Patents Issued in August 2, 2007
  • Cyclopeptide derivatives with anti-integrin activity
    Publication number: 20070178045
    Abstract: Formula (I) compounds are described c(R1-Arg-Gly-Asp-R2) where the meanings of the various groups are as described here below, which are integrin inhibitors, and particularly inhibitors of integrins of the ?,?3 and ?,?5 family, and therefore are useful as medicaments, particularly for the treatment of the diseases underlying abnormal angiogenesis, such as retinopathy, acute renal failure, osteoporosis and metastases. The compounds described herein, when suitably labelled, are also useful as diagnostic agents, especially for the detection of small tumour masses and arterial occlusion events, and as targeted drug vectors.
    Type: Application
    Filed: May 4, 2005
    Publication date: August 2, 2007
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Omelia Tinti, Loredana Vesci, Sergio Penco, Alma Dal Pozzo, Ni Minghong
  • System for correlating odors and tastes to objective elements
    Publication number: 20070178046
    Abstract: A kit containing a plurality of scent/flavor samples and taste samples contained in individual vessels. Methods of teaching an understanding of taste, smelling with the nose, smelling with the mouth, and the concept of “flavor,” is facilitated. Numerous possibilities of combining scents with tastes, thus enabling a person to explore creatively and deductively the creation of new scent and flavor mixtures, as well as learning what makes familiar flavors taste the way they do.
    Type: Application
    Filed: December 5, 2006
    Publication date: August 2, 2007
    Inventors: Rachel Herz, Kathleen McCann
  • Drug carrier and ultrasound apparatus
    Publication number: 20070178047
    Abstract: A drug carrier and an ultrasound apparatus used in combination therewith for releasing a drug. The drug carrier undergoes a reversible phase change from liquid to gas upon ultrasound irradiation, so that the presence of the drug can be detected with a diagnostic apparatus without causing the spilling of the encased drug. The drug carrier includes a drug that is contained in a mixture of a poorly water-soluble substance having a boiling point of 37° C. or lower and a poorly water-soluble substance having a boiling point of higher than 37° C., which mixture is further encapsulated by a membrane of amphipathic substance.
    Type: Application
    Filed: January 17, 2007
    Publication date: August 2, 2007
    Inventor: Kenichi Kawabata
  • Antiviral composition comprising p-menthane-3,8-diol
    Publication number: 20070178048
    Abstract: The use of p-menthane-3,8-diol (PMD) as an antiviral agent.
    Type: Application
    Filed: March 2, 2005
    Publication date: August 2, 2007
    Inventor: Paul Clarke
  • Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
    Publication number: 20070178049
    Abstract: The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies, and/or increased lung deposition.
    Type: Application
    Filed: December 19, 2006
    Publication date: August 2, 2007
    Applicant: Verus Pharmaceuticals, Inc.
    Inventor: Malcolm Hill
  • Methods and systems for the delivery of corticosteroids having an increased lung depositon
    Publication number: 20070178050
    Abstract: The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies.
    Type: Application
    Filed: December 19, 2006
    Publication date: August 2, 2007
    Applicant: Verus Pharmaceuticals, Inc.
    Inventor: Malcolm Hill
  • STERILIZED NANOPARTICULATE GLUCOCORTICOSTEROID FORMULATIONS
    Publication number: 20070178051
    Abstract: The invention is directed sterile to compositions of glucocorticosteroids useful in the prophylaxis and chronic treatment of asthma and other allergic and inflammatory conditions in adults and pediatric patients.
    Type: Application
    Filed: January 27, 2006
    Publication date: August 2, 2007
    Inventors: John Pruitt, Raj Kewalramani, David Slifer, Jack Shaw, Stephen Ruddy
  • DELIVERY OF OPIOIDS THROUGH AN INHALATION ROUTE
    Publication number: 20070178052
    Abstract: The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a method aspect of the present invention, an opioid is delivered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an opioid, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% opioid degradation products. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route is provided which comprises: a) a thin layer of an opioid and b) a device for dispensing said thin layer as a condensation aerosol.
    Type: Application
    Filed: January 9, 2007
    Publication date: August 2, 2007
    Applicant: ALEXZA PHARMACEUTICALS, INC.
    Inventors: Joshua Rabinowitz, Alejandro Zaffaroni
  • Antiperspirant compositions
    Publication number: 20070178053
    Abstract: Antiperspirant water in oil emulsions can suffer from inferior sensory properties, including wetness and/or slow “dry-down” and/or stickiness, even when the composition contains a polyhydric humectant, a known class of skin moisturiser. A balance of sensory properties can be achieved by formation of a base composition in the form of a water in oil emulsion in which the oil phase, preferably comprising 20 to 55% of the base composition, contains at least threshold proportions of both a volatile silicone and a sensory modifying oil, particularly selected from dicaprylyl ether and dicaprylyl carbonate, the sensory modifying oil advantageously being present in a weight ratio to the polyhydric humectant of from 3:4 to 4:1. Such compositions are particularly suitable for mixture with a liquifiable propellant to form aerosol compositions.
    Type: Application
    Filed: January 26, 2007
    Publication date: August 2, 2007
    Inventors: Kevin Ronald Franklin, Anne-Cecile Marie Eugenie Irvoas
  • ORAL ANTIMICROBIAL COMPOSITION
    Publication number: 20070178054
    Abstract: The present invention includes compositions and methods for inhibiting the growth and formation of biofilms. The compositions and methods can employ antimicrobial compounds and/or antimicrobial peptides. In an embodiment, a composition includes a combination of at least one antimicrobial compound and at least one CSP analogue or CSP. In an embodiment, a method to inhibit the growth and/or formation of an oral biofilm includes administering a composition comprising at least one antimicrobial compound and at least one CSP analogue or CSP.
    Type: Application
    Filed: November 9, 2006
    Publication date: August 2, 2007
    Inventors: Madhyastha Srinivasa, Karen LoVetri
  • Dissolvable tooth whitening strip
    Publication number: 20070178055
    Abstract: The present invention provides a dissolvable strip for whitening teeth. The strip, which is preferably a single layer, has a whitening agent and a water-soluble or water dispersible polymer system. The dissolution of the whitening composition is controlled by interaction of the whitening composition with an oral environment containing saliva. The present invention further provides a process for preparing the whitening strip in the form of a dry film and a method of whitening teeth.
    Type: Application
    Filed: March 31, 2005
    Publication date: August 2, 2007
    Inventors: Robert Buch, Robert Gambogi, Jose Velada
  • Mixture comprising a detergent and a co-detergent
    Publication number: 20070178056
    Abstract: The invention relates to a mixture comprising a surfactant and a cosurfactant, the cosurfactant being an amphiphilic polymer having one or more hydrophobic subunits (A) and one or more hydrophilic subunits (B), wherein one or more hydrophobic subunits (A) have been formed on the basis of a polyisobutene block whose polyisobutene macromolecules have terminal double bonds to an extent of at least 50 mol %.
    Type: Application
    Filed: February 11, 2005
    Publication date: August 2, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Cordula Mock-Knoblauch, Norbert Wagner, Gunter Oetter, Ludwig Volkel, Susanne Petrovic, Arno Lange, Darijo Mijolovic, Stephan Huffer
  • High efficiency sunscreen composition particularly useful for wipes and sprays
    Publication number: 20070178057
    Abstract: A sunscreen composition, either impregnating a wipe substrate or comprising a sunscreen spray, wherein the composition comprises an oil phase dispersed stably as emulsion droplets in a water phase that contains i) a booster for the sun protection factor (SPF), comprising a combination of water-dispersible particulate materials, one of which is smectite clay, and a water-soluble or water-dispersible phenolic polymer; and ii) a water-soluble or water-dispersible polymer having a weak acid group, a weight average molecular weight of 1,000-100,000 Dalton, and an anionic charge density of no less than 4 milliequivalent per gram of the polymer; the said sunscreen composition meeting the following specifications: i) the in-vivo sun protection factor (SPF) is ?1.
    Type: Application
    Filed: February 1, 2006
    Publication date: August 2, 2007
    Applicant: AMCOL International Corporation
    Inventors: Ashoke SenGupta, Kevin Cureton, Ilona Lin, Thomas Beihoffer
  • Methods of using stable ascorbic acid compositions
    Publication number: 20070178058
    Abstract: Excellent percutaneous absorption of vitamin C is achieved by pre-treating skin with a cationic constituent such as cationic salt or solution thereof prior to application of a vitamin C composition.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 2, 2007
    Inventors: Jose E. Ramirez, Joseph Faryniarz
  • Cosmetic and pharmaceutical uses of an extract of a plant belonging to the genus buchholzia
    Publication number: 20070178059
    Abstract: A cosmetic or dermopharmaceutical composition including an extract of a plant belonging to the genus Buchholzia and at least one auxiliary and/or additive is provided. A method for the cosmetic treatment of the skin or scalp and a method for the treatment of skin inflammation includes administering to a patient in need thereof a composition including an effective amount of a plant extract from a plant belonging to the genus Buchholzia.
    Type: Application
    Filed: March 15, 2005
    Publication date: August 2, 2007
    Inventors: Philippe Moser, Louis Danoux, Gilles Pauly
  • Fresh body care products and system
    Publication number: 20070178060
    Abstract: The present invention relates to body care products that are comprised of fresh ingredients. It has been found that fresh ingredients, such as fruits, vegetables, and natural herbs, when applied to the skin and hair, improve texture, tone, and other features. The products can be stored in containers and compartments, e.g., that extend their shelf-life.
    Type: Application
    Filed: January 30, 2006
    Publication date: August 2, 2007
    Inventor: Rulin Xiu
  • Therapeutic blended oil composition and method
    Publication number: 20070178061
    Abstract: A therapeutic blended oil composition is provided that is useful as a topical application to be absorbed into skin, protect the skin from sun without inducing acne, reduce skin wrinkles lines and dryness. The therapeutic oil composition is created by mixing grape seed oil, soy bean oil, sweet almond oil, sea buckthom seed oil and essential oils. The volume of each constituent added can be modified according to the desired treatment. The composition may be applied topically to absorb into the skin to aid skin tone, tanning, moisturizing, eczema, and bum symptoms. The composition is light oil that does not leave the skin feeling oily and is an effective and safe makeup remover.
    Type: Application
    Filed: February 2, 2006
    Publication date: August 2, 2007
    Inventors: Marco Venturi, Tara Venturi-Jackson
  • Treatment of presbyopia with picolinic acid and its analogs
    Publication number: 20070178062
    Abstract: Compositions and methods for inhibiting the growth of lens epithelial cells are provided. The compositions provided include a chelating agent in an amount sufficient for inhibiting the growth of lens epithelial cells. The compositions and methods provided may also be used for the treatment of disorders of the eye, especially in the treatment of presbyopia.
    Type: Application
    Filed: October 10, 2006
    Publication date: August 2, 2007
    Inventors: Nathan Ravi, Paul Hamilton
  • METHODS OF TREATING CANCER USING IL-21 AND MONOCLONAL ANTIBODY THERAPY
    Publication number: 20070178063
    Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
    Type: Application
    Filed: October 6, 2006
    Publication date: August 2, 2007
    Inventors: Wayne Kindsvogel, Steven Hughes, Richard Holly, Christopher Clegg, Donald Foster, Rebecca Johnson, Mark Heipel, Pallavur Sivakumar
  • Antisense IAP nucleobase oligomers and uses thereof
    Publication number: 20070178064
    Abstract: The present invention features nucleobase oligomers that hybridize to IAP polynucleotides, and methods for using them to enhance apoptosis and treat proliferative diseases.
    Type: Application
    Filed: June 8, 2006
    Publication date: August 2, 2007
    Inventors: Eric LaCasse, Daniel McManus, Jonathan Durkin
  • Neutralizing factors as vaccine adjuvants
    Publication number: 20070178065
    Abstract: The present invention is a vaccine adjuvant composed of a vaccinia virus vector that encodes a polypeptides capable of neutralizing immune suppressive factors thereby enhancing or stimulating an immune response to a vaccine.
    Type: Application
    Filed: July 25, 2006
    Publication date: August 2, 2007
    Inventors: Edmund Lattime, Claude Monken
  • PATHOTROPIC TARGETED GENE DELIVERY SYSTEM FOR CANCER AND OTHER DISORDERS
    Publication number: 20070178066
    Abstract: Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastic sites. Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.
    Type: Application
    Filed: November 3, 2006
    Publication date: August 2, 2007
    Inventors: Frederick Hall, John Levy, Rebecca Reed, Erlinda Gordon
  • System and method for cytological analysis by raman spectroscopic imaging
    Publication number: 20070178067
    Abstract: A method and system of differentially manipulating cells where the cells, suspended in a fluid, are irradiated with substantially monochromatic light. A Raman data set is obtained from the irradiated cells and where the data set is characteristic of a disease status. The data set is assessed to identify diseased cells. A Raman chemical image of the irradiated cells is also obtained. Based on the assessment and the Raman chemical image, the fluid in which the cells are suspended is differentially manipulated. The diseased cells are directed to a first location and other non-diseased cells are directed to a second location as part of the differential manipulation. The diseased cells may be treated with a physical stress, a chemical stress, and a biological stress and then returned to a patient from whom the diseased cells were obtained prior to the irradiation.
    Type: Application
    Filed: November 9, 2006
    Publication date: August 2, 2007
    Inventors: John Maier, Joseph Demuth, Jeffrey Cohen, Lindy McClelland, Shona Stewart
  • COMPOSITIONS AND METHODS FOR REGULATING COMPLEMENT SYSTEM
    Publication number: 20070178068
    Abstract: The disclosure provided herein provides for methods and compositions for modulating the human complement pathway by reducing the expression or production of one or more complement pathway protein and uses for such methods for treating diseases including ocular disease and macular degeneration related disease. The invention also includes active agents for mediating the modulation of the complement pathway including siRNA designed to cause the RNAi-mediated degradation of complement pathway proteins.
    Type: Application
    Filed: December 22, 2006
    Publication date: August 2, 2007
    Inventors: Samuel Reich, Nadine Dejneka
  • HERPES SIMPLEX VIRUS VECTOR
    Publication number: 20070178069
    Abstract: The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55.
    Type: Application
    Filed: March 30, 2007
    Publication date: August 2, 2007
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Joseph Glorioso, Darren Wolfe, David Krisky
  • Pharmaceutical compositions and methods for treating or preventing oxalate-related disease
    Publication number: 20070178070
    Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing pharmaceutical compositions to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions. A composition of the invention comprises an oral delivery vehicle comprising an oxalate degrading bacteria, one or more cryopreserving agents and one or more excipients. A composition of the invention is enteric coated and has a suitable shelf-life and acceptable properties to avoid negative impact from gastric fluid when it is orally administered.
    Type: Application
    Filed: December 14, 2006
    Publication date: August 2, 2007
    Inventors: Poonam Kaul, Harmeet Sidhu
  • Stem-cell, precursor cell, or target cell-based treatment of multiorgan failure and renal dysfunction
    Publication number: 20070178071
    Abstract: Methods for the treatment of acute renal failure, multi-organ failure, early dysfunction of kidney transplant, chronic renal failure, organ dysfunction, and wound healing are provided. The methods include delivering a therapeutic amount of hematopoietic stem cells, non-hematopoietic, mesenchymal stem cells, hemangioblasts, and pre-differentiated cells to a patient in need thereof.
    Type: Application
    Filed: March 31, 2004
    Publication date: August 2, 2007
    Inventor: Christof Westenfelder
  • Method for inducing differentiation of regulatory t cells usinggip-anchored protein agonist and pharmaceutical composition therefor ( as amended
    Publication number: 20070178072
    Abstract: An object of the present invention is to provide a method for inducing the differentiation of and/or promoting the proliferation of regulatory T cells, an immunosuppressive method using these methods, and pharmaceutical compositions for use in these methods. Furthermore, a method for inducing the differentiation of and/or promoting the proliferation of regulatory T cells and a method for immunosuppression using such methods are provided, which involve causing an agonist of a GIP anchored protein to act on T cells expressing the GIP anchored protein.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 2, 2007
    Inventor: Tomoko Watanabe
  • Composition Comprising Separated or Proliferated Cells from Umbilical Cord Blood for Treating Developmental and/or Chronic Lung Disease
    Publication number: 20070178073
    Abstract: The present invention relates to a composition comprising separated or proliferated cells from umbilical cord blood for treating developmental and/or chronic lung disease, more precisely a composition containing separated or proliferated cells from umbilical cord blood for intratracheal administration for treating developmental and/or chronic lung disease. The cells of the composition of the present invention have excellent activities of proliferation and differentiation, so that the extraction, separation and selection of a tissue donor are all very easy. Besides, the composition of the invention can be very effectively used for the treatment of developmental and/or chronic diseases by intratracheal administration.
    Type: Application
    Filed: June 22, 2006
    Publication date: August 2, 2007
    Applicants: Samsung Life Public Welfare Foundation, Medipost Co., Ltd.
    Inventors: Yun Sil Chang, Won Soon Park, Yoon-Sun Yang
  • Chondrocyte Culture Formulations
    Publication number: 20070178074
    Abstract: The present invention provides methods and compositions for providing graft recipients with chondrocytes. Specifically, the methods and compositions of the invention provide for populations of chondrocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of chondrocytes that exhibit great proliferation capacity. The invention is based, in part, on the discovery of a culture medium having serum, insulin and various growth factors for culturing chondrocytes that exhibit increased proliferative capacity. The invention provides novel in vitro methods for culturing chondrocytes, including those isolated from the cartilage of a healthy subject, to generate a proliferating population of chondrocytes. The methods and compositions of the invention may be used for transplantation to treat patients having damaged cartilage.
    Type: Application
    Filed: October 6, 2006
    Publication date: August 2, 2007
    Inventors: Dan-Ning Hu, Steven McCormick
  • Side Population Cells in Cardiac Repair
    Publication number: 20070178075
    Abstract: It has been discovered that side-population cells induce cardiac tissue repair of infarcted myocardium. Provided herein are methods directed to treatment of cardiac injury using side-population cells.
    Type: Application
    Filed: September 26, 2006
    Publication date: August 2, 2007
    Applicant: The Trustees of Columbia University In the City of New York
    Inventors: Hina Chaudhry, Debra Wolgemuth
  • Porous membrane device that promotes the differentiation of monocytes into dendritic cells
    Publication number: 20070178076
    Abstract: Dendritic cells (DCs) for research and clinical applications are typically derived from purified blood monocytes that are cultured in a cocktail of cytokines for a week or more. Because it has been suggested that these cytokine-derived DCs may be deficient in some important immunological functions and might not accurately represent antigen-presenting cell (APC) populations found under physiologic conditions, there is a need for methods that allow the generation of DCs in a more physiologically relevant manner. The present invention comprises a simple and reliable technique for generating large numbers of highly purified DCs, based on a single migration of blood monocytes through endothelial cells that are cultured in, for example, a Transwell® device.
    Type: Application
    Filed: December 21, 2006
    Publication date: August 2, 2007
    Inventors: Donald Drake, David Moe, Conan Li, Heather Fahlenkamp, Guzman Sanchez-Schmitz, Russell Higbee, Robert Parkhill, William Warren
  • Method for in vitro preconditioning of myoblasts before transplantation
    Publication number: 20070178077
    Abstract: Methods of pretreating healthy donor's myoblast cultures with growth or trophic factors on transplantation into subjects suffering from myopathic conditions such as muscular dystrophy. Compositions comprising myoblasts and fusion-promoting metalloproteases can be transplanted. Alternatively, myoblasts can be transplanted along with an agent inducing the expression of a fusion-promoting metalloprotease, or a composition comprising genetically-modified myoblasts capable of expressing a fusion-promoting metalloprotease can be transplanted.
    Type: Application
    Filed: January 26, 2007
    Publication date: August 2, 2007
    Inventor: Jacques Tremblay
  • Method for Modifying Gut Flora in Animals
    Publication number: 20070178078
    Abstract: A method for enhancing the balance of beneficial and deleterious bacteria in the gastrointestinal tract of an animal having or at risk for inflammatory bowel disease (IBD) by administering to the animal a composition comprising at least one antioxidant, optionally in conjunction with one or more of a probiotic and a prebiotic.
    Type: Application
    Filed: December 29, 2006
    Publication date: August 2, 2007
    Inventor: Christina Khoo
  • Novel probiotics for pet food applications
    Publication number: 20070178079
    Abstract: The present invention relates to novel lactic acid bacterial micro-organisms that have been isolated and selected for their probiotic potential and their use for the preparation of petfood compositions intended to improve the health of pets, and to compositions containing the same.
    Type: Application
    Filed: February 2, 2007
    Publication date: August 2, 2007
    Inventors: Ralf Zink, Roberto Reniero, Florence Rochat, Christoph Cavadini, Thierry Weid, Eduardo Schiffrin, Jalil Benyacoub, Virginie Rousseau, Pablo Perez
  • LECITHINIZED SUPEROXIDE DISMUTASE COMPOSITION AND A PROCESS FOR ITS PRODUCTION
    Publication number: 20070178080
    Abstract: To provide a lecithinized superoxide dismutase (PC-SOD) composition useful as a drug material and a process for its production. The PC-SOD composition contains a PC-SOD obtained by substituting at least amino group in a specific SOD with a lecithin moiety represented by the following formula (I), wherein the PC-SOD contains a PC-SOD (A) having an m number of amino groups substituted with the lecithin moieties (wherein m is an integer of from 1 to 4 and averages from 1.5 to 2.4] as a main component, and the PC-SOD (A) consists of a PC-SOD (a1) wherein m=1, a PC-SOD (a2) wherein m=2, a PC-SOD (a3) wherein m=3 and a PC-SOD (a4) wherein m=4.
    Type: Application
    Filed: April 11, 2007
    Publication date: August 2, 2007
    Applicant: ASAHI GLASS CO., LTD.
    Inventors: Hideo Nomoto, Toshiaki Nakayama, Maki Murahashi, Yoshitomi Morizawa
  • Combination therapy for treating protein deficiency disorders
    Publication number: 20070178081
    Abstract: This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides stable compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.
    Type: Application
    Filed: December 1, 2006
    Publication date: August 2, 2007
    Inventor: Jian-Qiang Fan
  • Stabilized single domain antibodies
    Publication number: 20070178082
    Abstract: The present invention relates to heterospecific polypeptide constructs comprising at least one single domain antibody directed against a therapeutic and/or diagnostic target and at least one single domain antibody directed against a serum protein, said construct having a prolonged lifetime in biological circulatory systems. The invention further relates to methods for stabilising VHHs in biological circulatory systems.
    Type: Application
    Filed: November 7, 2003
    Publication date: August 2, 2007
    Applicant: ABLYNX N.V.
    Inventors: Karen Silence, Marc Lauwereys, Torsten Dreier
  • Medicinal compositions containing Fc receptor gamma-chain activator
    Publication number: 20070178083
    Abstract: The present invention provides pharmaceutical compositions composing, as an active ingredient, a substance capable of activating the ? chain of Fc receptors (FcR?) (provided that the substance is not an immunoglobulin for intravenous injection), and agents for stimulating myelinogenesis. The invention also provides agents for stimulating the differentiation of oligodendroglial precursor cells, agents for activating Fyn tyrosine kinase, and agents for stimulating the expression of myelin basic protein, all comprising a substance capable of activating FcR? as an active ingredient. Further, the invention provides a method of detecting myelinogenetic oligodendroglias or precursor cells thereof which comprises using the expression of FcR? in oligodendroglias or precursor cells thereof as an indicator.
    Type: Application
    Filed: June 13, 2006
    Publication date: August 2, 2007
    Applicant: KEIO UNIVERSITY
    Inventors: Jin Nakahara, Hiroaki Asou, Sadakazu Aiso
  • Continuous flow chamber device for separation, concentration, and/or purfication of cells
    Publication number: 20070178084
    Abstract: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization.
    Type: Application
    Filed: December 4, 2006
    Publication date: August 2, 2007
    Inventors: Michael King, Nichola Charles, Jane Liesveld, John Gentile, Kuldeepsinh Rana, Nathan Clark, Nipa Mody
  • BoNT/A Peptides and Methods of Predicting and Reducing Immunoresistance to Botulinum Toxin Therapy
    Publication number: 20070178085
    Abstract: The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides.
    Type: Application
    Filed: March 29, 2007
    Publication date: August 2, 2007
    Inventor: M. Zouhair Atassi
  • Monoclonal antibody against ABCA1
    Publication number: 20070178086
    Abstract: The present invention provides a binding domain of ABCA1, wherein binding of a ligand to the domain is capable of modulating the biological activity of ABCA1. Also provided are methods for screening compounds capable of modulating ABCA1 activity, and antibodies useful in modulating ABCA1 activity.
    Type: Application
    Filed: November 27, 2006
    Publication date: August 2, 2007
    Applicant: Baker Medical Research Institute
    Inventors: Dmitri Sviridov, Nigora Mukhamedova, Ying Fu
  • Method for Treating Immune Dysfunction by Regulation of CD40 Ligand Expression
    Publication number: 20070178087
    Abstract: Techniques for treating immune dysfunction in a patient by regulation of CD40 Ligand (CD40L) expression are provided. For example, one technique includes suppressing TFE3 and/or TFEB in the patient to thereby suppress CD40L expression in the patient. In addition, the technique may include administering a TFE3 inhibitor and/or a TFEB inhibitor for suppressing TFE3 and/or TFEB, respectively, in the patient.
    Type: Application
    Filed: December 14, 2006
    Publication date: August 2, 2007
    Inventors: Christopher Roman, Chongmin Huan
  • Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunoglobulin folds, BGS2, 3 and 4 and variants thereof
    Publication number: 20070178088
    Abstract: The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: March 21, 2007
    Publication date: August 2, 2007
    Inventors: Shujian Wu, Stanley Krystek, Liana Lee, John Feder, Janet Cheng
  • Mucosal vascular addressins and uses thereof
    Publication number: 20070178089
    Abstract: The present invention relates to isolated antibodies and antigen-binding fragments that selectively bind human MAdCAM.
    Type: Application
    Filed: April 3, 2007
    Publication date: August 2, 2007
    Inventors: Michael Briskin, Douglas Ringler, Dominic Picarella, Walter Newman
  • Breast endothelial cell expression patterns
    Publication number: 20070178090
    Abstract: To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future.
    Type: Application
    Filed: March 31, 2004
    Publication date: August 2, 2007
    Applicants: GENZYME CORPORATION, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Saraswati Sukumar, Stephen Madden
  • Combination Therapy
    Publication number: 20070178091
    Abstract: The invention provides for the treatment of diseases or disorders characterized by cells expressing the CD40 membrane glycoprotein. The invention provides methods for the treatment of various diseases or disorders characterized by cells expressing CD40 with a combination of an agent causes the depletion of cells expressing CD40 and a second agent which causes the depletion of cells expressing the CD20 membrane antigen. Pharmaceutical compositions and articles of manufacture such as kits comprising the agents and combinations thereof are also provided.
    Type: Application
    Filed: September 29, 2006
    Publication date: August 2, 2007
    Applicant: GENENTECH, INC.
    Inventor: Iqbal Grewal
  • Humanized anti-CD3 specific antibodies
    Publication number: 20070178092
    Abstract: Novel aglycosylated antibodies having a binding affinity for the CD3 antigen complex are of value for use in therapy, particularly in immunosuppression.
    Type: Application
    Filed: December 11, 2006
    Publication date: August 2, 2007
    Applicant: BTG International Limited
    Inventors: Sarah Bolt, Michael Clark, Scott Gorman, Edward Routledge, Herman Waldman
  • LYMPHOCYTES; METHODS
    Publication number: 20070178093
    Abstract: Provided are methods of modulating activity of regulatory T cells, CD4+ T cells, and CD8+ T cells. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 2, 2007
    Applicant: Schering Corporation
    Inventors: Shino Hanabuchi, Rene de Waal Malefyt, Yong-Jun Liu
  • Hybrid peptides modulate the immune response
    Publication number: 20070178094
    Abstract: The present invention provides an MHC class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LRMKLPKPPKPVSKMR (SEQ ID NO: 1) and modifications thereof which retain antigen presentation enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure which binds to the antigenic peptide binding site of an MHC class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components.
    Type: Application
    Filed: April 4, 2007
    Publication date: August 2, 2007
    Inventors: Robert Humphreys, Sharlene Adams, Minzhen Xu