters with high alpha content
    Publication number: 20040087542
    Abstract: The present invention provides disaccharide and trisaccharide C6 to C12 mixed fatty acid esters having a high alpha content. Yet still further, the invention provides chemical processes for the preparation of the materials disclosed herein.
    Type: Application
    Filed: October 27, 2003
    Publication date: May 6, 2004
    Inventors: John Steele Debenham, Charles Michael Buchanan, Matthew Davie Wood, Michael Orlando Malcolm, Mary Kathleen Moore
  • Methods and products for mucosal delivery
    Publication number: 20040087543
    Abstract: The invention features methods and products associated with non-invasive delivery of polysaccharide preparations.
    Type: Application
    Filed: April 25, 2003
    Publication date: May 6, 2004
    Inventors: Zachary Shriver, Ganesh Venkataraman, Mallikarjun Sundaram, Ram Sasisekharan, Thomas Richardson, Yiwei Qi
  • Pharmaceutical compositions of topic use, applied in treatment of skin and/or mucous injuries use of compositions in treatment of skin and/or mucous injuries and use of compounds in treatment of skin and/or mucous injuries
    Publication number: 20040087544
    Abstract: The present invention describes new pharmaceutical compositions in treatment of skin and/or mucous injuries, new therapeutic use of compounds and use of compositions and compounds in treatment of injuries that involve skin and/or mucous, and/or therapies where regeneration or modelling of tissues growth is necessary. Particularly these pharmaceutical compositions are indicated for treatment of injuries caused by burns.
    Type: Application
    Filed: September 12, 2003
    Publication date: May 6, 2004
    Inventors: Elisa Mannochio De Souza Russo, Valter Freire Torres Russo
  • Method and composition for the treatment of a viral infection
    Publication number: 20040087545
    Abstract: Methods and compositions for the treatment, control or prophylaxis of a viral infection in a mammal, the method including administering to the mammal an effective amount of galactofucan sulfate from Undaria.
    Type: Application
    Filed: June 30, 2003
    Publication date: May 6, 2004
    Inventors: J. Helen Fitton, Charles Dragar
  • Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases
    Publication number: 20040087546
    Abstract: Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and/or the transplantation of blood or cells. Particular second active agents are capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of a myeloproliferative disease. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
    Type: Application
    Filed: April 11, 2003
    Publication date: May 6, 2004
    Inventor: Jerome B. Zeldis
  • C7 heterosubstituted acetate taxane compositions
    Publication number: 20040087547
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: November 24, 2003
    Publication date: May 6, 2004
    Applicant: FSU Research Foundation Inc.
    Inventor: Robert A. Holton
  • Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
    Publication number: 20040087548
    Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: February 14, 2002
    Publication date: May 6, 2004
    Inventors: Mark E. Salvati, Ricardo M. Attar, Marco M. Gottardis, James Aaron Balog, Dacia A. Pickering, Rogelio L. Martinez, Chongping Sun
  • Aryl phosphate derivatives of d4T having activity against resistant HIV strains
    Publication number: 20040087549
    Abstract: Methods of inhibiting virus replication of in a cell infected with a resistant strain of HIV that includes administering to the infected cell a virus replication inhibiting amount of an aryl phosphate derivative of d4T.
    Type: Application
    Filed: October 25, 2002
    Publication date: May 6, 2004
    Inventor: Fatih M. Uckun
  • Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
    Publication number: 20040087550
    Abstract: The present invention relates to a composition for prevention and/or treatment of metabolic diseases of bones comprising at least one bisphosphonate; viscosity agents comprising carboxymethylcellulose and xanthan gum; at least one flavouring agent; and purified water; a process for preparing a composition according to the present invention; and use of such a composition for prevention, treatment and/or diagnosis of metabolic diseases of bones, especially for children.
    Type: Application
    Filed: December 12, 2003
    Publication date: May 6, 2004
    Inventors: Daniel Zanetti, Damian Cairatti, Enrique Piccinni, Emilio J.A. Roldan, Socrates Papapoulos
  • Treatment of spinal mechanical pain
    Publication number: 20040087551
    Abstract: The invention is directed to a method of treating chronic spinal mechanical pain by intravenous administration to a subject in need of chronic spinal mechanical pain relief of an effective amount of bisphosphonate.
    Type: Application
    Filed: July 21, 2003
    Publication date: May 6, 2004
    Inventor: Marco Pappagallo
  • Pyrrolidine modulators of ccr5 chemokine receptor activity
    Publication number: 20040087552
    Abstract: Pyrrolidine compounds of Formula (I), (wherein R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Application
    Filed: July 17, 2003
    Publication date: May 6, 2004
    Inventors: Jeffrey J Hale, Charles G. Caldwell, Dooseop Kim, Dong-Ming Shen, Sander G. Mills, Kevin T. Chapman, Liya Chen, Malcolm MacCoss, Amy Gentry, Christopher L. Lynch, Christopher A. Willoughby, Yuan Cheng
  • Hypoestoxides, derivatives and agonists thereof for use in the treatment and prophylaxis of hyperlipidemia
    Publication number: 20040087553
    Abstract: Methods for treatment and prophylaxis of hyperlipidemias, including hypertriglyceridemia and hypercholesterolemia, are provided. The methods include administering to a host a therapeutically or prophylactically effective amount of a diterpene compound, such as a hypoestoxide.
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Applicant: Paraquest, Inc.
    Inventors: Emeka J. Nchekwube, Emmanuel A. Ojo-Amaize, Howard B. Cottam
  • Method of producing 1-hydroxy-1,1-diphosphonic acid compounds
    Publication number: 20040087554
    Abstract: The invention relates to a method of producing the 1-hydroxy-1,1-diphosphonic acid compounds of general formula (I), and/or the pharmacologically acceptable salts thereof, in which formula R1 represents hydrogen, OH, NO2, Cl, F, Br, C1-C6 alkyl that may be substituted with halogen, amine and/or aminoalkyl, C1-6 alkoxy, aryl, heteroaryl, a group NR3R4, wherein R3 and R4 may be the same or different and represent hydrogen, C1-C6 alkyl, halogen-substituted alkyl, hydroxy-C1-alkyl; R2 represents hydrogen, halogen, amine that may be substituted, C1-C6 alkyl that may be substituted with halogen, amine and/or aminoalkyl, C1-C6 alkoxy, aryl, heteroaryl; Y represents O, S or NH; Z represents C1-C5 alkylene that may be substituted with amine groups, and m and n are 0 or 1, with the proviso that if n=1, m=1.
    Type: Application
    Filed: September 15, 2003
    Publication date: May 6, 2004
    Inventors: Helmut Blum, Wolfgang Greb, Yurii Pustovit, Gerd-Volker Roschenthaler
  • Phosphohalohydrins, process for the production thereof and use thereof
    Publication number: 20040087555
    Abstract: The invention provides compounds comprising at least one phosphohalohydrin group of the formula: 1
    Type: Application
    Filed: October 14, 2003
    Publication date: May 6, 2004
    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICATE
    Inventors: Christian Belmant, Jean-Jacques Fournie, Marc Bonneville, Marie-Alix Peyrat
  • N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor
    Publication number: 20040087556
    Abstract: This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases.
    Type: Application
    Filed: November 6, 2002
    Publication date: May 6, 2004
    Inventors: Lynn Kirkpatrick, Garth Powis, Sarah J. Welsh
  • Treating muscle wasting with selective androgen receptor modulators
    Publication number: 20040087557
    Abstract: This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide or any combination thereof, as described herein.
    Type: Application
    Filed: December 5, 2002
    Publication date: May 6, 2004
    Inventors: Mitchell S. Steiner, Karen A. Veverka, James T. Dalton, Duane D. Miller
  • Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
    Publication number: 20040087558
    Abstract: Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Inventors: Jerome B. Zeldis, Herbert Faleck, Donald C. Manning
  • Methods for prevention and treatment of cancer
    Publication number: 20040087559
    Abstract: Methods for inhibiting, preventing, or treating cancer cell growth are disclosed. In one embodiment, the method comprises the step of administering to a patient an effective amount of a metabolic precursor of 1,25-dihydroxyvitamin D, or an analog or a derivative thereof, to increase levels of the metabolic precursor available to a target cell. In a preferred embodiment, the metabolic precursor is 25-hydroxyvitamin D.
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Inventors: Gary G. Schwartz, Balakrishna L. Lokeshwar, Tai C. Chen, Lyman W. Whitlatch, Michael F. Holick
  • Triterpenoid derivatives
    Publication number: 20040087560
    Abstract: The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, in the preparation of a medicament for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further embodiment relates to the use a compound of formula (I) in an assay for detecting the phosphorylation state of cellular substrates. The present invention also relates to novel compounds of formula (I), and the chemical synthesis thereof.
    Type: Application
    Filed: September 10, 2003
    Publication date: May 6, 2004
    Inventors: Marian Hajduch, Jan Sarek
  • Treatment of sexual dysfunction
    Publication number: 20040087561
    Abstract: Bombesin receptor antagonists have been found to be useful in the treatment of sexual dysfunction in both males and females. They may be selective BB1 antagonists or mixed BB1/BB2 antagonists. Combinations are disclosed of bombesin receptor antagonists with a range of other active compounds, for example PDE5 inhibitors, NEP inhibitors and lasofoxifene.
    Type: Application
    Filed: December 4, 2003
    Publication date: May 6, 2004
    Inventors: Maria Isabel Gonzalez, Michael Higginbottom, Alisdair MArk Naylor, Robert Denham Pinnock, Martyn Clive Pritchard, Herman Thijs Stock, Pieter Hadewijn Van Der Graaf, Christopher Peter Wayman
  • Processes for preparing 7-carboxy substituted steroids
    Publication number: 20040087562
    Abstract: This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, 1
    Type: Application
    Filed: March 21, 2003
    Publication date: May 6, 2004
    Inventor: Peter Guillaume Marie Wuts
  • Hormone replacement therapy with cardiovascular protection using antialdosteronic progestins
    Publication number: 20040087563
    Abstract: The present invention relates to methods of treating aldosterone-mediated diseases such as cardiovascular diseases in peri-menopausal or post-menopausal women by administering an agent with antimineralocorticoid and progestational activity, in particular drospirenone.
    Type: Application
    Filed: November 5, 2002
    Publication date: May 6, 2004
    Inventor: Siegfried Mayerhofer
  • Delivery composition and method
    Publication number: 20040087564
    Abstract: A composition which includes a membrane modulators is disclosed. The composition can be used in a wide range of therapies for delivering a membrane modulator which play an active function in regulating, controlling or causing a desired therapeutic effect to a target cell.
    Type: Application
    Filed: October 31, 2002
    Publication date: May 6, 2004
    Inventors: D. Craig Wright, John E. Mauk
  • 9-alpha-substituted estratrienes as selectively active estrogens
    Publication number: 20040087565
    Abstract: This invention describes the new 9&agr;-substituted estratrienes of general formula I 1
    Type: Application
    Filed: June 11, 2003
    Publication date: May 6, 2004
    Applicant: Schering AG
    Inventors: Dirk Kosemund, Gerd Mueller, Alexander Hillisch, Karl-Heinrich Fritzemeier, Peter Muhn
  • Biologically active macrolides, compositions, and uses thereof
    Publication number: 20040087566
    Abstract: The present invention provides a compound of the formula (I) or (II), wherein R1 is H, alkyl, alkenyl or aryl, R2 is H, alkyl or aryl, R3 is H, a alkyl, alkenyl or aryl, R4 and R4-R8 are independently R10, C(O)R10 or SO2R10, wherein R10 is H, alkyl, alkenyl or aryl, and R9 is R9a, C(O)R9a or SO2R9a, wherein R9a is H, alkyl, alkenyl or aryl. R9a can be unsubstituted or substituted with one or more oxo(═O), OR9b, OC(O)R9b, OSO2R9b, NHR9b, NHC(O)R9b and NHSO2R9b groups. R9a is H, alkyl, alkenyl, or aryl. R9b can be unsubstituted or substituted with one or more groups such as oxo(═O), OR9c, CO2R9c, CO2R9c and OC(O)R9c. R9c is H, or a unsubstituted or substituted alkyl, alkenyl or aryl. The present invention further provides a composition comprising at least one compound of the present invention and a pharmaceutically acceptable carrier, alone or in combination with at least one additional active agent.
    Type: Application
    Filed: June 11, 2003
    Publication date: May 6, 2004
    Inventors: Michael R Boyd, Kirk R Gustafson, Charles L Cantrell
  • Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition
    Publication number: 20040087567
    Abstract: The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer.
    Type: Application
    Filed: August 25, 2003
    Publication date: May 6, 2004
    Inventors: Jae Min Jeong, Young Ju Kim, Yun-Sang Lee, Dong Soo Lee, June-Key Chung, Myung Chul Lee
  • Substituted anthranilic amide derivatives and methods of use
    Publication number: 20040087568
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: July 8, 2003
    Publication date: May 6, 2004
    Applicant: Amgen Inc.
    Inventors: Qi Huang, Guoqing Chen, Aiwen Li, Babak Riahi, Andrew Tasker, Kevin Yang, Chester Chenguang Yuan
  • N-heterocyclic bicyclic lactone compounds
    Publication number: 20040087569
    Abstract: Novel N-heterocyclic bicyclic lactone compounds of formula I and its novel hydroxyamide precursors of formula IV, 1
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Inventors: Todd D. Nelson, Carl LeBlond, Michael H. Kress
  • N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa
    Publication number: 20040087570
    Abstract: This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing Factor Xa. The present invention is also directed to compositions containing said derivatives, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.
    Type: Application
    Filed: October 16, 2003
    Publication date: May 6, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Mark Czekaj, Scott I. Klein, Heinz W. Pauls
  • Methods of using CCR1 antagonists as immunomodulatory agents
    Publication number: 20040087571
    Abstract: The present invention relates to methods of using CCR1 antagonists as immunomodulatory agents.
    Type: Application
    Filed: October 16, 2003
    Publication date: May 6, 2004
    Applicant: Pfizer Inc
    Inventors: Matthew F. Brown, Anderson S. Gaweco, Ronald P. Gladue, John C. Kath, Christopher S. Poss
  • Method for inhibiting cataracts
    Publication number: 20040087572
    Abstract: This invention relates to a method for inhibiting cataracts comprising administering to a patient in need thereof an effective amount of a compound of the formula (I); or a pharmaceutical salt or solvate thereof wherein: R1 and R3 are independently hydrogen, methyl, benzoyl, substituted benzoyl, or C(O)—(C1-C6 alkyl); R2 is selected from the group pyrolidin-1-yl, piperidin-1-yl, and hexamethyleneimin-1-yl; where the R2 group is optionally the N-oxide.
    Type: Application
    Filed: March 7, 2003
    Publication date: May 6, 2004
    Inventors: Pamela Wang Anderson, Andreas Sashegyi
  • Phenylpiperidines and phenylpyrrolidines
    Publication number: 20040087573
    Abstract: Substituted phenylpiperidines and phenylpyrrolidines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Inventors: Richard L. Apodaca, Curt A. Dvorak, Chandravadan R. Shah, Wei Xiao
  • Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient
    Publication number: 20040087574
    Abstract: Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases.
    Type: Application
    Filed: March 25, 2003
    Publication date: May 6, 2004
    Inventors: Toshiya Takahashi, Takeshi Ishigaki, Miyuki Funahashi, Koji Taniguchi, Masayuki Kaneko, Mie Kainoh, Hiroyuki Meguro