Patents Issued in July 6, 2004
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Patent number: 6759352Abstract: A composite carbon fiber material is formed of one or more layers of carbon fiber material in which the carbon fibers are aligned all in the same direction and a mat of nonwoven, woven, or off-axis unidirectional carbon fibers are laminated together. Layers may be used individually or as a hybrid. The layers can be preimpregnated or impregnated during processing using thermoplastic or thermosetting resins. A layer of thermoplastic resin is applied either over the surface or within the composite structure, and the resin permeates the material so as to provide a more stable mechanical structure once the resin is processed. The material combines good mechanical strength with improved electrical current carrying properties when compared with the aligned carbon fiber layer alone. The layering sequence, layer type, and resin type can be specified to tailor electrical properties, mechanical properties, durability, and wear resistance.Type: GrantFiled: July 5, 2001Date of Patent: July 6, 2004Assignee: Sony CorporationInventors: Curt Delanoy, John Gillespie
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Patent number: 6759353Abstract: An absorbing article has a hydrophobic, liquid impermeable back side layer and a liquid permeable top layer together with an interposed hydrophilic core layer. The article is made so that at least the back side layer comprises hydrophobic vegetable fibers, preferably kapok fibers, and that the top lay can comprise wool fibers. Such an article is advantageous since it may be used for keeping the user warm in situations where there is need for liquid absorption without the risk of unintended temperature elevation known from plastic products.Type: GrantFiled: April 22, 2002Date of Patent: July 6, 2004Assignee: Panolana ApSInventors: Marianne Etlar Eriksen, Jeanette Almstrøm
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Patent number: 6759354Abstract: A dyed fabric, and apparel constructed therefrom, that has a high degree of colorfastness and a soft hand, formed by the process comprising the steps of applying dyestuffs directly to a polyester fabric that has been pre-treated with a wicking agent, and fixing the dyestuffs to the fabric by heating the fabric at between about 350 degrees Fahrenheit for between about 90 and 120 seconds, whereby the finished fabric has a crocking index of at least 4.0, and a soft hand.Type: GrantFiled: August 28, 2001Date of Patent: July 6, 2004Assignee: Intex CorporationInventors: Garnett H. Smith, James E. Bruce
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Patent number: 6759355Abstract: An air impermeable coated fabric, characterized in that it comprises a base fabric comprising fibers having a total fineness (yarn size) of 67 to 350 dtex and an elastomer film formed by application on at least one surface thereof, and the coated surface has friction coefficients (MIU) both in the warp direction and in the weft direction of 0.01 to 0.3, as measured according to KES measurement and the difference between the two friction coefficient values of 0.15 or less in an absolute value. The coated fabric has a coated surface having significantly improved sliding characteristics and thus is useful for manufacturing an air bag capable of being developed in a short time and with uniformity.Type: GrantFiled: July 23, 2002Date of Patent: July 6, 2004Assignee: Asahi Kasei Kabushiki KaishaInventors: Toshirou Nagaoka, Hideaki Ishii
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Patent number: 6759356Abstract: A thermoplastic polymer electret material comprising a porous substrate of a blend of a first thermoplastic polymer, such as a polyolefin or polyamide, and from 0.1% to about 25% by weight, of a compatible telomer. The porous substrate is electrostatically charge and is well suited for use in filter media, sterilization wraps, face masks, dust wipes and the like.Type: GrantFiled: June 28, 1999Date of Patent: July 6, 2004Assignee: Kimberly-Clark Worldwide, Inc.Inventor: David Lewis Myers
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Patent number: 6759357Abstract: A spunbonded non-woven fabric and a laminate composed of one or more such spunbonded non-woven fabrics and of one or more melt-blown non-woven fabrics under lamination, wherein the spunbonded non-woven fabric does scarcely suffer from occurence of rough surface and reveal scarce adherent touch with better hand feel due to permission of attaining more finer filament and can be produced efficiently without suffering from filament fracture on the spinning, wherein the said spunbonded non-woven fabric is made of fibers of a polypropylene resin composition having fiber finenesses of 0.8 to 2.8 denier and has an average friction factor (MIU) of 0.1 to 0.3, a thickness uniformity of 0.8 or less, a waterproof performance of at least 60 mmH2O and a gas permeability of not higher than 480 ml/cm2/sec.Type: GrantFiled: September 19, 2001Date of Patent: July 6, 2004Assignee: Mitsui Chemicals, Inc.Inventor: Michio Toriumi
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Patent number: 6759358Abstract: A method of producing a washcoated monolith catalyst utilizing a dual sol binder system, wherein the binder system is a blend of an alumina sol and a silica sol and wherein the ratio of the alumina to the silica in the dual sol binder system is from about 6:1 to about 1:3.Type: GrantFiled: August 21, 2001Date of Patent: July 6, 2004Assignee: Sud-Chemie Inc.Inventors: Yinyan Huang, Amiram Bar-Ilan
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Patent number: 6759359Abstract: A process for the production of a bleaching clay product which includes the steps of selecting a naturally occurring hormite clay product, cleaning and crushing the clay product to form clay clumps less than 6 in. in diameter, and aging the crushed hormite clay for at least about one (1) month. Acceptable bleaching clay products can also be produced by the addition of extremely small quantities of a concentrated acid to the aged hormite clay.Type: GrantFiled: November 21, 2002Date of Patent: July 6, 2004Assignee: Sud-Chemie Inc.Inventors: David Hill, Christian P. Fabry, Jorge Bello
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Patent number: 6759360Abstract: A method for the post synthesis modification of molecular sieves with organometallic reagents. The method may be used for large pore molecular sieves and small pore molecular sieves, such as SAPO-34. SAPO-34 is a useful catalyst for the conversion of oxygenates, such as methanol, to olefins. Post synthesis organometallic modification improves catalyst performance and increases light olefin selectivity in the conversion of methanol to olefins.Type: GrantFiled: March 29, 2002Date of Patent: July 6, 2004Assignee: ExxonMobil Chemical Patent Inc.Inventors: Kun Wang, Guang Cao, Michael Joseph Brennan, Karl G. Strohmaier, Richard B. Hall
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Patent number: 6759361Abstract: Single-site catalyst systems useful for polymerizing olefins are disclosed. The catalyst systems comprise an organometallic complex and an activator. The complex includes a Group 3-10 transition metal, M, and at least one indenoindolyl ligand that is pi-bonded to M. The activator is a reaction product of an alkylaluminum compound and an organoboronic acid. Catalyst systems of the invention significantly outperform known catalyst systems that employ a metallocene complex and similar aluminoboronate activators.Type: GrantFiled: June 4, 2001Date of Patent: July 6, 2004Assignee: Equistar Chemicals, LPInventors: Michael W. Lynch, Craig C. Meverden, Sandor Nagy, Karen L. Neal-Hawkins
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Patent number: 6759362Abstract: A process for making a solid composition comprising alkoxide groups, chloride groups, one or more metals, M, in the +2 oxidation state selected from Mg, Ca, Mn, Cu, Co or Zn, and one or more metals, T, in the +3, +4 or +5 oxidation state selected from Ti, Zr, V, Sm, Fe, Ni, Rh, Co, Cr, Mo, W or Hf, the molar ratio M/T of the composition being from 2.5 to 3.75, said process comprising contacting one or more alkoxide containing compounds of metal M, one or more alkoxide compounds of metal T, and a halide compound, the molar ratio M/T of the contacting compounds being from 2.5 to 3.5, and recovering the resulting solid.Type: GrantFiled: May 8, 2002Date of Patent: July 6, 2004Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventor: Robert Charles Job
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Patent number: 6759363Abstract: Activators with reduced volatility that are liquid at room temperature are obtained as the reaction product of (A) a secondary amine or primary alcohol having at least one tertiary amine group, (B) a polyisocyanate of the diphenylmethane series having a functionality of from 2.5 to 4.0 and an OH-functional reactive component capable of addition to isocyanate. These activators are useful for the production of polyurethane foams having improved emission behavior.Type: GrantFiled: November 9, 2001Date of Patent: July 6, 2004Assignee: Bayer AktiengesellschaftInventors: Peter Haas, Dirk Wegener, Hartwig Grammes
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Patent number: 6759364Abstract: A catalyst for removing arsenic from petroleum feedstocks comprising a porous refractory support impregnated with at least 8 wt. % of a Group VIB metal and an amount of Group VIII metal such that the atomic ratio of Group VIII metal to Group VIB metal is between about 1.5 and 2.5. A method of making such catalyst and a process for removing arsenic metals from a petroleum fraction using said catalyst.Type: GrantFiled: December 17, 2001Date of Patent: July 6, 2004Assignee: Shell Oil CompanyInventor: Opinder Kishan Bhan
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Patent number: 6759365Abstract: Catalysts for the oxychlorination of ethylene to 1,2-dichloroethylene, comprising compounds of Cu and Mg supported on alumina, in which the copper content, expressed as Cu, is 2 to 8% by weight, the Mg/Cu atomic ratio is from 1.2 to 2.5, and the specific surface of the catalyst is from 30 to 130 m2/g.Type: GrantFiled: October 22, 2002Date of Patent: July 6, 2004Assignee: SUD Chemie Mt S.r.l.Inventors: Luigi Cavalli, Francesco Casagrande
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Patent number: 6759366Abstract: The present invention relates to an image element for dual-sided imaging. The image element may include a substrate having first and second surfaces, a first coating, and a second coating. Generally, the first coating is applied to the first surface, where the coating includes a first imaging material for creating, in situ, a first image; and the second coating is applied to the second surface, where the coating includes a second imaging material for creating, in situ, a second image.Type: GrantFiled: December 18, 2001Date of Patent: July 6, 2004Assignee: NCR CorporationInventors: Christopher H. Beckerdite, John Long
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Patent number: 6759367Abstract: A monosheet black and white substantially light-insensitive thermographic recording material comprising a thermosensitive element and a support, the thermosensitive element containing a substantially light-insensitive organic silver salt, a 3,4-dihydroxybenzene compound in thermal working relationship therewith and a binder, wherein the 3,4-dihydroxybenzene compound is an aryloxo-3,4-dihydroxybenzene compound in which the aryl-group is substituted with at least one substituent having a &sgr;m-value greater than 0; or a heteroaryloxo-3,4-dihydroxybenzene compound in which the heteroaryl group has a unified aromaticity index IA greater than 53 and is optionally substituted with at least one group selected from the group consisting of aryl, hydroxy, carboxy, sulfo, sulfoalkyl, sulfoaryl, sulfonylalkyl, sulfonylaryl, annulated aryl, annulated heteroaryl, carboxyalkyl, carboxyaryl, oxoalkyl, oxoaryl, halogen, nitro, cyano and mercapto-alkyl groups; and a thermographic recording process therefor.Type: GrantFiled: March 27, 2002Date of Patent: July 6, 2004Assignee: AGFA-GevaertInventors: Johan Loccufier, Geert Defieuw, Ivan Hoogmartens
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Patent number: 6759368Abstract: A thermally imageable element can be imaged using heat alone without the need for photosensitivity or post-imaging processing. The element contains image-forming chemistry that comprises i) image precursor chemistry and ii) a catalyst or a catalyst precursor that upon imagewise heating is capable of promoting thermally induced image formation with the image precursor chemistry. The image-forming chemistry i) and ii) components are in reactive association and uniformly dispersed or dissolved within a binder in one or more layers of the element. Thus, the element is capable of being thermally addressed to provide a visible image as a result of thermally induced catalytic transformation of the image-forming chemistry.Type: GrantFiled: June 30, 2003Date of Patent: July 6, 2004Assignee: Eastman Kodak CompanyInventors: Mark Lelental, Henry J. Gysling, David F. Jennings
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Patent number: 6759369Abstract: Disclosed is a thermal dye transfer print bearing a protective overlayer comprising a polymeric binder containing dispersed heat expandable microspheres wherein the expandable microspheres have been selectively expanded in a predetermined pattern and a process for making same. The resulting prints bear a predetermined texture pattern in the protective overlayer.Type: GrantFiled: August 7, 2002Date of Patent: July 6, 2004Assignee: Eastman Kodak CompanyInventors: William H. Simpson, David A. Johnson, Cobb S. Goff, David E. Coons
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Patent number: 6759370Abstract: The presently claimed invention is directed to agricultural compositions which find primary use as a herbicide, through may also be used for pesticidal and fungicidal roles. The presently claimed invention comprises compositions combining monterpene compounds with fatty acid soaps. In particular monterpene alcohols are preferred as a primary phytoactive agent. Preferred embodiments are based on coniferous oils, such as pine oil, in combination with a tall oil reacted with an alkali to form a fatty acid soap. Preferred methods of application include spraying in a manner in which some foaming effect is observed, which appears to confer advantage over the spray application of monoterpene compounds alone.Type: GrantFiled: January 8, 2001Date of Patent: July 6, 2004Assignee: Organic Interceptor Products LimitedInventor: Rodney Mitchell Innes
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Patent number: 6759371Abstract: Herbicidal preparations which contain: (a) water; (b) a bromoxynil component; and (c) at least one compound corresponding to the general formula (I): RO—(C2H4O)n(C3H6O)m—R′ (I) wherein RO represents an alcohol moiety selected from the group consisting of C1-6 monohydric alcohols, and C2-12 polyols having from 2 to 6 hydroxyl groups; n represents a number of from 1 to 50; m represents a number of from 0 to 10; and wherein each R′ represents a substituent independently selected from the group consisting of hydrogen and an ester group of the general formula, —CO—R″, wherein each R″ independently represents an alkyl group having from 5 to 29 carbon atoms; with the proviso that at least one R′ represents —CO—R″, are described.Type: GrantFiled: December 2, 2002Date of Patent: July 6, 2004Assignee: Cognis Deutschland GmbH & Co. KGInventors: Horst-Werner Wollenweber, Hans-Georg Mainx, Benoit Abribat, Hans De Ruiter
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Patent number: 6759372Abstract: According to the invention there is provided a liquid friction control composition with enhanced retentivity comprising an anti-oxidant. The liquid friction control composition may also comprise other components such as a retentivity agent, a rheological control agent, a friction modifier, a lubricant, a wetting agent, a consistency modifier, and a preservative.Type: GrantFiled: April 12, 2002Date of Patent: July 6, 2004Assignee: Kelsan Technologies Corp.Inventor: John Cotter
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Patent number: 6759373Abstract: The present invention describes a refrigerating oil composition for a carbon dioxide refrigerant comprising a base oil composition which comprises (A) a polyoxyalkylene glycol having a kinematic viscosity of 3 to 50 mm2/s at 100° C. and at least one component selected from (B) a carbonate-based carbonyl derivative having a kinematic viscosity of 3 to 50 mm2/s at 100° C. and (C) a polyol ester having a kinematic viscosity of 3 to 50 mm2/s at 100° C., wherein an amount of (B) and/or (C) is 0.1 to 40% by weight of the total base oil composition. The composition exhibits sufficient antiwear, excellent lubricity and miscibility with carbon dioxide refrigerants and can be used for a long time with stability in the refrigerating cycle using a refrigerant comprising carbon dioxide in the supercritical condition of a high temperature and a high pressure as the main component.Type: GrantFiled: June 26, 2002Date of Patent: July 6, 2004Assignee: Idemitsu Kosan Co., Ltd.Inventor: Toshinori Tazaki
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Patent number: 6759374Abstract: The present invention provides a composition for cutting or abrasive working operations that comprises at least one lubricious additive and at least one hydrofluorocarbons. The present invention also provides a method for cutting or abrasive working.Type: GrantFiled: September 19, 2001Date of Patent: July 6, 2004Assignee: 3M Innovative Properties CompanyInventors: Dean S. Milbrath, Mark W. Grenfell
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Patent number: 6759375Abstract: A sump-lubricated internal combustion engine equipped with exhaust gas recycle, lubricated with (a) an oil of lubricating viscosity, (b) 0.05 to 1 percent by weight of an amide of an aliphatic carboxylic acid, and (c) at least one additional dispersant, detergent, or anti-wear agent, exhibits reduced temperature of the lubricant in the sump.Type: GrantFiled: May 23, 2002Date of Patent: July 6, 2004Assignee: The Lubrizol CorporationInventors: Thomas T. Curtis, Ewa A. Bardasz, Daniel H. Heath, Peter B. Thomson
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Patent number: 6759376Abstract: The invention relates to rinse-off personal care, liquid compositions comprising specifically defined particle wherein compositions also contain at least some hydrophobic benefit agent or emollient. The emollient allows particles to deposit and provide enhanced shine.Type: GrantFiled: September 11, 2002Date of Patent: July 6, 2004Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Xiaodong Zhang, Pravin Shah, Jennifer Chin
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Patent number: 6759377Abstract: A detergent for glass-ceramic surfaces has a certain abrasive agent content and a pH value lower than about 6. The abrasive agent contains particles of an organic material, preferably in an amount of at least about 20% of the abrasive agent, and more preferably substantially the entire abrasive agent. The organic material may be a polyolefin or polyurethane, for example, and may be predominantly present as particles with a particle size in the range of about 10 to 1000 &mgr;m. The abrasive agent may also include mineral particles.Type: GrantFiled: January 28, 2002Date of Patent: July 6, 2004Assignee: Reckitt Benckiser N.V.Inventors: Marion Hackenthal, Alexandra Hary, Mike Kosub, Edgar Endlein
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Patent number: 6759378Abstract: The present invention relates to an agent for the safe and environmentally friendly cleaning of components, for example from paint, lacquer, adhesive and rubber, in the absence of a negative effect on the components and the environment. The agent in accordance with the invention contains N-methyl 2-pyrrolidon with the addition of alkaline salt of unsaturated fatty acids and water.Type: GrantFiled: August 27, 2002Date of Patent: July 6, 2004Assignee: Stripp Chemicals ABInventors: Kjell Karlsson, Hans Magnusson
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Patent number: 6759379Abstract: The inclusion of one or more wrinkle reducing ingredients in a laundry detergent product is described. The benefits are delivered to the laundered item during the cleaning step and, therefore, reduces the need for further wrinkle reducing steps when the items are taken from the dryer or after hang drying.Type: GrantFiled: May 16, 2002Date of Patent: July 6, 2004Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Dennis Stephen Murphy, Daniel Fox
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Patent number: 6759380Abstract: A built laundry detergent composition contains a combination of anionic, nonionic and cationic surfactants which includes a highly ethoxylated nonionic surfactant which is a C8-C16 alcohol ethoxylated with an average of from 20 to 50 ethylene oxide groups. The cationic surfactant may advantageously be an ethoxylated quaternary ammonium compound. The composition exhibits improved oily soil detergency.Type: GrantFiled: September 12, 2003Date of Patent: July 6, 2004Assignee: Unilever Home & Personal Care USA division of Conopco, Inc.Inventors: Amrat Paul Singh, David Christopher Thorley
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Patent number: 6759381Abstract: Provided are azeotropic and azeotrope-like mixtures of 1-chloro-1,3,3,3-tetrafluoropropane and 1,2-dichloro-3,3,3-trifluoropropene that are useful as an intermediate in the production of HFC-245fa. HFC-245fa is useful as a nontoxic, zero ozone depleting fluorocarbon useful as solvents, blowing agents, refrigerants, cleaning agents, aerosol propellants, heat transfer media, gaseous dielectrics, fire extinguishing compositions and power cycle working fluids.Type: GrantFiled: May 6, 2003Date of Patent: July 6, 2004Assignee: Honeywell International Inc.Inventors: Robert C. Johnson, Daniel C. Merkel, Hsuehsung Tung
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Patent number: 6759382Abstract: The present invention relates to a novel super-concentrated, liquid detergent composition comprising a primary surfactant system, a secondary surfactant system, and water. In this composition, the primary surfactant system comprises at least one primary surfactant chosen from a linear alkyl benzene sulfonic acid, a linear alkyl benzene sulfonate, an &agr;-olefin sulfonate, an alcohol ether sulfate, an alkyl sulfate, and alkali metal, alkaline earth metal, amine and ammonium salts thereof, the secondary surfactant system comprises at least one secondary surfactant chosen from an alkyl polyglycoside and an &agr;-sulfomethyl ester, and the weight ratio of the at least one primary surfactant to the at least one secondary surfactant, based on the solids content of the detergent composition, is at least 3:1.Type: GrantFiled: June 1, 2001Date of Patent: July 6, 2004Assignee: Kay Chemical, Inc.Inventor: Fahim U. Ahmed
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Patent number: 6759383Abstract: The present invention relates to a biodegradable softener compounds with an acid value of no more than 6.5. A process for making said compound is also provided. The softener can be incorporated into softener compositions to form solid and liquid compositions, including liquid dispersions and clear compositions.Type: GrantFiled: December 19, 2002Date of Patent: July 6, 2004Assignee: The Procter & Gamble CompanyInventors: Hugo Jean-Marie Demeyere, Robert Otis Keys, Jans-Jürgen Köhle, Johan De Poortere, Errol Hoffman Wahl
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Patent number: 6759384Abstract: The invention provides compounds which specifically inhibit factor Xa activity having the structure A1—A2—(A3)m—B, where m is 0 or 1. A compound of the invention is characterized, in part, in that it exhibits a specific inhibition of factor Xa activity with a Ki≦100 &mgr;M, preferably ≦2 nM, and does not substantially inhibit the activity of other proteases involved in the coagulation cascade. The invention further provides methods of specifically inhibiting the activity of factor Xa and of inhibiting blood clotting in vitro and in an individual and methods of detecting factor Xa levels or activity.Type: GrantFiled: December 14, 1998Date of Patent: July 6, 2004Assignee: Aventis Pharmaceuticals Inc.Inventors: Fahad Al-Obeidi, Michal Lebl, James A. Ostrem, Pavel Safar, Alena Stierandova, Peter Strop, Armin Walser
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Patent number: 6759385Abstract: Isolated and purified peptides and variants thereof, useful to prevent or treat antibody-mediated diseases, or indications caused by an undesirable antibody response to a given antigen, are provided. Also provided are peptides and methods useful to prevent or treat indications associated with the use of viral vectors in gene replacement therapy. Further, a method to inhibit or prevent aberrant immune responses to exogenous, non-infectious antigen is provided.Type: GrantFiled: June 16, 2000Date of Patent: July 6, 2004Assignee: Regents of the University of MinnesotaInventor: Bianca M. Conti-Fine
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Patent number: 6759386Abstract: Disclosed herein is a rational, multi-tier approach to the administration of growth factor proteins in the treatment of heart disease. Also disclosed is a method to evaluate the effectiveness of the administration of growth factor proteins comprising the clinical assay of CPK-MB levels in a patient undergoing treatment with growth factor proteins. In addition, there is disclosed a method for treatment of heart disease comprising administration of a therapeutically effective amount of a growth factor protein by oral inhalation therapy.Type: GrantFiled: April 6, 2001Date of Patent: July 6, 2004Inventor: Wayne P. Franco
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Patent number: 6759387Abstract: This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length (SEQ ID NO:50).Type: GrantFiled: July 30, 2002Date of Patent: July 6, 2004Assignee: Cellgate, Inc.Inventors: Jonathan B. Rothbard, Paul A. Wender, P. Leo McGrane, Lalitha V. S. Sista, Thorsten A. Kirschberg
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Patent number: 6759388Abstract: Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages.Type: GrantFiled: April 29, 1999Date of Patent: July 6, 2004Assignee: Nanomimetics, Inc.Inventors: Roger E. Marchant, Tianhong Zhang, Yongxing Qiu, Mark A. Ruegsegger
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Patent number: 6759389Abstract: An isolated polynucleotide encoding motoneuronotrophic factor F6.Type: GrantFiled: June 12, 2000Date of Patent: July 6, 2004Assignee: Genervon Biopharmaceuticals LLCInventor: Raymond Ming Wah Chau
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Patent number: 6759390Abstract: Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. Preferred compounds of the invention are based on the substituted cyclitols, and in particular cyclitols linked to a sugar moiety where the molecule is substituted with a negatively charged group such as phosphate.Type: GrantFiled: March 2, 2001Date of Patent: July 6, 2004Inventors: Manuel Martin-Lomas, Thomas William Rademacher, Hugo Norberto Caro, Irene Francois
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Patent number: 6759392Abstract: Methods are described for the identification and preparation of nucleic acid ligand solutions to basic fibroblast growth factor (bFGF). Included in the invention are nucleic acid ligands to bFGF which are inhibitors of bFGF and 2′-amino-modified RNA ligands to bFGF.Type: GrantFiled: May 16, 1995Date of Patent: July 6, 2004Assignee: Gilead Sciences, Inc.Inventors: Nebojsa Janjic, Larry Gold
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Patent number: 6759393Abstract: The present invention relates to methods and compositions of growth hormone and/or growth hormone releasing hormone that promote of the release and the elevation of growth hormone when administered to animals. The present invention further relates to methods and compositions of growth hormone and/or growth hormone releasing hormone for treatment of diseases or disorders resulting from growth hormone related deficiencies. The invention also provides methods for producing novel growth hormone releasing hormone variants and their uses thereof.Type: GrantFiled: July 28, 2000Date of Patent: July 6, 2004Assignee: Pfizer Inc.Inventors: Mohamad A. Morsey, Michael G. Sheppard
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Patent number: 6759394Abstract: A novel gene therapy for cancer has been discovered, which unlike most prior appraches, does not require specific knowledge of the cancer cells, but instead targets a general characteristic that distinguishes cancer cells from normal cells, i.e., elevated eIF4E expression. The expression of a toxin or conditional toxin such as HTK is translationally repressed in normal cells by placing a complex 5′ UTR in front of its reading frame. In prototype experiments, this HTK mRNA, a transcriptional product of the BK-UTK vector, was translationally regulated so as to largely inhibit its production in normal murine and human cells, while cancer cells efficiently translated the protein, which a resulting increased sensitivity to GCV. Synthesis of the HTK protein from the BK-UTK vector (containing the 5′ UTR of Fibroblast growth factor −2 (“FGF-2”) readily occurred in a panel of murine and human breast carcinoma lines, but not in normal cell lines.Type: GrantFiled: July 26, 2001Date of Patent: July 6, 2004Assignee: Board of Supervisors of La. State Un. & Agricultural and Mechanical CollegeInventors: Arrigo DeBenedetti, Robert J. DeFatta
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Patent number: 6759395Abstract: The invention provides a novel soft gelatin capsule comprising a fill material consisting essentially of S-adenosylmethionine (SAMe) salt disposed within an enteric coated soft gelatin film.Type: GrantFiled: December 18, 2001Date of Patent: July 6, 2004Assignee: Orchid Chemicals & Pharmaceuticals, Ltd.Inventors: Canakapalli Bhaktavatsala Rao, Prasanta Kumar Chakrabarti, Hema Ravishankar
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Patent number: 6759396Abstract: A novel combination of one or more ligands with VDR receptor selective activity and one or more retinoids selective for RAR&ggr; receptors as opposed to RAR&agr; receptors is described, as well as the use thereof in cosmetic and skin-care applications for treating disorders related to a hyperproliferation of cells, in particular skin cells, such as psoriasis.Type: GrantFiled: July 11, 1997Date of Patent: July 6, 2004Assignee: Centre International de Recherches Dermatalogiques Galderma (C.I.R.D.) GaldermaInventors: Serge Michel, Veronique Dionisius-Pouget
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Patent number: 6759397Abstract: The invention provides for the use of ginsenoside Rh2 in pharmaceutical compositions used in methods of inhibiting the multiplication of cancer cells, and methods of treating cancer in patients, comprising administering to such patients therapeutically and synergistically effective amounts of Rh2 in combination with a chemotherapeutic selected from the group consisting of paclitaxel and mitoxantrone. The cancer cells to be treated may be multidrug resistant. The cancer cells may for example be prostate cancer cells or breast cancer cells.Type: GrantFiled: May 1, 2001Date of Patent: July 6, 2004Assignee: The University of British ColumbiaInventor: William Jia
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Patent number: 6759398Abstract: According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula (I), or a solvate thereof, together with a long-acting &bgr;2-adrenoreceptor agonist which formulation has a therapeutically useful effect in the treatment of inflammatory disorders of the respiratory tract over a period of 24 hours or more.Type: GrantFiled: February 4, 2002Date of Patent: July 6, 2004Assignee: SmithKline Beecham CorporationInventor: Keith Biggadike
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Patent number: 6759399Abstract: The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid activity sufficient to treat narcotic withdrawal symptoms.Type: GrantFiled: March 27, 2000Date of Patent: July 6, 2004Assignee: Aventis Pharma S.A.Inventors: Francis Petit, Daniel Philibert, Nick Goeders
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Patent number: 6759400Abstract: Certain compounds, structurally related to natural compounds which can be extracted i.a. from bull testes and from human follicular fluid, can be used for regulating the meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives. These compounds have the structural formula wherein the substituents are as defined in the specification.Type: GrantFiled: September 11, 2002Date of Patent: July 6, 2004Assignee: Novo Nordisk A/SInventors: Christian Grondahl, Frederik Christian Gronvald, Peter Faarup, Anthony Murray, Jan Lund Ottesen
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Patent number: 6759401Abstract: The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2—, —NH—, (ii) a C1-4-alkyl- or C1-6-acyl-substituted nitrogen atom or (iii) a C1-8-alkylene chain or a heteroalkylene chain having 2 to 8 chain atoms, which optionally contains at least one unsaturation, and which may be substituted and/or contain a bridge to form a saturated or partially or fully unsaturated ring having 3-8 ring members; B is —C(R4)(R5)—, —OC(R4)(R5)—, —N(R6)C(R4)(R5)—, —N(R6)—, —O—, —S— or —SO2—; R is optionally substituted C3-8-cycloalkyl, aryl or heteroaryl; R1 is (i) a saturated or unsaturated azacyclic or aminoazacyclic ring, or a saturated diazacyclic or aminodiazacyclic ring, which has 4 to 7 ring members, or a saturated aminoazabicyclic, azabicyclic or diazabicyclic ring which has 7 to 10 riType: GrantFiled: October 11, 2002Date of Patent: July 6, 2004Assignee: Biovitrum ABInventors: Björn Nilsson, Jan Tejbrant, Benjamin Pelcman, Erik Ringberg, Markus Thor, Jonas Nilsson, Mattias Jönsson
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Patent number: 6759402Abstract: The present invention relates to novel felbamate derivatives and their use to treat neurological diseases such as epilepsy and to treat tissue damage resulting form ischemic events. The felbamate derivatives are modified to prevent the formation of metabolites that are believed responsible for the toxicity associated with felbamate therapy.Type: GrantFiled: June 6, 2003Date of Patent: July 6, 2004Assignee: University of Virginia Patent FoundationInventors: Timothy L. Macdonald, Thomas A. Miller, Charles D. Thompson, Christine M. Dieckhaus