Abstract: A diagnostic imaging agent useful for selection of a therapy for cancerous bone metastasis is provided, which comprises 99mTc(V)-dimercaptosuccinic acid as an effective ingredient. The agent is administered to a patient, and a scintigram is taken. This is especially useful for identifying osteoclastic type or mixed type bone metastasis or for identifying a disease in which the bone resorption due to osteoclast is enhanced, and thus allows a proper selection of therapies for such diseases.

Abstract: Bronchodilating compositions and methods are provided. The compositions are intended for administration as a nebulized aerosol. In certain embodiments, the compositions contain formoterol, or a derivative thereof. Methods for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders using the compositions provided herein are also provided.

Abstract: The present invention relates to the delivery of compounds for the treatment of Parkinsons through an inhalation route. Specifically, it relates to aerosols containing antiparkinsonian drugs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antiparkinsonian drug. In a method aspect of the present invention, an antiparkinsonian drug is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antiparkinsonian drug to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal.

Abstract: The present invention relates to the delivery of physiologically active compounds through an inhalation route. Specifically, it relates to aerosols containing physiologically active compounds that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine. In a method aspect of the present invention, chlordiazepoxide, betahistine, clonidine, testosterone, conjugated estrogens, estrogen esters, estradiol, estradiol esters, ethinyl estradiol, ethinyl estradiol esters, or hyoscyamine is delivered to a mammal through an inhalation route.

Abstract: A non-flammable aerosol composition insectidal composition comprising 0.01 to 20 weight percent of one or more insecticides; 5 to 25 weight percent of one or more compounds selected from the group consisting of acetone, methyl ethyl ketone, and C1- to C8-alcohol; 5 to 30 weight percent of one or more compounds selected from the group consisting of hydrocarbon propellants, dimethyl ether, and 1,1-difluoroethane; and 60 to 90 weight percent of one or more non-combustible hydrofluorocarbons.

Abstract: A process for treating balding spots and a composition which when applied to areas of thinning or balding hair increases the width and visibility of the hairs within the thinning or balding area and thus obscures visibility of the scalp or skin underlying the hairs. A bonding agent helps make the spray more efficient in application, decreases undesirable overspray, and increases formula adherence to hair shafts.

Abstract: Food compositions, oral compositions and pharmaceutical compositions for preventing or treating periodontosis, the compositions comprising (A) one or more extracts containing natural polyphenol; and (B) one or more members selected from the group consisting of vitamin C, vitamin E, vitamin A and beta-carotene; and methods for preventing or treating periodontosis using the above compositions.

Abstract: The invention relates to agents with UV radiation-absorbing and/or reflecting action comprising solid, polymorphic, crystal-line or partially crystalline lipid and/or polymer particles, for application to the skin, mucous membranes, scalp, and hair for protection against health-damaging UV radiation and for strengthening the natural skin barrier.

Abstract: The use of hydroxystilbene compounds of formula wherein A is a radical of formula  or a radical of formula  and R1, R2, R3, R4 and R5 are each independently of the others hydrogen, halogen, hydroxy, C1-C16alkyl, C1-C16alkoxy, phenyl; C1-C3phenylalkyl; C6-C10aryloxy, amino, mono-C1-C5alkylamino, di-C1-C5alkylamino, or —NO2; as microbicidal active ingredients is described. The compounds exhibit a pronounced action against pathogenic gram-positive and gram-negative bacteria, and also against yeasts and moulds. They are therefore suitable for the antimicrobial treatment, especially the preservation and disinfection, of surfaces.

Abstract: Consumption of blue-green algae, or extracts thereof, enhances trafficking or homing of stem cells in animals by inducing a transient increase in the population of stem cells present in the animal's circulatory system. The animal may be healthy or suffering some disease or physiological condition.

Abstract: Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.

Abstract: Compositions and methods are provided that relate to a recombinant virus-based vector, e.g., a baculovirus-based vector, that allows the expression of an exogenous target protein in non-permissive cells (e.g., non-permissive insect cells or mammalian cells) in the absence of expression of a detectable selection marker. The vector includes a nucleic acid sequence encoding a detectable selection marker which is controlled by a promoter that is active in host cells used to screen for recombinant virus but is silent in the non-permissive cell used for expression of the exogenous target protein. The vector also includes an exogenous nucleic acid sequence encoding a target protein under the control of a promoter that is active in the non-permissive cell. This system allows the selection marker to be expressed during viral plaque screening, but not while the target protein is being produced.

Abstract: A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector molecule covalently joined to a second nucleic acid, wherein the second nucleic acid has a region of at least partial complementarity to the first nucleic acid, wherein the first nucleic acid is in a base pairing relationship with the second nucleic acid and the first or second effector molecules are proteins, polypeptides, lipids or sugars. The supramolecule may further have a third supramolecule component which includes a third effector molecule covalently joined to a third nucleic acid, wherein the third nucleic acid has a region of at least partial complementary to the first nucleic acid or the second nucleic acid and wherein the third nucleic acid is in a base pairing relationship with the second nucleic acid or the first nucleic acid.

Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

Abstract: This invention provides a method for treating a subject with glaucoma comprising the steps of administrating a compound or composition which antagonize, inhibits, inactivates, reduce, suppresses, antagonizes, and/or limits the release, synthesis, or production from cells of TNF-&agr; thereby treating the subject with glaucoma.

Abstract: The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.

Abstract: Isolated peptides, peptidomimetics, and antibodies which bind to the viral fusion protein binding domain of the RhoA protein or the RhoA binding domain of a viral fusion protein are useful for inhibiting infection in susceptible cells, in vitro and in vivo. Among these viruses are the Paramyxovirus respiratory syncytial virus (RSV) and the Lentivirus human immunodeficiency virus (HIV).

Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

Abstract: All Borrelia burgdorferi sensu lato isolates characterized to date have one or a combination of several major outer surface proteins (Osp). Mutants of B. burgdorferi lacking Osp proteins were selected with polyclonal or monoclonal antibodies at a frequency of 10−6 to 10−5. One mutant that lacked OspA, B, C and D was further characterized in the present study. It was distinguished from the OspA+B+ cells by its (i) auto-aggregation and slower growth rate, (ii) decreased plating efficiency on solid medium, (iii) serum- and complement-sensitivity, and (iv) diminished capacity to adhere to human umbilical vein endothelial cells. The Osp-less mutant was unable to evoke a detectable immune response after intradermal live cell immunization even though mutant survived in the skin the same duration as wild-type cells.

Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.

Abstract: A composition is disclosed which is suitable for the prevention and/or treatment of vasculopathic, cardiac, central and peripheral cerebral disturbances and for the prevention of learning disorders or disorders related to ageing, as well as for coping with increased energy requirements, and which may take the form of a dietary supplement or an actual medicine in its own right, containing the following as its characterising active ingredients: (a) propionyl L-carnitine or one of its pharmacologically acceptable salts; and (b) coenzyme Q10.

Abstract: The present invention relates to the cosmetic use, as a gelling agent, of at least one linear or cyclic polyorganosiloxane which comprises at least two organosiloxy units and at least two side and/or end groups each capable of forming at least one hydrogen bond with one or more partner groups. The invention also relates to a cosmetic composition comprising at least one such polyorganosiloxane in a cosmetically acceptable medium. This cosmetic composition is intended to be used for making up and/or caring for the skin, including the skin of the eyelids, and also for the lips and superficial body growths.

Abstract: The present invention is directed to ion-sensitive, water-dispersible polymers. The present invention is also directed to a method of making ion-sensitive, water-dispersible polymers and their applicability as binder compositions. The present invention is further directed to fiber-containing fabrics and webs comprising ion-sensitive, water-dispersible binder compositions and their applicability in water-dispersible personal care products.

Abstract: The present invention concerns a food composition comprising a foodstuff and substantially pure eritadenine. The invention also concerns a food additive comprising a liquid or solid-material intended to be added to a foodstuff, said material being supplemented with substantially pure eritadenine. Furthermore, the invention concerns methods for preparation of the food composition so as to provide a food composition having an increased level of eritadenine in comparison to the inherent eritadenine level of the foodstuff(s) included in the food composition.

Abstract: A transdermal therapeutic system (TTS), in particular a patch, is described, comprising: a detectable protective layer a pressure-sensitive adhesive reservoir layer and a backing layer with or without a coating of pressure-sensitive adhesive and featuring a unintentionally, preferably longitudinally, elastic material having an elasticity of at least 20%. The TTS is particularly suitable for use as a multi-day plaster, for the treatment, for instance, of pain or of drug dependency.

Abstract: The present invention is directed to a formulation comprising a lipid-regulating agent dissolved in at least one medium chain glycerol ester of a fatty acid as the primary solvent medium for said agent. One or more emulsifiers may be added to the formulation.

Abstract: The invention relates to a process for preparing a soft tablet capable of being chewed or disintegrated in the oral cavity. The tablet is prepared by forming a tablet having a friability of less than about 2% from a mixture comprising a pharmaceutically active ingredient, an excipient in the form of a hydrate, and a water-swellable excipient, and then applying sufficient energy, preferably in the form of heat, to the tablet for a sufficient time to decrease the hardness of the tablet by at least about 20%.

Abstract: Disclosed is an osmotic pharmaceutical delivery system comprising (a) a semi-permeable wall that maintains its integrity during pharmaceutical delivery and which has at least one passage therethrough; (b) a single, homogeneous composition within said wall, which composition consists essentially of (i) a pharmaceutically active agent, (ii) at least one non-swelling solubilizing agent which enhances the solubility of the pharmaceutically active agent; (iii) at least one non-swelling osmotic agent and (iv) a non-swelling wicking agent dispersed throughout the composition which enhances the surface area contact of the pharmaceutical agent with the incoming aqueous fluid.

Abstract: The present invention relates to novel compositions comprising microspheres and/or nanospheres containing condensed polyanionic bioactive agents, such as DNA. The polyanionic bioactive agent in the microspheres and/or nanospheres is preferably condensed using a polycationic condensing agent, such as poly-L-lysine. The present invention further relates to methods for producing the microspheres and/or nanospheres containing condensed polyanionic bioactive agents.

Abstract: An immunostimulating complex comprising one or more ganglosides, illustrated by the ganglosides GM2, GD2, GD3 or GT3, is useful as a prophylactic or therapeutic agent in the treatment of tumors, inter alia, especially melanomas.

Abstract: The present invention concerns a suspension of crystallized particles of an EPI-hNE protein, methods for preparing said suspension, a dry powder aerosol derived from said suspension, an inhalable pharmaceutical formulation comprising said suspension or said dry powder aerosol, and the use of said inhalable pharmaceutical formulation in the treatment of various pathological conditions.

Abstract: The present invention relates to compositions comprising various vitamins and minerals and methods for using these compositions for nutritional supplementation in, for example, pregnant or lactating subjects.

Abstract: The present invention is directed to frozen biocidal compositions. Specifically, the biocidal compositions comprise a frozen aqueous solution of a plurality of ions selected from the group consisting of halide and oxyhalide ions. The frozen biocidal compositions are useful in preserving or extending the shelf-life of perishable articles.

Abstract: The present invention relates generally to a composition for the treatment or prophylaxis of allergic and inflammatory reactions such as but not limited to Type I hypersensitivity reactions in mammals. More particularly, the present invention is directed to compositions comprising herbs or extracts of herbs or botanical or horticultural equivalents of the herbs or chemical or functional equivalents of the herbal extracts useful in the treatment or prophylaxis of allergic and inflammatory reactions such as but not limited to respiratory disorders. The present invention further contemplates a method of treating allergic and inflammatory reactions in mammals and in particular Type I hypersensitivity disorders and even more particularly respiratory disorders by the administration of a herbal composition or its chemical or functional equivalent.

Abstract: The invention relates to a composition for the curative and prophylactic treatment of obesity, comprising a catechol-rich extract of green tea, in particular containing from 20% to 50% by mass of catechols expressed as epigallocatechol gallate (EGCG).

Abstract: The invention relates to compositions and methods for preventing, treating, or managing sleeplessness, restlessness, weight gain including weight gain due to stress or lack of sleep, or all three comprising the administration of a prophylactically and therapeutically effective amount of Magnoliaceae plant or extracts thereof to a mammal in need of such therapy. Preferably the mammal is human and the compositions have comprise at least two compounds selected from magnolol, honokiol, and magnoflorine. Alternatively, the compositions may also comprise about 2% honokiol by weight of the composition.

Abstract: A method of supplying a ruminant with its nutritional requirements for methionine is provided wherein a hydroxy analogue of methionine that is available for absorption by a ruminant is administered to the ruminant. Preferably, the, ruminant is administered an isopropyl ester of a hydroxy analogue of methionine, wherein at least 40% of the isopropyl ester of the hydroxy analogue of methionine is available for absorption by the cow.

Abstract: A method of tenderizing pork comprising providing an amount of pork and treating the pork with a composition comprising an enzyme mixture consisting of bromelin, ficin and papain.

Abstract: A portable beverage system is provided for allowing consumers to combine one or more portions of beverage or other concentrates with a liquid to form a drink. The system includes an inner storage container for the portions and an outer container for mixing the portions with a liquid. The portions may contain beverage concentrates, soup flavorings and spices, or nutritional additives, such as herbs, vitamins, and minerals. Different portions may be provided with system, allowing consumers to make drinks customizable according to personal preferences. The portions may be provided in capsules, gelatin compositions, or other forms.

Abstract: Packaging container, packaged food and packaged feed, with the packaging container being produced by: preparing a hole-sealing sheet by providing, on a back surface of a base material whose bending strength (S) represented by the following formula (A) is no less than 0.20 m3/N, a pressure sensitive adhesive layer whose vertical peeling strength at 40° C., with respect to a surface of the gas-impermeable container, is in the range of 0.3-2 N/cm; and sealing a vent hole in the gas-impermeable container by the hole-sealing sheet. Packaged food and feed are obtained by enclosing food and feed in the packaging container. S=L/W(m3/N)  (A) wherein L: Critical length measured by a Clark degree testing machine (m) W: Weight per 1 m2 of the sheet base material (N/m2).

Abstract: A method and apparatus for monitoring a liquid undergoing anaerobic fermentation in a vessel is disclosed. The apparatus comprises an airlock containing a fluid for sealing the vessel and an electrical circuit operatively arranged to pass a current through the fluid to detect passage of bubbles through the airlock.

Abstract: A system and method for planning all of the operations in a kitchen on the basis of estimated sale data and actual sale outcome data (sale situation). The system and method provides workers with detailed instructions about each cooking operation, such as its starting and finishing time, so that fresh-cooked food product of a needed type may be supplied at a needed volume on an as needed basis through works as simple as possible by general workers of a minimum number in a simple fashion so as to satisfy the demand of customers or the demand for the product.

Abstract: The method includes eliminating the two side caps of the fruit, cutting the remaining portion into slices, optionally classifying by diameter the obtained slices, and finally peeling the slices. The device includes slice cutter (1) provided with two conveyor belts (2) to position the fruit, and blades (4 and 5), —transport equipment for the slices (102) with a diameter gauging device to classify the slices (102) by size, —a slice (102) turning machine and—a slice (102) peeling module to separate the flesh (103) from the pith (104).

Abstract: This invention seeks to provide an all-purpose food material which can be mixed in various kinds of foods, specifically in a cheese-like food in large quantities without limitation. The food material is produced by subjecting a processed cheese-like food to heating and melting treatment at at least 120° C.

Abstract: The present invention is directed to nutritionally superior cheese products and their methods of manufacture. More particularly, this invention is directed to the manufacture of nutritionally superior cheese products having at least two phases wherein at least one phase is cheese (e.g., process cheese, uncured natural cheese, cured natural cheese, and the like) and at least one phase is a second edible phase (e.g., a cheese different from the first phase, vegetables, meats, mixtures of vegetables and meats, fruit, nuts, and the like). The nutritionally superior cheese products of the present invention are prepared by co-extruding the two or more phases such that the use of adhesives or heat to bind the at least two phases is not required. Nutritional supplements (e.g., vitamins, calcium, minerals, and the like) can be incorporated into one or more of the at least two phases.

Abstract: The present invention relates to a soluble coffee beverage which closely assimilates the texture characteristics of an Italian espresso, namely a beverage with a fine crema, but which has a reduced bitterness compared with freshly brewed espresso but which nevertheless is strong in aroma. The soluble coffee beverage powder includes a soluble gas containing matrix that has between 10% and 35% soluble coffee solids by weight of the total dry matter of the matrix, from about 10% to about 35% pre-flocculated creamer by weight, and from about 12% to about 30% oligosaccharrides effective to dilute protein in the creamer by weight. The soluble beverage powder upon reconstitution with hot water provides a foamed upper surface based upon all of the ingredients, and in which the foamed upper layer substantially all of the foam is made up of bubbles having a diameter in the range of 0.05 to 0.5 mm. In another aspect, the invention relates to a process for making such a product.

Abstract: The purpose of the present invention is to extract oil from the soybean material containing soybean germ as a main component, and to utilize it. The present invention relates to a method for producing a soybean material, comprising crudely crushing selected soybeans into a size of less than ½, and separating and concentrating a soybean germ fraction by means of sieving, sorting with air, separation based on the grain shape and the like, to the soybean germ fraction produced by said method, to oil prepared form the soybean material containing soybean germ as a main component, to oil containing 0.8% by weight or more of sterols' content, and to foods containing said oil.

Abstract: The present process relates to forming of precooked egg patties for future heating within a microwave oven for consumption as a portion of a food article. The process involves the initial step of acquisition of liquid whole eggs, liquid egg whites and/or liquid egg yolks mixed with leavening ingredients (a mix of an acid and a base) to create an egg patty with improved texture and appearance for use within a breakfast sandwich following initial cooking. The following ingredients may be added to further improve the product: non-fat dry milk, modified food starch, gums, and emulsifiers. The process in summary involves adding to liquid eggs leavening ingredients or agents and then cooking of the mixed eggs and leavening ingredients prior to the dissipation of the leavening ingredients to form an egg patty having improved appearance and a light and airy texture.

Abstract: A jerky product resembling real meat jerky and methods of forming the same are provided. Generally, methods of forming jerky include providing an extruded dry material including a non-meat protein isolate and starch. The dry material is hydrated thereby forming a moist material which is then formed into an elongated body and dried to a moisture content of about 15-24% by weight. Smoke flavor may be added to the body by a smoking step or by the addition of an artificial smoke flavoring during the formulation thereof.

Abstract: A method of manufacturing an electronic device including a step of giving a droplet 12 of a liquid containing a formation material of a member that constitutes the electronic device to a plurality of portions on a substrate 1 while said substrate 1 and a droplet ejecting portion 7 are moved relatively in an in-surface direction of said substrate 1, wherein the droplet 12 is given while a position on a droplet given surface to which the droplet is given is corrected in accordance with the distribution of distances between the ejecting portion 7 and the droplet 12 given surface on the substrate which occurs when the substrate 1 and the ejecting portion 7 are relatively moved. Thereby forming the member constituting the electronic device accurately at the plural portion on the substrate 1, and thus forming plural electronic device of same charactoristics.