Patents Issued in May 31, 2011
  • Patent number: 7951814
    Abstract: The present invention provides Quinazolinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: May 31, 2011
    Assignee: Glenmark Pharmaceuticals, S.A.
    Inventors: Meyyappan Muthuppalniappan, Abraham Thomas, Sukeerthi Kumar, Sanjay Margal, Neelima Khairatkar-Joshi, Indranil Mukhopadhyay, Srinivas Gullapalli
  • Patent number: 7951815
    Abstract: Novel 1,4,8-triazaspiro[4,5]decan-2-one compounds corresponding to formula I processes for the preparation thereof, related methods of treatment and pharmaceutical formulations containing such compounds.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: May 31, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Corinna Sundermann, Bernd Sundermann, Stefan Ober-Boersch, Werner Englberger, Hagen-Heinrich Hennies
  • Patent number: 7951816
    Abstract: The present invention relates to a compound represented by formula (I-0): wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous disease (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 31, 2011
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Masaya Kokubo, Yoshikazu Takaoka, Shiro Shibayama
  • Patent number: 7951817
    Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: May 31, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, Southern Research Institute, University of New England College of Osteopathic Medicine, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca
  • Patent number: 7951818
    Abstract: Novel imidazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: May 31, 2011
    Assignee: Galapagos NV
    Inventors: Paul John Edwards, Sébastien Laurent Xavier Martina, Martin James Inglis Andrews, Grégory Louis Joseph Bar, Brigitte Allart, Andrew Burritt, Xueliang Tao, Friedrich Erich Karl Kroll
  • Patent number: 7951819
    Abstract: The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5 b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., B-RAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and conditions that are ameliorated by the inhibition of RAF, RTK, etc., proliferative conditions such as cancer (e.g., colorectal cancer, melanoma), etc.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: May 31, 2011
    Assignees: Cancer Research Technology Limited, The Institute of Cancer Research: Royal Cancer Hospital, Astex Therapeutics Limited
    Inventors: Dan Niculescu-Duvaz, Caroline Joy Springer, Richard Malcolm Marais, Harmen Dijkstra, Delphine Menard, Ion Niculescu-Duvaz, Lawrence Davies, Arnaud Nourry
  • Patent number: 7951820
    Abstract: This invention describes novel triazole compounds of formula IX: wherein Z1 is nitrogen or CR9 and Z2 is nitrogen or CH, provided that at least one of Z1 and Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring; R1, R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: May 31, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Ronald Knegtel, Hayley Binch, Julian M. C. Golec, Pan Li, Jean-Damien Charrier
  • Patent number: 7951821
    Abstract: This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: May 31, 2011
    Assignee: sanofi-aventis
    Inventors: Gihad Dargazanli, Genevieve Estenne-Bouhtou, Benoit Marabout, Pierre Roger, Mireille Sevrin
  • Patent number: 7951822
    Abstract: The object is to provide a novel LXR? agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: May 31, 2011
    Assignee: Kowa Company, Ltd.
    Inventors: Ayumu Okuda, Takayuki Matsuda, Toru Miura, Koichi Yamazaki, Yuki Yamaguchi, Minoru Koura, Sayaka Kurobuchi, Yuichiro Watanabe, Kimiyuki Shibuya
  • Patent number: 7951823
    Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: May 31, 2011
    Assignee: IRM LLC
    Inventors: David C. Tully, Arnab K. Chatterjee, Agnes Vidal, Hank Michael James Petrassi, Zhiwei Wang, Badry Bursulaya, Glen Spraggon
  • Patent number: 7951824
    Abstract: The present invention relates to novel pyridine-2-carboxyamide derivatives of formula (I) useful as metabotropic glutamate receptor antagonists: wherein Y, Z, R1, R2 and R3 are as defined in the specification herein.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: May 31, 2011
    Assignee: Hoffman-La Roche Inc.
    Inventors: Georg Jaeschke, Will Spooren, Eric Vieira
  • Patent number: 7951825
    Abstract: To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: May 31, 2011
    Assignee: Astellas Pharma Inc.
    Inventors: Hironori Harada, Kazuyuki Hattori, Kazuya Fujita, Masataka Morita, Sunao Imada, Yoshito Abe, Hiromichi Itani, Tatsuaki Morokata, Hideo Tsutsumi
  • Patent number: 7951826
    Abstract: The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: May 31, 2011
    Assignee: Eli Lilly and Company
    Inventors: Lisa Selsam Beavers, Don Richard Finley, Robert Alan Gadski, Philip Arthur Hipskind, Cynthia Darshini Jesudason, Richard Todd Pickard, Freddie Craig Stevens, Takako Takakuwa
  • Patent number: 7951827
    Abstract: Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: May 31, 2011
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Richard R. Tidwell, Svetlana M. Bakunova, Stanislav Bakunov, Donald A. Patrick
  • Patent number: 7951828
    Abstract: An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A1, A2 and A3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., W is oxygen atom or sulfur atom, etc., X is halogen atom, C1-C6haloalkyl, etc., Y is halogen atm, C1-C6alkyl, etc., R1 is —CH?NOR1a, —C(O)OR1c, —C(O)NHR1d, phenyl substituted with (Z)p1, D-14, D-52, D-53, D-55 to D-59, etc., R1a is C1-C6alkyl, etc., R1c is C1-C6alkyl, etc., R1d is hydrogen atom, —C(O)R15, —C(O)OR15, etc., R2 is C1-C6alkyl, —CH2R14a, C1-C6alkynyl, —C(O)R15, —C(O)OR15, etc., further when R1 is —CH?NOR1a, —C(O)OR1c or —C(O)N(R1e)R1d, R2 may be hydrogen atom, R3 is C1-C6haloalkyl, etc., R14a is cyano, —OR25, etc., R15 is C1-C6alkyl, C1-C6haloalkyl, C1-C4alkoxy C1-C4alkyl, C1-C4alkylthio C1-C4alkyl, C3-C6cycloalkyl, C2-C6alkenyl, etc., R25 is C1-C4alkyl, C1-C4haloalkyl, —C(O)R32 or —C(O)OR32, etc., R32 is C1-C6alkyl or C3-C6cycloalkyl, etc., Z is halogen atom, cyano, nitro, C1-C6alkyl, C1-C6alkoxy, etc.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 31, 2011
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Takeshi Mita, Yuki Furukawa, Ken-ichi Toyama, Manabu Yaosaka, Eitatsu Ikeda, Yoshihide Masuzawa, Mitsuaki Komoda
  • Patent number: 7951829
    Abstract: The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: May 31, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Mark R. Player, Scott L. Dax, William H. Parsons, Michael Richard Brandt, Raul R. Calvo, Sharmila Patel, Jian Liu, Wing S. Cheung, Michele C. Jetter, Yu-Kai Lee, Mark A. Youngman, Wenxi Pan, Kenneth M. Wells, Derek A. Beauchamp
  • Patent number: 7951830
    Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: May 31, 2011
    Assignee: AstraZeneca AB
    Inventors: Scott Boyd, Peter William Rodney Caulkett, Rodney Brian Hargreaves, Suzanne Saxon Bowker, Roger James, Clifford David Jones, Darren McKerrecher, Michael Howard Block, Craig Johnstone
  • Patent number: 7951831
    Abstract: The invention relates to methods, compositions, and uses of those compositions for making medicaments, for potentiating the beneficial effects of inhibitors of COX-1, COX-2, and 5-LOX, and reducing adverse effects, by also administering inhibitors of soluble epoxide hydrolase (“sEH”), with or without also administering one or more cis-epoxyeicosantrienoic acids. The invention further relates to the use of inhibitors of sEH as analgesics and to methods and compositions of epoxides of eicosapentaenoic acid and docosahexaenoic acid, optionally with an inhibitor of sEH, to reduce pain or inflammation or both.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: May 31, 2011
    Assignee: The Regents of the University of California
    Inventors: Bruce D. Hammock, Kara Schmelzer, Ahmet Bora Inceoglu
  • Patent number: 7951832
    Abstract: The present invention provides compounds having the general structure I, or a pharmaceutically acceptable salt thereof: wherein X is a six-member ring selected from phenyl, pyridine, or pyrimidine; Y is H, an alkenyl, a substituted alkenyl, or alkynyl, and R is H or alkyl. Pharmaceutical compositions for treating various disorders such as cancers, the compositions including compound I are also provided.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: May 31, 2011
    Assignee: Burnham Institute for Medical Research
    Inventors: Maurizio Pellecchia, Surya De, Elisa Barile
  • Patent number: 7951833
    Abstract: New crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid; their use in the inhibition of 11?HSD1, processes for making them and pharmaceutical compositions comprising them are also described.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: May 31, 2011
    Assignee: AstraZeneca AB
    Inventors: Gary Peter Tomkinson, Martin John Packer, James Stewart Scott, Paul Robert Owen Whittamore, Andrew Stocker
  • Patent number: 7951834
    Abstract: This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an ?,?-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: May 31, 2011
    Assignee: University of Cape Town
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Patent number: 7951835
    Abstract: The present invention provides salt crystals of non-natural stereoisomer forms of monatin and to the use thereof.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: May 31, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yusuke Amino, Kazuko Yuzawa, Kenichi Mori, Tadashi Takemoto
  • Patent number: 7951836
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, X, n, and m are as defined herein and to pharmaceutically acceptable acid addition salts thereof, to pharmaceutical compositions containing them, and to methods for treating neurological and neuropsychiatric disorders.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: May 31, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Patent number: 7951837
    Abstract: The present invention is concerned with duloxetine free base in crystalline form, and also novel polymorphic forms thereof.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: May 31, 2011
    Assignee: Cipla Limited
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Srinivas Laxminarayan Pathi, Revikumar Puppala
  • Patent number: 7951838
    Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, X and Z are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions. The invention also comprises further embodiments of Formula II, intermediates and processes useful for the preparation of compounds of Formulas I and II.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: May 31, 2011
    Assignee: Amgen Inc.
    Inventors: Daniel La, Patricia Lopez, Vinod F. Patel, Wenge Zhong
  • Patent number: 7951839
    Abstract: The present invention related to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppression of aging and stress. It becomes possible to develop medical substances using the pheromone relating to aging, stress, metabolism, signal transfer system in vivo, and anticancer, obesity and a suppressing agent for aging and stress.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 31, 2011
    Assignee: KDR Biotech. Co. Ltd.
    Inventors: Mankil Jung, Young Ki Paik
  • Patent number: 7951840
    Abstract: The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: May 31, 2011
    Inventors: Shanta M. Modak, Milind S. Shintre, Lauser Caraos, Trupti Gaonkar
  • Patent number: 7951841
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: May 31, 2011
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, Matthew Batten
  • Patent number: 7951842
    Abstract: This invention relates to the use of compounds of the general formula (I): R?—CONH—X—NR2R3—R4—Y in which R1 represents an alkyl moiety containing 11 to 21 carbon atoms, X stands for a (CH2)n- group and n is an integer from 1 to 6, R2 and R3 independently represent an alkyl moiety with 1 to 4 carbon atoms or an hydrogen atom, Y stands for a COO— group, in cosmetic compositions, characterized in that the compound of formula (I): is prepared by reacting the oil from Theo-broma grandiflorum with an amine of the formula (II): H2N—X—NR2R3 and subsequently reaction with sodium monochloroacetic acid.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: May 31, 2011
    Assignees: Cognis Brasil Ltda., Natura Cosmeticos S.A.
    Inventors: Rosa Maria Teixeira Tagé Biaggio, Setsuo Sato, Juliana Bucchi Alencastre, Carlos Alberto Moura, Henrique Sales, Tiago Costa Beber, Rosa Maria da Cunha Canto Friedlander, Tereza Maria de Senne Peranovich Victorio, Edjane dos Santos Lima
  • Patent number: 7951843
    Abstract: The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, R1 R2, R3, R4, R5, R6, R7, and R8 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with ?-secretase activity, including Alzheimer's disease.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: May 31, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventor: Chih Yung Ho
  • Patent number: 7951844
    Abstract: This invention provides a pharmaceutical and functional food which are made of a safe food ingredient or nutrient which has been used for a long period of time, and which have tranquilizing effect such as anti-anxiety effect, anti-depression effect, and anti-stress effect. The tranquilizer of the invention contains vitamin K as an active ingredient. Vitamin K is preferably menaquinone-4 and/or menaquinone-7. This invention also provides a supplement, health food or functional food for tranquilizing purpose that contains vitamin K as an active ingredient.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: May 31, 2011
    Assignee: J-Oil Mills, Inc.
    Inventors: Toshiro Sato, Shuichi Kamo, Rumi Kawahara
  • Patent number: 7951845
    Abstract: A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: May 31, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Josef Miller, Colleen LePrell, Jochen Schacht, Diane Prieskorn
  • Patent number: 7951846
    Abstract: Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: May 31, 2011
    Inventors: You Han Bae, Kun Na, Eun Seong Lee
  • Patent number: 7951847
    Abstract: Provided are methods of treating HIV patients by administering to the patient a nutrient composition and at least one anti-retrovial drug. The method results in an increase in the patient's CD4+ cell count by at least 25% during a treatment period. The nutrient composition includes alpha lipoic acid; acetyl L-carnitine; N-acetyl-cysteine; zinc; selenium; vitamin C; bioflavinoid complex; vitamin E; one or more antioxidants selected from co-enzyme Q10 and glutathione; and one or more vitamins or minerals selected from beta-carotene, vitamin A, vitamin B1, vitamin B2, vitamin B6, niacinamide, calcium pantothenate, folic acid, vitamin B12, copper, manganese, chromium, and molybdenum.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: May 31, 2011
    Assignee: K-PAX Vitamins, Inc.
    Inventor: Jon D. Kaiser
  • Patent number: 7951848
    Abstract: Aqueous dispersions of partly hydrophobic silica exhibit a smooth change in viscosity with pH over a wide pH range, without gelling or exhibiting local maxima. The dispersions have numerous uses, including use in O/W Pickering emulsions.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: May 31, 2011
    Assignee: Wacker Chemie AG
    Inventors: Torsten Gottschalk-Gaudig, Klaus Obermeir
  • Patent number: 7951849
    Abstract: The present invention relates to the field of gels. The invention also relates to an improved method for manufacturing gels. In particular the invention relates to a new class of material, fluid-bicontinuous particle-stabilized gels, and a method of making the same. The fluid-bicontinuous particle-stabilized gels comprise at least a first fluid, a second fluid, and a continuous layer of particles positioned at a continuous interface between the first fluid and the second fluid.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: May 31, 2011
    Assignee: The University Court of the University of Edinburgh
    Inventors: Michael Elmhirst Cates, Paul Stephen Clegg, Stefan Ulrich Egelhaaf, Wilson Che Poon
  • Patent number: 7951850
    Abstract: A method of forming carbon nanotube-polymer composites includes the steps of forming a mixture solution including a plurality of carbon nanotubes dispersed in a co-solvent. The co-solvent includes an organic solvent and a second solvent being a short chain fluorinated carboxylic acid having a boiling point below 150° C. which is less oxidizing than nitric acid, and is soluble in both the organic solvent and water. The first polymer is mixed with the mixture solution to form a polymer including mixture. The co-solvent is removed from the polymer mixture to form a dispersed nanotube-polymer composite. The second solvent can be trifluoroacetic acid.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: May 31, 2011
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Qun Huo, Saiful Khondaker, Jianhua Zou, Lei Zhai, Hui Chen, Harish Muthuraman
  • Patent number: 7951851
    Abstract: A curable composition for dental use, containing a polymerizable monomer, inorganic particles (A) having irregular shapes and an average particle size of from 1.0 to 5.0 ?m, wherein the inorganic particles (A) are surface-treated with a silane coupling agent (a) represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group, R2 is a hydrolyzable group, R3 is a hydrocarbon group having 1 to 6 carbon atoms, X is an oxygen or sulfur atom, p is 2 or 3, and q is an integer of from 8 to 13, and inorganic particles (B) having irregular shapes and/or spherical or nearly spherical shapes, and an average particle size of from 0.01 to 0.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: May 31, 2011
    Assignee: Kuraray Medical Inc.
    Inventors: Yoshiko Kuboe, Takahiro Sekiguchi
  • Patent number: 7951852
    Abstract: A matrix which is a polymer, plastic or polymer-wood composite includes a composition of a biocide and a processing additive therewith in the form of a free-flowing powder.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: May 31, 2011
    Assignee: ISP Investments Inc.
    Inventor: Joseph P. Bartko
  • Patent number: 7951853
    Abstract: The present invention relates to antimicrobial agents, methods for the production of these agents, and the use of these agents. The antimicrobial agent of the present invention includes a water-soluble polymer and oligodynamic metal ions which interact with counter-ions of the polymer such that the metal ions are bound to corresponding counter-ions. The water-soluble polymer controls a sustained release of the metal ions. The oligodynamic metal ions preferably include small size metal particles (e.g., nano-sized silver particles) that interact to the water-soluble polymer as well as metal ions derived from one or more water-soluble oligodynamic metal compositions (e.g., metal sulfates and/or metal nitrates). The agent may also include one or more acids, including organic acids (such as sulfates, carboxylic acids, amines, hydroxyls, nitrates, and phosphates) and/or non-organic acids (such as boric acid and dioctylborate).
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: May 31, 2011
    Assignee: Smart Anti-Microbial Solutions, LLC
    Inventors: Ashraf A. Ismail, Leonard Pinchuk, Orley R. Pinchuk, David Pinchuk
  • Patent number: 7951854
    Abstract: An ink composition includes: first particles which are insoluble and dispersed in an aqueous dispersion medium, a polarity of the first particles being one of positive and negative; and second particles which are insoluble and dispersed in the aqueous dispersion medium, the second particles including both a cationic group and an anionic group, the second particles having a zeta potential that changes along with a change in pH of the aqueous dispersion medium, percentage of a water-soluble component in the second particles being not higher than 5% by mass.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: May 31, 2011
    Assignee: FUJIFILM Corporation
    Inventors: Terukazu Yanagi, Akio Tamura, Takahiro Ishizuka, Takashi Hirakawa, Katsuyuki Hirato
  • Patent number: 7951855
    Abstract: What is disclosed is a plurality of prepaints which are used in any combination to produce base paints and/or colored paints of varying end-use application characteristics. Additionally, a mobile paint factory for producing a plurality of lines of architectural coatings from a plurality of prepaints en route to and/or at various locations is disclosed. The mobile paint factory may include a vehicle having a paint production system and a paint mixer located thereon. Furthermore, a method of producing a plurality of lines of user-selected architectural coatings from a plurality of prepaints en route to and/or at various locations is disclosed. The method may include: providing a mobile paint factory; prompting a user to select through the paint production system an interior or exterior application environment, a paint sheen, and a paint quality; automatically dispensing predetermined amounts of appropriate prepaints; and agitating the dispensed prepaints.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: May 31, 2011
    Assignee: Microblend Technologies, Inc.
    Inventors: Daniel K. Trevino, III, Mel Sauder, Randall L. Hughes, David C. Philbrook, C. Daniel McClain
  • Patent number: 7951856
    Abstract: A coating composition including an unsaturated resin selected from polyesters, alkyds or combinations thereof; an alkoxy(meth)acrylic functional monomer, and a thermoplastic compound containing active hydrogen groups; a curing agent; and a curing promoter such as at least one metal drier.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: May 31, 2011
    Assignee: Valspar Sourcing, Inc.
    Inventors: Shaobing Wu, Larry B. Brandenburger
  • Patent number: 7951857
    Abstract: The present invention relates to bituminous compositions suitable for use in paving applications containing water-in-oil bitumen dispersion of paving grade bitumen such as penetration-graded, viscosity-graded and/or penetration-graded varieties that is substantially free of volatile solvents and made by controlling temperature-dependent interfacial rheology through the use of selected surfactants. The invention paving compositions are suitable for use in the construction of load-bearing, high-traffic pavements at a temperature range lower than that required for conventional hot-mix bituminous paving compositions, yet with similar or superior compaction to densities property and at least equal cure rate.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: May 31, 2011
    Assignee: MeadWestvaco Corporation
    Inventors: Everett Crews, Tom Girardeau, Iain Jack
  • Patent number: 7951858
    Abstract: The invention concerns novel bituminous products, as well as novel aqueous emulsions of bituminous products, mixtures thereof with coated granules, useful for sealing application, building and maintaining road surfaces, sidewalks and runways, road surfaces, sidewalks, bicycle paths, parking lots and runways.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: May 31, 2011
    Assignee: CECA S,A,
    Inventors: Gilles Barreto, Lionel Grampre
  • Patent number: 7951859
    Abstract: Compositions including a polymer, a primary antioxidant, a secondary antioxidant, and a metal deactivator selected from at least one of 2,2?-oxamido bis[ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate] and oxalyl bis(benzylidenehydrazide), are disclosed. The compositions can also include a light stabilizer. The compositions can be used to manufacture insulations for wire and cable. The compositions have improved long-term heat aging and also retain their color when exposed to heat. A method of making an insulation for a conductor, such as a wire or a cable, made from a composition is also provided.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: May 31, 2011
    Assignee: Union Carbide Chemicals & Plastics Technology LLC
    Inventors: Thomas S. Lin, Jeffrey M. Cogen
  • Patent number: 7951860
    Abstract: Polymer composite materials having improved gas barrier properties are generally disclosed, along with process of making the same. The polymer composite materials can include phosphonate particles, oxide particles, and combinations thereof. For example, the particles can be metal phosphonate particles, synthetic oxide particles, or combinations thereof.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: May 31, 2011
    Assignee: University of South Carolina
    Inventors: Hans-Conrad zur Loye, Tara Hansen, Baolong Zhang, John W. Stone
  • Patent number: 7951861
    Abstract: A method of decreasing the roiling resistance of a tire formed from a sulfur-vulcanized elastomeric by combining at least one diene elastomer and at least one reinforcing filler, with an effective amount of a coupling agent consisting of a combination of: 10 to 90%, of a product (I) consisting of a blend of poly(alkylphenol) polysulfides of formula: in which: R is an alkyl radical containing 1 to 20 carbon atoms; n and n? are two integers, which may be identical or different, from 1 to 8; p is an integer from 0 to 50; and 10 to 90% of a product (II) consisting of bis(triethoxysilylpropyl)tetrasulfide, to form a mixture; thereafter working said mixture; and thereafter heating said mixture to vulcanize said mixture. 90% of bis(triethoxysilylpropyl)tetrasulfide.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: May 31, 2011
    Assignee: Arkema France
    Inventor: Thierry Aubert
  • Patent number: 7951862
    Abstract: The present disclosure presents materials comprising hydrogenated and/or partially hydrogenated polymerized vegetable oils. Non-limiting applications of the polymerized oils, including coatings, binders, blends, and greases are presented. Methods for forming these materials are also disclosed.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: May 31, 2011
    Assignee: Archer Daniels Midland Company
    Inventors: Paul D. Bloom, David P. Holzgraefe
  • Patent number: 7951863
    Abstract: Method for packaging a photo detector integrated circuit (IC) and a pigment filter and resulting package are described. An encapsulated package (e.g., an epoxy-encapsulated package) that includes a first surface is provided. A filter layer is then coated directly onto the first surface. The filter layer provides optical filtering properties (e.g., a predetermined filtering profile) in addition to the filtering provided by the pigment filter.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: May 31, 2011
    Assignee: Avago Technologies ECBU IP (Singapore) Pte. Ltd.
    Inventors: Kean Loo Keh, Chin Hin Oon, Boon Keat Tan