Patents Issued in April 6, 2010
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Patent number: 7691768Abstract: A process for the preparation and modification of additives, with a zeolite base and a high silica alumina ratio (SAR) like the ZSM-5, to increase the yield of propene and LPG in low severity FCC operations, that seeks to maximize the production of medium-distillates with low aromaticity and to minimize molecular cracking in the LCO range. The additives involved guarantee an increase in light olefin yields without altering the yield or the quality of the LCO produced. The innovative process includes surprising actions from rare earths (RE) on the active sites of zeolite, that at once partially block their pores and, in this way, make molecular cracking in the medium-distillate range difficult, which preferably occur at low reaction temperatures and keeps the remaining sites quite active.Type: GrantFiled: March 6, 2007Date of Patent: April 6, 2010Assignee: Petroleo Basileiro S.A. - PetrobrasInventors: Lam Yiu Lau, Raquel Bastiani, Claudia Maria de Lacerda Alvarenga Baptista
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Patent number: 7691769Abstract: A Selective Catalytic Reduction (SCR) catalyst was prepared by slurry coating ZSM-5 zeolite onto a cordierite monolith, then subliming an iron salt onto the zeolite, calcining the monolith, and then dipping the monolith either into an aqueous solution of manganese nitrate and cerium nitrate and then calcining, or by similar treatment with separate solutions of manganese nitrate and cerium nitrate. The supported catalyst containing iron, manganese, and cerium showed 80 percent conversion at 113 degrees Celsius of a feed gas containing nitrogen oxides having 4 parts NO to one part NO2, about one equivalent ammonia, and excess oxygen; conversion improved to 94 percent at 147 degrees Celsius. N2O was not detected (detection limit: 0.6 percent N2O).Type: GrantFiled: April 7, 2008Date of Patent: April 6, 2010Assignee: Los Alamos National Security, LLCInventor: Kevin C. Ott
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Patent number: 7691770Abstract: A method of making an electrode structure is provided. The method includes disposing an electrocatalytic material on an electrode, applying heat to the electrocatalytic material to form a volatile oxide of the electrocatalytic material, and applying a voltage to the electrode to reduce the volatile oxide to provide a number of nano-sized electrocatalytic particles on or proximate to a triple phase boundary, where the number of nano-sized electrocatalytic particles is greater on or proximate to the triple phase boundary than in an area that is not on or proximate to the triple phase boundary, and where the triple phase boundary is disposed on the electrode.Type: GrantFiled: September 2, 2005Date of Patent: April 6, 2010Assignee: General Electric CompanyInventors: James Anthony Ruud, Kenneth Walter Browall, Timothy Joseph Rehg, Stephane Renou, Todd-Michael Striker
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Patent number: 7691771Abstract: A process for regenerating a used acidic ionic liquid catalyst comprising the steps of contacting the used ionic liquid catalyst and hydrogen with a supported hydrogenation catalyst comprising a hydrogenation component on a support in a reaction zone under hydrogenation conditions for a time sufficient to increase the activity of the used catalyst is disclosed.Type: GrantFiled: December 20, 2005Date of Patent: April 6, 2010Assignee: Chevron U.S.A. Inc.Inventors: Thomas V. Harris, Saleh Elomari
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Patent number: 7691772Abstract: The present invention provides a method for producing a catalyst comprising the steps of: producing a metal salt solution containing salts of one or more metals; dispersing the metal salt solution, an organic matter and a porous carrier made of one or more metal oxides in a solvent to form a composite complex comprising one or more metal ions having 10 to 50,000 atoms, the organic matter bonded to the metal ions, and simultaneously make the composite complex carried on the porous carrier; and calcining the carrier having the composite complex carried thereon. The method may further comprise a step of reducing the metal ions on the porous carrier by reducing the carrier, after the step of making the composite complex carried on the carrier.Type: GrantFiled: March 22, 2005Date of Patent: April 6, 2010Assignee: Tanaka Kikinzoku Kogyo K.K.Inventor: Masayuki Saito
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Patent number: 7691773Abstract: The invention provides and a highly-dispersed supported catalyst that has a reduced average particle size of catalytic metal particles and is also supported by a porous support material. A method of preparing a supported catalyst that can reduce the average particle size of catalytic metal particles supported by a support material includes first mixing a charged support material with a solution containing a polymer electrolyte having a charge opposite to that of the support material to adsorb the polymer electrolyte on the support material. Next, the support material having the polymer electrolyte adsorbed thereon is mixed with a solution containing a catalytic metal precursor ion having a charge opposite to that of the polymer electrolyte to adsorb the catalytic metal precursor ion on the support material having the polymer electrolyte adsorbed on it.Type: GrantFiled: May 10, 2007Date of Patent: April 6, 2010Assignee: Samsung SDI Co., Ltd.Inventors: Sang-Hyuk Suh, Chan-Ho Pak, Hae-Kyoung Kim
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Patent number: 7691774Abstract: A process for producing a catalyst for hydrodesulfurization and isomerization of a sulfur-containing hydrocarbon oil, which comprises supporting palladium on a composition comprising a platinum-supported sulfated zirconia and alumina.Type: GrantFiled: February 28, 2003Date of Patent: April 6, 2010Assignees: Petroleum Energy Center, Cosmo Oil Co., Ltd.Inventors: Katsuya Watanabe, Takao Kimura, Takahito Kawakami, Kouji Baba
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Patent number: 7691775Abstract: A catalyst is disclosed herein. The catalyst includes a reducible oxide support and at least one noble metal fixed on the reducible oxide support. The noble metal(s) is loaded on the support at a substantially constant temperature and pH.Type: GrantFiled: May 4, 2007Date of Patent: April 6, 2010Assignee: The Regents of The University of MichiganInventors: Levi T. Thompson, Chang Hwan Kim, Shyamal K. Bej
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Patent number: 7691776Abstract: The invention relates to an oxidic catalyst containing cesium and tungsten for the synthesis of alkyl mercaptans from alkanols and hydrogen sulfide, and to a process for the production of this catalyst, wherein the molar ratio of cesium to tungsten is <2:1.Type: GrantFiled: August 14, 2009Date of Patent: April 6, 2010Assignee: Evonik Degussa GmbHInventors: Hubert Redlingshöfer, Christoph Weckbecker, Andreas Dörflein, Michael Rückriegel
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Patent number: 7691777Abstract: An oxidation catalyst for purifying an exhaust gas, which can provide an excellent catalyst activity at lower temperatures for particulates and high boiling point hydrocarbons in an exhaust gas of an internal combustion engine, is provided. The oxidation catalyst for purifying an exhaust gas is composed of a composite metal oxide represented by the general formula: Y1-xAgxMnO3, wherein 0.01?x?0.15. The composite metal oxide is represented by the general formula: Y1-xAgxMn1-yAyO3, wherein A is one metal selected from the group consisting of Ti, Nb, Ta and Ru, and 0.005?y?0.2.Type: GrantFiled: October 18, 2007Date of Patent: April 6, 2010Assignee: Honda Motor Co., Ltd.Inventors: Yuji Isogai, Kiyoshi Tanaami
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Patent number: 7691778Abstract: An exhaust gas purification catalyst comprises: an oxygen storage component constituted by a mixed oxide containing cerium and zirconium; and a catalytic metal carried on the oxygen storage component. The oxygen storage component is in the form of hollow secondary particles each formed so that primary particles of an average particle size of less than 10 nm cohere into a shell.Type: GrantFiled: November 2, 2006Date of Patent: April 6, 2010Assignees: Toda Kogyo Corporation, Mazda Motor CorporationInventors: Tomohiro Honda, Tomoaki Urai, Ryota Fujimoto, Seiji Miyoshi, Hiroshi Yamada, Hideharu Iwakuni, Koichiro Harada, Koji Minoshima, Akihide Takami
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Patent number: 7691780Abstract: The present invention relates to particle and nanoparticle composites useful as oxygen-reduction electrocatalysts. The particle composites are composed of a palladium or palladium-alloy particle or nanoparticle substrate coated with an atomic submonolayer, monolayer, bilayer, or trilayer of zerovalent platinum atoms. The invention also relates to a catalyst and a fuel cell containing the particle or nanoparticle composites of the invention. The invention additionally includes methods for oxygen reduction and production of electrical energy by using the particle and nanoparticle composites of the invention.Type: GrantFiled: December 22, 2004Date of Patent: April 6, 2010Assignee: Brookhaven Science Associates, LLCInventors: Radoslav Adzic, Junliang Zhang, Yibo Mo, Miomir Branko Vukmirovic
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Patent number: 7691781Abstract: This invention provides layered porous titanium oxide comprising an inorganic oxide as a core and titanium oxide deposited on the surface of the inorganic oxide, wherein the titanium localization index B/A represented by the ratio of the proportion of titanium (Ti) to the sum of the constituent metal (M) of the inorganic oxide and titanium (Ti) determined by X-ray photoelectron spectroscopy (XPS) [B=Ti XPS/(Ti XPS+M XPS)] to the bulk mixing molar ratio of titanium (Ti) to the sum of the constituent metal (M) of the inorganic oxide and titanium (Ti) [A=Ti/(Ti+M)] is 1.6 or more and the titanium oxide is deposited on the surface of the inorganic oxide so as to be chemically and/or microscopically united to the inorganic oxide and also provides a process for producing the same and a catalyst comprising the same. The layered porous titanium oxide of this invention has a regulated pore structure, a large specific surface area, and excellent mechanical strength and is useful as a catalyst or a catalyst carrier.Type: GrantFiled: December 25, 2003Date of Patent: April 6, 2010Assignee: Chiyoda CorporationInventors: Shinichi Inoue, Akihiro Mutou, Yukitaka Wada, Hidehiko Kudou, Tateo Ono, Hisashi Nomura
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Patent number: 7691782Abstract: The present invention relates to an active carbon containing an alkaline earth metal compound inside the particle and having a specific surface area of 10 to 2,000 m2/g, which is suitable to be used for polarizable electrodes in an electric double layer capacitor. The active carbon of the present invention enables to increase the capacitance of an electric double layer capacitor as well as to control the expansion of electrodes. The active carbon of the present invention can be obtained by adding an alkaline earth metal compound to a material such as pitch and performing heat treatment and activation.Type: GrantFiled: November 12, 2003Date of Patent: April 6, 2010Assignee: Showa Denko K.K.Inventor: Masako Tanaka
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Patent number: 7691783Abstract: A transfer substrate includes a support base which transmits laser light with a predetermined wavelength, a photothermal conversion layer provided on the support base, and a transfer layer provided on the photothermal conversion layer, the transfer layer including at least a luminescent layer. The photothermal conversion layer is composed of a first material and a second material having different absorptances with respect to the laser light.Type: GrantFiled: April 25, 2006Date of Patent: April 6, 2010Assignee: Sony CorporationInventors: Eisuke Matsuda, Masao Nishiguchi
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Patent number: 7691784Abstract: A main object of the present invention is to provide a receptor layer forming resin which makes it possible to obtain a receptor layer for a thermal transfer image receptor sheet having excellent dyeing property. The present invention achieves the above object by providing a receptor layer forming polyurethane resin for a thermal transfer image receptor sheet obtained by copolymerizing: a high molecular weight polyol having a number average molecular weight of 1000 or higher (A); an organic isocyanate (B); and according to need, a polyol compound having a number average molecular weight of 500 or lower (C), wherein the receptor layer forming polyurethane resin for a thermal transfer image receptor sheet meets the following requirements (1) to (4): (1) the resin has at least two glass transition temperatures; (2) at least one of the glass transition temperatures is between ?200 to 0° C., and at least one is between 20 to 100° C.Type: GrantFiled: March 30, 2006Date of Patent: April 6, 2010Assignee: Dai Nippon Printing Co., Ltd.Inventors: Masahiro Yuki, Kazuya Yoshida, Kuniyuki Doi, Hirotoshi Kizumoto
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Patent number: 7691785Abstract: Compounds of the formula I in which the substituents are as defined in claim 1 are suitable for use as herbicides.Type: GrantFiled: May 23, 2008Date of Patent: April 6, 2010Assignee: Syngenta Crop Protection, Inc.Inventors: Andrew Edmunds, Alain De Mesmaeker, Christoph Luthy, Jurgen Schaetzer
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Patent number: 7691786Abstract: The present invention relates to a method of preparing an oxide superconducting film, the method includes reacting a metal acetate containing metal M selected from the group consisting of lanthanum, neodymium and samarium with fluorocarboxylic acid having not less than three carbon atoms, reacting barium acetate with fluorocarboxylic acid having two carbon atoms, reacting copper acetate with fluorocarboxylic acid having not less than two carbon atoms, respectively, followed by refining reaction products, dissolving the reaction products in methanol such that a molar ratio of the metal M, barium and copper is 1:2:3 to prepare a coating solution, and coating a substrate with the coating solution to form a gel film, followed by calcining and firing the gel film to prepare an oxide superconducting film.Type: GrantFiled: March 3, 2008Date of Patent: April 6, 2010Assignees: Kabushiki Kaisha Toshiba, International Superconductivity Technology CenterInventors: Takeshi Araki, Koichi Nakao, Izumi Hirabayashi
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Patent number: 7691787Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.Type: GrantFiled: July 9, 2002Date of Patent: April 6, 2010Assignee: SurModics, Inc.Inventors: Ralph A. Chappa, Sheau-Ping Hu, Dale G. Swan, Melvin J. Swanson, Patrick E. Guire
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Patent number: 7691788Abstract: Compositions and methods of using same are described for negating asphaltene deposition in a formation, wellbore, near wellbore region, and production tubing. Compositions of the invention comprise an asphaltene solvent and a viscosity reducing agent, the asphaltene solvent and viscosity reducing agent present in a ratio so as to substantially reduce viscosity of an asphaltene-containing material while substantially negating deposition of asphaltenes either in a reservoir, in production tubing, or both when mixed or otherwise contacting the asphaltene-containing material.Type: GrantFiled: June 26, 2006Date of Patent: April 6, 2010Assignee: Schlumberger Technology CorporationInventors: Jiasen Tan, Ahmed Hammami, Moin Muhammad, Hussein Alboudwarej, Abdel M. Kharrat
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Patent number: 7691789Abstract: A composition and method is given for a well control fluid that is injected into a well during completion or remediation and prevents fluid flow from a formation into the well during operations (such as shut-in, or placement or adjustment of tools/hardware) when no fluid flow is desired. The composition includes a viscoelastic surfactant fluid system (VES) and a decomposable first solid material, preferably in fiber form, that forms a pack or plug in the well at the location where fluid would otherwise leak off, and then decomposes without intervention to release a product that is a breaker for the surfactant or the micelles of the VES. The composition optionally also contains a pH control agent and a second solid (that may also be a fluid loss agent) that affect the decomposition of the first solid.Type: GrantFiled: March 31, 2006Date of Patent: April 6, 2010Assignee: Schlumberger Technology CorporationInventors: Diankui Fu, Steve Russell, Mathew Samuel
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Patent number: 7691790Abstract: The present invention includes a cost effective custom-designed blend of organic chemicals to stimulate oil production. The invention includes a chemical composition for use in drilling operations for oil recovery and the method of using the chemical composition. The chemical composition includes an ammonia compound, an alcohol, and aqueous carrier solution. The aqueous carrier solution is of sufficient volume such that it is operable to fully dissolve the ammonia compound and alcohol in the aqueous carrier solution.Type: GrantFiled: October 16, 2008Date of Patent: April 6, 2010Assignee: Coriba Technologies, L.L.C.Inventor: Harvey G. Cobb
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Patent number: 7691791Abstract: A lubricant molded body, which is to be applied to a surface of a photosensitive layer for electrophotography in an image forming apparatus, for example, is composed of at least two kinds of higher fatty acid metallic salts having respectively different carbon numbers. As the higher fatty acid metallic salt that forms lubricant molded body, compounds such as zinc stearate, calcium stearate, barium stearate, aluminum stearate, zinc laurate, calcium laurate, etc. may be recited. The higher fatty acid metallic salts may contain at least one kind of fillers selected from the group consisting of silica, alumina, tungsten disulfide, molybdenum disulfide, graphite fluoride, graphite, boron nitride, polytetrafluoroethylene (PTFE), ethylene tetrafluoroethylene (ETFE), and polyvinylidene fluoride (PVDF).Type: GrantFiled: November 22, 2006Date of Patent: April 6, 2010Assignee: Ricoh Company, Ltd.Inventor: Joe Usami
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Patent number: 7691792Abstract: Compositions comprising a farnesane dimer and/or a farnesene dimer and a compound selected from squalene, squalene and dehydrosqualene are described. The compositions provided comprise conventional additives. Methods of making and using the compounds and composition are also disclosed.Type: GrantFiled: October 9, 2009Date of Patent: April 6, 2010Assignee: Amyris Biotechnologies, Inc.Inventors: Karl Fisher, Frank X. Woolard
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Patent number: 7691793Abstract: A composition is disclosed that comprises the reaction product of an acidic organic compound and a boron compound. The composition is useful as a detergent additive for lubricants and hydrocarbon fuels.Type: GrantFiled: May 9, 2005Date of Patent: April 6, 2010Assignee: Chemtura CorporationInventor: Ronald J. Muir
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Patent number: 7691794Abstract: Disclosed herein are reaction products of an acidic organic compound, a boron compound, and an alkoxylated amine and/or alkoxylated amide. Also disclosed are lubricating oil compositions and fuel compositions containing the reaction products.Type: GrantFiled: January 4, 2006Date of Patent: April 6, 2010Assignee: Chemtura CorporationInventor: Ronald J. Muir
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Patent number: 7691795Abstract: The invention provides a grease composition comprising a stable dispersion of a metal hydroxide with a number average particle size in the range 20 nanometres to 2 micrometres, a surfactant with a HLB of less than 10, a mono- or poly-carboxylic acid, and an oil of lubricating viscosity. The method of preparing a grease composition is also disclosed with benefits including a reduction in reaction time, amount of foam produced and environmental hazards.Type: GrantFiled: August 14, 2003Date of Patent: April 6, 2010Assignee: The Lubrizol CorporationInventors: Stephen J. Nolan, Carl F. Kernizan, Paul S. Greenfield, Claire L. Hollingshurst
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Patent number: 7691796Abstract: A method of improving the compatibility of an overbased detergent with other additives in a lubricating oil composition. The method includes the step of adding an oil-soluble, hydrocarbyl sulphonic acid to the detergent.Type: GrantFiled: July 10, 2006Date of Patent: April 6, 2010Assignee: Infineum International LimitedInventors: Christopher J. Adams, Peter J. Dowding
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Patent number: 7691797Abstract: The present invention relates to acrylic block copolymers synthesized by a controlled radical process, and their use as thickeners in oil-based compositions. The acrylic copolymers are especially useful as viscosity index improvers in lubricating oil.Type: GrantFiled: October 15, 2004Date of Patent: April 6, 2010Assignee: Arkema Inc.Inventors: Scott Charles Schmidt, Peter Anthony Callais, Noah Eliot Macy, Olivier Guerrett
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Patent number: 7691798Abstract: A polymer coating applied to a load bearing or contact surface of objects such as skis and snowboards is provided. The polymer coating is a drag reducing, water soluble long chain polymer such as polyethylene oxide. The polymer coating is applied to the contact surface of the object and dissolves into the thin layer of water that forms between the contact surface and a water-containing surface over which the object is passed. The polymer readily dissolves in the thin water layer, decreasing the friction between the contact surface of the ski or snowboard and the surface of the snow or ice.Type: GrantFiled: December 8, 2005Date of Patent: April 6, 2010Assignee: The United States of America as represented by the Secretary of the NavyInventors: Richard H. Nadolink, Charles W. Henoch, Susan Yan
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Patent number: 7691799Abstract: The present invention is related to a conditioning composition for hair comprising at least one arylated silicone and at least one silicone quaternary compound. The conditioning composition of the present invention can be in the form of a shampoo, cleansing-conditioning composition, or in the form of a conditioner used after washing hair with cleansing compositions. It has surprisingly been found out that a composition comprising at least one arylated silicone and at least one silicone quaternary compound gives hair its natural excellent shine, volume and body, elasticity and it is easily manageable.Type: GrantFiled: August 7, 2008Date of Patent: April 6, 2010Assignee: KPSS-Kao Professional Salon Services GmbHInventors: Michael Molenda, Martin Hoffmann, Iika Tietjen, Vera Bistram, Andrea Ast, Claudia Arbter
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Patent number: 7691800Abstract: The present invention generally relates to a cleaning agent for a spray gun and a method and apparatus for cleaning the spray gun, and more specifically, to the agent and method of use thereof for cleaning a water-based spray gun using a novel cleaning agent comprising a solvent of n-butanol, a solvent of n-propanol, a surfactant of ethoxylated nonylphenol, and water. The cleaning agent may also be used under specific pH conditions and an emulsifier or a foam suppressor may be used. What is also contemplated is the use of a spray gun having smooth interior and exterior surfaces. The method contemplates the contacting of the cleaning agent with the spray gun, the recovering of the cleaning agent, the separating of the cleaning agent and the reuse of the cleaning agent. What is also contemplated is the use of the cleaning agent in an automatic washing apparatus and the use of the cleaning agent as part of a fluid supply to an automated spray gun to clean the spray gun access.Type: GrantFiled: August 30, 2006Date of Patent: April 6, 2010Assignee: B-Tech IP Holdings, LLCInventor: William S. Weiss
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Patent number: 7691801Abstract: A liquid fabric treatment composition comprising from 50 to 92% by weight of water, from 1 to 15% by weight of one or more alkylated sugars, from 1 to 15% by weight of one or more fatty acids, from 5 to 25% by weight of one or more fatty acid esters, and from 1 to 15% by weight of fatty acid soap.Type: GrantFiled: May 29, 2007Date of Patent: April 6, 2010Assignee: The Sun Products CorporationInventors: Stephen Leonard Briggs, Craig Warren Jones, Glyn Roberts
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Patent number: 7691802Abstract: Novel compounds of formula I and their use in flavour and fragrance compositions. R1 to R13 have the meaning as described in the specification.Type: GrantFiled: June 20, 2003Date of Patent: April 6, 2010Assignee: Givaudan SAInventor: Andreas Goeke
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Patent number: 7691803Abstract: The present invention a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of a compound of formula: wherein R is absent, hydrogen or methyl; R1, R2, and R3 are independently hydrogen or methyl; and the broken lines represent independently single or double bonds, with the proviso that when R1, R2, and R3 are hydrogen, R is methyl.Type: GrantFiled: November 12, 2008Date of Patent: April 6, 2010Assignee: International Flavors & Fragrances Inc.Inventors: Feng Geng, Richard M. Boden
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Patent number: 7691804Abstract: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.Type: GrantFiled: February 15, 2002Date of Patent: April 6, 2010Assignees: Biogen Idec MA Inc., Apoxis SAInventors: Browning Jeffrey, Ambrose Christine, MacKay Fabienne, Tschopp Jurg, Schneider Pascal, Thompson Jeffrey
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Patent number: 7691805Abstract: The invention relates to compositions comprising a compound based on the general formula (I) R1-Arg-R2—NH—CH(R3)—CH2—NH—R4 ??(I) and a carrier, diluent or an excipient.Type: GrantFiled: November 10, 2005Date of Patent: April 6, 2010Assignee: Neobiotics ABInventors: Anders Grubb, Aftab Jasir, Claes Schalén, Franciszek Kasprzykowski, Regina Kasprzykowska
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Patent number: 7691806Abstract: Biomolecular conjugates are provided which comprise the conjugation product of a repeat sequence protein polymer and at least one active agent. Additional aspects provide methods for their manufacture and various industrial and consumer applications.Type: GrantFiled: February 10, 2006Date of Patent: April 6, 2010Assignee: Genencor International, Inc.Inventors: Katherine D. Collier, William A. Cuevas, Manoj Kumar
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Patent number: 7691807Abstract: The present invention relates to compositions and methods for producing therapeutic oligomeric compounds. In one aspect the invention relates to methods for administering the oligomeric compounds for the treatment and prevention of disease, for example, a fungal infection, bacterial infection, or cancer, in a mammal. In particular, the invention relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the invention may optionally be administered with at least one of a pharmaceutically acceptable excipient, pharmacologically active agent or a combination thereof.Type: GrantFiled: March 17, 2006Date of Patent: April 6, 2010Assignees: Centre National de la Recherche Scientifique (CNRS), ImmuPharma France SAInventors: Aude Violette, Jean-Paul Briand, Robert Zimmer, Gilles Guichard
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Patent number: 7691808Abstract: Disclosed herein are compositions and methods for the treatment or prevention of neurological disorders. Also disclosed are compositions and methods for the treatment or prevention of skin pathologies. The invention further discloses compositions and methods for the modulation of acetylcholine receptor activity. Antibodies generated against SLURP-1 and related proteins are also included.Type: GrantFiled: September 6, 2006Date of Patent: April 6, 2010Assignee: Merck Serono SAInventors: Fabrice Chimienti, Ronald Hogg, Marcel Huber, Daniel Bertrand, Daniel Hohl
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Patent number: 7691809Abstract: The method of the present invention provides a novel use of lactoferrin to modulate the molecular events during development of age-related disorders in humans. More specifically, the present invention is directed to the use of lactoferrin to treat or prevent autoimmune, neurodegenerative and immune hypersensitivity disorders, and its use for the manufacture of a medicament for the treatment or prevention of such conditions.Type: GrantFiled: January 22, 2005Date of Patent: April 6, 2010Assignee: Vitaerx Pharmaceutical, Inc.Inventors: Marian L. Kruzel, Tadeusz Kruzel, Michal Zimecki
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Patent number: 7691810Abstract: The present invention provides a process for producing an antithrombin III composition comprising an antithrombin III molecule having complex type N-glycoside-linked sugar chains, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains.Type: GrantFiled: October 7, 2004Date of Patent: April 6, 2010Assignee: Kyowa Hakko Kirin Co., LtdInventors: Tsuyoshi Yamada, Mitsuo Satoh, Yutaka Kanda, Kazuya Yamano
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Patent number: 7691811Abstract: Methods and compositions for enhancing the activity and/or duration of action of loteprednol etabonate and other soft anti-inflammatory steroids of the haloalkyl 17?-alkoxycarbonyloxy-11?-hydroxyandrost-4-cn-3-one-17?-carboxylate type and the corresponding ?1,4-compounds are described. The enhancing agents have the formula: wherein Z1 is carbonyl, ?-hydroxymethylene or methylene; R2 is H, —OH or —OCOR3 wherein R3 is C1-5 alkyl; Y is —OH, —SH or —OCOR4 wherein R4 is C1-5 alkyl, cyclopentylethyl or diethylaminoethyl; and the dotted line in ring A indicates that the 1,2-linkage is saturated or unsaturated. Ophthalmic administration in the treatment of dry eye is specifically targeted.Type: GrantFiled: November 20, 2007Date of Patent: April 6, 2010Inventor: Nicholas S. Bodor
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Patent number: 7691812Abstract: Methods are provided for inhibiting growth of prolactin-responsive cancer cells and treating prolactin-responsive malignancies via administration of an agent such as cyclosporine A which directly inhibits an enzymatic activity of a cyclophilin.Type: GrantFiled: October 26, 2005Date of Patent: April 6, 2010Assignee: Trustees of the University of PennsylvaniaInventor: Charles V. Clevenger
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Patent number: 7691813Abstract: Provided are lactam-cyclized peptide CXCR4 antagonists useful in the treatment of cancers, rheumatoid arthritis, pulmonary fibrosis, and HIV infection.Type: GrantFiled: May 20, 2008Date of Patent: April 6, 2010Assignee: Eli Lilly and CompanyInventors: Wayne David Kohn, Sheng-Bin Peng, Liang Zeng Yan
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Patent number: 7691814Abstract: Novel osteogenic compositions and methods are provided. In a broad aspect, the composition comprises either a first amino acid sequence which is capable of being phosphorylated by CAMK2; or a nucleic acid sequence encoding the first amino acid sequence; or a combination thereof. Optionally, the first amino acid sequence may further comprise a second amino acid sequence which is capable of binding the Smurf1 protein. Further, the composition may comprise a BMP protein and/or an agent capable of decreasing an amount or an activity of CAMK2. The compositions of the instant invention may be incorporated into an implant or delivered via a catheter.Type: GrantFiled: December 5, 2006Date of Patent: April 6, 2010Inventors: Scott D. Boden, Sreedhara Sangadala
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Patent number: 7691815Abstract: This invention relates to a general methodology for efficient creation of trimeric soluble receptors for therapeutic applications. The process involves gene fusion between a soluble receptor with a ligand binding domain and a trimerization tag from the C-propeptide domain of pro-collagen, which is capable of self-assembly into a covalently linked trimer. Using both in vitro bioassays and an in vivo mouse model for collagen-induced arthritis (CIA), we show that the homotrimeric soluble TNF receptor produced with such method is a more potent blocker than dimeric TNF receptor decoys in inhibiting TNF-? mediated inflammatory diseases.Type: GrantFiled: December 21, 2006Date of Patent: April 6, 2010Assignee: Gen Hunter CorporationInventor: Peng Liang
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Patent number: 7691816Abstract: The invention provides pharmaceutical compositions comprising TGF-? superfamily members and sugars, the compositions allowing improved recovery and/or increased biological activity of the TGF-? superfamily member incorporated therein. The invention also relates to uses of sugars to improve the recovery or increase the biological activity of TGF-? superfamily members in a pharmaceutical composition. Uses of the pharmaceutical compositions are also described, particularly with reference to wound healing and fibrosis. Furthermore, the invention discloses medicaments for the prevention or reduction of injection pain.Type: GrantFiled: July 12, 2006Date of Patent: April 6, 2010Assignee: Renovo Ltd.Inventors: Mark Ferguson, Sharon O'Kane, Hugh Laverty, Nick Occleston, Jane Kelly, Wayne Burrill
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Patent number: 7691817Abstract: Systems and methods are described providing therapeutic preparations of tachykinins, and more specifically sialokinins, for treating various types of abnormal cellular proliferation conditions in regions of tissue associated with the body of a patient. The sialokinins may be isolated and purified from natural or bioengineered sources, or may be synthesized, and may be combined into, with, or on an implant for local elution or otherwise as a powder mixed in a carrier vehicle for injection delivery. Tumors, warts, and restenosis are abnormal cellular proliferation conditions treated by therapeutic doses of sialokinin. Size of the tissue structure to be treated is used to determine the therapeutic dose of sialokinin. The sialokinins are either locally or systemically delivered at therapeutic doses for the desired effect. Implants such as stents are coated with sialokinins for local elution at the site of injury or tissue otherwise vulnerable to harmful conditions treated by the sialokinin.Type: GrantFiled: November 19, 2004Date of Patent: April 6, 2010Inventors: Nathan C. Maier, Amiel G. Jarstfer
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Patent number: 7691818Abstract: New peptidomimetic inhibitors of retroviral proteases are in particular for human immunodeficiency virus (HIV) protease. These inhibitors include as the core structure a new diamiriodiol isostere of the dipeptide Phe-Pro having four stereogenic centers. The inhibitors have been shown to inhibit HIV-protease and can therefore be usefully employed as antivirals for post-exposure prophylaxis and as a therapy for viral infections by a retrovirus, in particular HIV. The syntheses processes of the isosteres and inhibitors are also described.Type: GrantFiled: June 15, 2005Date of Patent: April 6, 2010Assignee: Universita' Degli Studi Di TreisteInventors: Fabio Benedetti, Alessandro Tossi, Federico Berti, Pietro Campaner, Francesca Dinon