Abstract: The present invention is directed to an ophthalmic solution for soft contact lenses for controlled release of polyethers into an eye's tear film. Polyether components of the subject solution are released from the soft contact lens material matrix over long time periods to produce longer lasting wetting performance, improved lubricity, improved end-of-the-day comfort and reduced feeling of dryness from wearing contact lenses. The present invention also includes the use of cationic polyelectrolytes for controlling the swelling of hydrogel contact lenses typically caused by the absorption of high concentrations of polyethers.

Abstract: A compact ceramic fuel property sensor comprises a plurality of laminated ceramic layers. The heater, temperature sensor, and capacitance measurement electrodes are embedded between the layers. The capacitance electrodes include interdigitated electrodes and fuel traps for containing a sample of liquid fuel disposed between the interdigitated electrodes. The dimensions of the fuel traps are selected so that the fuel traps remain filled with liquid after said sensor has been bathed in fuel. A method for monolithically preparing the sensors provides a reduced cost method and a sensor that can survive indefinitely in liquid fuel.

Abstract: The invention relates to a method of the dosed application of a liquid onto to selected portion of the surface of a substrate (A) by means of spraying under the influence of an electric current. According to the invention the liquid is fed at a flow rate between 0.01 pl/s and 1 ml/s to a distal tip (3) of a capillary (1) having an inside diameter of less than 150 ?m, wherein the distance between the distal tip and the surface (A) is less than 2 mm. Surprisingly it has been shown that it is possible in this manner to apply liquid to a restricted surface of a defined size.

Abstract: A thin layer chromatograph residue applicator sampler. The residue applicator sampler provides for rapid analysis of samples containing high explosives, chemical warfare, and other analyses of interest under field conditions. This satisfied the need for a field-deployable, small, hand-held, all-in-one device for efficient sampling, sample dissolution, and sample application to an analytical technique. The residue applicator sampler includes a sampling sponge that is resistant to most chemicals and is fastened via a plastic handle in a hermetically sealed tube containing a known amount of solvent. Upon use, the wetted sponge is removed from the sealed tube and used as a swiping device across an environmental sample. The sponge is then replaced in the hermetically sealed tube where the sample remains contained and dissolved in the solvent. A small pipette tip is removably contained in the hermetically sealed tube.

Abstract: The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular the devices and methods of the invention utilize microchannels of specific cross-sectional configuration and of specific arrangement as well as application of AC current orthogonal to the direction of fluid flow, in order to preventing/ameliorating formation of precipitate blockages in microfluidic devices.

Abstract: A gel extraction device comprising a hollow cutting member and a plunger ejector member. The hollow cutting member has a proximal tubular body terminating at one end in a circular rim having oppositely disposed spring engaging structures and a distal sloped transition portion ending in a rectangular receptacle and a tapered end portion with a sharp perimeter cutting edge. The plunger ejector member has a proximal cap atop and connected to a split stem portion having outer legs with shoulder stop extensions; an inner ribbon spring leg having a distal end inserted into a spring engaging structure in the assembled device; and a solid rectangular distal portion. In a second embodiment the split end portion is replaced by a stem having a plurality of lateral protrusions and a coiled spring is placed within the hollow cutting member tubular body. A third embodiment is a hybrid of the first two embodiments.

Abstract: Described herein is a microreactor for carrying out chemical reactions between a reaction partner in liquid form and a reaction partner in gaseous form, if necessary in the presence of a solid catalyst, whereby the chemical process guidance takes place in spaces that are formed by two or more essentially coplanar plates or layers, with at least one of these plates or layers being a fluid guidance plate (1) that is structured and/or arranged in such a way that the fluid reaction partner flows in at least one essentially uninterrupted capillary thread along the surface of this plate or layer only due to the influence of gravity and/or capillary forces and thereby comes into contact and reacts with the gaseous reaction partner.

Abstract: An automatic synthesis machine is used for synthesis of compounds using a plurality of vessels, allowing reagents to chemically react with each other. The automatic synthesis machine comprises a selection means for selecting a specific vessel among a plurality of vessels, a display device for displaying the vessel selected by the selection means in a manner such that it can be identified, together with the operation contents (suction and injection) related to the selected vessel, and an analysis means for analyzing a protocol prescribing a series of operational procedures for synthesis of compounds and picked-out commands related to the selected vessel from the protocol.

Abstract: An automated computer controlled ground water system for monitoring and analysis for an analyte, has a sampling device in a well casing with a valve and sensor to provide a predetermined sample volume, a treatment assembly to prepare a calibration standard, a calibration assembly to provide a standard of known concentration and volume, an analytical assembly to analyze for analyte concentration, and a communication system to receive analysis data and transmit it to a cognizant agency.

Abstract: System for removal of targeted pollutants from combustion and other industrial process gases and processes utilizing the system. Metal oxides are introduced from feeders into reaction zones of the system where they are contacted with a gas from which pollutants are to be removed. With respect to pollutant removal, the sorbent may interact with a pollutant as a catalyst, reactant, adsorbent or absorbent. Removal may occur in single-stage, dual-stage, or multi-stage systems with a variety of different configurations and reaction zones, e.g., bag house, cyclones, fluidized beds, and the like. Process parameters, particularly system differential pressure, are controlled by electronic controls to maintain minimal system differential pressure, and to monitor and adjust pollutant removal efficiencies. Reacted sorbent may be removed from the reaction action zones for recycling or recycled or regenerated with useful and marketable by-products being recovered during regeneration.

Abstract: A multibed catalyzer (1) is for an exhaust system of a combustion engine, of a motor vehicle. In a housing (2), at least two catalytic monoliths (3, 4) are arranged axially adjacent to be flowed-through in succession. The two monoliths (3, 4) are encased on the circumferential side by a common heat-resistance bearing mat (5) and supported by means of this bearing mat (5) in the housing (2). In order to enable a predetermined axial minimal distance between the two monoliths (3, 4), at least two heat-resistant distancing elements (9) are distributed circumferentially and axially between the two monoliths (3, 4), so that the monoliths are axially supported on one another by means of the distancing elements (9).

Abstract: A methanation assembly for use with a water supply and a gas supply containing gas to be methanated in which a reactor assembly has a plurality of methanation reactors each for methanating gas input to the assembly and a gas delivery and cooling assembly adapted to deliver gas from the gas supply to each of said methanation reactors and to combine water from the water supply with the output of each methanation reactor being conveyed to a next methanation reactor and carry the mixture to such next methanation reactor.

Abstract: The invention relates to a method for the removal of metals from their aqueous solution with lime precipitation, in conditions where a precipitate of metal hydroxide and gypsum is formed, which settles well and is easy to filter. The metals are precipitated from their aqueous solutions at a high pH value and the slurry is recirculated several times in the precipitation space, whereby the gypsum is precipitated as separate crystals instead of a solid layer. The method is particularly suitable for neutralization of the aqueous solution from the pickling of refined steel. Using this method enables the removal of metals and fluoride from the water in question.

Abstract: The invention concerns a process for preparing an oxide based on zirconium and titanium in which a liquid medium containing a zirconium compound and a titanium compound is formed; said medium is then heated; the precipitate obtained from the end of the preceding step is recovered and optionally, said precipitate is calcined. The invention also concerns an oxide based on zirconium and titanium. Said oxide can comprise in the range 30% to 40% by weight of titanium oxide and in this case it has a pure ZrTiO4 type structure or a mixture of phases of structure type ZrTiO4 and structure type anatase. Said oxide can also comprise in the range 10% to 20% by weight of titanium oxide and it then has a specific surface area of at least 40 m2/g after calcining for 5 hours at 800° C.

Abstract: A process to regenerate wet flue gas scrubber purge liquid into NaOH caustic suitable for make-up caustic for the scrubber is disclosed. Further, sulfur is removed from waste effluent in the form of gypsum with the process described herein. Lime is added to the spent, sodium sulfate-containing purge liquid to result in the formation of gypsum and sodium hydroxide.

Abstract: A method for reducing the cost of emission control by utilizing a combination of low cost, combustion and post-combustion processes to eliminate emissions of sulfur and nitrogen oxides, and trace metals, including mercury, and trace dioxins and furans. These processes are applied sequentially to the combustion flow train of an air-cooled, slagging combustor-boiler, and include two groups of process steps. One group is implemented in the combustor and the other in post combustion zones.

Abstract: A process for production of sodium borohydride. The process comprises the steps of: (a) combining a boric acid ester, B(OR)3 and sodium aluminum hydride to produce sodium borohydride and Al(OR)3; and (b) combining Al(OR)3 and sulfuric acid to produce alum and ROH.

Abstract: The invention is directed to a method of synthesising silicoaluminophosphate and aluminophosphate molecular sieves using synthesis templates that contain at least one template of general formula R1R2N—R3, wherein R1 and R2 are independently selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms and hydroxyalkyl groups having from 1 to 3 carbon atoms; R3 is selected from the group consisting of 4- to 8-membered cycloalkyl groups, optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms, and 4- to 8-membered heterocyclic groups having from 1 to 3 heteroatoms, said heterocyclic groups being optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms and the heteroatoms in said heterocyclic groups being selected from the group consisting of O, N, and S. In particular, the present invention relates to the synthesis of silicoaluminophosphate molecular sieves of the CHA framework type having a low silicon to aluminium atomic ratio.

Abstract: Provided is a method for production of nanocrystalline hydroxyapatite particles, and nanocrystalline hydroxyapatite particles produced according to the method. The nanocrystalline hydroxyapatite particles exhibit substantially superior cell transformation abilities as compared to known and commercially-available calcium phosphate kits. The nanocrystalline hydroxyapatite particles also find use in tissue engineering applications, for example bone and tooth engineering and repair applications.

Abstract: A porous aluminum fluoride on which SbClxF5-x (wherein x represents a numeral of 0 to 5) is supported, SbClxF5-x being obtainable by supporting SbCl5, or the like on a porous aluminum fluoride and treating it with hydrogen fluoride. The resulting porous aluminum fluoride has a high activity as a fluorinating agent, a fluorination catalyst, or the like, is easy to handle, can be used for a flow-type reaction, and also can be used even at a high temperature.

Abstract: Coagulation spinning produces structures such as fibers, ribbons, and yarns of carbon nanotubes. Stabilization, orientation, and shaping of spun materials are achieved by post-spinning processes. Advantages include the elimination of core-sheath effects due to carbonaceous contaminants, increasing mechanical properties, and eliminating dimensional instabilities in liquid electrolytes that previously prohibited the application of these spun materials in electrochemical devices. These advances enable the application of coagulation-spun carbon nanotube fibers, ribbons, and yarns in actuators, supercapacitors, and in devices for electrical energy harvesting.

Abstract: The present invention relates to nano sized sulfide compounds of cerium and a process for the preparation thereof. More particularly, the present invention provides novel nano sized particles of cerium sulfide as well as a novel process for the preparation of nano sized sulfide compounds of cerium by the bioreduction of cerium sulfate or cerium acetate, without resorting to chemical methods. A bioprocess is disclosed to treat trivalent Cerium salt with sulfate-reducing bacteria (SRB) under controlled conditions to obtain a biomass, which is subjected to staggered heating upto a temperature of 600-1500° C. The sulfide of Cerium is finally separated for application in pigment industry.

Abstract: A method for producing aluminum hydroxide includes a step of elevating a temperature of a slurry of aluminum hydroxide suspended in a sodium aluminate solution from 70° C. or lower to 85° C. or higher, and a step of applying a centrifugal force to the slurry. The aluminum hydroxide constituting the slurry is obtained beforehand through the Bayer's process.

Abstract: A process for the producton of pure syngas (hydrogen and carbon dioxide) by fast gasification of liquid, muddy, or solid raw materials, either produced for the purpose or from industrial processes in which they can not be recycled, or fuels from wastes or biomass, which process is carried out in a modular reactor including a raw materials feeding area, a gasification area, a discharging area of the residues in powdery or vitrified form. The obtained syngas is sent to a purification and compression step.

Abstract: Cosmetic compositions and methods, particularly for skin lightening, using 7-hydroxy-2-phenyl coumarin and derivatives of general formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where R1 and/or R2 may be positioned at the 1-, 2-, 3-, 5-, and/or 6-positions on the phenyl ring. Each or both R1 and/or R2 represents a hydrogen atom, OH, C1–C4 acyl group, or C1–C4 alkyl group; and R represents a hydrogen atom, C1–C4 acyl group, or C1–C4 alkyl group.

Abstract: The invention relates to a method for inhibiting the growth of organisms causing body odor on a human or animal body. The invention comprises the following step: topical application of 1,2-decanediol, wherein the amount of 1,2-decanediol applied is sufficient to inhibit the growth of organisms forming body odor at the site of application.

Abstract: The invention can be summarized as follows. According to the present invention there is provided an attenuated, tumour-targeting bacterium comprising a heterologous nucleotide sequence encoding a protein permitting the accumulation of a radionuclide within the bacterium. The heterologous nucleotide sequence may encode a sodium iodide symporter protein. The invention also relates to the use of such bacteria and methods of treating diseases using the bacteria of the present invention.

Abstract: The present invention provides for improved vectors for use in gene therapy. Utilizing the cancer specific DF3/MUC1 promoter to drive a replication essential gene, vectors are made conditionally replication-competent, permitting wider infection and expression of tumor cells. In addition, therapeutic genes and adjunct therapies further increase anti-tumor efficacy.

Abstract: The present invention relates to the treatment of brain damage by cellular transplantation. According to one aspect of the invention, a method for treating a motor, sensory and/or cognitive deficit comprises administering a composition comprising pluripotent cells into the damaged brain in a region contra-lateral to that containing the site of damage. The cells are preferably conditionally immortal.

Abstract: Antimicrobial compounds from Bacillus subtilis for use against animal and human pathogens. A novel strain of Bacillus subtilis was isolated from the gastrointestinal tract of poultry and was found to produce a factor or factors that have excellent inhibitory effects on Clostridium perfringens, Clostridium difficile, Campylobacter jejuni, Campylobacter coli, and Streptococcus pneumoniae. The factor(s) retain full viability and antimicrobial activity after heat treatment. The invention provides a method of treatment of pathogenic microorganisms including C. perfringens.

Abstract: The present invention provides soluble forms of CD39L3 polypeptides and compositions, and methods useful inhibiting platelet activation and recruitment for the treatment and prevention of thrombotic disorders in mammals administered with soluble forms of CD39L3 polypeptides.

Abstract: Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Abstract: The present invention provides a method for inhibiting immunoglobulin-induced toxicity resulting from immunotherapy in a subject comprising administering an immunoglobulin or Ig fusion protein molecule to the subject, the immunoglobulin molecule having a variable region and a constant region, the immunoglobulin molecule being modified prior to administration by inactivation of at least a portion of the constant region.

Abstract: Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.

Abstract: Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Abstract: The invention is directed to a peptide comprising the amino acid sequence substantially as denoted by SEQ ID NO:1 and biologically functional homologues and derivatives thereof.

Abstract: The present invention concerns an isolated bacteriocin, Divergicin M35, derived form Carnobacterium divergens M35. It also concerns a composition comprising an effective amount of Divergicin M35 and the use of that bacteriocin to kill or limit the proliferation of a microorganism.

Abstract: This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity of, bacterial infections. More particularly it relates to the use of polysaccharides containing the tetrasaccharide repeat unit: (?3)-?-DGalpNAc-(1?2)-?-D-PerpNAc-(1?3)-?-L-Fucp-(1?4)-?-D-Glcp-(1?), and conjugates thereof, to induce serum antibodies having bactericidal (killing) activity against hemolytic-uremic syndrome (HUS) causing E. coli, in particular E. coli O157. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies which have bactericidal or bacteriostatic activity against E. coli, in particular E. coli O157, and are useful to prevent and/or treat illnesses caused by E. coli O157.

Abstract: The present invention relates to antigens, more particularly an antigen of Streptococcus pygenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine component for therapy and/or prophylaxis.

Abstract: The present invention relates to coccidia strains and, in one embodiment, to microbiological cultures comprising such strains. In preferred embodiments, the coccidia strains are selected for tolerance to one group of coccidiostatic drugs, sensitivity to a second group of coccidiostatic drugs, and decreased proliferative capacity. Another embodiment of the invention relates to vaccines based on the coccidia strains according to the invention.

Abstract: A tumor vaccine which comprises a microparticle or a lysate prepared from a solidified tumor material selected from the group consisting of a tumor tissue, a tumor cell, and a component thereof, and at least one cytokine and/or cytokine-inducing agent (e.g., a granulocyte-macrophage-colony stimulating factor and/or interleukin-2 and the like), and optionally an adjuvant. The vaccine can be easily prepared and widely applied for prevention of recurrence, inhibition of metastasis and therapeutic treatment regardless of a type of a tumor, and has excellent antitumor effect.

Abstract: Insect barriers for building structures include rigid foam sheets and sheets of film or mesh formed of polymer material impregnated throughout with a synthetic pyrethroid insecticide such as permethrin. Foam sheets are applied to exterior and interior surfaces of foundation walls to provide both thermal and insect barrier functions. Film and/or mesh sheets are positioned around exterior and interior perimeters of foundation walls to form skirts serving as insect barriers. Plant containers for containing growing plants are formed of polymer material impregnated throughout with a synthetic pyrethroid insecticide. Agricultural mulching film for covering the soil beneath and around a growing plant is formed of polymer material impregnated throughout with synthetic pyrethroid insecticide.

Abstract: The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).

Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.

Abstract: The invention relates to transdermal delivery patches comprising a drug-containing drug reservoir wherein the drug reservoir comprises a plasticizer composition selected to adjust the rate of drug flux out of the transdermal delivery patch device. The invention also specifically relates to methods of producing the transdermal delivery patches of the invention, the methods comprising the use of an alcohol drug dispersing agent. The invention further specifically relates to methods of treating acute and chronic pain and methods of inducing and maintaining analgesia with the transdermal delivery patches of the invention.

Abstract: This invention provides methods for treating neoplasias in a mammal. In particular, the invention provides methods for treating various types of lymphomas, including relapsed forms of non-Hodgkin's Lymphoma. These methods involve the administration of liposome-encapsulated vinca alkaloids, e.g., vincristine, to a mammal with a lymphoma.

Abstract: Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt of this compound and lung surfactant

Abstract: The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate release formulations of the drug, and the duration of effect falls rapidly at the end of the dosing interval.

Abstract: Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintaining the microparticles at a conditioning temperature for a period of time. The conditioning can be used with microparticles containing an active agent, and with placebo microparticles, and it is reversible.