Abstract: A method for separation of molecular hydrogen from a gaseous mixture containing the molecular hydrogen, which method employs a dense mixed oxide ion/electronic/hydrogen atom conducting membrane or separator having a feed side and a permeate side that enables two mechanisms for hydrogen separation—ambi-polar conduction and hydrogen atom conduction. In this method, at least a portion of the molecular hydrogen is converted on the feed side of the membrane to hydrogen atoms, which hydrogen atoms are conducted through the membrane to the permeate side thereof where they are converted back to molecular hydrogen. The permeate side of the membrane is contacted with steam, forming water and/or steam on the feed side of the membrane and additional molecular hydrogen on the permeate side of the separator.

Abstract: A subject afflicted with a cancer or precancerous condition is treated by administering an agent that increases expression of somatostatin receptors, and a cytotoxic recognition ligand. In an alternative embodiment, somatostatin analogs, which are radiolabeled are used to treat cancer or precancerous conditions.

Abstract: Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of normal human tissues. The corresponding cancer-specific antigen or antigens with an apparent molecular weight of 40-52 130-200 kDa and polynucleotides encoding the antigen and the CDR regions of the antibody are also disclosed, as well as methods for diagnosis, prognosis and treatment of human breast cancer. The antibodies have tumor specificity and are useful for therapy, diagnosis, monitoring, detecting and imaging of cancers. The antibody-recognized cancer-specific surface antigens can serve as targets for detecting, diagnosing, inhibiting or killing cancer cells.

Abstract: This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.

Abstract: The present invention relates to endothelial cell-specific genes and encoded polypeptides and materials and uses thereof in the imaging, diagnosis and treatment of conditions involving the vascular endothelium.

Abstract: The present invention features stems cells from lungs, methods of isolating such stem cells, methods of diagnosing lung diseases, and method of treating lung diseases, including cancer, chronic obstructive pulmonary disease, cystic fibrosis, and emphysema.

Abstract: The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the present invention provides a newly identified complex between AM and a specific AM-binding protein 1 (AMBP-1); which has been isolated and identified herein as factor H (fH). The invention also provides AM/AMBP complexes, particularly AM/FH complexes, and antibodies specifically reactive with this complexes. Further provided are methods for identifying and purifying complexes of AM and an AM binding protein using anti-AM/fH antibodies, and methods for treating conditions such as cancer or diabetes utilizing compositions comprising these antibodies.

Abstract: Compositions and methods for treating, preventing and diagnosing Helicobacter infection are disclosed. The methods use proteins and/or nucleic acids derived from Helicobacter cerdo, a new pathogen isolated from swine. In addition, porcine models for studying bacterial gastritis and gastric and duodenal ulcer disease caused by Helicobacter pathogens, such as H. pylori and H. cerdo are described, as well as methods of identifying vaccines and compounds for treating and/or preventing Helicobacter infection using the animal models. Also described are methods of preventing Helicobacter infection in swine, such as infection caused by H. cerdo, using immunogenic proteins and nucleic acids derived from Helicobacter pathogens, such as H. pylori.

Abstract: Methods and compositions for detecting and localizing light from a subject are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the subject. Also disclosed are methods for locating a target in a subject, such as by detecting light emission from a target site.

Abstract: The invention relates to carbon-13 enriched fullerene and carbon nanotube (CNT) compositions for improved magnetic resonance imaging (“MRI”). The invention also relates to a dynamic nuclear polarization (DNP) method of MRI utilizing the carbon-13 enriched fullerene and CNTs of the invention.

Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

Abstract: Aerosol solution formulations for use in an aerosol inhaler include 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methyl ethyl]amino]ethyl]-2(1H)-quinolinone or a salt thereof, preferably the hydrochloride thereof, as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid and optionally by the use of a suitable can having part or all of its internal metallic surfaces lined with an inert organic coating.

Abstract: The use of calcium channel blockers administered intra-nasally to inhibit olfactory sensory perception to treat eating disorders, including obesity, is described. Also described is a method of reducing food intake in a subject by administering a pharmaceutical composition comprising an effective amount of a calcium channel blocker to the nasal mucosa, as well as screening methods for drugs to be used in treating obesity or associated disorders.

Abstract: The present invention provides a method of attenuating the formation or reducing the severity of neurogenic pain in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent to a portion of the surface of the skin in an amount and at a location sufficient to attenuate formation of or reduce the severity of neurogenic pain.

Abstract: The invention relates to new method of treatment of respiratory diseases, in particular the treatment of asthmatic children.

Abstract: The present invention provides a method of attenuating the formation or reducing the severity of swelling and/or inflammation in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent to a portion of the surface of the skin in an amount and at a location sufficient to attenuate formation of or reduce the severity of swelling and/or inflammation.

Abstract: The present invention provides a method of attenuating the formation or reducing the severity of neurogenic swelling and/or neurogenic inflammation in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric hydrophilic agent to a portion of the surface of the skin in an amount and at a location sufficient to attenuate formation of or reduce the severity of neurogenic swelling and/or neurogenic inflammation.

Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Abstract: The present invention includes a method for making a formulation for treating mucosal discontinuities, comprising: providing phenolic compounds and treating the purified phenolic compounds with sulfuric acid to make sulfonic acids and sulfonate salts. The present invention also includes formulations prepared by the method.

Abstract: Disclosed are oral compositions comprising a stannous ion source, a polyvalent cation source and a mineral surface active agent, said compositions providing enhanced therapeutic efficacy derived from stannous fluoride and/or other stannous salt, including antimicrobial effects, control of breath malodor, control of dental plaque growth and metabolism, reduced gingivitis, decreased progression to periodontal disease, reductions in dentinal hypersensitivity and reduced coronal and root dental caries. The aforementioned benefits are provided along with significant improvements compared to conventional stannous containing compositions, including: 1) reduced levels of dental staining; 2) reduced astringency thereby improving aesthetic characteristics of the compositions; 3) reduction in dental calculus formation, and 4) enhanced stability, bioavailability and thus, efficacy of stannous.

Abstract: A toothpowder oral care composition of fluoride ion source particulate (such as stannous fluoride particulate) dispersed in an oral calcium carbonate abrasive particulate bed is achieved with careful adjustment of the particle sizes of both the fluorinated particulate and the abrasive particulate to achieve a bed of toothpowder where neither the fluorinated particulate or the abrasive particulate will settle to create a localized concentration of the fluoride significantly different from the average concentration of the fluoride throughout the bed.

Abstract: The present invention relates to dibenzoylmethane-based compounds of formula 1, and also to salts or solvates thereof, and to the process for preparing them. The invention also relates to the use of a compound of formula (I) as an agent for protecting the skin or the hair against UV radiation and to a cosmetic and/or dermatological product, characterized in that it comprises a compound of formula (I) as active principle.

Abstract: The invention relates to a method of producing powdered preparations comprising 2,4,6-trianilino-p-carbo-2?-ethylhexyl-1?-oxy)-1,3,5-triazine of formula I by the method comprising: a) dispersing the triazine of formula I in an aqueous molecularly disperse or colloidally disperse solution of a protective colloid and b) converting the dispersion obtained into a dry powder by removing the water and and drying, wherein the protective colloid used in process step a) is modified starch.

Abstract: A kit for application of self-tanning preparations includes a self-tanning composition and an application glove for applying the composition to the skin which is constructed from fabric including microfibers of 1 denier or less. The inner surface of the glove has a liner of an impermeable flexible material adhered thereto. The microfiber fabric can be knit or woven, and can be cellulosic fiber, polyester or other synthetic fiber, or a combination of mechanical or intimate blends. In a preferred embodiment, the microfiber fabric is 85% polyester and 15% spandex, with the technical front including polyester microfiber yarn of 1 denier or less. The technical front of the fabric forms the application surface of the glove. The kit can include a cleansing/exfoliating composition, at least one disposable plastic glove for handling the application glove after use, a disposable tray for receiving the glove after use and a moisturizing preparation for the skin.

Abstract: The composition comprises of a component A selected from a hydroxylated derivative of benzoic acid or of cinamic acid, their esters, amides or salts, a glycoside of a hexose, and their mixtures; and a component B selected from quinic acid, shikimic acid, their alkaline metal or alkaline earth salts, their methyl esters, and mixtures of the same. This composition is suitable for protecting the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms. For application in the field of dermatology and nutrition, and, in particular, in the photoprotection of the skin and mucosa, photo-ageing and photocarcinogenesis, including protection of the immune system associated with the skin.

Abstract: A nail varnish composition containing, in a cosmetically acceptable medium comprising an organic solvent medium, at least 0.1% of at least one polymer that is soluble in the organic solvent medium, the polymer containing at least one polyoxyalkylene chain in its main chain or in the form of a graft, and at least one gelling agent. The invention also relates to the use of such a composition to obtain a glossy film with good staying power when deposited on the nails.

Abstract: Nail varnish composition containing, in a cosmetically acceptable medium comprising an organic solvent medium, at least one block copolymer of formula (I) and at least one gelling agent. The invention also relates to a nail varnish composition containing at least one copolymer comprising at least one polyethylene glycol block and at least one polypropylene glycol block and at least one gelling agent. The invention further relates to the use of such compositions to obtain a glossy film with good staying power when deposited on the nails.

Abstract: A method of manufacturing a decorative appliqué and the appliqué itself are disclosed. At least two formulations of high viscosity decorative liquid such as liquid nail enamel are provided and heated. A layer of pressure-sensitive adhesive material is applied onto a substrate, and a layer of the formulations are applied adjacent each other atop the layer of adhesive material on the substrate. The two formulations are preferably of different colors and are preferably confined to separate portions of the appliqué. In one fingernail-shaped embodiment, a small crescent-shaped section contains one formulation, and the remainder contains another formulation. A score or perforation is made between the two sections to facilitate application as a “French manicure”. Double-ended of such appliqués are preferably provided with side handling tabs to facilitate handling of the appliqués and enable use of both ends of the same appliqué.

Abstract: Disclosed are compositions for application to skin, comprising hydroquinone or a derivative thereof, and a cosmetically acceptable vehicle comprising an effective amount of absolute ethanol or an effective amount of an ethanol composition comprising ethanol and methyl alcohol or isopropyl alcohol as a denaturant. Also disclosed are methods of whitening skin and reducing discoloration of hydroquinone compositions.

Abstract: The present invention relates to a cosmetic kit for depigmenting human skin comprising a multi-unit receptacle containing a first unit containing a microdermabrasion composition; a second unit containing a skin depigmenting composition; a third unit containing ascorbic acid in powder form; a fourth unit containing a skin soothing composition; optionally, a fifth unit containing a maintenance composition, and optionally a sixth unit containing a photoprotective composition. The present invention also relates to a method for treating human skin in need of depigmentation comprising the successive application, to an area of skin, of the compositions contained in the multi-unit receptacle.

Abstract: Disclosed are compositions for application to skin, comprising hydroquinone or a derivative thereof, a stabilizer selected from the group consisting of tetraphthalylidene dicamphor sulfonic acid (Mexoryl SX) and benzophenone-4, and a cosmetically acceptable vehicle. Also disclosed are methods of whitening skin, and methods of reducing discoloration of compositions containing hydroquinone.

Abstract: Disclosed are cosmetic compositions for application to the lips, comprising a cosmetically acceptable metal salt of stearic acid, aluminum starch octenyl succinate, an oil and a structuring agent, and methods for making and using them.

Abstract: Disclosed are liquid lipgloss compositions comprising an oil, a wax and aluminum starch octenyl succinate, and methods of making and using them.

Abstract: A clear gel emulsion antiperspirant or deodorant composition comprising at least one antiperspirant or deodorant active, a water phase, and an oil phase containing at least one high refractive index oil, wherein the composition is prepared from an oil phase and a water phase that, prior to emulsification, are both optically clear; a clear gel emulsion antiperspirant or deodorant composition containing at least one polymeric alpha olefin in the oil phase; and a method for improving the clarity of a clear gel emulsion antiperspirant or deodorant composition.

Abstract: Disclosed are cosmetic compositions comprising a film forming polyurethane and a film forming (meth)acrylate copolymer, and a cosmetically acceptable carrier, and methods of making and using them.

Abstract: Disclosed are cosmetic compositions containing xanthan gum and a non-gelling polysaccharide, and methods of making and using same.

Abstract: A stabilized pharmaceutical and cosmetic composition of catechins is disclosed. The pharmaceutical composition includes antioxidants, metal chelating agents, catechins or derivatives, and water. The pharmaceutical composition disclosed here can inhibit the oxidation of the catechins and derivatives thereof, and therefore extend the shelf life of the pharmaceutical composition of catechins and increase the medical application of the compostions.

Abstract: A polymer that includes at least one monomeric unit having a pendant substituent group according to formula (II): wherein: R1 is H, chloro, bromo, alkyl, hydroxyalkyl, aryl, or aralkyl, R2 and R3 are each independently H, alkyl, hydroxyalkyl, aryl, aralkyl, uriedo, or carboxyalkylene, R4 is alkylene or R5, R7, and R10 are each independently alkylene, R6, R8, and R9 are each independently H or alkyl, A is O or N—R11, provided if A is O and R4 is methylene, then R1 cannot be H, chloro, or bromo, R11 is H or alkyl, and X? is an anion, is useful in personal care application, such as hair stying compositions.

Abstract: A cosmetic kit for treating human skin comprising a multi-unit receptacle containing: (a) at least one unit containing a skin preparatory composition containing at least one skin peeling agent; (b) at least one unit containing a keratolytic composition containing at least one anti-acne agent; (c) at least one unit containing a skin soothing composition; (d) optionally, at least one unit containing a maintenance composition having at least one agent chosen from a skin peeling agent and an anti-acne agent; (e) optionally, at least one unit containing a photoprotective composition.

Abstract: The present invention provides a germicidal antiseptic composition for dilution, which is superior in preparation stability, and free of formation of insoluble precipitation even when diluted with water containing an inorganic ion (e.g., tap water etc) when in use, thereby retaining superior germicidal disinfection ability. The present invention relates to a germicidal antiseptic composition for dilution, which is an aqueous liquid comprising chlorhexidine gluconate as a main ingredient, (1) 1-10 w/v % of chlorhexidine gluconate; (2) 1-10 w/v % of one or more selected from the group consisting of a polyoxyethylene alkyl ether and a polyoxyethylene alkenyl ether, each having an HLB of 10-15 and a congeal point of not more than 35° C.; (3) 0.001-0.5 w/v % of a water-soluble organic monocarboxylic acid having 2 to 6 carbon atoms; and (4) water.

Abstract: A cosmetic kit for treating human skin comprising a multi-unit receptacle containing: (a) a unit containing a microdermabrasion composition having at least one type of skin abrading particle; (b) a unit containing a peeling composition having at least one skin peeling agent; (c) a unit containing an anti-ageing composition having at least one anti-ageing ingredient; (d) a unit containing a skin soothing composition having at least one skin soothing ingredient; (e) optionally, a unit containing a maintenance composition; and (f) optionally, a unit containing a photoprotective composition.

Abstract: A composition for reducing the appearance of cellulite is provided that comprises guarana extract and vitamin K. In addition, a method of treating cellulite with a topical composition comprising guarana extract and vitamin K is provided.

Abstract: Skin care compositions containing xanthones extracted from plants are described. These compositions include lotions, creams, ointments, and the like that reduce wrinkles, give skin a more youthful appearance, provide antioxidant effects, protect the skin, and moisturize the skin. The compositions contain an admixture of a base and a xanthone-containing plant extract.

Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

Abstract: Methods of treating diseases such as diabetes are disclosed. Methods of modulating elevated fructosamine levels, elevated HbA1c levels, impaired glucose tolerance, and impaired fasting glucose are also disclosed. In some embodiments, methods include co-administration of a bile acid sequestrant and two or more additional compounds selected from the group consisting of a biguanide, a sulfonylurea and insulin, or pharmaceutically acceptable salts thereof. Drug products including a bile acid sequestrant and two or more additional compounds selected from the group consisting of a biguanide, a sulfonylurea and insulin, or pharmaceutically acceptable salts thereof, in combination are also disclosed.

Abstract: Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.

Abstract: A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.

Abstract: Provided herein are water-soluble polymer conjugates and polymer-based compositions of non-steroidal anti-inflammatory drugs. Also provided are methods for synthesizing and administering such conjugates and compositions.

Abstract: Methods of treating or preventing eye disease in a subject, involving administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a polypeptide having a vascular endothelial targeting amino acid sequence and a cytotoxic amino acid sequence are disclosed. For example, the vascular endothelial targeting amino acid sequence may be a VEGF sequence, such as a VEGF121 sequence. Exemplary cytotoxic amino acid sequences include toxin sequences, such as gelonin, pro-apoptotic sequences, and anti-angiogenic sequences. The eye disease may be any eye disease, such as an eye disease associated with choroidal neovascularization, retinal neovascularization, iris neovascularization, or corneal neovascularization.

Abstract: The present invention provides compositions and methods of immunotherapy to treat cancer or other antigen-producing diseases or lesions. According to one embodiment of the invention, a composition is provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion, the composition comprising an effective amount of a cytokine mixture, preferably comprising IL-1, IL-2, IL-6, IL-8, IFN-? (gamma) and TNF-? (alpha). The cytokine mixture acts as an adjuvant with the antigen associated with the antigen-producing disease or lesion to enhance the immune response of the patient to the antigen. Methods are therefore also provided for eliciting an immune response to at least one antigen in a patient having an antigen-producing disease or lesion utilizing the cytokine mixture of the invention. The compositions and methods are useful in the treatment of antigen-producing diseases such as cancer, infectious diseases or persistent lesions.