Patents Issued in July 3, 2007
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Patent number: 7238753Abstract: The invention relates to a carpet comprising a stainproof-treated textile, wherein the carpet has stainproof ratio (%) of at least 30% as defined below: Stainproof ratio (%)=100×(?EN?ETn)/?EN ?EN: Color difference after stainproof test of untreated carpet; ?ETn: Color difference after stainproof test of carpet treated by the stainproof agent; n: the number of cleaning; cleaning is conducted according to AATCC-138, n?20.Type: GrantFiled: August 17, 2004Date of Patent: July 3, 2007Assignee: Daikin Industries, Ltd.Inventors: Fumihiko Yamaguchi, Masamichi Morita, Yasushi Nakamae, Hiroko Yano, Kazuyuki Satoh, Masato Ioki
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Patent number: 7238754Abstract: A process for improving the melt characteristics of polyethylene resins is provided. The process involves contacting a polyethylene resin powder with a low level of free radical initiator at a temperature below the melting point of the resin.Type: GrantFiled: December 12, 2005Date of Patent: July 3, 2007Assignee: Equistar Chemicals, LPInventors: Andrew J. Scheie, Harilaos Mavridis
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Patent number: 7238755Abstract: Highly branched alkenyl-functional organopolysiloxane polymers are highly efficient antimisting additives for use in the preparation of silicone release coatings in high speed coating operations. The antimisting additives are miscible with the crosslinkable silicone coating components and produce storage stable compositions which can be used to provide coatings with good release properties.Type: GrantFiled: July 10, 2003Date of Patent: July 3, 2007Assignee: Wacker Chemie AGInventors: Christian Herzig, Reinhard Stallbauer, Christine Weizhofer
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Patent number: 7238756Abstract: Methods of controlling the flow index and/or molecular weight split of a polymer composition are disclosed. The method of producing a polymer composition in one embodiment comprises incorporating a high molecular weight polymer into a low molecular weight polymer to form the polymer composition in a single polymerization reactor in the presence of polymerizable monomers, a bimetallic catalyst composition and at least one control agent; wherein the control agent is added in an amount sufficient to control the level of incorporation of the high molecular weight polymer, the level of low molecular weight polymer, or both. Examples of control agents include alcohols, ethers, amines and oxygen.Type: GrantFiled: October 15, 2003Date of Patent: July 3, 2007Assignee: Univation Technologies, LLCInventors: Fred D. Ehrman, Pradeep P. Shirodkar, Mark Bradley Davis, Daniel P. Zilker, Jr., Porter C. Shannon
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Patent number: 7238757Abstract: Disclosed are compounds of formula (I) which compounds are useful as cocatalysts in olefinic polymerisation reactions, e.g., as Ziegler-Natta catalysts.Type: GrantFiled: September 13, 2002Date of Patent: July 3, 2007Assignee: Merck Patent GesellschaftInventors: Katrin Koehler, Eike Poetsch, Jens Eichhorn, Herbert Schumann, Birgit Wassermann, Sebastiain Dechert, Markus Hummert, Stefan Schutte, Walter Kaminsky, Andrea Eisenhardt, Manfred Arnold
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Patent number: 7238758Abstract: The invention has an object to provide a catalyst for polymerizing or copolymerizing an ?-olefin, catalyst constituent thereof, and method of polymerizing ?-olefins with the catalyst, for production of ?-olefin polymers or copolymers with high hydrogen response, high polymarization reaction rate, high stereoregularity and excellent melt fluidity. The invention discloses a catalyst constituent of the catalyst for polymerizing or copolymerizing an ?-olefin, represented by Formula 37 or 38: Si(OR1)3(NR2R3)Formula 37 (where in Formula 37, R1 is a hydrocarbon group with 1 to 6 carbon atoms; R2 is a hydrocarbon group with 1 to 12 carbon atoms or hydrogen; and R3 is a hydrocarbon group with 1 to 12 carbon atoms) RNSi(OR1)3Formula 38 (where in Formula 38, R1 is a hydrocarbon group with 1 to 6 carbon atoms; and RN is a cyclicl amino group).Type: GrantFiled: August 19, 2003Date of Patent: July 3, 2007Assignee: Ube Industries, Ltd.Inventors: Motozo Yoshikiyo, Toshifumi Fukunaga, Hiroshi Sato, Toshikazu Machida, Hiroyuki Ikeuchi, Takefumi Yano, Yasuhiro Tanaka
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Patent number: 7238759Abstract: Unique copolymers comprising propylene, ethylene and/or one or more unsaturated comonomers are characterized as having: at least one, preferably more than one, of the following properties: (i) 13C NMR peaks corresponding to a regio-error at about 14.6 and about 15.7 ppm, the peaks of about equal intensity, (ii) a B-value greater than about 1.4 when the comonomer content of the copolymer is at least about 3 wt %, (iii) a skewness index, Six, greater than about ?1.20, (iv) a DSC curve with a Tme that remains essentially the same and a Tmax that decreases as the amount of comonomer in the copolymer is increased, and (v) an X-ray diffraction pattern that reports more gamma-form crystals than a comparable copolymer prepared with a Ziegler-Natta catalyst These polypropylene polymers are made using a nonmetallocene, metal-centered, heteroaryl ligand catalyst. These polymers can be blended with other polymers, and are useful in the manufacture of films, sheets, foams, fibers and molded articles.Type: GrantFiled: November 15, 2004Date of Patent: July 3, 2007Assignee: Dow Global Technologies Inc.Inventors: James C. Stevens, Daniel D. Vanderlende
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Patent number: 7238760Abstract: The invention relates to water-soluble or water-swellable copolymers which contain sulfo groups and which are based on (meth)acrylamide-alkylsulfonic acids and (meth)acrylamide or N-vinyl compounds, and to their use as additives for aqueous construction materials systems or for water-based paint and coating systems. The inventive copolymers also represent water retention agents which are highly effective, even when used in relatively small quantities, and which are highly compatible in construction material and paint systems of this type.Type: GrantFiled: August 2, 2001Date of Patent: July 3, 2007Assignee: Construction Research & Technology GmbHInventors: Michael Schinabeck, Gerhard Albrecht, Alfred Kern, Manfred Schuhbeck, Michaela Melzer
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Patent number: 7238761Abstract: Multifunctional biocompatible hydrophilic gel contains, in % (w/w), acrylamide—1.95-8.0, methacrylamide—0.54-3.0, 2-hydroxyethyl methacrylate—0.003-0.4, N,N?-methylene-bis-acrylamide—0.006-0.6 and water—q.s. to 100. The hydrophilic gel is produced by co-polymerization of the above mentioned monomers in water medium in the presence of a peroxide initiator of polymerization in three stages which include (1) incubation of the reaction mixture at 20-30° C. for 12-24 hours, (2) exposure to ?-radiation at a dose of 0.4-1.0×106 rads, and (3) incubation at a temperature of 100-130° C. and pressure of 0-1.2 atm. for 20-40 minutes.Type: GrantFiled: September 9, 2004Date of Patent: July 3, 2007Assignee: Obschestvos Organichennoy Otvetstvennostyu “Vitagel”Inventor: Vladislav Victorovich Lopatin
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Patent number: 7238762Abstract: The present invention relates to a process for producing weakly acidic cation exchangers of the polymethacrylic acid type by alkaline saponification of a crosslinked copolymer of alkyl methacrylate and methacrylic acid.Type: GrantFiled: August 25, 2006Date of Patent: July 3, 2007Assignee: Lanxess Deutschland GmbHInventors: Wolfgang Podszun, Olaf Halle, Reinhold Klipper, Rudolf Wagner, Pierre Vanhoorne, Wolfgang Zarges
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Patent number: 7238763Abstract: An unsaturated monocarboxylic ester compound has at least two structures represented by the following general formula (1): wherein R1 represents a hydrogen atom or an alkyl group of 1 to 6 carbon atoms, and R2, R3 and R4 independently represent a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, an aryl group, an aralkyl group, a cyano group, a fluorine atom, or a furyl group. A curable composition comprises (A) the unsaturated monocarboxylic ester compound having two or more structures represented by the general formula (1) mentioned above, (B) a polymerization initiator, and optionally (C) a diluent.Type: GrantFiled: September 28, 2005Date of Patent: July 3, 2007Assignee: Kanagawa University and Taiyo Ink Manufacturing Co., Ltd.Inventors: Tadatomi Nishikubo, Atsushi Kameyama, Masaki Sasaki, Masatoshi Kusama
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Patent number: 7238764Abstract: A process for production of higher linear alpha olefins and/or alkyl-branched alpha olefins, which comprises the co-oligomerisation of one or more alpha olefins with ethylene in the presence of a metal catalyst system employing one or more bis-aryliminepyridine MXa complexes and/or one or more [bis-aryliminepyridine MYp.Lb+][NC?]q complexes; and said process is carried out at an ethylene pressure of less than 2.5 MPa.Type: GrantFiled: December 18, 2003Date of Patent: July 3, 2007Assignee: Shell Oil CompanyInventors: Eric Johannes Maria De Boer, Hendrikus Hyacinthus Deuling, Harry Van Der Heijden, Quoc An On, Aart Bartus Van Oort, Arie Van Zon
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Patent number: 7238765Abstract: High density polyethylene having reduced melt elasticity and a reduced level of highly short-chain branched polymer molecules and wire and cable insulation compositions based thereon having improved strippability and oxidative stability are provided.Type: GrantFiled: August 5, 2004Date of Patent: July 3, 2007Assignee: Equistar Chemicals, LPInventors: Chun D. Lee, Timothy S. Schloemer
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Patent number: 7238766Abstract: A carborane-siloxane compound is provided having the repeat unit Q contains any of —SiR2—, —SiR2—O—, —C?C—C?C—, carboranyl, and U?. Each R and R? is alkyl, aryl, alkylaryl, haloalkyl, haloaryl, or mixtures thereof. Each U? is derivable from hydrosilation of an alkenyl or alkynyl group. Each T is alkyl, aryl, alkylaryl, haloalkyl, haloaryl, mixtures thereof, —(O—SiR?2)xH, or the repeat unit. Each x and x? is a positive integer. The compounds may be made be reacting a carborane-siloxane precursor having unsaturated end groups with a siloxane crosslinker in the presence of a hydrosilation catalyst.Type: GrantFiled: June 22, 2004Date of Patent: July 3, 2007Assignee: The United States of America as represented by the Secretary of the NavyInventors: Teddy M. Keller, Manoj K. Kolel-Veetil
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Patent number: 7238767Abstract: The present invention includes a novel polyol prepolmer including an aliphatic amine, aromatic amine, or a mixture of both aliphatic and aromatic amines with an epoxy functional silicone to produce the novel polyol prepolymer chain extender. In another aspect of the invention, the novel polyol prepolymer chain extender is reacted with a polyisocyanate to produce a novel silicone modified polyurea having improved adhesion, chemical resistance, UV stability, and decreased shrinkage properties.Type: GrantFiled: October 25, 2005Date of Patent: July 3, 2007Assignee: Reactamine Technology, LLCInventor: Stuart B. Smith
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Patent number: 7238768Abstract: An amino-functional polysiloxane is prepared by reacting an aminosilane (A) which contains an aminoalkyl group and at least one alkoxy group bonded to Si with a carboxylic acid and a silanol-functional polysiloxane (B). The aminosilane (A) is partially converted into its carboxylate salt which acts as a catalyst for the siloxane condensation polymerization reaction between (A) and (B).Type: GrantFiled: November 21, 2006Date of Patent: July 3, 2007Assignee: Dow Corning CorporationInventors: Peter Cheshire Hupfield, Avril Surgenor, Stephen Westall
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Patent number: 7238769Abstract: The present invention provides a method for joining liquid-crystalline polyester resin composition parts, characterized in that the melting point of the liquid crystalline polyester resin measured by differential scanning calorimeter is 190-250° C. and that the parts are jointed by means of welding. By using the method of the present invention, jointed articles with sufficient joint strength are provided with accuracy.Type: GrantFiled: May 10, 2005Date of Patent: July 3, 2007Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Masaya Kitayama, Naoshi Saito
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Patent number: 7238770Abstract: The present invention relates to methods of making imide-modified polyester imide resins. The present invention further relates to forming these imide-modified polyester imide resins into articles, such as preforms, bottles, containers, sheets, films, fibers, and injection molded parts.Type: GrantFiled: January 28, 2005Date of Patent: July 3, 2007Assignee: Wellman, Inc.Inventors: Walter L. Edwards, Marion L. Andrews
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Patent number: 7238771Abstract: Dibenzodiazocine polymers, methods for producing dibenzodiazocine polymers, products formed from dibenzodiazocine polymers, and uses for such dibenzodiazocine polymers are provided.Type: GrantFiled: April 22, 2005Date of Patent: July 3, 2007Assignee: Solvay Advanced Polymers, L.L.C.Inventors: Virgil J. Lee, Li-Sheng Wang
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Patent number: 7238772Abstract: The present invention relates to a process comprising using ionic liquids for the polycondensation of 1,3-propanediol reactants to produce polytrimethylene ether glycol and copolymers thereof.Type: GrantFiled: September 22, 2006Date of Patent: July 3, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Mark Andrew Harmer, Christopher P. Junk
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Patent number: 7238773Abstract: Countercurrent stripping pipe for removing volatile organic constituents from reaction products, having a column pipe (201) composed of a plurality of pipe sections (201a-d), in which trays (202) are arranged, connections (205, 208) for supplying and removing the reaction products and connections (206, 207) for supplying and removing at least one stripping agent in countercurrent to the reaction products. In accordance with the invention, a plurality of successive trays (202) in each case are joined to one another and form at least two inserts (211a-c) which can be removed from the column pipe (201).Type: GrantFiled: March 18, 2005Date of Patent: July 3, 2007Assignee: BASF AktiengesellschaftInventors: Wolfgang Huebinger, Günter Staufer, Peter Keller
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Patent number: 7238774Abstract: The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.Type: GrantFiled: November 7, 2005Date of Patent: July 3, 2007Assignee: Boehringer Ingelheim International GmbHInventors: Stefan Peters, Klaus Fuchs, Christian Eickmeier, Werner Stransky, Cornelia Dorner-Ciossek, Sandra Handschuh, Herbert Nar, Klaus Klinder, Marcus Kostka
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Patent number: 7238775Abstract: Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA1,2,4,5,12,13[Ala7]-SRIF; des-AA1,2,4,5,12,13[Aph7]-SRIF, des-AA1,2,4,5,12,13[Aph7]Cbm-SRIF; des-AA1,2,4,5,12,13[Tyr2,Ala7]-Cbm-SRIF, and des-AA1,2,4,5,12,13[Tyr7,C?Me-L-2Nal8]-SRIF, and counterparts incorporating D-Cys3 and/or D-Trp8 and/or Ala11, bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.Type: GrantFiled: January 24, 2005Date of Patent: July 3, 2007Assignee: The Salk Institute for Biological StudiesInventors: Jean E. F. Rivier, Jean Claude Reubi, Judit Erchegyi, Roland Riek
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Patent number: 7238776Abstract: The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.Type: GrantFiled: July 3, 2001Date of Patent: July 3, 2007Assignee: Amgen Inc.Inventors: Rudolf Hauptmann, Adolf Himmler, Ingrid Maurer-Fogy, Christian Stratowa
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Patent number: 7238777Abstract: The object of the present invention is to provide an agent for specific adsorption of type 5 adenoviral vector to undifferentiated blood cells which enables infection with a viral concentration that does not impart toxicity to undifferentiated blood cells, without requiring the construction of a new viral genome, or special modification of viral particles such as biotination, etc. The above objective has been achieved by providing a polypeptide which has affinity for both adenovirus and undifferentiated blood cells. Use of the polypeptide of the present invention enables improved efficiency of adenoviral vector-mediated gene transfer of any gene to undifferentiated blood cells, and there is provided a method of introducing any gene for which transient expression in these cells is desired. In particular, the method is useful for intracellular DNA recombination by transiently expressing site-specific recombinase, and for induction into any cells of different lines by transient expression of master genes.Type: GrantFiled: October 16, 2002Date of Patent: July 3, 2007Assignee: Asahi Kasei Kabushiki KaishaInventors: Akira Itoh, Yutaka Hanazono, Takashi Okada, Keiya Ozawa
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Patent number: 7238778Abstract: A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning the test NR polypeptide sequence with at least one reference NR polypeptide sequence for which an X-ray structure is available; building a three-dimensional model for the test NR polypeptide using the three-dimensional coordinates of the X-ray structure(s) of at least one reference polypeptide and its sequence alignment with the test NR polypeptide sequence; examining the three-dimensional model of the test NR polypeptide sequence for characteristic differences with the reference polypeptide; and mutating at least one amino acid residue in the test NR polypeptide sequence at a characteristic difference, whereby the test NR polypeptide is modified.Type: GrantFiled: July 17, 2002Date of Patent: July 3, 2007Assignee: SmithKline Beecham CorporationInventors: Christopher J. Apolito, Randy K. Bledsoe, Millard H. Lambert, III, David D. McKee, Valerie Gail Montana, Kenneth H. Pearce, Thomas B. Stanley, Huaqiang Eric Xu, Christopher J Delves
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Patent number: 7238779Abstract: Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.Type: GrantFiled: February 12, 2004Date of Patent: July 3, 2007Assignee: The Regents of the University of CaliforniaInventors: Sylvaine Cases, Robert V. Farese, Jr., Sandra K. Erickson, Sabine Novak, Michel Accad
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Patent number: 7238780Abstract: The present invention is directed to a novel neurotensin-like receptor expressed in the central nervous system of humans. The invention encompasses the receptor protein as well as nucleic acids encoding the protein. In addition, the invention is directed to methods and compositions which utilize the receptor.Type: GrantFiled: July 14, 2004Date of Patent: July 3, 2007Assignee: Astrazeneca Canada Inc.Inventors: Sultan Ahmad, Jack Cao, Dajan O'Donnell, Philippe Walker
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Patent number: 7238781Abstract: This invention relates to plant defensin polypeptides, nucleic acids encoding them, and methods of use thereof. The invention also relates to a chimeric protein containing all or a portion of the plant defensin.Type: GrantFiled: September 30, 2004Date of Patent: July 3, 2007Assignee: E. I. DuPont de Nemours and CompanyInventors: Omolayo O. Famodu, Rafael Herrmann, Albert L. Lu, Billy Fred McCutchen, Guo-Hua Miao, James K. Presnail, Zude Weng
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Patent number: 7238782Abstract: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3?-untranslated region of CD154.Type: GrantFiled: March 27, 2006Date of Patent: July 3, 2007Assignee: Trustees of Dartmouth CollegeInventor: William F. C. Rigby
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Patent number: 7238783Abstract: The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.Type: GrantFiled: October 7, 2005Date of Patent: July 3, 2007Assignee: The Texas A&M University SystemInventors: Magnus Höök, Slawomir Lukomski, Yi Xu
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Patent number: 7238784Abstract: Rh antibody hybrids for use in testing red blood cells for the presence of one or more Rh factors. The Rh hybrid antibody may also be used in therapeutic procedures which require the use of Rh antisera. The hybrid antibody includes an IgG anti-Rh antibody which has a polymeric tailpiece attached to the carboxy terminal end of each of the IgG antibody heavy chains. A hemagglutinin method is provided for Rh phenotyping in which agglutination of Rh-positive red blood cells is achieved in a one-step process involving addition of the hybrid Rh antisera to the red blood cells being tested.Type: GrantFiled: July 12, 2002Date of Patent: July 3, 2007Assignee: The Regents of the University of CaliforniaInventors: Sherie L. Morrison, Ramon Montaño
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Patent number: 7238785Abstract: This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.Type: GrantFiled: March 3, 2003Date of Patent: July 3, 2007Assignee: Immunomedics, Inc.Inventors: Serengulam Govindan, Zhengxing Qu, Hans Hansen, David Goldenberg
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Patent number: 7238786Abstract: This invention relates to monovalent and multivalent, monospecific antibodies and to monovalent and multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these antibodies has two or more binding sites where these binding sites have affinity towards different epitopes on a target antigen or different target antigens, or have affinity towards a target antigen and a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional antibodies in a host. More specifically, the present invention relates to the tumor-associated antibody designated PAM4. The invention further relates to chimeric PAM4 antibodies, and the use of such antibodies in diagnosis and therapy.Type: GrantFiled: June 16, 2003Date of Patent: July 3, 2007Assignee: Immunomedics, Inc.Inventors: David V. Gold, David M. Goldenberg, Hans J. Hansen
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Patent number: 7238787Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: May 7, 2002Date of Patent: July 3, 2007Assignee: Genentech, Inc.Inventors: Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, William I. Wood
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Patent number: 7238788Abstract: Disclosed are antibodies to phosphorylated tau, methods of making and methods of use.Type: GrantFiled: February 18, 2005Date of Patent: July 3, 2007Assignee: University of Iowa FoundationInventor: Gloria Lee
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Patent number: 7238789Abstract: Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a variety of contexts, including cell surface assays employing intact, live cells and in nucleic acid detection methods. The new dyes are water soluble and can be conjugated to a variety of substrates, such as polynucleotides, nucleosides, nucleotides, peptides, proteins, antibodies, carbohydrates, ligands, particles and surfaces.Type: GrantFiled: October 8, 2002Date of Patent: July 3, 2007Assignee: Applera CorporationInventors: Xiongwei Yan, Pau Miau Yuan
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Patent number: 7238790Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.Type: GrantFiled: September 11, 2002Date of Patent: July 3, 2007Assignee: Genentech, Inc.Inventors: Audrey Goddard, Austin L. Gurney, Jean Philippe Stephan, William I. Wood
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Patent number: 7238791Abstract: Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.Type: GrantFiled: December 16, 2005Date of Patent: July 3, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Mitali Ghoshal, Gerald F. Sigler
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Patent number: 7238792Abstract: Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.Type: GrantFiled: March 17, 2004Date of Patent: July 3, 2007Assignee: Washington State University Research FoundationInventors: Alexander D. Q. Li, Wei Wang
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Patent number: 7238793Abstract: The present invention relates to an estrogen receptor co-regulator and to antibodies specific therefor. The invention further relates to methods of screening test compounds for their suitability as estrogen receptor modulators and to methods of using same in disease treatment.Type: GrantFiled: March 29, 2002Date of Patent: July 3, 2007Assignee: Duke UniversityInventors: Donald P. McDonnell, John D. Norris, Daju Fan
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Patent number: 7238794Abstract: The present invention provides an organic conductor comprising a deoxyribonucleic acid (DNA) and an electric charge-donating material bonded to the deoxyribonucleic acid, and an organic conductor comprising at least two DNAs; and an electric charge-transfer substance bonding to each base of the two DNAs.Type: GrantFiled: December 23, 2002Date of Patent: July 3, 2007Assignee: Fuji Xerox Co., Ltd.Inventors: Taishi Shigematsu, Kei Shimotani, Chikara Manabe, Hiroyuki Watanabe, Masaaki Shimizu
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Patent number: 7238795Abstract: The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.Type: GrantFiled: July 31, 2001Date of Patent: July 3, 2007Assignee: Roche Molecular Systems, Inc.Inventors: Frank Seela, Frank Bergmann, Herbert Von Der Eltz, Dieter Heindl, Christoph Seidel, Georg Becher
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Patent number: 7238796Abstract: Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.Type: GrantFiled: August 23, 2002Date of Patent: July 3, 2007Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Akira Nakagawara, Masahira Hattori, Yoshiyuki Sakaki
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Patent number: 7238797Abstract: The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.Type: GrantFiled: March 8, 2005Date of Patent: July 3, 2007Assignee: Animal Technology InstituteInventors: Wen-Chuan Lee, Ming-Yu Chen
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Patent number: 7238798Abstract: The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may be operatively linked to promoter sequences and transformed into host cells. Methods of production of an Or83b odorant receptor protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Antibodies to an Or83b odorant receptor protein, and derivatives and analogs thereof, are provided. Methods for identifying molecules that bind or modulate the activity of these Or83b odorant receptor genes are provided. Molecules found to bind or modulate the activity of Or83b genes may be formulated into pest control agents by providing a carrier.Type: GrantFiled: August 14, 2002Date of Patent: July 3, 2007Assignee: SentiSearch, Inc.Inventors: Kevin J. Lee, Thuy-Ai T. Nguyen, Brian Kloss
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Patent number: 7238799Abstract: The present invention relates to a novel nucleotide sequence and the amino acid sequence encoded therein which comprise a novel gene and protein called Mustang. The present invention also relates to methods and compositions based on these sequences. These sequences are useful in the medical diagnosis, growth and regeneration of bone.Type: GrantFiled: December 18, 2003Date of Patent: July 3, 2007Assignee: Research Foundation of State University of New York at Stony BrookInventors: Michael Hadjiargyrou, Frank Lombardo, David Komatsu
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Patent number: 7238800Abstract: The present invention provides compositions of peptides and polynucleotides encoding the peptides, which peptides are useful for generating an immunological response in an individual and in therapeutic and diagnostic applications of infections due to pathogenic Coccidioides spp. fungi, such as C. immitis or C. posadasii.Type: GrantFiled: April 17, 2006Date of Patent: July 3, 2007Assignee: Arizona Board of Regents on Behalf of the University of ArizonaInventors: John N. Galgiani, Kris Orsborn, Tao Peng, Lisa Shubitz
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Patent number: 7238801Abstract: A phthalocyanine compound (1) of a specific structure excelling in ability to absorb near infrared, ability to effect selective absorption of near infrared radiation particularly in a wavelength range exceeding 920 nm and falling short of 1050 nm, solubility in a solvent as well, compatibility with resin, and in such characteristic properties as heat resistance, light resistance, and weatherability, and a near infrared absorbing filter characterized by using the phthalocyanine compound (1) and phthalocyanine compound (2) having a maximum absorption wavelength at least in the range of 800–920 nm are provided. It enjoys a long service life and permits extensive use without selecting a substrate.Type: GrantFiled: June 10, 2003Date of Patent: July 3, 2007Assignee: Nippon Shokubai Co., Ltd.Inventors: Kiyoshi Masuda, Masunori Kitao
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Patent number: 7238802Abstract: An intermediate for vinblastine synthesis represented by general formula A. general formula A. (in the formula, R1, R2, R3 and R4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R6 is an alkyl group of carbon number 4 or less, R7 is a substituted or non-substituted aryl group, R8 is a substituted or non-substituted aryl group or lower alkyl group and R9 is an acyl group or trialkylsilyl group.Type: GrantFiled: August 9, 2002Date of Patent: July 3, 2007Assignee: Japan Science Technology AgencyInventors: Tohru Fukuyama, Hidetoshi Tokuyama, Satoshi Yokoshima