Patents Issued in February 26, 2008
  • Patent number: 7335468
    Abstract: Isolated protein complexes are provided comprising Tsg101 and HIV GAG or GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAG or GAGp6 interaction within the protein complexes.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: February 26, 2008
    Assignee: Myriad Genetics, Inc.
    Inventors: Kenton Zavitz, Scott Morham, Daniel Albert Wettstein
  • Patent number: 7335469
    Abstract: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in the protein tyrosine phosphatase gene PTPN11 and its expression product, PTPN11, as well as mutations in other components in a PTPN11 signal transduction pathway promoting an increased signaling flux. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to PTPN11 and PTPN11 variants, and cells expressing such variants.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: February 26, 2008
    Assignee: Mt. Sinai School of Medicine of New York University
    Inventors: Bruce D. Gelb, Marco Tartaglia
  • Patent number: 7335470
    Abstract: In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: February 26, 2008
    Assignee: PerkinElmer, LAS, Inc.
    Inventors: Mansoor Mohammed, Jason Kang, Shishir Shah, Wei-Wen Cai
  • Patent number: 7335471
    Abstract: Mutant RNA polymerases of phagic origin in which the peptide chain is modified by substitution, deletion or addition of at least one amino acid, the modification having the effect of reducing the sensitivity of the RNA polymerases to the initial transcription sequence of the DNA sequence coding for the RNA, for a method for production of the RNA, or proteins coded by the RNA, from given nucleotide sequences, comprising a sequence of DNA coding for the RNA, the transcription of which is placed under the control of a promoter recognised by wild-type RNA polymerases and the mutant RNA polymerases as above. The method has a higher yield of RNA than the yield obtained when using the wild-type RNA polymerases in the presence of the same non-consensual ITS as that found in the sequence of DNA coding for the RNA.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: February 26, 2008
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean Guillerez, Pascal Lopez, Marc Dreyfus
  • Patent number: 7335472
    Abstract: The present invention relates to a method for simultaneously detecting hybridization reactions and immunoreactions in a sample which may contain target analytes consisting of at least one nucleic acid and of at least one other ligand that is different in nature, characterized in that it comprises the steps consisting in: (i) depositing a known amount of volume of the sample diluted in a reaction buffer, onto a capture surface pre-coated with the partners for capturing said target analytes, said capture partners consisting of at least one nucleic acid probe and at least one antiligand, (ii) reacting at a temperature of between 15° C. and 60° C. and (iii) visualizing the hybridization reactions and immunoreactions thus obtained, and also to the use of this method for detecting diseases of infectious or metabolic origin or viral origin, for the industrial diagnosis of the presence of bacteria, and for identifying and/or quantifying biological molecules.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: February 26, 2008
    Assignee: Biomerieux
    Inventors: Bernard Mandrand, Agnès Perrin, Alain Theretz
  • Patent number: 7335473
    Abstract: Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino acid sequence. Lelystad Agent-specific antibodies.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 26, 2008
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Gert Wensvoort, Catharinus Terpstra, Joannes Maria Anthonis Pol, Robertus Jacobus Maria Moormann, Johanna Jacoba Maria Meulenberg
  • Patent number: 7335474
    Abstract: Methods and systems for identifying biological marker-placebo effect correlations are provided. Clinical trial design and data analysis of clinical trial data is modified to accommodate marker-placebo effect correlations.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: February 26, 2008
    Assignee: Perlegen Sciences, Inc.
    Inventors: Bradley Margus, David Cox, Jesse Hsu
  • Patent number: 7335475
    Abstract: The present invention provides an isolated nucleic acid molecule encoding a PFM/SET polypeptide. Also provided is an isolated nucleic acid molecule encoding a functional fragment of a PFM/SET polypeptide that contains a PR, SET, PRAZ or PKZL domain of a PFM/SET polypeptide of the invention. Further provided by the invention are PFM/SET polypeptides, and functional fragments thereof that contain a PR, SET, PRAZ or PKZL domain of a PFM/SET polypeptide. The invention also provides PFM/SET antibodies, PFM/SET modulatory compounds, and related methods. The molecules of the invention can be used in methods of screening for a compound that modulates PFM/SET polypeptide histone methyltransferase activity and to modulate cell proliferation to prevent or treat proliferative disorders, including cancer. Additionally, the molecules and methods of the invention can be used to diagnose and prognose proliferative disorders.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: February 26, 2008
    Assignee: The Burnham Institute
    Inventor: Shi Huang
  • Patent number: 7335476
    Abstract: The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to ?-linolenic acid (GLA); ?-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-?-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to ETA; eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA); and arachidonic acid (ARA) to EPA. Nucleic acid sequences encoding codon-optimized desaturases and elongases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the codon-optimized desaturase or elongases, and recombinant host microorganisms expressing increased levels of desaturase or elongase are described.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: February 26, 2008
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Stephen K. Picataggio, Quinn Qun Zhu
  • Patent number: 7335477
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: February 26, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Patent number: 7335478
    Abstract: This invention provides methods and systems for linking the functional activation of a responder molecule to the interaction of two or more binding ensemble members of interest either in vitro or in vivo, and thereby producing a signal, phenotype, or other functional output in response to the interaction of the binding ensemble members. The systems comprise a responder, an inhibitor of the responder, and an inhibitor of the inhibitor, or “reactivator” of the responder, and interacting components. Two binding ensemble members are complexed to the other components of the system in such a way that interaction of the binding ensemble members, either directly or via additional ensemble members, causes a shift in the equilibrium of inhibitor binding from the responder to the reactivator, thereby functionally activating the responder.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: February 26, 2008
    Assignee: KaloBios Pharmaceuticals, Inc.
    Inventors: Robert F. Balint, Jeng-Horng Her
  • Patent number: 7335479
    Abstract: The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory cell specific G-protein alpha subunit.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: February 26, 2008
    Assignee: The Regents of the University of California
    Inventor: Charles S. Zuker
  • Patent number: 7335480
    Abstract: The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is enriched by having been raised in an environment that maintains antigenically active antigen. These antibodies may be used in an immunoreactive environment for detecting the presence of a mycobacterial infection in a sample from a subject.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: February 26, 2008
    Assignee: Chemogen, Inc.
    Inventors: Vladimir A. Koulchin, Elena V. Molokova, Jill L. Kerrick
  • Patent number: 7335481
    Abstract: The present invention provides methods for screening and identifying compounds that affect the metabolism of fatty acids and fatty acid derivatives, and thus for compounds that possess anti-diabetic as well as anti-obesity properties and possess the ability to affect the levels of chylomicrons, triacylglycerols, cholesterols, and fatty acids in a patient. Kits and compositions for screening and identifying such compounds are also provided. The invention is predicated on the identification of a physiological receptor for free fatty acids and anti-diabetic and anti-obesity drugs.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: February 26, 2008
    Inventors: Christer Owman, Bjorn Olde, Knut Kotarsky, Niclas Nilsson, Erik Flodgren
  • Patent number: 7335482
    Abstract: A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a living body and various pathology-associated abnormal cells such as tumor cells, into cells and being expressed specifically in tumor cells compared with normal cells; and drugs for treating various pathogenic conditions such as tumor (cancer) which are obtained by identifying and isolating the above amino acid transporter molecule and identifying a substance capable of inhibiting the biological activity and/or expression of this molecule. Intensive studies were made to identify a tumor cell membrane surface molecule associating or interacting with a cell membrane surface 4F2hc molecule seemingly playing an important role in the activation of an unknown amino acid transporter.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: February 26, 2008
    Assignee: Japan Science and Technology Corporation
    Inventors: Hitoshi Endou, Yoshikatsu Kanai
  • Patent number: 7335483
    Abstract: A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally together with a reaction accelerator; a method for quantitating cholesterol in specific lipoproteins by using the above method; and a kit for quantitating cholesterol in specific lipoproteins to be used in the above quantification method. By using this quantification method, cholesterol in a specific fraction can be conveniently, accurately and efficiently quantitated fundamentally without resort to polyanion, etc. Thus, this method is appropriately usable in various automatic analyzers.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: February 26, 2008
    Assignee: Daiichi Pure Chemicals Co., Ltd.
    Inventors: Mitsuhiro Nakamura, Yuriko Taniguchi, Mitsuhisa Manabe, Mitsuaki Yamamoto
  • Patent number: 7335484
    Abstract: Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: February 26, 2008
    Assignee: Queen's University at Kingston
    Inventors: P. Martin Petkovich, Jay A. White, Barbara R. Beckett, Glenville Jones
  • Patent number: 7335485
    Abstract: The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: February 26, 2008
    Assignee: Creighton University
    Inventors: Jennifer A. Black, Ellen S. Moland, Kenneth Thomson
  • Patent number: 7335486
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: February 26, 2008
    Assignee: Restoragen, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • Patent number: 7335487
    Abstract: This invention provides novel genes and polypeptides of the sweet receptor family, methods for production of the polypeptides, methods for screening compounds that specifically bind to and/or modulate the activity of these polypeptides; and antibodies specific for the polypeptides.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: February 26, 2008
    Assignees: IRM LLC, The Scripps Research Institute
    Inventors: Jiayu Liao, Sheng Ding, Peter G. Schultz
  • Patent number: 7335488
    Abstract: The present invention is directed to novel spontaneously fluorescent proteins having a unique chromophore formed from the amino acid sequence FR1R2R3F where R1 is Q or S; R2 is Y, W, F or H; and R3 is G, A or S (SEQ ID NO:34). The invention also encompasses the expression of nucleic acids that encode the proteins of the invention in a wide variety of engineered host cells, and the isolation of engineered proteins. In other embodiments, the invention comprises methods of use, generally including tagging a molecule or cell with the proteins of the invention by either chemical means or recombinant techniques.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: February 26, 2008
    Assignee: The Chinese University of Hong Kong
    Inventors: David Chi-Cheong Wan, Denis Tsz-Ming Ip
  • Patent number: 7335489
    Abstract: Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: February 26, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Reiner L. Gentz, Henry Hongjun Ji, Jian Ni, Jing-Shan Hu, Craig A. Rosen
  • Patent number: 7335490
    Abstract: Provided are uses of erythropoietin, or a derivative or functional analogue thereof, for the production of a medicament for the preventive or curative treatment of patients suffering from, or at risk of suffering from, cardiac failure.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: February 26, 2008
    Assignees: Crucell Holland B.V., Stichting Klinische Farmacologie Groningen
    Inventors: Wiekert Hendrikus Van Gilst, Ronald Hendrik Peter Brus, Dirk Jan Van Veldhuisen, Robert Henk Henning, Rudolf Allert De Boer
  • Patent number: 7335491
    Abstract: An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration greater than about 70 mM; ii) a molar cumulative glutamine to cumulative asparagine ratio of less than about 2; iii) a molar cumulative glutamine to cumulative total amino acid ratio of less than about 0.2; iv) a molar cumulative inorganic ion to cumulative total amino acid ratio between about 0.4 to 1; or v) a combined cumulative glutamine and cumulative asparagine concentration between about 16 and 36 mM, is provided. The use of such a system allows high levels of protein production and lessens accumulation of certain undesirable factors such as ammonium and/or lactate. Additionally, culture methods including a temperature shift, typically including a decrease in temperature when the culture has reached about 20-80% of it maximal cell density, are provided.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: February 26, 2008
    Assignee: Wyeth Research Ireland Limited
    Inventors: Denis Drapeau, Yen-Tung Luan, James R. Mercer, Wenge Wang, Daniel R. Lasko
  • Patent number: 7335492
    Abstract: The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the ability of carrying said protein into one of the phases.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: February 26, 2008
    Assignee: Valtion Teknillinen Tutkimuskeskus
    Inventors: Merja Penttilä, Tiina Nakari-Setälä, Richard Fagerström, Klaus Selber, Maria-Regina Kula, Markus Linder, Folke Tjerneld
  • Patent number: 7335493
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: February 26, 2008
    Assignee: sanofi pasteur limited
    Inventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
  • Patent number: 7335494
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: February 26, 2008
    Assignee: sanofi pasteur limited
    Inventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
  • Patent number: 7335495
    Abstract: The present invention describes the development and standardization of a facile method for the isolation and purification of cyclosporin A from a new source, viz., Fusarium nivale and evaluation of its novel antifungal activity against the food spoilage Aspargellius strains and few dermatophytes.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: February 26, 2008
    Assignee: Council of Scientific and Industrial Research
    Inventors: Siddarth Bhosale, Chandrakant Govid Naik, Perunnikulath Subrayan Parameswaran
  • Patent number: 7335496
    Abstract: A target substance is produced by culturing a bacterium which has the ability to produce the target substance in a medium to cause accumulation of said target substance in the medium and collecting the target substance from the medium, wherein the bacterium is modified so that a system for uptake of a byproduct of the target substance or a substrate for a biosynthesis system of the target substance into the bacterial cell.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: February 26, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoko Yamamoto, Hisao Ito
  • Patent number: 7335497
    Abstract: A method for efficiently producing theanine is provided, wherein glutamine and ethylamine are reacted by Pseudomonas citronellosis GEA FERM BP-8353, which is newly separated/selected from natural soil, belongs to the genus, Pseudomonas, and the species citronellosis and is a theanine producing bacteria with activities of transferring the ?-glutamyl group. Theanine production increased by four times by using glutaminase derived from the bacteria in a mixture of glutamine and ethylamine at a pH in a range of 9-12 in comparison with conventional methods.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: February 26, 2008
    Assignee: Taiyokagaku Co., Ltd.
    Inventors: Takashi Tachiki, Yukitaka Okada, Makoto Ozeki, Tsutomu Okubo, Lekh Raj Juneja, Nagahiro Yamazaki
  • Patent number: 7335498
    Abstract: The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of producing soyasapogenol B on a large scale using the same. A protein according to the present invention are concerned with (a), (b) or (c), namely (a) a protein comprising an amino acid sequence selected from the group consisting of the amino acid sequences shown in SEQ ID NOs: 2, 4, and 6; (b) a protein that has at least 50% homology to the protein comprising the amino acid sequence of the sequence described in (a) and having saponin-decomposing activity; or (c) a protein comprising a modified amino acid sequence of the sequence described in (a) that has one or more amino acid residues deleted, substituted, inserted, or added and having saponin-decomposing activity.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: February 26, 2008
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Manabu Watanabe, Naoki Mido, Takayoshi Tamura, Naomi Sumida, Takashi Yaguchi
  • Patent number: 7335499
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: February 26, 2008
    Assignee: Replidyne, Inc.
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • Patent number: 7335500
    Abstract: This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. The phosphorylated glycosides are then used to produce sugar nucleotides that are in turn used as donor sugars for glycosylation of acceptor carbohydrates. Especially preferred herein is the use of a disclosed method for fucosylation.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: February 26, 2008
    Assignee: The Scripps Research Institute
    Inventors: Chi-Huey Wong, Yoshitaka Ichikawa, Gwo-Jenn Shen, Kun-Chin Liu
  • Patent number: 7335501
    Abstract: The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel phytases derived from fungi of the Penicillium genus, in particular of the Penicillium sp. CBS 109899 strain, and also to the polynucleotides encoding these phytases. The invention also relates to vectors containing the polynucleotides, and to transformed host organisms expressing the phytases.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: February 26, 2008
    Assignee: Adisseo France S.A.S.
    Inventors: Jerome Pierrard, Ralph Bohlmann, Olivier Nore, Didier Saunier, Olivier Testeniere, Fanny Moussu
  • Patent number: 7335502
    Abstract: The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from Enterobacter sp. DS-S-75 strain (FERM BP-5494) which is bacteria belonging to the genus Enterobacter, a EnHCH gene shown by base sequence of SEQ. ID. NO: 1, a gene encoding a protein having an amino acid sequence of SEQ. ID. NO: 2, and E. coli DH5? (pKK-EnHCH) deposited to International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology as a deposition No. FERM BP-08466.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: February 26, 2008
    Assignee: Daiso Co., Ltd.
    Inventors: Atsushi Nakagawa, Toshio Suzuki, Atsuhiko Shinmyo, Ko Kato, Hideaki Idogaki
  • Patent number: 7335503
    Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: February 26, 2008
    Assignee: Genencor International, Inc.
    Inventors: Toby M. Baldwin, Benjamin S. Bower, Nigel Dunn-Coleman, Suzanne E. Lantz, Michael J. Pepsin
  • Patent number: 7335504
    Abstract: The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for research, nutritional care, personal care and industrial purposes.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: February 26, 2008
    Assignee: DIREVO Biotechnology AG
    Inventors: Ulrich Haupts, Andre Koltermann, Andreas Scheidig, Christian Votsmeier, Ulrich Kettling
  • Patent number: 7335505
    Abstract: The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor protein is associated with a disease state in which the precursor protein aggregates pathologically (e.g. a tauopathy), and the methods comprise: (a) providing a stable cell line transfected with nucleic acid encoding: (i) a template fragment of the precursor protein such that the template fragment is constitutively expressed in the cell at a level which is not toxic to the cell; and (ii) the precursor protein, which protein is inducibly expressed in the cell in response to a stimulus, whereby interaction of the template fragment with the precursor protein causes a conformational change in the precursor protein such as to cause aggregation and proteolytic processing of the precursor protein to the product fragment.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: February 26, 2008
    Assignee: Wista Laboratories Ltd.
    Inventors: Claude Michel Wischik, David Horsley, Janet Elizabeth Rickard, Charles Robert Harrington
  • Patent number: 7335506
    Abstract: A DNA encoding a variant of a protein, the protein having a loop region and six hydrophobic helices and involved in secretion of L-lysine to the outside of a cell, wherein the DNA encodes a variant of a protein not containing the loop region and facilitates secretion of L-lysine, L-arginine or both of these L-amino acids to the outside of a methanol-assimilating bacterium when the DNA is introduced into the bacterium, specifically lysE24, is introduced into a Methylobacillus bacteria to improve L-amino acid productivity, especially L-lysine and L-arginine productivities.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: February 26, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yoshiya Gunji, Hisashi Yasueda
  • Patent number: 7335507
    Abstract: Sperm cells are stained according to processes that involve the combining of sperm cells with a fluorescent DNA selective dye at an elevated temperature in excess of about 40° C. The methods allow for a decreased staining time. The cells may thereafter be efficiently sorted according to common separation methods, including flow cytometry.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: February 26, 2008
    Assignee: Monsanto Technology LLC
    Inventors: Muhammad Anzar, Cindy L. Ludwig, Jeffrey A. Graham, Jeanette A. Glaenzer
  • Patent number: 7335508
    Abstract: The present invention relates to porous freeze-dried plasma protein matrices having an open channel structure and a concentration gradient of plasma proteins crosslinked by the action of thrombin, and methods of producing said matrices. The compositions of the present invention are useful clinically, per se or as cell-bearing implants.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: February 26, 2008
    Assignee: ProChon Biotech Ltd.
    Inventors: Avner Yayon, Hilla Barkay, Malkit Azachi
  • Patent number: 7335509
    Abstract: Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: February 26, 2008
    Assignee: University of Pittsburgh
    Inventors: Leaf Huang, Xiang Gao, Frank L. Sorgi
  • Patent number: 7335510
    Abstract: Methods and materials for modulating (e.g., increasing or decreasing) nitrogen levels in plants are disclosed. For example, nucleic acids encoding nitrogen-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Plants and plant products having increased nitrogen levels are also disclosed.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: February 26, 2008
    Assignee: Ceres, Inc.
    Inventors: Richard Schneeberger, Emilio Margolles-Clark, Joon-Hyun Park, Boris Jankowski, Steven Craig Bobzin
  • Patent number: 7335511
    Abstract: Robust classification methods analyze magnetic resonance spectroscopy (MRS) data (spectra) of fine needle aspirates taken from breast tumors. The resultant data when compared with the histopathology and clinical criteria provide computerized classification-based diagnosis and prognosis with a very high degree of accuracy and reliability. Diagnostic correlation performed between the spectra and standard synoptic pathology findings contain detail regarding the pathology (malignant versus benign), vascular invasion by the primary cancer and lymph node involvement of the excised axillary lymph nodes. The classification strategy consisted of three stages: pre-processing of MR magnitude spectra to identify optimal spectral regions, cross-validated Linear Discriminant Analysis, and classification aggregation via Computerised Consensus Diagnosis. Malignant tissue was distinguished from benign lesions with an overall accuracy of 93%.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: February 26, 2008
    Assignees: University of Sydney, National Research Council of Canada
    Inventors: Carolyn E. Mountford, Peter Russell, Ian C. P. Smith, Rajmund L. Somorjai
  • Patent number: 7335512
    Abstract: The invention provides methods and kits to detect liver cirrhosis in mammals. The diagnostic test is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: February 26, 2008
    Assignees: Vlaams Interubiversitair Instituut voor Biotechnologie vzw, Universiteit Gent
    Inventors: Nico L. M. Callewaert, Roland H. Contreras
  • Patent number: 7335513
    Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: February 26, 2008
    Assignee: Symyx Technologies, Inc.
    Inventors: Matthew F. Smith, John F. Varni, G. Cameron Dales, Trevor G. Frank, Rakesh Jain, Lynn Van Erden
  • Patent number: 7335514
    Abstract: The present invention relates to an optical biosensor comprising a porous matrix. In the specific case, reference is made to anodized porous alumina, on the surface of which the biological component specific for the analyte in question is immobilized, and to an optical-signal detector connected to said matrix. The present patent further relates to a biosensor having the porous matrix and the optical detector integrated in a single structure, in particular to biosensors with porous matrix other than porous alumina, for example porous silicon.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: February 26, 2008
    Assignee: CRF Societa Consortile per Azioni
    Inventors: Valentina Grasso, Federica Valerio, Vito Guido Lambertini, Marco Pizzi, Piero Perlo
  • Patent number: 7335515
    Abstract: A (1?3)-?-D-glucan binding protein, a fluorescence-labeled (1?3)-?-D-glucan binding domain protein, a (1?3)-?-D-glucan measuring agent comprising the same, a method for measuring (1?3)-?-D-glucan using the same, and a (1?3)-?-D-glucan assay kit comprising the same.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: February 26, 2008
    Assignee: Seikagaku Kogyo Kabushiki Kaisha
    Inventors: Hiroshi Tamura, Masayuki Tanaka, Tatsushi Muta
  • Patent number: 7335516
    Abstract: A method of improving specific immune responses to small immunogens, haptens, has been developed by changing the linkage between the hapten and carrier being used for immunization. Antibodies to a glycated protein have been developed, utilizing an immunogen which is composed of a glycated peptide mimic of the glycated peptide sequence which is the target epitope, wherein the peptide mimic is constructed to conformationally mimic the conformation of the peptide in the native protein, the peptide mimic contains no charged groups or other immunodominant group, and the peptide mimic is connected to a spacer sequence equivalent to a peptide spacer of between one and thirty amino acids in length, which serves to position the peptide epitope in a conformation that approximates its conformation in the native protein. In a further embodiment the peptide mimic and spacer are linked to a carrier molecule.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: February 26, 2008
    Assignee: Serex, Inc.
    Inventors: Judith Fitzpatrick, Regina Lenda
  • Patent number: 7335517
    Abstract: A multichip semiconductor device is disclosed in which chips are stacked each of which comprises a semiconductor substrate formed on top with circuit components and an interlayer insulating film formed on the top of the semiconductor substrate. At least one of the chips has a connect plug of a metal formed in a through hole that passes through the semiconductor substrate and the interlayer insulating film. The chip with the connect plug is electrically connected with another chip by that connect plug.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: February 26, 2008
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Nobuo Hayasaka, Katsuya Okumura, Keiichi Sasaki, Mie Matsuo