Abstract: The invention relates to a method or process for the manufacture of blood pressure lowering agents, such as valsartan, novel intermediates as well as process steps in said synthesis. The method or process leads via the novel intermediate salts of the formula IA, or a tautomer thereof, wherein [kat]n+ is a cation and n is 1, 2, 3, 4, 5 or 6.

Abstract: A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided. A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R1 represents an aryl, etc.; R2 represents a hydroxy, etc.; R3 represents a —C1-6 alkyl, etc.; R4 represents a —C1-6 alkyl, etc.; X5 represents —O—, etc.

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).

Abstract: The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to intermediates useful in this process.

Abstract: Substituted imidazoline derivatives corresponding to Formula I: a method for producing them from substituted aldehyde compounds of Formula B: and the use of such imidazoline derivatives and aldehyde compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

Abstract: Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

Abstract: A chemical genus of biphenyl heterocycle derivative inhibitors of LTA4H (leukotriene A4 hydrolase) of the formula: is disclosed. In these compounds Q and Z are (CH2)1-10; in which one or two (CH2) may optionally be replaced by —O—, —NR1—, —SO—, —S(O)2—, —C(?O)— or —C?O(NH)—; Het is a 5-7 membered non-aromatic nitrogen heterocycle; and W is acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, —COOalkyl, —CHO, heterocyclyl, substituted aryl, or substituted heterocyclyl, or taken together ZW can be H or —COOalkyl. The compounds are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

Abstract: The present invention relates to a method of treating diabetic nephropathy with a combination of an immunosuppressive agent and an ACE inhibitor.

Abstract: The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.

Abstract: Compounds that may have anti-inflammatory activity are of general formula (I); wherein X1, is H or COR1, and X2 is H or COR2 but X1, and X2 are not both H; R1 and R2 are the same or different and are each C1-4 alkyl substituted with R3, or a four to seven-membered ring which can be optionally substituted with R8 and can contain one or more additional heteroatoms selected from O, S(O)n and NR9; is R3 is F, CF3, OR4, NR5R6 O, S(O)n R7; R4, R5 and R6 are the same or different and are each H or C1-4 alkyl optionally substituted with R3, or NR5R6 is a C4-6 heterocycloalkyl ring containing one or more heteroatoms selected from O, NR8 and S(O)n; each n is 0-2; R7 is C1-4 alkyl; R8 is as defined for R3 or C1-4 alkyl optionally substituted with R3 or halogen; and R9 is H or C1-4 alkyl; or a salt, solvate or hydrate thereof.

Abstract: The present invention provides kits, methods and compositions for the treatment of tumor and other proliferative diseases such as tumors. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues.

Abstract: Novel stable and pharmacologically acceptable salts of L-carnitine and lower alkanoyl L-carnitines with alpha-ketoglutaric acid are disclosed as well as the compositions useful as dietary and dietetic supplements, nutraceuticals or drugs containing same.

Abstract: The invention relates to compositions and methods of treatment using an iron chelator, an antioxidant, estrogen, and/or combinations thereof, optionally, linked to a nanoparticle, to treat a subject in need thereof. The compositions and methods may be used to restore or protect the normal functions of osteoblast and osteoclast by depleting iron and inhibiting oxidative damage. The compositions and methods may also be used to increase the bone formation rate in a subject.

Abstract: Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumor, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumors.

Abstract: Polyamine compounds, method of synthesis and method of use for anti-cancer purposes, for enhancing the activity of existing anti-cancer drugs, as well as, for inhibiting N-Methyl-D-Aspartate (NMDA) receptors found in neurotransmission systems are provided. Certain polyamine motifs have been identified that can be attached to toxic agents to facilitate their access to cancer cells as well as polyamine compounds of surprising cytotoxicity with selectivity in killing cancer cells, and surprising utility in the treatment of Alzheimer's disease and brain stroke. It includes an illustrative conjugate system with examples of a triamine or a tetraamine appended to a cytotoxic agent. Included is a general strategy to enhance cell uptake by attaching a polyamine vectoring system with an example of a triamine vector attached to an existing anti-cancer drug to improve its chemotherapeutic potency.

Abstract: Disclosed herein are motuporamine mimic agents and methods of making and using same. Particularly exemplified are motuporamine mimic agents comprising cytotoxic activity and/or anti-metaplastic activity.

Abstract: The invention relates to a liquid crystal gel containing polyoxyethylene-glyceryl-trioleate, propylene-glycol, isopropyl myristate and a hyaluronic acid salt or complex for use in the manufacture of transdermal pharmaceutical compositions and healing cosmetics. The invention also relates to transdermal pharmaceutical composition consists of an estrogen and a progestin component as well as a liquid crystal gel containing polyoxyethylene-glyceryl-trioleate, propylene-glycol, isopropyl myristate and a hyaluronic acid salt or complex. The invention can be applied for transdermal hormone replacement therapy and for other transdermal depending on the active principles included.

Abstract: The invention provides methods for treating beta-amyloid protein-involved ocular disease including age-related macular degeneration and glaucoma, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from Curcuma sp., Zingiber sp., Ginkgo biloba, Salvia sp., and Rosmarinus sp. and synthetic chemical analogues thereof, for the treatment of a beta-amyloid protein-involved ocular disease.

Abstract: Fluids viscosified with viscoelastic surfactants (VESs) may have their viscosities affected (increased or reduced, e.g. gels broken) by the indirect or direct action of a composition that contains at least one fatty acid that has been affected, modified or reacted with an alkali metal base, an alkali earth metal base, ammonium base, and/or organic base compound, optionally with an alkali metal halide salt, an alkali earth metal halide salt, and/or an ammonium halide salt. The composition containing the resulting saponification product is believed to either act as a co-surfactant with the VES itself to increase viscosity and/or possibly by disaggregating or otherwise affecting the micellar structure of the VES-gelled fluid. In a specific, non-limiting instance, a brine fluid gelled with an amine oxide surfactant may have its viscosity broken with a composition containing naturally-occurring fatty acids in canola oil or corn oil affected with CaOH, MgOH, NaOH and the like.

Abstract: The process according to the invention for production of an absorbent polymer comprising the following process steps: i) polymerization of an aqueous monomer solution to obtain a polymer gel; ii) comminution of the polymer gel to obtain a gel granulate; and iii) drying of the gel granulate, and is characterized in that the gel granulate after step ii) has a spread behavior. The production process of an absorbent polymer distinguishes itself by a particularly efficient drying step iii), which enables a particularly gentle and uniform drying of the gel granulate. The obtained absorbent polymers and products and items produced therefrom have a particularly uniform product quality and constant physical-chemical properties.

Abstract: A synthesis gas is produced from a carbon-containing starting material such as a coal; a CO-containing gas is separated from the resultant synthesis gas, whereby obtaining a gas containing carbon monoxide and hydrogen; a methanol- and/or dimethyl ether-containing gas is produced from the resultant gas containing carbon monoxide and hydrogen; meanwhile, a H2-containing gas is produced from the CO-containing gas and the H2O-containing gas separated from the lower-paraffin-containing gas by a shift reaction; a lower-paraffin-containing gas containing propane or butane as a main component of hydrocarbons contained therein is produced from the methanol- and/or dimethyl ether-containing gas and the H2-containing gas; and a H2O-containing gas is separated from the resultant lower-paraffin-containing gas, whereby obtaining a liquefied petroleum gas.

Abstract: The invention relates to an enhanced process for the recycling of expanded polystyrene. Said process essentially comprises the reduction in volume of expanded polystyrene by means of dissolution in a solvent, separation of the insoluble components, selective precipitation of the polystyrene with an anti-solvent, separation, drying and extrusion of the precipitated polystyrene, recovery by distillation and recycling of the solvent. The process is characterized in that the anti-solvent is a butanol selected form n-butanol, iso-butanol or sec-butanol and the solvent is dimethyl carbonate, alone or in a mixture containing up to 25% by weight of butanol.

Abstract: the invention provides a composition having laser engraving properties, comprising a host material and a laser enhancing additive. The host material comprises a material, such as a polymer, modified by a first process, whereby the host material as modified by the first process has increased thermal conductivity as compared to the host material before the first process. The laser enhancing additive comprises a first quantity of at least one of copper potassium iodide (CuKI3), Copper Iodide (CuI), potassium iodide (KI), sodium iodide (NaI), and aluminum iodide (AlI), and a second quantity of at least one substance selected from the group consisting of zinc sulfide (ZnS), barium sulfide (BaS), alkyl sulfonate, and thioester.

Abstract: Disclosed is a radiation-crosslinkable thermoplastic polymer composition, a process for the preparation thereof, an angioplasty balloon and a medical catheter made using such a composition. The composition contains a reactive monomer cross-linker facilitates cross-linking of the reaction product upon contact of the cross-linker-containing composition with energy from a radiation source.

Abstract: According to the present invention, provided are a curable composition containing a (A) compound which has a structure having two or more cyclic ether groups, in the molecule and a linking group linking the cyclic ether groups, which contains an alkylene group having 4 or more carbon atoms, or a curable composition containing a compound which has, in the molecule, two or more moiety structures containing 4-membered or more cyclic ether and a moiety structure represented by the following formula (Y-I), and an ink composition comprising the curable composition and a compound represented by the following formula (i).

Abstract: Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.

Abstract: A thermal interface material (10) includes 100 parts by weight of a silicone oil (11) and 800˜1200 parts by weight of a metal powder (12) mixed into the silicone oil. An outer surface of each metal particle (121) of the metal powder is coated with a metal oxide layer (122). A method of producing the thermal interface material includes steps of: (1) applying a layer of organo coupling agent on the metal powder; (2) heating the metal powder at a temperature between 200 to 300° C. to coat a metal oxide layer on an outer surface of the metal powder; and (3) adding the metal powder with the coated metal oxide layer to a silicone oil. The thermal interface material has an excellent thermal conductivity and an excellent electrical insulating property.

Abstract: A plastic housing composition for embedding semiconductor devices in a plastic housing includes a multicomponent plastic material, where at least one component is distributed in the plastic material in drop-shaped and/or spherical units. The drop-shaped and/or spherical units are surrounded by dimensionally stable sheaths made from a plastic sheath material. The multicomponent plastic further includes a reactive curing system that cures when the plastic sheaths are torn open. The dimensionally stable plastic sheath material is deformation-sensitive, so that the sheaths tear open under mechanical deformation loading, which initiates and/or accelerates the curing process.

Abstract: The invention relates to binding agents for radiation-cured aqueous paints, said agents containing reaction products ABCDE composed of A epoxy compounds with at least two epoxy groups per molecule, B unsaturated fatty acids, C olefinically unsaturated monomers, D compounds containing unsaturated aliphatic hydroxyl groups and E multi-functional isocyanates, whereby the compounds C are always directly bonded to the compounds B, the compounds D are always directly bonded to the compounds E and the compounds A are always directly bonded to the compounds B. The invention also relates to methods for producing said binding agents and to the use thereof.

Abstract: An object of the present invention is to provide a new granulating process which can recover desired coagulated latex particles with a significantly excellent yield, and can suppress secondary coagulation under the condition having a higher temperature than a softening point of a polymer, without deteriorating the original quality of the polymer itself. A process for producing coagulated latex particles which can suppress the secondary coagulation under the condition having the broad temperature range, without deteriorating the original quality of the polymer itself by spraying or dropping a polymer latex into a gas-phase containing an inorganic salt and/or an acid, and a dispersant in an aerosol form, and dropping or feeding the droplets of the polymer latex into an aqueous phase containing a dispersant.

Abstract: Disclosed are resinous compositions comprising a colorant combination comprising at least one inorganic infrared reflecting pigment and at least one organic colorant, wherein the combination of inorganic pigment and organic colorant results in a molded part with an L* value of less than about 30 with specular component included, and a heating build-up (HBU) as measured according to ASTM D4803-89 of less than about 34° C. A method to make such compositions is also an embodiment of the invention as are articles made from such compositions.

Abstract: The present invention relates to the use, for stabilizing polymers, in particular polyolefins, with respect to exposure to UV radiation, of fine-particle polymer powders comprising at least one UV absorber. The present invention further relates to stabilizer mixtures for stabilizing polymers with respect to exposure to UV radiation, oxygen and heat, which, inter alia, comprise these polymer powders, and to a process for stabilizing polymers, in particular polyolefins, with respect to exposure to UV radiation, oxygen and heat, which comprises adding, to the polymers, in particular to the polyolefins, an effective amount of these stabilizers.

Abstract: Dispersion additive system can be applied to fibers or particles, exhibiting improved dispersion, by including in the additive system a sulfonic-acid derived compound such as 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof.

Abstract: A composition is disclosed having minimum halogen content, fire-retardance and/or drip-resistant characteristics. The composition comprises an effective amount of a polycarbonate, a glass fiber, a polysiloxane-polycarbonate copolymer, and a synergistic combination of an aromatic sulfone sulfonate such as potassium diphenylsulfone sulfonate with an aromatic sulfonate such as sodium salt of toluene sulfonic acid, optionally in the presence of an anti-drip agent. The polycarbonate composition is useful for manufacture of electronic and mechanical articles, among others.

Abstract: A rubber component containing at least one of diene rubber and ethylene-propylene-diene rubber is dynamically crosslinked. Thereby the rubber component is dispersed in a mixture of a thermoplastic elastomer and a thermoplastic resin. An ethylene oxide-propylene oxide-allyl glycidyl ether and an anion-containing salt having fluoro groups and sulfonyl groups are added to the elastomer composition to obtain a conductive dynamically crosslinked thermoplastic elastomer composition. A mixture of the obtained conductive dynamically crosslinked thermoplastic elastomer composition and a micro-capsule composed of a polymer, having acrylic groups, which forms an outer shell thereof is molded to obtain a conductive roller having Shore A hardness specified in JIS K6253 not more than 40 measured at 23° C.

Abstract: To provide an adhesive composition which is easily transported and stored, is remarkably excellent in redispersibility in water at a site where it is used and exhibits high performance as an adhesive agent or a coating agent. The above problem is solved by an adhesive composition composed of a synthetic resin powder (A) obtained by drying an aqueous emulsion (EM) containing a polyvinyl alcohol polymer (PVA-1) as a dispersant and a polymer having at least one monomer unit selected from the group consisting of ethylenically unsaturated monomers and diene monomers as a dispersoid, an inorganic powder (B) and a polyvalent isocyanate compound, wherein (A)/(B) is to 100/250.

Abstract: Briefly described, embodiments of this disclosure include ink formulation and modified pigments. One exemplary modified pigment, among others, includes a pigment A represented by the formula in FIG. 3.

Abstract: The present invention relates to the use of a copolymer comprising, in polymerized form, (a) from 80 to 99.9 mol %, based on the total amount of the monomers polymerized to prepare the copolymer, of at least one monomer A which in each case comprises a heterocycle having at least 1 nitrogen atom and composed of from 3 to 10 ring members and a C2-C6-alkenyl group bonded to a carbon or nitrogen ring atom of the heterocycle; and (b) from 0.1 to 20 mol %, based on the total amount of the monomers polymerized to prepare the copolymer, of at least one monomer B copolymerizable with monomer A, said monomer B having a monoethylenically unsaturated double bond and also a linear or branched poly-C2-C4-alkylene oxide group having on average from 4 to 500 C2-C4-alkylene oxide units, in liquid and in solid detergent formulations. In addition, the invention relates to a process for preparing such a copolymer, and also to a liquid or solid detergent formulation comprising at least one such copolymer.

Abstract: Disclosed is an aqueous liquid dispersion of water and oil repellent agent containing surfactants wherein there are contained (I) a homopolymer or copolymer of at least one polymerizable compound having a perfluoroalkyl or perfluoroalkenyl group and an acrylate, methacrylate or alpha-substituted acrylate group, or a copolymer of such a polymerizable compound with another copolymerizable compound which is copolymerizable with such a polymerizable compound, and (II) three nonionic surfactants, namely (a) a nonionic surfactant having an HLB of less than 12, (b) a nonionic surfactant having an HLB of not less than 12 and less than 17, and (c) a nonionic surfactant having an HLB of not less than 17. Such an aqueous liquid dispersion of a water and oil repellent agent containing surfactants is excellent in shelf life stability and dilution stability, and provides high water and oil repellency to an object.

Abstract: To provide a material for forming an exposure light-blocking film which includes at least one of a silicon compound expressed by the following structural formula (1) and a silicon compound expressed by the following structural formula (2), wherein at least one of R1 and R2 is replaced by a substituent capable of absorbing exposure light.

Abstract: A conductive resin molding for use in the separator of a fuel cell and its producing method in which lowering of production yield and increase of machining cost, which are the most important problems with the spread of fuel cell, can be suppressed. The conductive resin molding is characterized by containing 1-9 vol % of high boiling point oil against the entire resin composition. Alternatively, high density expanded graphite prepared to have a specific gravity of 1.8 or above is employed as a conductive compounding agent. Alternatively, the conductive resin molding can be molded by flash flow compression molding.

Abstract: An adjuvant composition comprising (A) a C1-C2carboxylic acid ester of a polyhydroxy compound containing from 2 to 20 hydroxyl groups and (B) an N-heterocyclic compound having a pKa, value of from 6 to 8 is storage-stable and suitable as an acid donor in the dyeing of polyamides.

Abstract: The present invention provides coating compositions that include reactive diluents and have high performance, low VOC levels, and low irritation levels.

Abstract: Disclosed are reactive cyclic carbonates and ureas of formula (I) or (II), wherein R and X have the meaning indicated in the description. Said carbonates and ureas allow functional groups to be specifically introduced into biomolecules, polymers, and surfaces in mild conditions.

Abstract: A method of producing cross-linked polymerisation hardened droplets in a continuous aqueous medium in a microchannel device is provided. At least two aqueous streams are brought together before entering a hydrophobic phase and thus forming droplets. One aqueous phase comprises an acid source and another comprises a metal ion salt. The slow release of metal ions slows down the rate of polymerisation so that it does not interfere with the droplet formation process.

Abstract: A gear for an electric power steering device for reducing the rotation speed of an electric motor for steering assist with a reduction gear mechanism and transmitting the rotation to a steering mechanism, the gear being incorporated and used in the reduction gear mechanism, wherein at least the teeth of the gear are formed from a resin composition of a non-reinforced type comprising (a) a polyamide resin having a carboxyl group at least at a terminal end; (b) 0.5-5 wt. % a polycarbodiimide compound, and (c) 3-15 wt. % an elastic material modified with a reactive functional group.

Abstract: An epichlorohydrinamine polymer has a ratio of amine units to epichlorohydrin units of from 0.8:1.2 to 1.0:1.0, dimethylaminopropylamine and benzylamine preferably being used as amine and/or ammonium units. The novel epichlorohydrinamine polymer is used, for example, for the surface treatment of semifinished leather products and textile materials.

Abstract: The present invention relates to thermoplastic molding compositions comprising a mixture of (A) from 30 to 69% by weight, based on the sum of components (A), (B) and (C), of a methyl methacrylate polymer, (B) from 30 to 69% by weight, based on the sum of components (A), (B) and (C), of a copolymer obtainable by polymerizing a styrenic monomer and a vinyl cyanide, and (C) from 1 to 40% by weight, based on the sum of components (A), (B) and (C), of a graft copolymer obtainable from (C1) from 60 to 90% by weight, based on (C), of a core obtainable by polymerizing a 1,3-diene and a styrenic monomer, (C2) from 5 to 20% by weight, based on (C), of a first graft shell, and (C3) from 5 to 20% by weight, based on (C), of a second graft shell composed of an alkyl (meth)acrylate polymer, with the proviso that the ratio of (C2) to (C3) is in the range from 2:1 to 1:2.