Abstract: Dosage regimens of buprenorphine achieving rapid pain relief without increasing nausea, vomiting, or other adverse effects, are described. Also described are buprenorphine dosage regimens for treating chronic pain comprising administering to the patient (1) a first buprenorphine-containing transdermal dosage form for a first dosing period that is no more than about 5 days; (2) a second buprenorphine-containing transdermal dosage form for a second dosing period that is no more than 5 days, the second dosage form comprising the same dosage of buprenorphine as, or a greater dosage of buprenorphine than, the first dosage form; and (3) a third buprenorphine-containing transdermal dosage form for a third dosing period, the third dosage form comprising a greater dosage of buprenorphine than the second dosage form.

Abstract: A specific dosage regimen of buprenorphine achieves pain relief from painful episodes due to sickle cell disease. The dosage regimen comprises administering to a patient in need of pain relief from sickle cell disease at least one BTDS transdermal patch. Alternatively, the dosing regimen comprises administering to the patient (1) a first buprenorphine-containing transdermal dosage form for a first dosing period; (2) administering to the patient a second buprenorphine-containing transdermal dosage form for a second dosing period, where the second dosage form comprises the same dosage of buprenorphine as, or a greater dosage of buprenorphine than, the first dosage form; and (3) administering to the patient a third buprenorphine-containing transdermal dosage form for a third dosing period, where the third dosage form comprises a greater dosage of buprenorphine than the second dosage form.

Abstract: The present invention relates to transdermal dosage forms for delivery of androgens.

Abstract: Provided by the present invention are formulations suitable for application to mammalian eyes which contain a lipid binding protein and a polar lipid, present as a soluble complex in an aqueous electrolyte. The formulations described have shear-thinning (non-Newtonian viscosity) and surface tension properties to natural tears and are therefore useful as artificial tear substitutes for the treatment of dry eyes (e.g. keratoconjunctivitis sicca) and useful in ophthalmic applications in general.

Abstract: Compositions comprising lamellar bodies for removal of extra and intra-vascular fibrin for therapeutic purposes are disclosed. These lamellar compositions are also useful in surgical procedures wherein formation of post-surgical adhesions are likely. Methods of preventing and/or modifying fibrin clots and treating and/or preventing adhesions by administering a therapeutically effective amount of a composition to a patient requiring such treatment are also disclosed.

Abstract: Liposomal system formed from a peptide having a ubiquitinatable region and an antigenic region, a pH-sensitive liposomal carrier; and a bilayer-associated adjuvant, such as MPL are useful as vaccine compositions. These compositions are surprisingly effective in inducing an in vivo immune response to the antigen corresponding to the antigenic region.

Abstract: The new process can be summarized in five general phases: the manufacture and coating of active-loaded beads with a sustained release coat, an enteric coat; a colonic coat, or a taste-masking coat; the manufacture of the cushioning components the co-processing of active-loaded beads with cushioning components into a single component known as a Cushioning Bead™; the use of freeze-drying to produce the intended outcome, and the compression of the resultant Cushioning Beads™ into tablets.

Abstract: The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The composition need not contain ascorbic acid in order to obtain desirable stability.

Abstract: This disclosure relates to compositions suitable for a variety of treatments, including ameliorating the undesirable side effects associated with compounds such as lipase inhibitors (e.g., anal leakage of undigested fat or oil). In particular, one embodiment of the present invention relates to compositions that are suitable for administration to an animal for the purpose of stiffening one or more lipophilic substances present in the gastrointestinal tract of the animal. The stiffening agents have a complete melting point of about 33° C. or greater. Various kits comprising the compositions are also described herein.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: An implantable delivery system includes a macrostructure formed of bioresorbable material selected from a group of alphahydroxy acids and defined to include an internal architecture of intercommunicating void spaces. A first cytotoxic agent in the preferred form of cisplatin is joined to the macrostructure during formation. A microstructure in the preferred form of a blend of high molecular weight hyaluronic acid conjugated with a second cytotoxic agent in the preferred form of paclitaxel and of pure high molecular weight hyaluronic acid is invested in the void spaces. Thus, when implanted, the paclitaxel and cisplatin are released sequentially, each initially at high level concentrations followed by lower release. Radiotherapy can be begun after the release of the paclitaxel has been completed but while the cisplatin is being released.

Abstract: A unit dosage form, such as a capsule or the like for delivering drugs into the body in a sustained release fashion similar to that produced by INDERAL® LA indicated for the treatment of cardiovascular diseases, comprises two populations of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a pre-designed rapid release profile (i.e., substantially complete release within 60 minutes) or sustained release profile over a period of 24 hours. Such a cardiovascular drug delivery system is designed by combining immediate release (IR) beads and sustained release (SR) beads. SR beads may be obtained by membrane coating IR beads with a water-insoluble polymer such as ethylcellulose or a mixture of a water insoluble polymer and a water-soluble polymer such as hydroxypropylcellulose at a ratio of from about 65/35 to 95/5.

Abstract: The present invention provides a pharmaceutical that includes, in combination, a core, and a coating surrounding the core comprising a resinate of an opiate. The pharmaceutical oral dosage form is failsafe, and not subject to abuse.

Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate.

Abstract: The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.

Abstract: The invention concerns a novel method for preparing, by solvent extraction, PLGA/PLA-type polymer microspheres encapsulating water-soluble substances. The invention also concerns the microspheres obtained by said method.

Abstract: A composition for use in cardiovascular therapy includes transfer factor. The transfer factor may be nonmammalian transfer factor, such as that derived from eggs, or mammalian transfer factor, such as that derived from colostrum. The composition may also include one or more of the following: an LDL receptor-binding element; a blood flow-enhancing element; a cholesterol reducing element; a fat oxidation prevention element, and an antioxidant. Treatment methods include enlisting the immune system of a subject receiving therapy to attack pathogens that cause inflammation of blood vessels or to otherwise reduce inflammation of blood vessels.

Abstract: Methods of enhancing the photostabilizing of silver in medical materials are described. More particularly, the methods increase the photostabilization of silver in certain materials comprising hydrophilic, amphoteric and anionic polymers by subjecting the polymers to solutions containing an organic solvent and silver, during or after which one or more agents are added which facilitate the photostablization of the material.

Abstract: The present invention provides an oral formulation of arsenic trioxide (As2O3) for the treatment of a variety of hematological malignancies, including acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL). The present invention also provides methods for making the oral arsenic trioxide formulation. Methods of using the oral arsenic trioxide formulation are also described.

Abstract: Ectoparasites, such as fleas, ticks, mites and lice, are removed from a human or animal host after applying a composition to the affected area that causes desiccation of the organism. In one embodiment, treatment is effected by applying a substantially anhydrous composition that has a strong affinity for water. As the composition hydrates, it desiccates the pests and facilitates their mechanical removal, such as by combing.

Abstract: Compositions for assisting in the removal of human cerumen are disclosed. The compositions may include bicarbonate and an otologically acceptable vehicle; a cerumenolytically acceptable enzyme and an otologically acceptable vehicle; or bicarbonate, a cerumenolytically acceptable enzyme, and an otologically acceptable vehicle.

Abstract: The present invention refers to achemical process for separation of different kinds of substances which are present in Brazilian propolis, by means of HPLC and GC-MS combined techniques. This provided a process for a HPLC separation which is able to identify the majority components of the propolis sample by using a suitable analysis software for this end.

Abstract: The present invention is directed toward a method for inhibiting COX-2 in an organism. In particular, the method is preferably directed toward selectively inhibiting COX-2 in an organism. The method comprises administering to the organism an organic extract isolated from a plant wherein such extract inhibits COX-2. A method to purify a composition that exhibits COX-2 inhibition and COX-2 selective inhibition from the organic extract is also provided. In addition, a method for treating and/or preventing COX-2 mediated inflammation or inflammation-associated disorders in an organism is provided.

Abstract: The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of producing said composition and also a method of treating a subject using said composition.

Abstract: An oral compound of water; glycerin; a cranberry source; methylsulfonylmethane; melaleuca alternifolia oil; hydroxyethylcellulose; and a surfactant, in proper combination for use by injecting the compound around a person's gum line followed by its use in a dental tray over a person's teeth and gums for a specified period of time.

Abstract: An anti-cough, anti-tussive, and throat soothing synergistic herbal formulation comprising of an extract of Piper cubeba, Glycyrrhiza glabra, Acorus calamus Alpinia galanga, Zingiber officinale and pharmaceutically acceptable additives as a syrup, lozenges or chewable tablets for preventing cracking of voice, dryness of mouth and toning of voice, vocal cord; the present invention also provides a method of preparation of this formulation.

Abstract: This invention concerns to a topical pharmaceutical composition comprising an water soluble Curcuma extract, and suitable excipients for said topical administration; the process for obtaining said pharmaceutical compositions; the use of different Curcuma extracts as photosensitizing agents for the treatment of proliferative diseases; and the use of Curcuma extract or curcuminoids in combination with a radiation for the treatment of proliferative diseases on eukaryote cells.

Abstract: A method for producing a composition containing soluble isoflavones is described, which uses soybean materials as raw materials. The composition is obtained in a natural state without addition of solubilizing agents and chemical modification, and has high solubility under neutral to acidic conditions and good long-term stability under refrigeration. By removing the insoluble materials from the water-extract liquid of a soybean material having a pH value of 2-7 and a temperature of 0-17° C., a composition containing isoflavones can be efficiently obtained with high solubility under neutral to acidic conditions and good stability under refrigeration.

Abstract: The invention concerns a preparation having the property of fixing fats (so as to eliminate from digestion part of the fats ingested during a meal), based on cladodes of cactaceae of the edible type and at least partly non-available. The invention is characterised in that the cactaceae is in the form of powder particles whereof at least 70 wt. % have a size less than 100 &mgr;m (sieve-controlled particle size distribution). Advantageously, the inventive particles of cactaceae cladodes are in the form of granules coated with an acid-resistant film soluble in the intestine and/or with prolonged release. The invention also concerns a method for obtaining such a preparation.

Abstract: A healing composition with a broad-spectrum sanative effect, substantially consisting of laurel extract in wine and especially a wine laurel extract, is disclosed.

Abstract: In an extraction process comprising extracting a raw extract from Emblica officinalis the improvement comprising conducting the extraction under conditions of time, temperature and atmosphere, to inhibit the formation of black specks and/or oligomeric and/or polymeric tannins and/or oxidation products thereof.

Abstract: The present invention provides extract fractions of Dioscorea sp. prepared by the method according to the present invention, which enhance the proliferation and differentiation of bone marrow cells, and provides a method for treatment of osteoporosis and a method for alleviation of side effects caused by chemotherapy.

Abstract: The present invention provides for a sexual dysfunction compound comprising a rapid-onset pharmaceutical composition that further comprises cocoa powder. The invention also provides for a process for manufacturing the composition, and use of the composition in sexual dysfunction therapy.

Abstract: The invention describes a unique composition of ingredients for improving the skin's visual appearance, function, and biophysical properties that has been changed by factors such as chronological age, chronic sun exposure, adverse environmental pollutants, household chemicals, disease pathologies, smoking, and malnutrition. In particular, the present invention relates to the composition of topically-applied cosmetics formulas that effectively treat aged and environmentally-damaged skin. These formulas may comprise various combinations of cosmetically compatible plant lectins, a high energy source for skin cell metabolism such as lactobacillus ferment, hydrolyzed wheat protein, glycine, arginine, and methionine and &bgr;-Glucans, which are formulated into different types of cosmetic vehicles. The invention provides for an effective alternative to the use of mono- and polyhydroxy acids, retinoid compounds, vitamins, nutraceuticals, physical corneum desquamating devices, and various plant and animal extracts.

Abstract: This invention relates to a method for using electromagnetic radiation to destroy data stored on a device that includes a data storage region and a conductive region. For example, common Compact Disks (often called a CD) and Digital Versatile Disks (often called a DVD) both have regions of the disk constructed to have at least one data storage layer and at least one conductive layer. The method disclosed in this invention relies on electromagnetic radiation, such as microwave radiation, to set up an electric field in the conductive layer of the data storage disk, where the electrical field is strong enough to alter the physical proprieties of a fraction of the data storage region of the disk. The data stored in and near these physically altered regions is destroyed.

Abstract: A mold for sequentially curing sections of a belt includes two end zones, a center zone, and transition zones between each end zone and the center zone. The mold is heated and/or cooled by heat transfer fluid flowing from intake manifolds through heat transfer cavities. The intake manifolds are preferably arranged perpendicular to the mold length. In the end zones and in the center zone, the heat transfer cavities are arranged substantially parallel to the length of the mold. The arrangement of the heat transfer cavities provides for a more controlled cure of the belt by allowing the center zone to maintain a consistent temperature throughout the center zone while allowing a cooler consistent temperature to be maintained in the end zones. The transition zones allow a steep temperature gradient from the cooler end zones to the hotter center zone. Heat transfer rates are adjustable without modification to the body of the mold.

Abstract: An apparatus which extrudes flowable material from a liquifier includes a system for loading filament supplied in a cassette. The cassette is loaded into a loading bay of the apparatus. A strand of filament from the cassette is engaged and advanced along a path to the liquifier using a drive wheel or roller pair. A conduit having an entrance in the loading bay guides the filament as it is advanced. The filament loading system of the present invention provides a convenient manner of loading and unloading filament in a three-dimensional modeling machine, and can be implemented in a manner that protects the filament from environmental moisture.

Abstract: A screw rotates in a containment barrel, and comprises a shaft having an upstream end and a downstream end At least one flight is secured to the surface of the shaft and extends helically in successive turns around the circumference of the shaft. An upstream barrier member extends radially from the surface of the shaft and generally transversely between successive turns of the flight. The upstream barrier is disposed proximal the upstream end of the shaft. A downstream barrier member extends radially from the surface of the shaft and generally transversely between successive turns of the flight. The downstream barrier is disposed proximal the downstream end of the shaft.

Abstract: The present invention provides a series of plates for distributing a molten polymer composition, the series of plates includes at least two plates: a first plate that includes an upper surface, a lower surface, and a plurality of polymer distribution channels connecting the upper surface and the lower surface.

Abstract: An insert for a mold, particularly a thermoplastic injection mold, including a stamper having an impression surface and a backing surface. The insert also has a support block having a facing surface having a plurality of projections thereon, with the plurality of projections in contact with the backing surface. A quantity of adhesive is disposed between the sides of the projections adhering the facing surface to the backing surface. A method for fabricating such an insert for a mold is also disclosed.

Abstract: Fluid flow grooves (11) with a flat cross section being formed between the back surface of a metal mold (2) for blow molding and a back-up member (4) which adheres tightly to this back surface. A plurality of these fluid flow grooves (11) are provided, and these fluid flow grooves are disposed densely in parallel with partition walls (21) interposed between the grooves. Fluid inlets (12) and outlets (13) are formed in the respective fluid flow grooves (11). A heating fluid or cooling fluid enters the respective fluid flow grooves (11) via the inlets (12) from a fluid supply manifold (14). The fluid flows out of the outlets (13), enters a fluid discharge manifold (15), and is discharged to the outside. Rapid heating and rapid cooling of the metal mold (2) are performed, no irregularity occurs in temperature, and the cycle time can be shortened, so that a metal mold device for blow molding in which the energy consumption is small can be obtained.

Abstract: A compact disc (CD) molding apparatus. The CD molding apparatus comprises a movable mold, a fixed mold, a mold cavity, an outer ring, a gas passage, an outlet and an auxiliary gas channel. The movable mold is disposed adjacent to the fixed mold. The mold cavity is defined between the movable mold and the fixed mold. The outer ring surrounds the mold cavity, and the outlet is defined between the fixed mold and the outer ring. The gas passage is defined between the fixed mold and the outer ring and connects the mold cavity and the outlet. Particularly, the auxiliary gas channel is disposed in the fixed mold and connected to the gas passage to facilitate exhaust of high temperature gas from the mold cavity, wherein a material is injected into the mold cavity and the high temperature gas passes through the gas passage before exiting through the outlet.

Abstract: Disclosed herein are a method for producing a koji of a hot pepper paste with reduced capsaicin and/or dihydrocapsaicin content through action of enzymes secreted from a koji fungus, comprising adding a predetermined amount of hot pepper powders once or more time to a starchy raw material in any one of a preparatory step, a cultivating step and a finishing step, a koji produced by the method, and a hot pepper paste prepared from the koji.

Abstract: The present invention relates to a feedstuff with a performance-increasing effect which comprises sorbic acid and at least one enzyme and/or enzyme product. The feedstuff can be employed for improving performance in agricultural livestock rearing.

Abstract: A method by which plant ash is reacted with individual acids or mixtures of acids to obtain the naturally occurring minerals and trace elements from the ash for the purpose of producing palatable mineral supplements for consumption by humans and animals. Uncontaminated plant material can be specifically selected for high concentrations of certain minerals to provide specific supplements high in the desired mineral or minerals. Additional ingredients can be added to said mineral supplements, such as vitamins, herbal extracts, bioflavonoids, nutraceuticals, antioxidants, natural or artificial sweeteners, thickeners, fragrances, food colorings, and stabilizing agents, such as grape seed extract or benzoic acid to increase nutritional value, improve taste, flavor, appearance, consistency and shelf life.

Abstract: A composition that contains (1) quercetin and vitamin B3, or (2) quercetin and vitamin C. Also disclosed is a method of using the composition for enhancing physical performance.

Abstract: A consumable pet chew comprising a formed, three-dimensional body of chewable material, and a method of making same, are disclosed. The body has an outer surface and at least one recess extending generally perpendicularly from the outer surface. The recess has walls and a machined edge at said outer surface, and defines a receptacle within the body of the pet chew. A filling comprising an edible substance is fixedly positioned in the receptacle. The machined edge at the outer surface of the body is formed by machining operations selected from the group consisting of drilling, punching, cutting and stamping. The walls of the recess are scored during machining operations to enhance retention of the filling in the receptacle. The chew is attractive to dogs as it combines the flavor of the chewable material forming the body of the chew with one or more differently flavored fillings.

Abstract: Drops of Honey is a capsule that is filled with honey. This capsule filled with honey is a food product in which the capsule dissolves in boiling water. This allows for the honey to escape into the beverage of choice, preferably tea. It is a food product that will be mainly used with tea and other hot beverages. A method of the product is to sweeten tea. Another method for Drops of Honey is to be used as a dietary supplement. The objective of Drops of Honey is to make it more convenient for the consumer to consume honey within tea or other hot beverages.

Abstract: A creamy product with a lubricious mouthfeel is bake-stable and suitable as a filler or topping for baked goods. In a preferred form, it comprises: at least 30% by weight of a discontinuous fat portion; at least 20% of a continuous aqueous liquid component for providing sweetness and stability, comprising liquid sugar and liquid polyol, wherein the combined weight of liquid sugars and liquid polyols amounts to from 40 to 95% solids by weight of the aqueous liquid component, and the continuous aqueous liquid component preferably contains less than 20% water. An optional suspended solids portion can be employed. The creamy product, wherein the moisture content is from 2 to 10% by weight of the total composition, and the combined amount of the sugar, polyol and other soluble solids comprises from about 25 to 65% of the total product and is sufficient to provide an Aw of less than 0.5 for the total product, can be combined with a bakeable dough and baked.

Abstract: The present invention relates to the ingredients for nontoxic bubble liquid that mainly contains pure water, blowing agent, thickener, sweetener, seasoning and enhancer. Besides blowing bubbles with the stick soaked with the edible bubble liquid, users can also blow bubbles from their mouth. Such unique bubble liquid not only draws people's attention, but eliminates harm to human bodies. Moreover, the sweetness and fragrance of the bubble liquid makes it more tasty.