Patents Issued in September 25, 2008
  • Hair Treatment Compositions
    Publication number: 20080233070
    Abstract: Aqueous hair treatment compositions which comprise a mono C14-C22 trimethylammonium surfactant, a di-(C20-C24) imidazoline quaternary surfactant, and a mono C12-C22 alkyl hydroxyethyl dimethylammonium surfactant provide improved hair conditioning benefits.
    Type: Application
    Filed: February 10, 2005
    Publication date: September 25, 2008
    Inventors: Colin Christopher David Giles, Artit Kijchotipisarn, Anuchai Sinsawat
  • PULVERULENT STYLING COMPOSITION
    Publication number: 20080233071
    Abstract: A pulverulent composition comprising 50 to 95% by weight of an aqueous solvent, hydrophobicized silicon dioxide powder and at least one film-forming and/or setting polymer for the temporary shaping of keratin fibers and a corresponding pulverulent styling composition. Upon mechanical stress, the powder releases the solvent and the film-forming and/or setting polymer so that the desired shaping or setting of, for example, a mechanically produced shape of the treated fibers is achieved.
    Type: Application
    Filed: April 15, 2008
    Publication date: September 25, 2008
    Inventors: Dirk Hentrich, Bernd Richters
  • Process and Kit-of-Parts for Improved Hair Conditioning After Coloring, Bleaching or Perming
    Publication number: 20080233072
    Abstract: The present invention relates to the field of hair care. More specifically, the present invention relates to the conditioning of hair after it has been oxidised in a coloring, bleaching or perming treatment. Superior conditioning is obtained by providing a cationic polymer to the hair while it is subjected to the oxidising treatment, and then the oxidised hair is subjected to a conditioning treatment with a composition comprising a functionalized silicone.
    Type: Application
    Filed: May 29, 2008
    Publication date: September 25, 2008
    Inventors: Andrei Sergeevich Bureiko, Simon Paul Godfrey, Olivier Charles Raineau
  • ION BINDING POLYMERS AND USES THEREOF
    Publication number: 20080233073
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Application
    Filed: March 26, 2008
    Publication date: September 25, 2008
    Applicant: RELYPSA, INC.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Gerrit Klaerner
  • Composition and Method For Dry Cow Udder Protection
    Publication number: 20080233074
    Abstract: A composition for dry cow udder protection includes a bimodal interpenetrating polymer system having both cationic and anionic functionalities and capable of forming a stable aqueous solution and ionic bonds between polar chains. The bimodal inter-penetrating polymer system, preferably, includes two acrylate copolymers, Polyacrylate-18 and Polyacrylate-19. The bimodal interpenetrating polymer system is approximately 20% to approximately 40%, by weight, of the aqueous solution, and preferably has a thixotropic viscosity of from approximately 500 cps to approximately 5,000 cps, as measured with a Brookfield Viscometer at 20 rpm with a #3 spindle. The composition, as part of an aqueous solution, is applied to the region of a cow teat to be protected and allowed to dry, resulting in a water-insoluble protecting film.
    Type: Application
    Filed: March 23, 2005
    Publication date: September 25, 2008
    Inventor: Robert D. Kross
  • COSMETIC COMPOSITION FOR SKIN TIGHTENING
    Publication number: 20080233075
    Abstract: The present invention provides a topical composition that contains a water-soluble film-forming polymer, a bimodal copolymer comprising a first polymeric component with anionic functional groups and a second polymeric component with cationic functional groups, and one or more biological polymers that are derived from a source selected from the group consisting of animals, plants, algae, fungi, and bacteria or are biotechnologically synthesized. The first and second polymeric components of the bimodal copolymer form an interpenetrating polymeric network that interacts with the water-soluble film-forming polymer and the biological polymers to form a polymeric film with superior skin-firming and skin-toning effects. Such a topical composition can be applied to saggy or wrinkled skin for enhancing the appearance of the skin.
    Type: Application
    Filed: March 22, 2007
    Publication date: September 25, 2008
    Inventors: Marina Sokolinsky, Krisztina Toth, Peter Lentini, Geoffrey Hawkins, Ken Marenus
  • Process for stabilizing ascorbic acid compositions
    Publication number: 20080233076
    Abstract: The present invention relates to a process for inhibiting radical-induced damage to skin involving contacting the skin with a composition containing: a) ascorbic acid and/or a water soluble derivative thereof; b) at least one cinnamic acid derivative; c) water; d) at least one non-aqueous organic solvent; e) at least one pH adjusting agent; and, f) optionally, a surfactant, and wherein the pH of the composition is from about 4 to about 9.
    Type: Application
    Filed: March 21, 2007
    Publication date: September 25, 2008
    Applicant: L'OREAL
    Inventors: Isabelle Hansenne, Hani Fares, Dana Smith
  • Cosmetic Use of a Particular Copolymer as Skin Tensor in a Cosmetic Composition
    Publication number: 20080233077
    Abstract: The present invention relates to the cosmetic use, as a skin-tensioning agent in a cosmetic composition, of a copolymer comprising units derived from styrene and units derived from ethyl (meth)acrylate, in which the weight ratio between the units derived from styrene and the units derived from ethyl (meth)acrylate is greater than or equal to 1.
    Type: Application
    Filed: March 17, 2006
    Publication date: September 25, 2008
    Applicant: L'OREAL
    Inventor: Guillaume Cassin
  • THERAPEUTIC POLYESTERS AND POLYAMIDES
    Publication number: 20080233078
    Abstract: Polymers (i.e. polyesters, polyamides, and polythioesters or a mixture thereof) which degrade hydrolytically into biologically active compounds are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided.
    Type: Application
    Filed: December 13, 2007
    Publication date: September 25, 2008
    Inventor: Kathryn E. Uhrich
  • CROSSLINKED AMINE POLYMERS
    Publication number: 20080233079
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
    Type: Application
    Filed: May 27, 2008
    Publication date: September 25, 2008
    Applicant: Ilypsa, Inc.
    Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
  • Inulins, Levans, Fructans And Other Smaller-Than-Cellulose Termite Feeding Attractants, And Termite
    Publication number: 20080233080
    Abstract: The present invention discloses Resistance Management (RM) practices that are critical to safeguarding Bacillus thuringiensis as a natural resource and to sustaining genetically modified crops that express Bt toxins for managing ECB and WCRW. The methods involve blending seed transformed with a nucleic acid encoding a different pesticidal protein, where both proteins target the same pest, but use different modes of pesticidal action. The seed can be also treated with pesticidal agents.
    Type: Application
    Filed: March 22, 2005
    Publication date: September 25, 2008
    Inventors: Rachael Perrott, Dini M. Miller, Donald E. Mullins
  • PRO-ANGIOGENIC PEPTIDES
    Publication number: 20080233081
    Abstract: This present invention generally relates to peptides, compositions, treatment methods, and devices useful for the medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the production of therapeutically beneficial cytokines. The peptides of the invention can regulate the release of a specific pattern of cytokines that promote angiogenesis, and modulate the immune system of a subject, without inducing deleterious side effects such as inflammation. Therefore, the peptides have therapeutic importance, particularly with respect to wound healing and restoration of circulation to damaged tissues.
    Type: Application
    Filed: December 12, 2007
    Publication date: September 25, 2008
    Applicant: SUSAVION BIOSCIENCES, INC.
    Inventors: Laura L. Eggink, J. Kenneth Hoober
  • POLYMER WITH ABILITY TO SIGNAL THE RECRUITMENT OF VASCULAR PROGENITOR CELLS
    Publication number: 20080233082
    Abstract: The present invention provides polymeric compositions, devices, and methods for repair of vascular injury, particularly endothelial injury and impaired vascular repair, such as from intracranial aneurysms and carotid atherosclerosis. The invention particularly provides polymers incorporating signaling factors useful for recruiting circulating vascular progenitor cells. The polymers can be used alone or as a coating for various devices for placement at sites of vascular injury to promote repair by the body's natural systems.
    Type: Application
    Filed: March 19, 2008
    Publication date: September 25, 2008
    Inventors: Brian Hoh, Chris Batich, Edward Scott
  • Methods and Compositions for Vaccination of Animals with Prrsv Antigens with Improved Immunogenicity
    Publication number: 20080233083
    Abstract: Pigs challenged with hypoglycosylated variants of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) major surface protein GP5 exhibited increased production of PRRSV-neutralizing antibodies relative to the levels of neurtalizing antibodies produced by pigs immunized with wild type (wt) or glycosylated GP5. This invention provides for methods of obtaining improved immune responses in pigs to PRRSV, compositions useful for obtaining the improved immune responses as well as isolated polynucleotides that encode hypoglycosylated variants of PRRSV major surface protein GP5.
    Type: Application
    Filed: August 30, 2006
    Publication date: September 25, 2008
    Applicant: Board of Regents Of The University of Nebraska
    Inventors: Israrul H. Ansari, Fernando A. Osorio, Asit K. Pattnaik
  • Interleukin-8 Labelled Via One or More Site Specifically Conjugated Hydrazinonicotinamide (Hynic) Moieties and its Use in Diagnosis of Infection and Inflammation
    Publication number: 20080233084
    Abstract: Interleukin-8, or an analog or derivative thereof, labelled via one or more hydrazinonicotinamide (HYNIC) moieties site-specifically conjugated to one or 5 more internal lysines and/or an N-terminal amino acid, for use in diagnosis of infection and inflammation.
    Type: Application
    Filed: October 13, 2006
    Publication date: September 25, 2008
    Inventors: Otto Boerman, Huub Rennen
  • Use of Il-18Bp Isoforms for the Treatment and/or Prevention of Neurological Inflammatory Diseases
    Publication number: 20080233085
    Abstract: The invention relates to the use of an IL18-BP isoform that does not bind to IL18, or of an agonist thereof, for treatment or prevention of a neurological and/or inflammatory disease. Preferred isoforms for use in the frame of the invention include IL-18BPb and IL-18BPd.
    Type: Application
    Filed: June 2, 2006
    Publication date: September 25, 2008
    Applicant: Laboratoires Serono SA
    Inventors: Yves Sagot, Yolande Chvatchko, Anne Corbaz
  • Expression Vectors for Treating Bacterial Infections
    Publication number: 20080233086
    Abstract: The present invention is compositions and methods for producing anti-bacterial polypeptides, and for using those compositions and methods for treating diseases and conditions caused by a bacterial infection. More specifically, the compositions and methods include treating a gram-negative bacterium with a gram-positive host that produces a polypeptide effective against the gram-negative bacterium.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 25, 2008
    Applicant: CANBIOCIN INC.
    Inventors: Michael E. Stiles, Liru Wang, Marius J. van Belkum
  • Methods for identifying, isolating, and utilizing endocrine progenitor cells from adult human pancreata
    Publication number: 20080233087
    Abstract: The presence of the cell surface marker CD133 or the presence of a glycosylated form of the prominin-1 gene product on adult pancreatic cells is used to identify pancreatic endocrine progenitor cells, and useful in methods of isolation and enrichment. Isolated pancreatic endocrine progenitor cells can be used for cell based therapy for insulin-dependent diabetes and pancreatectomy patients.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 25, 2008
    Inventors: Michael J. Shamblott, Michael Cohen
  • PREPARATIVE REGIMEN FOR ENGRAFTMENT, GROWTH AND DIFFERENTIATION OF NON-HEMATOPOEITIC CELLS IN VIVO AFTER TRANSPLANTATION
    Publication number: 20080233088
    Abstract: The invention relates to methods of obtaining an expanded population of mammalian ex vivo cells and/or for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested for further use or be left at the engraftment site of a subject to be treated. The invention also provides methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury.
    Type: Application
    Filed: February 15, 2008
    Publication date: September 25, 2008
    Applicants: Varian Medical Systems Technologies, Inc., Montefiore Medical Center
    Inventors: Chandan Guha, Robert M. Sutherland, Alan Alfieri, Jayanta Roy-Chowdury
  • Modified Cells Expressing a Protein That Modulates Activity of Bhlh Proteins, and Uses Thereof
    Publication number: 20080233089
    Abstract: The present invention relates to modified cells carrying a heterologous gene sequence encoding a protein, such as an Inhibitor of differentiation (Id) gene sequence that binds a basic helix-loop-helix (bHLH) protein to inhibit cell growth, differentiation and/or tumorigenesis of the modified cells. The modified cells are differentiated, proliferate and do not become tumorigenic when grafted into a recipient subject. Additionally, the modified cells produce a factor or factors that enhance the viability of co-grafted organs, tissues or cells. Thus, the modified cells are useful for testing agents for effects on the cells, for co-grafting with transplant organs, tissues or cells. The modified cells are also useful for enhancing the viability of thawing cells that have been cryo-preserved. In one embodiment, the modified cells are modified Sertoli cells.
    Type: Application
    Filed: April 29, 2005
    Publication date: September 25, 2008
    Inventors: Michael K. Skinner, Jaideep Chaudhary
  • Method of Treatment by Administration of Rna
    Publication number: 20080233090
    Abstract: A method of effecting a treatment response in a target tissue of a subject, comprising: administering to the subject isolated RNA comprising an RNA sequence extractable or extracted from a source tissue such that said treatment response is effected; wherein the RNA is isolated polyA positive RNA in substantially pure form.
    Type: Application
    Filed: January 19, 2006
    Publication date: September 25, 2008
    Inventor: Stephen Ray
  • Use of Probiotic Bacteria in the Treatment of Infection
    Publication number: 20080233091
    Abstract: The invention relates to the live cultures of probiotic bacteria to treat infectious diseases in humans and animals. Food-grade or non-pathogenic cultures are used to treat localised infections.
    Type: Application
    Filed: October 15, 2004
    Publication date: September 25, 2008
    Inventors: Paul Ross, Stephen Hallahan
  • METHODS AND COMPOSITIONS FOR TREATING LACTOSE INTOLERANCE
    Publication number: 20080233092
    Abstract: The invention provides methods and compositions for treating lactose intolerance. In embodiments, the invention provides methods and composition for decreasing symptoms of lactose intolerance by administering to an individual suffering from lactose intolerance increasing doses of lactose using a protocol such that at the end of treatment the individual's symptoms of lactose intolerance are decreased and such that symptoms remain decreased after a period of time.
    Type: Application
    Filed: March 26, 2008
    Publication date: September 25, 2008
    Inventor: Andrew J. Ritter
  • Preventing and Reducing Biofilm Formation and Planktonic Proliferation
    Publication number: 20080233093
    Abstract: The present invention relates to methods for preventing and/or reducing biofilm formation and/or planktonic proliferation with one or more selected bacteria strains or bacterial blends.
    Type: Application
    Filed: March 20, 2008
    Publication date: September 25, 2008
    Applicant: Novozymes Biologicals, Inc.
    Inventors: Sarah McHatton, Irene Michelle Williams, David Drahos
  • Attenuated Salmonella Enterica Serovar Paratyphi a and Uses Thereof
    Publication number: 20080233094
    Abstract: The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, and methods of using these strains.
    Type: Application
    Filed: October 30, 2006
    Publication date: September 25, 2008
    Applicant: University of Maryland, Baltimore
    Inventors: Christofer Vindurampulle, Eileen M. Barry, Myron M. Levine
  • METHOD FOR OBTAINING ANTIGEN-SPECIFIC TR1 REGULATORY LYMPHOCYTES
    Publication number: 20080233095
    Abstract: The invention relates to a method for preparing antigen-specific Tr1 regulatory lymphocytes. The inventive method involves the use of artificial antigen-presenting cells, expressing a molecule from the HLA class II system and a human LFA-3 molecule and expressing none of the B7-1, B7-2, B7-H1, CD40, CD23 or ICAM-1 costimulation molecules.
    Type: Application
    Filed: October 30, 2007
    Publication date: September 25, 2008
    Applicant: INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Herve GROUX, Francoise Cottrez, Abdelilah Wakkach
  • Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels
    Publication number: 20080233096
    Abstract: A method of reducing extracellular brain glutamate levels. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent capable of reducing blood glutamate levels thereby reducing extracellular brain glutamate levels.
    Type: Application
    Filed: May 28, 2008
    Publication date: September 25, 2008
    Applicant: Yeda Research And Development Co. Ltd.
    Inventor: Vivian I. Teichberg
  • Phosphorylation Site Of Mitogen-Activated Protein Kinases, Modified Proteins And Applications
    Publication number: 20080233097
    Abstract: A new phosphorylation site of mitogen-activated kinase proteins (MAPK) has been found. Phosphorylated MAPKs in said phosphorylation site can be used as a diagnostic marker of pathologies mediated by MAPKs.
    Type: Application
    Filed: June 9, 2006
    Publication date: September 25, 2008
    Applicant: UNIVERSIDAD AUTONOMA DE MADRID
    Inventors: Cristina Murga Montesinos, Federico Mayor Menendez, Maria Jurado Pueyo, Pedro Manuel Campo Muelas, Sandra Peregrin Pedrique
  • RHO Family Antagonists and Their Use to Block Inhibition of Neurite Outgrowth
    Publication number: 20080233098
    Abstract: The invention relates to an antagonist of one or more of Rho family members having ability to elicit neurite outgrowth from cultured neurons in an assay method which includes culturing neurons on a substrate that incorporates a growth-inhibiting amount of Rho family member and exposing the cultured neurons to a candidate Rho family member antagonist agent to permit neuron growth. Candidates which elicit neurite outgrowth from the cultured neurons are thus identified as Rho family antagonists.
    Type: Application
    Filed: November 30, 2007
    Publication date: September 25, 2008
    Inventors: Lisa McKerracher, Maxime Lehmann
  • Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels
    Publication number: 20080233099
    Abstract: A method of reducing extracellular brain glutamate levels. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent capable of reducing blood glutamate levels thereby reducing extracellular brain glutamate levels.
    Type: Application
    Filed: May 28, 2008
    Publication date: September 25, 2008
    Applicant: Yeda Research And Development Co. Ltd.
    Inventor: Vivian I. Teichberg
  • TARGETED ENZYMES
    Publication number: 20080233100
    Abstract: The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
    Type: Application
    Filed: January 10, 2008
    Publication date: September 25, 2008
    Inventors: Yiyou Chen, Anthony G. Day, David A. Estell, Christopher J. Murray, Scott D. Power, Volker Schellenberger
  • RNA-mediated epigenetic regulation of gene transcription
    Publication number: 20080233101
    Abstract: The invention provides a method of regulating transcription of a gene that is a target for an epigenetic regulator; a method of characterizing the transcriptional activity of such a gene; a method of screening for a chromosomal element (CE) for an epigenetic regulator of a target gene; an isolated complex including an epigenetic regulator for a target gene, wherein the epigenetic regulator is specifically bound to a non-coding polynucleotide; and a method of screening for a modulator of transcription of a gene that is a target for an epigenetic regulator.
    Type: Application
    Filed: September 12, 2006
    Publication date: September 25, 2008
    Inventor: Frank Sauer
  • Drug Therapy for Celiac Sprue
    Publication number: 20080233102
    Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: November 12, 2004
    Publication date: September 25, 2008
    Inventors: Chaitan Khosla, Kihang Choi
  • Mycobacterial peptide deformylase
    Publication number: 20080233103
    Abstract: The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from Mycobacterium tuberculosis. The use of this Antisense-oligonucleotide on mycobacterial culture inhibits the production of the peptide deformylase enzyme by hybridizing within the region, which is found to be responsible for maintaining stability as well as retaining the functionality of the enzyme and thus in turn affecting the growth of the cells. This invention also establishes the essentiality of the peptide deformylase enzyme in mycobacteria and claims it as a drug target in this microorganism.
    Type: Application
    Filed: August 1, 2007
    Publication date: September 25, 2008
    Applicant: Council of Scientific and Industrial Research
    Inventors: Rahul Saxena, Pardip K. Chakraborti
  • Probiotic, lactic acid-producing bacteria and uses thereof
    Publication number: 20080233104
    Abstract: The present invention discloses compositions and methodologies for the utilization of probiotic organisms in therapeutic compositions. More specifically, the present invention relates to the utilization of one or more species or strains of lactic acid-producing bacteria, preferably strains of Bacillus coagulans, for the control of gastrointestinal tract pathogens, including antibiotic-resistant gastrointestinal tract pathogens, and their associated diseases by both a reduction in the rate of colonization and the severity of the deleterious physiological effects of the colonization of the antibiotic-resistant pathogen. In addition, the present invention relates to the utilization of therapeutic compounds comprised of lactic acid-producing bacteria and anti-microbial agents such as antibiotics, anti-fungal compounds, anti-yeast compounds, or anti-viral compounds.
    Type: Application
    Filed: April 23, 2008
    Publication date: September 25, 2008
    Inventor: Sean Farmer
  • Compositions and methods for preventing or treating a viral infection
    Publication number: 20080233105
    Abstract: The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in particular embodiments, an anti-CD40 antibody. The compositions of the instant invention find application in the prevention or treatment of a viral infection.
    Type: Application
    Filed: September 12, 2006
    Publication date: September 25, 2008
    Inventors: William R. Green, Kathy A. Green, Edward J. Usherwood
  • Markers for labour
    Publication number: 20080233106
    Abstract: The invention relates to markers which find use in the diagnosis of labour or pre-term labour, to assays comprising such markers, to methods of identifying therapeutic agents which can prolong pregnancy, using these markers and to methods of treatment of pre-term labour, methods of prolonging gestation, or methods of suppressing labour contractility based on the markers.
    Type: Application
    Filed: March 22, 2007
    Publication date: September 25, 2008
    Applicant: National University of Ireland
    Inventors: Terence James Smith, Margaret O'Brien
  • SELECTIVE DELIVERY OF MOLECULES INTO CELLS OR MARKING OF CELLS IN DISEASED TISSUE REGIONS USING ENVIRONMENTALLY SENSITIVE TRANSMEMBRANE PEPTIDE
    Publication number: 20080233107
    Abstract: A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjugated with various functional moieties delivers and accumulates them at cell membrane with low extracellular pH. The functional moiety conjugated with polypeptide terminus placed inside cell are translocated through the cell membrane in cytosol. The peptide and its variants or non-peptide analogs can be used to deliver therapeutic, prophylactic, diagnostic, imaging, gene regulation, cell regulation, or immunologic agents to or inside of cells in vitro or in vivo in tissue at low extracellular pH.
    Type: Application
    Filed: July 16, 2007
    Publication date: September 25, 2008
    Applicant: BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND THE PROVIDE
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Ursula Lehnert, Donald M. Engelmann
  • METHODS FOR DETECTING AND INHIBITING ANGIOGENESIS USING ANTAGONISTS
    Publication number: 20080233108
    Abstract: The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting ?5?1 integrin in the tissue with an agent that interferes with specific binding of the ?5?1 integrin to a ligand expressed in the tissue; and methods of identifying angiogenesis in a tissue, by contacting the tissue with an agent that specifically binds ?5?1 integrin, and detecting specific binding of the agent to ?5?1 integrin associated with a blood vessel in the tissue. Also provided are methods of diagnosing a pathological condition characterized by angiogenesis in a tissue in an individual.
    Type: Application
    Filed: August 20, 2007
    Publication date: September 25, 2008
    Applicant: The Regents of the University of California
    Inventor: Judith A. Varner
  • Transgenic mammal carrying GANP gene transferred thereinto and utilization thereof
    Publication number: 20080233109
    Abstract: It is an object of the present invention to provide a high affinity antibody effective as a diagnostic or therapeutic for various diseases; a transgenic mammal for producing the high affinity antibody; and a medicine comprising the high affinity antibody or a cell producing the high affinity antibody. According to the present invention, a transgenic mammal carrying a GANP gene transferred thereinto, its progeny, or a part thereof, and a method of producing a high affinity antibody using the same are provided.
    Type: Application
    Filed: August 17, 2007
    Publication date: September 25, 2008
    Applicant: Immunokick Incorporation
    Inventor: Nobuo Sakaguchi
  • Intrabodies with defined framework that is stable in a reducing environment and applications thereof
    Publication number: 20080233110
    Abstract: A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined framework a scFv library can be generated wherein the framework is conserved while at least one complementary determining region (CDR) is randomized. Such library, e.g. in yeast cells, is suitable for screening for antibody/CDR-interactions or for screening for antibodies.
    Type: Application
    Filed: August 20, 2007
    Publication date: September 25, 2008
    Applicant: ESBATECH AG
    Inventors: Adrian Auf Der Maur, Alcide Barberis, Dominik Escher
  • HUMAN RECEPTOR PROTEINS; RELATED REAGENTS AND METHODS
    Publication number: 20080233111
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 25, 2008
    Applicant: Schering Corporation
    Inventors: Christi L. Parham, Kevin W. Moore, Nicholas J. Murgolo, J. Fernando Bazan
  • Treatment of Diseases
    Publication number: 20080233112
    Abstract: Methods of treatment of various non-demyelinating and demyelinating neural disorders are provided, comprising administering a serum composition obtained from a goat after challenge with an immunogen. Also provided are methods of treatment of certain autommune disorders using such a composition.
    Type: Application
    Filed: April 1, 2005
    Publication date: September 25, 2008
    Inventor: Bryan Youl
  • METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH HUMAN ANTI-FACTOR C3 ANTIBODIES AND USE THEREOF
    Publication number: 20080233113
    Abstract: A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3B inhibitor to the subject to inhibit at least one of C3b binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation of C3a, C5a, and MAC.
    Type: Application
    Filed: March 23, 2007
    Publication date: September 25, 2008
    Inventor: Rekha Bansal
  • NOVEL FGF HOMOLOGS
    Publication number: 20080233114
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
    Type: Application
    Filed: May 22, 2007
    Publication date: September 25, 2008
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella C. Raymond, Thomas R. Bukowski, Susan D. Holderman, Paul O. Sheppard
  • ANTI-IL-20 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION
    Publication number: 20080233115
    Abstract: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
    Type: Application
    Filed: November 27, 2007
    Publication date: September 25, 2008
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Yasmin A. Chandrasekher, Stacey R. Dillon, Joyce M. Lehner, Anthony W. Siadak, Pallavur V. Sivakumar, Margaret D. Moore
  • Human monoclonal antibodies to CTLA-4
    Publication number: 20080233116
    Abstract: In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 25, 2008
    Applicants: Abgenix, Inc., Pfizer Inc.
    Inventors: Douglas Charles Hanson, Mark Joseph Neveu, Eileen Elliott Mueller, Jeffrey Herbert Hanke, Steven Christopher Gilman, C. Geoffrey Davis, Jose Ramon Corvalan
  • REDUCING TUMOR GROWTH
    Publication number: 20080233117
    Abstract: This document provides methods and materials for reducing tumor growth in a mammal. For example, methods and materials for using PLVAP inhibitors to reduce tumor growth in a mammal (e.g., a human) are provided.
    Type: Application
    Filed: January 17, 2008
    Publication date: September 25, 2008
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Lewis R. Roberts, Michael R. Charlton
  • Uses Of Antibody To M-Csf
    Publication number: 20080233118
    Abstract: Methods of using M-CSF antibodies to treat macrophage-associated diseases including atherosclerosis and HIV are provided.
    Type: Application
    Filed: July 27, 2006
    Publication date: September 25, 2008
    Applicants: NOVARTIS AG, XOMA Technology Ltd.
    Inventor: William M. Kavanaugh
  • COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY LUNG DISEASE
    Publication number: 20080233119
    Abstract: The invention provides a method of modulating a T cell immune response by modulating DR3 function in the T cell, wherein the T cell response causes a symptom of inflammatory lung disease. The invention also provides a method of treating a reactive airway disease in an animal subject by administering to the subject an agent which modulates at least one functional activity of CD30. The invention additionally provides a method for treating an inflammatory lung disease by administering an agent that decreases the activity of DR3 or CD30, whereby IL-13 expression is decreased.
    Type: Application
    Filed: August 20, 2004
    Publication date: September 25, 2008
    Applicant: University Of Miami
    Inventor: Eckhard Podack