Abstract: A method for treating advanced epithelial ovarian cancer patients who attain a clinically-defined complete response after initial platinum/paclitaxel-based chemotherapy is described. The method involves administering a chemotherapeutic agent, such as doxorubicin, entrapped in liposomes.

Abstract: Cationic liposome encapsulated antimonial drugs formulations are provided. The drug-loaded liposome have enhanced efficacy as antileismanial agents and provide improved therapeutic index as compared to the minimal dose of free drug.

Abstract: Stable tablets and pharmaceutical compositions in particulate form comprising a fibrate, for example fenofibrate, dissolved or dispersed in an non-aqueous vehicle with improved bioavailability, thereby eliminating the food effect so that the tablet or composition can be administered to a patient irrespective of being in fed or fasted state.

Abstract: The present invention is a composition for coating comprising a wet-milled product obtained by suspending low-substituted cellulose ether having a molar substitution of from 0.05 to 1.0 per anhydrous glucose unit in water and then applying a shear force to the aqueous dispersion. The present invention is also a coated preparation prepared using the composition for coating so as to mask an unpleasant taste and to control a sticky or slimy feel by administration.

Abstract: Oral solid dosage forms having holographic markings or identification marks such as a watermark thereon and methods of preparing the same are disclosed. One preferred method of applying an identification mark on a pharmaceutical dosage form described herein includes applying a film coating having a first color to an oral solid dosage form such as a tabet and thereafter applying an identification mark to the film coated oral solid dosage form using an ink which not only contains a pearlescent pigment therein but also has a second color which is substantially similar in color to the first color used for film coating.

Abstract: The present invention relates to solid, modified-release pharmaceutical dosage forms which can be administered orally and comprise 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, and process for their production, their use as medicaments, their use for the prophylaxis, secondary prophylaxis and/or treatment of disorders, and their use for producing a medicament for the prophylaxis, secondary prophylaxis and/or treatment of disorders.

Abstract: A solid orally ingested delivery system having at least one lipid, dry particles including at least one pharmaceutical, and at least one filler, where the dry particles are continuously coated by the lipid and form a homogeneous suspension with the lipid, and at least part of the pharmaceutical is microencapsulated with a polymer that releases in the pH range of about 5.0 to 7.0.

Abstract: Disclosed are dosage forms including a controlled release dosing structure; and a liquid formulation contained within the controlled release dosing structure; wherein the liquid formulation comprises a benzisoxazole derivative and a liquid carrier. Also disclosed are methods of making and using such dosage forms.

Abstract: The present invention provides a dosage form that prevents misuse of the medicament contained within. The dosage form contains an inactivating substance in combination with the medicament, wherein the two substances are separated by a permeable or semi-permeable partition. The partition becomes impermeable upon activation by a medical professional, thereby effectively sequestering the inactivating substance from the medicament and allowing for the intended administration of the medicament to the patient. Unless activated, however, the inactivating substance and medicament remain commingled in the dosage form, and any attempt to dispense the medicament before activation will result in the release of inactivated medicament.

Abstract: The invention provides a three-dimensional construct including a polymeric matrix and a nanoparticle as shown in FIG. 1 having a diameter of about 5 nm to about 10 microns, wherein the nanoparticle is (a) coated with at least two monomolecular layers each carrying biological information and (b) dispersed in the polymeric matrix at a density of at least 0.01 vol %. The invention further provides a method of presenting biological information to a cell or a tissue and thereby affecting at least one parameter of the cell or the tissue, the method involves providing the three-dimensional construct and contacting it with the cell or the tissue to present the biological information and thereby affecting at least one characteristic of the cell or the tissue. In certain embodiments, the diameter, the biological information and the density are selected to affect at least one characteristic of the cell or the tissue.

Abstract: The present invention provides a process for making cross-linked polysaccharide gels under basic conditions. More particularly, the present invention provides a process for forming cross-linked hyaluronic acid gels under basic conditions. The resulting gels possess improved degradation characteristics, and are useful in a variety of medical and cosmetic applications.

Abstract: The present invention concerns oral dosage formulations of sparingly to very slightly water soluble proton pump inhibitors, the oral dosage forms so made, and methods of use thereof. The oral dosage form has a core tablet of compressed particles composed of powder particles of a pharmaceutically acceptable material, having coated thereon admixture of a sparingly to very slightly water soluble magnesium salt of a benzimidazole proton pump inhibitor; and a hydrophilic polymer having a surfactant functionality that increases the water solubility of the magnesium salt of the benzimidazole proton pump inhibitor. The coated core tablet has a pharmaceutically acceptable sub-coating on the core tablet; and a pharmaceutically acceptable enteric coating on the sub-coating. The coated tablet may provide enhanced absorption when administered orally.

Abstract: Benzoquinone compositions of enhanced solubility and bioavailability are described that contain at least one benzoquinone with at least one solubility-enhancing polymer. In one embodiment, the benzoquinone is coenzyme Q1O. Described methods to produce the bioenhanced products comprise dry blending and solvent spray drying. One aspect of the method includes the steps of providing a mixture comprising benzoquinone, a solubility-enhancing polymer and a solvent and removing the solvent to form amorphous benzoquinone. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.

Abstract: Efavirenz compositions of enhanced bioavailability are described that contain efavirenz with at least one solubility-enhancing polymer. Described methods to produce the bioenhanced products comprise solvent spray drying. One aspect of the method includes the steps of providing a mixture comprising efavirenz, a solubility-enhancing polymer and a single solvent, a solvent blend or solvent/non-solvent blend removing and then evaporating the mixture to form amorphous efavirenz.

Abstract: A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.

Abstract: Gelled donepezil compositions and methods for making and using the same are provided. The subject compositions include a donepezil active agent in a gelled oral pharmaceutically acceptable vehicle comprising an emulsion of water and oil. Also provided are kits of the subject compositions.

Abstract: T cell immune responses are enhanced by presentation of antigen to CD8+ T cells using a chimeric nucleic acid immunogen or vaccine that links DNA encoding an antigen with DNA encoding a polypeptide that targets or translocates the antigenic polypeptide to which it is fused (immunogenicity-potentiating polypeptides or “IPP”). By inhibiting apoptosis in the vicinity of a T cell responses to such a nucleic acid immunogen, even more potent immune responses are attained. The present strategy prolongs the survival of DNA-transduced cells, including dendritic cells (DCs), thereby enhancing the priming of antigen-specific T cells and increase potency.

Abstract: The invention relates to a method of producing dosage units of a solid drug form containing as the active substance warfarin sodium salt in an amount of 1 to 10 mg and having high degree of content uniformity satisfying the Bergum criterion, wherein an aqueous solution of warfarin sodium salt and/or its clathrate which optionally contains in the dissolved state one of the pharmaceutically acceptable excipients co-forming the solid drug form to be prepared but not all the pharmaceutically acceptable excipients co-forming the solid drug form to be prepared, is brought into contact with solid particles of at least one pharmaceutically acceptable excipient co-forming the solid drug form to be prepared, whereupon optionally the particles are dried and optionally mixed with a required amount of solid particles of the remaining pharmaceutically acceptable excipients co-forming the solid drug form to be prepared, and the thus-obtained particulate mixture is formulated into dosage units of the solid drug form.

Abstract: A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.

Abstract: Provided are methods of increasing KATP channel activity in the hypothalamus of a mammal, methods of reducing glucose production in a mammal, methods of reducing peripheral glucose levels in a mammal, methods of reducing triglyceride levels in a mammal, methods of reducing very low density lipoprotein (VLDL) levels in a mammal, methods of methods of reducing gluconeogenesis in the liver of a mammal, methods of treating metabolic disorders such as diabetes, hyperglycemia, insulin resistance, glucose intolerance, metabolic syndrome and/or obesity, and methods of increasing glucose production and peripheral glucose levels in a mammal. Also provided are methods of treating heart failure, ischemia, coronary heart disease, familial lipoprotein lipase deficiency, hypopituitarism, hyperlipidemia, hypertriglyceridemia, hyperVLDLemia, atherosclerosis, hypercholesterolemia, hypertension, polycystic ovary syndrome, gonadotropin deficiency and/or amenorrhea.

Abstract: Disclosed herein is a manufacturing process for the preparation of tigecycline suitable for intravenous infusion.

Abstract: Microparticles comprising or consisting of a therapeutic agent having a particle density of at least 80% of the solid agent and a shape factor of 1 to 5. The microparticles may be produced by spray drying and may be used in needleless injection.

Abstract: The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 ?m and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents.

Abstract: A method for preparing solid materials is described. One aspect of the method includes the steps of providing a mixture comprising an organic material in a blend of a solvent and non-solvent for the organic material, distributing the mixture into either droplets or granules, and evaporating the solvent and non-solvent mixture to form particles having an average size of from about 0.5 ?m to about 5000 ?m.

Abstract: An isolated extract of deer velvet which contains components which have molecular weights that are substantially less than or equal to 10 kDa and which have a proliferative effect on endothelial cells and/or promote angiogenesis.

Abstract: An antimicrobial and antiviral barrier composition for topical application to the proximal anterior nares includes an antiseptic solution in combination with cocos nucifera (coconut oil) and one or more citrus oils such as, for example, citrus sinensis (orange oil). Various embodiments may also include one or more of the following additional ingredients: lauric acid; d-limonene; soy oil; emu oil; grapefruit seed extract; glycine soja; aloe vera and a preservative, such as sodium benzoate.

Abstract: The present invention relates to method for the isolation of at least one biologically active substance from an industrial dairy by-product or waste flow, comprising—selecting at least one industrial dairy waste or by-product flow containing at least one biologically active substance;—bringing the at least one industrial dairy waste or by-product flow into contact with at least one solid insoluble support material for sufficient time to cause the at least one biologically active substance to selectively adsorb on said support material;—recovering the insoluble solid support material carrying the adsorbed at least one biologically active substance.

Abstract: An antiviral agent is provided which is effective in treating coronaviruses and can be formed into various products whose efficacy sustainability is promising. In particular, the present invention provides an antiviral agent which is effective in treating a coronavirus, comprising a silver ion carrier; a product capable of inactivating a coronavirus, comprising the same; and a method of inactivating a coronavirus. The silver ion carrier is at least one selected from a compound represented by the following formula (1), potassium titanate, potassium uranate, potassium vanadate, potassium niobate, sodium tangustate, magnesium molybdate, calcium pentaborate, aluminosilicate, aluminum phosphate, nickel hexacyanoferrate, sepiolite, montmorillonite, silica gel, zeolite, ?-alumina, titanium oxide hydrate, hydroxyapatite and a glassy carrier. AgaAbM2c(PO4)d.

Abstract: An antidiabetic composition embodied in the form of a powder extracted from hardened antlers. The powdered extract contains 0.5 ng of insulin and insulin-like growth factor-I in the quantity of 18 ng per 1 g of the composition.

Abstract: The present invention is to provide a touch screen having a bacteria inhibition layer for prohibiting bacteria from growing thereon and a method for manufacturing the same comprising uniformly dispersing particles of nano metal material in a solution to be applied to a surface treatment so that the solution can have a concentration of 20 ppm to 500 ppm; evenly spray coating the solution on a screen of the touch screen; and subjecting the solution coated on the screen of the touch screen to a heat treatment until solvent in the solution is completely evaporated so that the particles of the nano metal material are densely adhered to the screen of the touch screen to form a bacteria inhibition layer thereon.

Abstract: The present invention is of a method for reducing activity of inflammatory immune cells by exposure to selenium. Particularly, the invention relates to a method of short-term, high dose dietary selenium supplementation for treating a subject having an inflammatory disease, particularly inflammatory bowel disease (IBD). An article of manufacture comprising a pharmaceutical composition providing a therapeutic selenium unit dosage suitable for the method of the present invention is also provided.

Abstract: A method of orally administering jojoba for fat reduction, blood lipid reduction, and cancer prevention and treatment in humans is disclosed. The method incorporates a sufficient quantity of jojoba, defatted jojoba meal, jojoba extract, defatted jojoba meal extract, naturally derived or synthesized simmondsin, or any naturally derived or synthesized simmondsin derivative or analogue, including aglycon, or any mixture thereof into an individual's diet in the form of a food, dietary supplement, or drug to provide simmondsin component in an amount greater than 0.01% of one's total daily diet by weight, or 0.05 gram/day. The dosage amount and duration of the administration can vary to achieve and maintain one's desired body composition and blood lipid levels. The dosage and duration of administration are increased for cancer prevention and treatment.

Abstract: A method for the extraction of pharmacologically active components from the oleander plant using supercritical carbon dioxide and combining the extraction with other isolation methods. The extraction is carried out using carbon dioxide at supercritical conditions, with or without the addition of a modifier. The isolated product is recovered in higher yield than with traditional hot water extraction.

Abstract: An apparatus and method in a portable electronic device for slowing down a spinning device to provide power to a system or charge a battery. The apparatus includes a spinning device coupled to a boost device and at least one switch. The boost device may boost a voltage generated by slowing down the spinning device to power a system or charge a battery. The apparatus and method may decrease the demand on the battery of a portable device and may lengthen the time that the portable device may operate independent of an outside power source.

Abstract: A gas directing/exhausting structure for use is an injection-molding system including a mold, a mold cavity and a channel. The gas directing/exhausting structure includes a head part and a rod body. The head part is accommodated within the channel and having a flat surface aligned with an edge of the channel. The head part has a first circumscribed radius. A first gas-flowing space is formed between the head part and the channel. The rod body is connected to the head part and partially accommodated within the channel. The rod body is substantially polygonal in shape but the intersect portion of every two adjacent edge surfaces has a corner rim. The rod body has a second circumscribed radius greater than the first circumscribed radius. The second gas-flowing space is formed between the rod body and the channel.

Abstract: The invention relates to the extrusion of filamentary strands of reconstituted tobacco through a die plate and the downstream handling thereof. The die plate is configured such that each filament is of a square or rectangular cross-section, the downstream handling of which effects draw down of the extruded filament.

Abstract: The invention provides an injection molding capable of adjusting a detection level with a simple structure and detecting a deposit level of the resin pellets near a plasticizing screw. A cooling jacket is mounted so that a resin supplying hole of the cooling jacket communicates with a resin supplying hole of a heating cylinder. A sensor head mounted on a sensor mounting plate is inserted into the resin supplying hole through a sensor insertion port provided on a hopper plate and a resin inlet and detects the deposit level of the resin pellets deposited in the resin supplying hole. Changing the extent of insertion of the sensor head enables the resin pellets deposit detection level to be changed, and further, enables the deposit level near the outer periphery of the screw to be detected. Setting the sensor detection direction perpendicular to the resin deposit direction enables dirtying of the sensor detection surface by the resin pellets to be reduced, thus enabling erroneous detection readings to be reduced.

Abstract: A cover for an opening of an ejector housing of a mold assembly comprises a cover portion and a mounting portion, the mounting portion is attached to a member defining the ejector housing at a side thereof comprising an interior wall of the ejector housing and the cover portion covering the opening defined by the ends of the members surrounding the ejector housing. The cover is attached to a side of the member by at least one fastener located so as not to be accessible for removing the housing cover as the mold assembly is mounted in a machine. A mold assembly comprises a cover in accordance with the invention. The cover advantageously comprising at least one opening therethrough to permit guarded examination of components of an ejector device within the ejector housing and viewable from the end of the ejector housing at which the cover is attached.

Abstract: A moulding device for the production of containers in thermoplastic material, by blowing or blow-drawing, including a mould with two mould halves mutually mobile and provided with a locking device with two lock elements extending over the total height of the respective mould halves and provided with a number of projecting fingers in catches spaced at intervals, one lock element being fixed on one mould half and the other lock element sliding on the other mould half under the action of an actuator device.

Abstract: A powder sinter layered manufacturing apparatus is provided with a first container 13 of a cylindrical shape for defining a first manufacturing region, a first manufacturing table 15 configured to move vertically along an inner wall of the first container 13, a second container 17 of the cylindrical shape for defining a second manufacturing region within the first manufacturing region, detachably fitted to the first container easily, and provided with a flange which covers an upper face located outside the second manufacturing region but inside first container 13, and a second manufacturing table 15b configured to move vertically up and down along an inner wall of the second container 17.

Abstract: Disclosed herein is a hot tool which machines a workpiece made of foam material. The hot tool of the present invention includes a motor, a rotary unit which is coupled to the motor, and an electrode terminal which is connected to an outside power supply and contacts an electrode of the rotary unit. The hot tool further includes a heating body which is coupled to the rotary unit so that the heating body is heated by electric current supplied through the electrode terminal, with a spiral groove formed in a circumferential outer surface of the heating body. The hot tool further includes a polymer storage case which is provided at an upper position on the circumferential outer surface of the heating body, so that molten polymer that moves along the spiral groove is stored in the polymer storage case. Therefore, the hot tool of the present invention has increased machining accuracy and prevents a workshop from becoming messy due to molten polymer.

Abstract: The slit mechanism of an image recording apparatus includes slitter units, each including a pair of slitters, for slitting margins on a periphery of each of one or more images recorded on an image recording medium side by side along a width direction in a conveying direction by utilizing a conveying force of the recording medium, a guide unit for guiding a scrap that is cut off when the recording medium is slit by a slitter of the slitter unit and a slitter moving unit for moving the slitter and the guide unit in synchronization in the width direction of the recording medium between a slitting position at which the recording medium is slit into a predetermined width corresponding to the predetermined print size and a position outside the recording medium in the width direction. The guide unit is disposed only at a position where the scrap is cut off by slitting the margins of the recording medium with the slitter.

Abstract: Solid freeform fabrication systems, powder supply bins for solid freeform fabrication systems, and methods of solid freeform fabrication are disclosed. One exemplary solid freeform fabrication system includes a removable powder supply bin, a build bin, a roller, and a print head disposed above the build bin that deposits a binder onto the powder in the build bin in a preselected pattern.

Abstract: The present invention relates to pure oxygen-containing soju and a manufacturing method thereof. The invention provides the pure oxygen-containing diluted soju, which has excellent economy and shows a greatly reduced degree of a hangover after drinking thereof, because the amount of lost oxygen is minimized by injecting the largest possible amount of oxygen while preventing the release of oxygen using a method of injecting oxygen, and the amount of dissolved oxygen in the soju is maximized by injecting fine oxygen bubbles at low temperature, as well as a manufacturing method thereof.

Abstract: A novel gene having a function of improving acetic acid fermentation in practical level was cloned from a practical acetic acid bacterium belonging to the genus Gluconacetobacter by a method for obtaining a gene having a growth-promoting function in acetic acid-containing medium from the chromosomal DNA library of the acetic acid bacterium. It was made possible to significantly shorten the growth induction period and significantly improve the acetic acid fermentation rate of transformants obtained by introducing the gene into acetic acid bacteria, when such transformants are cultured in the presence of ethanol.

Abstract: The present invention relates to a method of preparing an unfermented carbonated beverage including barley concentrate and hop extract and an unfermented carbonated beverage prepared using the method.

Abstract: A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without a substantial increase in the free fatty acid content of the foodstuff. Preferably, the lipid acyltransferase is one which is capable of transferring an acyl group from a lipid to one or more of the following acyl acceptors: a sterol, a stanol, a carbohydrate, a protein or a sub-unit thereof, glycerol. Preferably, in addition to an emulsifier one or more of a stanol ester or a stanol ester or a protein ester or a carbohydrate ester or a diglyceride or a monoglyceride may be produced. One or more of these may function as an additional emulsifier.

Abstract: Mold growth monitoring and prediction systems and methods for an environment are disclosed. The system includes a processing unit, a temperature sensor, and a humidity sensor. The processing unit obtains a temperature reading and a humidity reading of the environment from the sensors. The processing unit uses an algorithm to determine a probability of mold growth based on the temperature reading, the humidity reading, and a time reading. For example, the algorithm defines an envelope based on temperature, humidity, and one or more species of mold. The envelope substantially separates conditions detrimental to mold growth from conditions conducive to mold growth for the species of mold. The processing unit uses the algorithm to determine whether the temperature reading and the humidity reading fall within detrimental or conducive conditions to mold growth. Based on the conditions, the processing unit either increases or decreases the probability of mold growth.

Abstract: Nutritional supplement drink compositions containing extracted xanthones, flavoring agents, aqueous carriers, and one or more vitamins, minerals, carotenoids, flavonoids, or other nutrients are described. The xanthones are extracted from xanthone-rich plants, such as the mangosteen tree, Brazilian malva-do-santo, and a Chinese herb, Swertia davidi.

Abstract: A nutritional supplement composition containing extracted xanthones, vitamins, minerals, carotenoids, flavonoids, and other nutrients is described. The xanthones are extracted from xanthone-rich plants, such as the mangosteen tree, Brazilian malva-do-santo, and a Chinese herb, Swertia davidi.