Patents Issued in July 3, 2007
  • Patent number: 7238753
    Abstract: The invention relates to a carpet comprising a stainproof-treated textile, wherein the carpet has stainproof ratio (%) of at least 30% as defined below: Stainproof ratio (%)=100×(?EN?ETn)/?EN ?EN: Color difference after stainproof test of untreated carpet; ?ETn: Color difference after stainproof test of carpet treated by the stainproof agent; n: the number of cleaning; cleaning is conducted according to AATCC-138, n?20.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: July 3, 2007
    Assignee: Daikin Industries, Ltd.
    Inventors: Fumihiko Yamaguchi, Masamichi Morita, Yasushi Nakamae, Hiroko Yano, Kazuyuki Satoh, Masato Ioki
  • Patent number: 7238754
    Abstract: A process for improving the melt characteristics of polyethylene resins is provided. The process involves contacting a polyethylene resin powder with a low level of free radical initiator at a temperature below the melting point of the resin.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: July 3, 2007
    Assignee: Equistar Chemicals, LP
    Inventors: Andrew J. Scheie, Harilaos Mavridis
  • Patent number: 7238755
    Abstract: Highly branched alkenyl-functional organopolysiloxane polymers are highly efficient antimisting additives for use in the preparation of silicone release coatings in high speed coating operations. The antimisting additives are miscible with the crosslinkable silicone coating components and produce storage stable compositions which can be used to provide coatings with good release properties.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: July 3, 2007
    Assignee: Wacker Chemie AG
    Inventors: Christian Herzig, Reinhard Stallbauer, Christine Weizhofer
  • Patent number: 7238756
    Abstract: Methods of controlling the flow index and/or molecular weight split of a polymer composition are disclosed. The method of producing a polymer composition in one embodiment comprises incorporating a high molecular weight polymer into a low molecular weight polymer to form the polymer composition in a single polymerization reactor in the presence of polymerizable monomers, a bimetallic catalyst composition and at least one control agent; wherein the control agent is added in an amount sufficient to control the level of incorporation of the high molecular weight polymer, the level of low molecular weight polymer, or both. Examples of control agents include alcohols, ethers, amines and oxygen.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: July 3, 2007
    Assignee: Univation Technologies, LLC
    Inventors: Fred D. Ehrman, Pradeep P. Shirodkar, Mark Bradley Davis, Daniel P. Zilker, Jr., Porter C. Shannon
  • Patent number: 7238757
    Abstract: Disclosed are compounds of formula (I) which compounds are useful as cocatalysts in olefinic polymerisation reactions, e.g., as Ziegler-Natta catalysts.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: July 3, 2007
    Assignee: Merck Patent Gesellschaft
    Inventors: Katrin Koehler, Eike Poetsch, Jens Eichhorn, Herbert Schumann, Birgit Wassermann, Sebastiain Dechert, Markus Hummert, Stefan Schutte, Walter Kaminsky, Andrea Eisenhardt, Manfred Arnold
  • Patent number: 7238758
    Abstract: The invention has an object to provide a catalyst for polymerizing or copolymerizing an ?-olefin, catalyst constituent thereof, and method of polymerizing ?-olefins with the catalyst, for production of ?-olefin polymers or copolymers with high hydrogen response, high polymarization reaction rate, high stereoregularity and excellent melt fluidity. The invention discloses a catalyst constituent of the catalyst for polymerizing or copolymerizing an ?-olefin, represented by Formula 37 or 38: Si(OR1)3(NR2R3)Formula 37 (where in Formula 37, R1 is a hydrocarbon group with 1 to 6 carbon atoms; R2 is a hydrocarbon group with 1 to 12 carbon atoms or hydrogen; and R3 is a hydrocarbon group with 1 to 12 carbon atoms) RNSi(OR1)3Formula 38 (where in Formula 38, R1 is a hydrocarbon group with 1 to 6 carbon atoms; and RN is a cyclicl amino group).
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: July 3, 2007
    Assignee: Ube Industries, Ltd.
    Inventors: Motozo Yoshikiyo, Toshifumi Fukunaga, Hiroshi Sato, Toshikazu Machida, Hiroyuki Ikeuchi, Takefumi Yano, Yasuhiro Tanaka
  • Patent number: 7238759
    Abstract: Unique copolymers comprising propylene, ethylene and/or one or more unsaturated comonomers are characterized as having: at least one, preferably more than one, of the following properties: (i) 13C NMR peaks corresponding to a regio-error at about 14.6 and about 15.7 ppm, the peaks of about equal intensity, (ii) a B-value greater than about 1.4 when the comonomer content of the copolymer is at least about 3 wt %, (iii) a skewness index, Six, greater than about ?1.20, (iv) a DSC curve with a Tme that remains essentially the same and a Tmax that decreases as the amount of comonomer in the copolymer is increased, and (v) an X-ray diffraction pattern that reports more gamma-form crystals than a comparable copolymer prepared with a Ziegler-Natta catalyst These polypropylene polymers are made using a nonmetallocene, metal-centered, heteroaryl ligand catalyst. These polymers can be blended with other polymers, and are useful in the manufacture of films, sheets, foams, fibers and molded articles.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: July 3, 2007
    Assignee: Dow Global Technologies Inc.
    Inventors: James C. Stevens, Daniel D. Vanderlende
  • Patent number: 7238760
    Abstract: The invention relates to water-soluble or water-swellable copolymers which contain sulfo groups and which are based on (meth)acrylamide-alkylsulfonic acids and (meth)acrylamide or N-vinyl compounds, and to their use as additives for aqueous construction materials systems or for water-based paint and coating systems. The inventive copolymers also represent water retention agents which are highly effective, even when used in relatively small quantities, and which are highly compatible in construction material and paint systems of this type.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: July 3, 2007
    Assignee: Construction Research & Technology GmbH
    Inventors: Michael Schinabeck, Gerhard Albrecht, Alfred Kern, Manfred Schuhbeck, Michaela Melzer
  • Patent number: 7238761
    Abstract: Multifunctional biocompatible hydrophilic gel contains, in % (w/w), acrylamide—1.95-8.0, methacrylamide—0.54-3.0, 2-hydroxyethyl methacrylate—0.003-0.4, N,N?-methylene-bis-acrylamide—0.006-0.6 and water—q.s. to 100. The hydrophilic gel is produced by co-polymerization of the above mentioned monomers in water medium in the presence of a peroxide initiator of polymerization in three stages which include (1) incubation of the reaction mixture at 20-30° C. for 12-24 hours, (2) exposure to ?-radiation at a dose of 0.4-1.0×106 rads, and (3) incubation at a temperature of 100-130° C. and pressure of 0-1.2 atm. for 20-40 minutes.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: July 3, 2007
    Assignee: Obschestvos Organichennoy Otvetstvennostyu “Vitagel”
    Inventor: Vladislav Victorovich Lopatin
  • Patent number: 7238762
    Abstract: The present invention relates to a process for producing weakly acidic cation exchangers of the polymethacrylic acid type by alkaline saponification of a crosslinked copolymer of alkyl methacrylate and methacrylic acid.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: July 3, 2007
    Assignee: Lanxess Deutschland GmbH
    Inventors: Wolfgang Podszun, Olaf Halle, Reinhold Klipper, Rudolf Wagner, Pierre Vanhoorne, Wolfgang Zarges
  • Patent number: 7238763
    Abstract: An unsaturated monocarboxylic ester compound has at least two structures represented by the following general formula (1): wherein R1 represents a hydrogen atom or an alkyl group of 1 to 6 carbon atoms, and R2, R3 and R4 independently represent a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, an aryl group, an aralkyl group, a cyano group, a fluorine atom, or a furyl group. A curable composition comprises (A) the unsaturated monocarboxylic ester compound having two or more structures represented by the general formula (1) mentioned above, (B) a polymerization initiator, and optionally (C) a diluent.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: July 3, 2007
    Assignee: Kanagawa University and Taiyo Ink Manufacturing Co., Ltd.
    Inventors: Tadatomi Nishikubo, Atsushi Kameyama, Masaki Sasaki, Masatoshi Kusama
  • Patent number: 7238764
    Abstract: A process for production of higher linear alpha olefins and/or alkyl-branched alpha olefins, which comprises the co-oligomerisation of one or more alpha olefins with ethylene in the presence of a metal catalyst system employing one or more bis-aryliminepyridine MXa complexes and/or one or more [bis-aryliminepyridine MYp.Lb+][NC?]q complexes; and said process is carried out at an ethylene pressure of less than 2.5 MPa.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: July 3, 2007
    Assignee: Shell Oil Company
    Inventors: Eric Johannes Maria De Boer, Hendrikus Hyacinthus Deuling, Harry Van Der Heijden, Quoc An On, Aart Bartus Van Oort, Arie Van Zon
  • Patent number: 7238765
    Abstract: High density polyethylene having reduced melt elasticity and a reduced level of highly short-chain branched polymer molecules and wire and cable insulation compositions based thereon having improved strippability and oxidative stability are provided.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: July 3, 2007
    Assignee: Equistar Chemicals, LP
    Inventors: Chun D. Lee, Timothy S. Schloemer
  • Patent number: 7238766
    Abstract: A carborane-siloxane compound is provided having the repeat unit Q contains any of —SiR2—, —SiR2—O—, —C?C—C?C—, carboranyl, and U?. Each R and R? is alkyl, aryl, alkylaryl, haloalkyl, haloaryl, or mixtures thereof. Each U? is derivable from hydrosilation of an alkenyl or alkynyl group. Each T is alkyl, aryl, alkylaryl, haloalkyl, haloaryl, mixtures thereof, —(O—SiR?2)xH, or the repeat unit. Each x and x? is a positive integer. The compounds may be made be reacting a carborane-siloxane precursor having unsaturated end groups with a siloxane crosslinker in the presence of a hydrosilation catalyst.
    Type: Grant
    Filed: June 22, 2004
    Date of Patent: July 3, 2007
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Teddy M. Keller, Manoj K. Kolel-Veetil
  • Patent number: 7238767
    Abstract: The present invention includes a novel polyol prepolmer including an aliphatic amine, aromatic amine, or a mixture of both aliphatic and aromatic amines with an epoxy functional silicone to produce the novel polyol prepolymer chain extender. In another aspect of the invention, the novel polyol prepolymer chain extender is reacted with a polyisocyanate to produce a novel silicone modified polyurea having improved adhesion, chemical resistance, UV stability, and decreased shrinkage properties.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: July 3, 2007
    Assignee: Reactamine Technology, LLC
    Inventor: Stuart B. Smith
  • Patent number: 7238768
    Abstract: An amino-functional polysiloxane is prepared by reacting an aminosilane (A) which contains an aminoalkyl group and at least one alkoxy group bonded to Si with a carboxylic acid and a silanol-functional polysiloxane (B). The aminosilane (A) is partially converted into its carboxylate salt which acts as a catalyst for the siloxane condensation polymerization reaction between (A) and (B).
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: July 3, 2007
    Assignee: Dow Corning Corporation
    Inventors: Peter Cheshire Hupfield, Avril Surgenor, Stephen Westall
  • Patent number: 7238769
    Abstract: The present invention provides a method for joining liquid-crystalline polyester resin composition parts, characterized in that the melting point of the liquid crystalline polyester resin measured by differential scanning calorimeter is 190-250° C. and that the parts are jointed by means of welding. By using the method of the present invention, jointed articles with sufficient joint strength are provided with accuracy.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: July 3, 2007
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Masaya Kitayama, Naoshi Saito
  • Patent number: 7238770
    Abstract: The present invention relates to methods of making imide-modified polyester imide resins. The present invention further relates to forming these imide-modified polyester imide resins into articles, such as preforms, bottles, containers, sheets, films, fibers, and injection molded parts.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: July 3, 2007
    Assignee: Wellman, Inc.
    Inventors: Walter L. Edwards, Marion L. Andrews
  • Patent number: 7238771
    Abstract: Dibenzodiazocine polymers, methods for producing dibenzodiazocine polymers, products formed from dibenzodiazocine polymers, and uses for such dibenzodiazocine polymers are provided.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: July 3, 2007
    Assignee: Solvay Advanced Polymers, L.L.C.
    Inventors: Virgil J. Lee, Li-Sheng Wang
  • Patent number: 7238772
    Abstract: The present invention relates to a process comprising using ionic liquids for the polycondensation of 1,3-propanediol reactants to produce polytrimethylene ether glycol and copolymers thereof.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: July 3, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Mark Andrew Harmer, Christopher P. Junk
  • Patent number: 7238773
    Abstract: Countercurrent stripping pipe for removing volatile organic constituents from reaction products, having a column pipe (201) composed of a plurality of pipe sections (201a-d), in which trays (202) are arranged, connections (205, 208) for supplying and removing the reaction products and connections (206, 207) for supplying and removing at least one stripping agent in countercurrent to the reaction products. In accordance with the invention, a plurality of successive trays (202) in each case are joined to one another and form at least two inserts (211a-c) which can be removed from the column pipe (201).
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: July 3, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Huebinger, Günter Staufer, Peter Keller
  • Patent number: 7238774
    Abstract: The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: July 3, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Klaus Fuchs, Christian Eickmeier, Werner Stransky, Cornelia Dorner-Ciossek, Sandra Handschuh, Herbert Nar, Klaus Klinder, Marcus Kostka
  • Patent number: 7238775
    Abstract: Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA1,2,4,5,12,13[Ala7]-SRIF; des-AA1,2,4,5,12,13[Aph7]-SRIF, des-AA1,2,4,5,12,13[Aph7]Cbm-SRIF; des-AA1,2,4,5,12,13[Tyr2,Ala7]-Cbm-SRIF, and des-AA1,2,4,5,12,13[Tyr7,C?Me-L-2Nal8]-SRIF, and counterparts incorporating D-Cys3 and/or D-Trp8 and/or Ala11, bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: July 3, 2007
    Assignee: The Salk Institute for Biological Studies
    Inventors: Jean E. F. Rivier, Jean Claude Reubi, Judit Erchegyi, Roland Riek
  • Patent number: 7238776
    Abstract: The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: July 3, 2007
    Assignee: Amgen Inc.
    Inventors: Rudolf Hauptmann, Adolf Himmler, Ingrid Maurer-Fogy, Christian Stratowa
  • Patent number: 7238777
    Abstract: The object of the present invention is to provide an agent for specific adsorption of type 5 adenoviral vector to undifferentiated blood cells which enables infection with a viral concentration that does not impart toxicity to undifferentiated blood cells, without requiring the construction of a new viral genome, or special modification of viral particles such as biotination, etc. The above objective has been achieved by providing a polypeptide which has affinity for both adenovirus and undifferentiated blood cells. Use of the polypeptide of the present invention enables improved efficiency of adenoviral vector-mediated gene transfer of any gene to undifferentiated blood cells, and there is provided a method of introducing any gene for which transient expression in these cells is desired. In particular, the method is useful for intracellular DNA recombination by transiently expressing site-specific recombinase, and for induction into any cells of different lines by transient expression of master genes.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: July 3, 2007
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Akira Itoh, Yutaka Hanazono, Takashi Okada, Keiya Ozawa
  • Patent number: 7238778
    Abstract: A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning the test NR polypeptide sequence with at least one reference NR polypeptide sequence for which an X-ray structure is available; building a three-dimensional model for the test NR polypeptide using the three-dimensional coordinates of the X-ray structure(s) of at least one reference polypeptide and its sequence alignment with the test NR polypeptide sequence; examining the three-dimensional model of the test NR polypeptide sequence for characteristic differences with the reference polypeptide; and mutating at least one amino acid residue in the test NR polypeptide sequence at a characteristic difference, whereby the test NR polypeptide is modified.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: July 3, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Christopher J. Apolito, Randy K. Bledsoe, Millard H. Lambert, III, David D. McKee, Valerie Gail Montana, Kenneth H. Pearce, Thomas B. Stanley, Huaqiang Eric Xu, Christopher J Delves
  • Patent number: 7238779
    Abstract: Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: July 3, 2007
    Assignee: The Regents of the University of California
    Inventors: Sylvaine Cases, Robert V. Farese, Jr., Sandra K. Erickson, Sabine Novak, Michel Accad
  • Patent number: 7238780
    Abstract: The present invention is directed to a novel neurotensin-like receptor expressed in the central nervous system of humans. The invention encompasses the receptor protein as well as nucleic acids encoding the protein. In addition, the invention is directed to methods and compositions which utilize the receptor.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: July 3, 2007
    Assignee: Astrazeneca Canada Inc.
    Inventors: Sultan Ahmad, Jack Cao, Dajan O'Donnell, Philippe Walker
  • Patent number: 7238781
    Abstract: This invention relates to plant defensin polypeptides, nucleic acids encoding them, and methods of use thereof. The invention also relates to a chimeric protein containing all or a portion of the plant defensin.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: July 3, 2007
    Assignee: E. I. DuPont de Nemours and Company
    Inventors: Omolayo O. Famodu, Rafael Herrmann, Albert L. Lu, Billy Fred McCutchen, Guo-Hua Miao, James K. Presnail, Zude Weng
  • Patent number: 7238782
    Abstract: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3?-untranslated region of CD154.
    Type: Grant
    Filed: March 27, 2006
    Date of Patent: July 3, 2007
    Assignee: Trustees of Dartmouth College
    Inventor: William F. C. Rigby
  • Patent number: 7238783
    Abstract: The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: July 3, 2007
    Assignee: The Texas A&M University System
    Inventors: Magnus Höök, Slawomir Lukomski, Yi Xu
  • Patent number: 7238784
    Abstract: Rh antibody hybrids for use in testing red blood cells for the presence of one or more Rh factors. The Rh hybrid antibody may also be used in therapeutic procedures which require the use of Rh antisera. The hybrid antibody includes an IgG anti-Rh antibody which has a polymeric tailpiece attached to the carboxy terminal end of each of the IgG antibody heavy chains. A hemagglutinin method is provided for Rh phenotyping in which agglutination of Rh-positive red blood cells is achieved in a one-step process involving addition of the hybrid Rh antisera to the red blood cells being tested.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: July 3, 2007
    Assignee: The Regents of the University of California
    Inventors: Sherie L. Morrison, Ramon Montaño
  • Patent number: 7238785
    Abstract: This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: July 3, 2007
    Assignee: Immunomedics, Inc.
    Inventors: Serengulam Govindan, Zhengxing Qu, Hans Hansen, David Goldenberg
  • Patent number: 7238786
    Abstract: This invention relates to monovalent and multivalent, monospecific antibodies and to monovalent and multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these antibodies has two or more binding sites where these binding sites have affinity towards different epitopes on a target antigen or different target antigens, or have affinity towards a target antigen and a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional antibodies in a host. More specifically, the present invention relates to the tumor-associated antibody designated PAM4. The invention further relates to chimeric PAM4 antibodies, and the use of such antibodies in diagnosis and therapy.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: July 3, 2007
    Assignee: Immunomedics, Inc.
    Inventors: David V. Gold, David M. Goldenberg, Hans J. Hansen
  • Patent number: 7238787
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: July 3, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
  • Patent number: 7238788
    Abstract: Disclosed are antibodies to phosphorylated tau, methods of making and methods of use.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: July 3, 2007
    Assignee: University of Iowa Foundation
    Inventor: Gloria Lee
  • Patent number: 7238789
    Abstract: Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a variety of contexts, including cell surface assays employing intact, live cells and in nucleic acid detection methods. The new dyes are water soluble and can be conjugated to a variety of substrates, such as polynucleotides, nucleosides, nucleotides, peptides, proteins, antibodies, carbohydrates, ligands, particles and surfaces.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: July 3, 2007
    Assignee: Applera Corporation
    Inventors: Xiongwei Yan, Pau Miau Yuan
  • Patent number: 7238790
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: July 3, 2007
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Austin L. Gurney, Jean Philippe Stephan, William I. Wood
  • Patent number: 7238791
    Abstract: Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: July 3, 2007
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Mitali Ghoshal, Gerald F. Sigler
  • Patent number: 7238792
    Abstract: Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: July 3, 2007
    Assignee: Washington State University Research Foundation
    Inventors: Alexander D. Q. Li, Wei Wang
  • Patent number: 7238793
    Abstract: The present invention relates to an estrogen receptor co-regulator and to antibodies specific therefor. The invention further relates to methods of screening test compounds for their suitability as estrogen receptor modulators and to methods of using same in disease treatment.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: July 3, 2007
    Assignee: Duke University
    Inventors: Donald P. McDonnell, John D. Norris, Daju Fan
  • Patent number: 7238794
    Abstract: The present invention provides an organic conductor comprising a deoxyribonucleic acid (DNA) and an electric charge-donating material bonded to the deoxyribonucleic acid, and an organic conductor comprising at least two DNAs; and an electric charge-transfer substance bonding to each base of the two DNAs.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: July 3, 2007
    Assignee: Fuji Xerox Co., Ltd.
    Inventors: Taishi Shigematsu, Kei Shimotani, Chikara Manabe, Hiroyuki Watanabe, Masaaki Shimizu
  • Patent number: 7238795
    Abstract: The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: July 3, 2007
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Frank Seela, Frank Bergmann, Herbert Von Der Eltz, Dieter Heindl, Christoph Seidel, Georg Becher
  • Patent number: 7238796
    Abstract: Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: July 3, 2007
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Akira Nakagawara, Masahira Hattori, Yoshiyuki Sakaki
  • Patent number: 7238797
    Abstract: The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: July 3, 2007
    Assignee: Animal Technology Institute
    Inventors: Wen-Chuan Lee, Ming-Yu Chen
  • Patent number: 7238798
    Abstract: The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may be operatively linked to promoter sequences and transformed into host cells. Methods of production of an Or83b odorant receptor protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Antibodies to an Or83b odorant receptor protein, and derivatives and analogs thereof, are provided. Methods for identifying molecules that bind or modulate the activity of these Or83b odorant receptor genes are provided. Molecules found to bind or modulate the activity of Or83b genes may be formulated into pest control agents by providing a carrier.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: July 3, 2007
    Assignee: SentiSearch, Inc.
    Inventors: Kevin J. Lee, Thuy-Ai T. Nguyen, Brian Kloss
  • Patent number: 7238799
    Abstract: The present invention relates to a novel nucleotide sequence and the amino acid sequence encoded therein which comprise a novel gene and protein called Mustang. The present invention also relates to methods and compositions based on these sequences. These sequences are useful in the medical diagnosis, growth and regeneration of bone.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: July 3, 2007
    Assignee: Research Foundation of State University of New York at Stony Brook
    Inventors: Michael Hadjiargyrou, Frank Lombardo, David Komatsu
  • Patent number: 7238800
    Abstract: The present invention provides compositions of peptides and polynucleotides encoding the peptides, which peptides are useful for generating an immunological response in an individual and in therapeutic and diagnostic applications of infections due to pathogenic Coccidioides spp. fungi, such as C. immitis or C. posadasii.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: July 3, 2007
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: John N. Galgiani, Kris Orsborn, Tao Peng, Lisa Shubitz
  • Patent number: 7238801
    Abstract: A phthalocyanine compound (1) of a specific structure excelling in ability to absorb near infrared, ability to effect selective absorption of near infrared radiation particularly in a wavelength range exceeding 920 nm and falling short of 1050 nm, solubility in a solvent as well, compatibility with resin, and in such characteristic properties as heat resistance, light resistance, and weatherability, and a near infrared absorbing filter characterized by using the phthalocyanine compound (1) and phthalocyanine compound (2) having a maximum absorption wavelength at least in the range of 800–920 nm are provided. It enjoys a long service life and permits extensive use without selecting a substrate.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: July 3, 2007
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Kiyoshi Masuda, Masunori Kitao
  • Patent number: 7238802
    Abstract: An intermediate for vinblastine synthesis represented by general formula A. general formula A. (in the formula, R1, R2, R3 and R4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R6 is an alkyl group of carbon number 4 or less, R7 is a substituted or non-substituted aryl group, R8 is a substituted or non-substituted aryl group or lower alkyl group and R9 is an acyl group or trialkylsilyl group.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: July 3, 2007
    Assignee: Japan Science Technology Agency
    Inventors: Tohru Fukuyama, Hidetoshi Tokuyama, Satoshi Yokoshima