Abstract: A method for performing an inferior lift in the sinus includes preparing an initial opening in the bone that is drilled to a depth just prior to reaching a sinus floor. Using a sonic drilling device, a final portion of the sinus floor is removed until a schneiderian membrane is reached. A bone graft is inserted into the opening, lift said schneiderian membrane. After ossification of the bone graft, an implant is inserted into the opening and graft.

Abstract: The present invention refers to an analog implant for a dental model which has such a geometry as to allow its height positioning, axial positioning and angular orientation in a bore or blind hole of a dental model, the analog implant having a distal portion and a proximal portion, where the proximal portion has a rotationally symmetric geometry in a cross-section which is perpendicular to the axis of the proximal portion, where the rotationally symmetric geometry is adapted to ensure securing against rotation and repositioning of the analog implant in a bore or blind hole of a dental model, the external geometry of the proximal portion being such that the analog implant can be removed from the dental model, and where a proximally positioned shoulder of the distal portion forms a height stop which allows precise height positioning of the analog implant on the dental model or on the soft tissue of the dental model, respectively.

Abstract: Disclosed is an implant, particularly to be employed in implant operations, to be implanted in bone tissue. Such implants may assist in reducing pressure of the implant on the surrounding bone tissue. The abstract of the disclosure is submitted herewith as required various rules and regulations of different Patent Offices. A purpose of the abstract is to enable the Patent Offices and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Abstract: A method for producing a tooth stump structure that is to be anchored in a root canal comprises the following steps: flexible needles are introduced one after the other into a recess in the form of a root canal or into an exposed cavity; the length of the protruding ends of the needles is adjusted to the form of a core of the stump structure, the core is then modelled from a semi-liquid, polymerizable composition and subsequently hardened; and an outer jacket of a crown is applied to the core. The tooth stump structure produced by said method is formed by a structural core made of a hardened composition, wherein individual flexible needles are anchored in said core and protrude therefrom, a cross section of the needles being circular, elliptical or polygonal and their diameter ranging from 0.1 to 0.8 mm. The protruding parts of the needles occupy a space that corresponds essentially to the space of the root canal or the cavity.

Abstract: A device is disclosed for acoustically determining one or more characteristics of a powered oral care (POC) implement. The device comprises a transducer and a processor, wherein: the transducer receives sound generated by the POC implement and converts the sound into a signal representative of the sound; the transducer is in electrical communication with the processor and transmits the signal representative of the sound to the processor; and the processor determines one or more characteristics of the POC implement based on the signal representative of the sound.

Abstract: A training game that requires a player to role-play a conversation in which the player is judged according to the player's demonstration of a Hidden Skill. Skills relevant to successful performance in a particular type of conversation (for example, a sales call) are identified. The player is aware that these are the skills the player is expected to learn and to demonstrate. The player is judged, however, as to the player's performance on a subset of the skills. The player does not know which of the skills form the subset on which the player will be judged. By hiding the specific skill being evaluated from the role player, the game encourages the player to perform all necessary conversation skills during the role-play. Only then is the player guaranteed to execute the Hidden Skill. The game thereby trains players in all aspects of the relevant conversation skills.

Abstract: Teaching accessories that will help children learn and love arithmetic. Using a table with chips and sectional slots on the table, the child will solve problems by themselves or with others. Starting at a young age will help boost mathematical skills in school, just like learning reading at a young age has helped boost reading skills for children. The parent will select the type of problem the child will solve. The problem is then given and the child will use the chips provided in the corner of the table to solve the problem. The table has ten slots that can hold up to 100 chips on their side alone. The child will move up in skill level and feel accomplishment that will make them want to learn more and do more problems.

Abstract: A method and apparatus for automated analysis of emotional content of speech for discovery and assistance in early diagnosis of stress-related psychological health (PH) related issues is presented. Further, methods and apparatus for evaluation of treatments for PH disorders are also presented. Telephony calls are routed via a network such as a public service telephone network (PSTN) and delivered to an interactive voice response system (IVR) where prerecorded or synthesized prompts guide the caller to speech responses. The caller is led through a self-report questionnaire used by psychological professionals to identify stress-related disorders. These speech responses are analyzed for emotional content in real time or collected via recording and analyzed in batch. This data may be included in multi-dimensional databases for analysis and comparison to other collected patient data.

Abstract: The invention satisfies this need. The invention is an elongate prayer mat having a first end and a second end and further comprising (a) a first tactile sensor disposed proximate to the first end; (b) a second tactile sensor disposed proximate to the second end; (c) a third tactile sensor disposed proximate to the second tactile sensor and between the second tactile sensor and the first tactile sensor; (d) a fourth tactile sensor disposed to the right of the third tactile sensor, proximate to the second tactile sensor and between the second tactile sensor and the first tactile sensor; (e) a top layer for concealing each of the tactile sensors; (f) a microprocessor for receiving electrical signals from the tactile sensors and for displaying the progress of prayer steps on a display device.

Abstract: A physical skills training apparatus particularly useful for training various close-contact sports skills and techniques related to stance, balance, hand positioning accuracy, leg movement, muscle strength, action and reaction times, resistance, movement finesse, and others, includes a main structure or body that provides at least geometric form, structural integrity, engageability by at least one user if the apparatus is connected to a mount or support and, by two or more users (as, e.g., opposing participants), and is characterized by its geometric form to be portable, relatively light-weight, and easily transportable by a single person. Illustratively, the main body of the apparatus may be in the form of a one-piece, high aspect ratio plate that is flat or curved. The main body will have (holding) means for gripping, grasping or holding the apparatus by a user on one side of the apparatus, which may be in the form of shaped and oriented openings to accommodate both hands of a user, or handles.

Abstract: A dental hygiene instructional apparatus comprising a three dimensional figure with an open mouth and a plurality of simulated, three dimensional upper teeth protruding downwardly from an upper surface of the open mouth in an arc shaped pattern and a plurality of simulated, three dimensional lower teeth protruding upwardly from a lower surface of the open mouth in an arc shaped pattern. At least one light emitting source is positioned within each of the upper teeth and the lower teeth so that each of the upper teeth and the lower teeth may be individually illuminated during successive intervals of time.

Abstract: A training aid for a dental injection, including a human-like head model, a first apparatus for alerting when the dental injection is properly positioned in the human-like head model, and a second apparatus for alerting when the dental injection is not properly positioned in the human-like head model. The interior structure of the human-like head includes for targeting purposes the maxilla with appropriate arteries and nerves being clearly visible, the mandible with appropriate arteries and nerves being clearly visible, and the buccal gingiva over the mandibular canal being clearly visible. The first apparatus and the second apparatus are so positioned within the human-like head model to allow for training for the dental injection including a V2 block including infiltration, posterior superior alveolar, middle superior alveolar anterior superior, infraorbital, greater palatine, and nasopalatine, and V3 blocks including inferior alveolar, buccal nerve, and mental block.

Abstract: A remote control controls a karaoke device to select songs. The remote control stores a controller identifier, obtains a user unique code and control instructions input by a song selector, and combines the controller identifier, the user unique code, and each of the control instructions into a controlling message. The remote control transmits the controlling messages to the karaoke device to enable the karaoke device to collectively display the songs selected by the song selector and the user unique code corresponding to the song selector.

Abstract: A method wherein live, in-person academic coursework that is cancelled for extended periods due to an exigency, for example a natural disaster, pandemic, or other socially distancing event, can be quickly, efficiently, gracefully, and cost-effectively transitioned into an online environment in order to ensure academic continuity by identifying a triggering event whereby in-person academic coursework is cancelled, initiating an academic continuity process, querying a student information system for data, interfacing this student information system data with a learning management system to populate the learning management system, simultaneously scaling the learning management system utilizing a cloud computing infrastructure, and transitioning the cancelled in-person academic coursework to an online environment.

Abstract: An interactive computer system and method collects, aggregates and distributes information derived from free-text responses to questions. The system and method collect free-text responses from a subject user and aggregates them with free-text responses from other users. The system and method then uses these free-text responses in learning methodologies (such as temporal spacing) and styles to facilitate long-term learning and knowledge retention.

Abstract: A computer implemented learning system 10 includes a database 20 containing a plurality of structured symbols 12, each symbol 12 being representative of a particular theme selected to enhance multisensory learning by a student. A user interface 14 presents the structured symbols 12 to the student in a form discernible to the student.

Abstract: The present disclosure is directed to a system and method for inflating and perfusing a body organ. The system and method includes a housing, a vacuum source, a perfusion pump and a temperature control module. The housing defines a cavity for containing an ex vivo body organ. In embodiments, the housing may include a cover. The housing includes one or more apertures that are defined therethrough and configured to mechanically interface with one or more sensors. The vacuum source is configured to inflate and deflate the body organ. The perfusion pump is configured to circulate a solution into the body organ. The temperature control module is operatively connected to one or more heating elements and one or more cooling elements. In addition, the temperature control module is configured to regulate the temperature of the body organ within the housing.

Abstract: Methods of decreasing non-specific binding in solid phase assays for an analyte are disclosed. In the methods, the solid phase apparatus (lateral flow solid phase apparatus or capillary flow solid phase apparatus) is subjected to elevated heat. The elevated heat can be applied subsequent to application of a test sample to the solid phase apparatus.

Abstract: Provided is a label for an analyte, which label is attached to a magnetic or magnetisable substance, the label comprising: (a) a recognition moiety for attaching the label to the analyte; and (b) a moiety for binding or encapsulating the magnetic or magnetisable substance; wherein the moiety for binding or encapsulating the magnetic or magnetisable substance comprises a metal-binding protein, polypeptide, or peptide.

Abstract: Methods are provided for genotyping a target nucleic acid in a sample. In various aspects, the methods comprise generating nucleic acid hybrids between probes specific for the genotypes of interest and the target nucleic acid and detecting hybridization in the sample. In other aspects, the methods comprise using multi-probe mixtures to reduce the volume of sample necessary to determine the genotype of the target nucleic acid.

Abstract: Provided herein are methods and apparatus for detecting a target nucleic acid in a sample and related methods and apparatus for diagnosing a condition in an individual. The condition is associated with presence of nucleic acid produced by certain pathogens in the individual.

Abstract: A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system.

Abstract: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for increasing such titers as well as expression vectors capable of enhancing such titers. The invention also relates to CHS4 chromatin insulator-derived functional insulator sequences. The invention further relates to methods for genetic correction of diseases or reducing symptoms thereof, such as sickle cell anemia, a lysosomal storage disease. The invention further relates to a method of improving and/or correcting one or more central nervous system (CNS) abnormalities caused by one or more lysosomal storage disease.

Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.

Abstract: The invention provides improved methods for sequencing nucleic acids, e.g., for medical applications and biomedical research. The disclosed methods can be applied to rapid personalized medicine, genetic diagnosis, pathogen identification, and sequencing species genomes.

Abstract: A nucleic acid sequencing device includes at least one nanochannel, a first electrode and a second electrode disposed at opposite ends of the nanochannel for applying a voltage in the lengthwise direction of the nanochannel, and a first detector that detects a location signal of a target nucleic acid passing through the nanochannel and a second detector that detects a signal from a detectable label bound to the target nucleic acid.

Abstract: The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.

Abstract: The invention relates to a method of determining the strain or strains of yeast in a sample, comprising: obtaining and screening nucleic acid from yeast for target sequences comprises all or part of a gene, or a flanking region associated with a gene, in the yeast mitochondrial DNA; and determining from the results of the screen the yeast strain or strains in the sample. Also provided is a method of determining the genetic stability of a yeast strain in a sample, wherein one target sequences in the nucleic acid comprises all or part of a gene, or a flanking region associated with a gene, in the yeast mitochondrial DNA or all or part of a gene, or a flanking region associated with a gene, located in the subtelomeric region of a chromosome; and determining from the results of the screen if the yeast strain is genetically stable.

Abstract: A primer set for amplifying a region including sites to be detected of SULT1A1*2 and SULT1A1*3 in the SULT1A1 gene by a gene amplification method is provided, wherein the primer set can amplify the region specifically. A pair of primer set is used including a forward primer consisting of the base sequence of SEQ ID NO: 7 as well as a reverse primer consisting of the base sequence of SEQ ID NO: 18. The use of this primer set makes it possible to specifically and efficiently amplify a region including both sites where two types of polymorphisms (SULT1A1*2 and SULT1A1*3) of the SULT1A1 gene are generated.

Abstract: The invention provides methods and compositions for determining whether a subject is at risk of developing age-related macular degeneration, for example, the wet or neovascular form of age-related macular degeneration. The method involves determining whether the subject has a protective variant and/or a risk variant at a polymorphic site in the HTRA1 gene. In addition, the invention provides a method of treating or slowing the progression of age-related macular degeneration by reducing the expression of the HTRA1 gene, or reducing the biological activity of the HTRA1 gene product.

Abstract: Methods for preparation of 2?,3?-dideoxynucleotides support structures, such as 2?,3?-dideoxyguanosine, 2?,3?-dideoxyadenosine, and 3?-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.

Abstract: The present invention provides methods for detecting and/or diagnosing cancer through the determination of the expression level of the STC2 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer. Moreover, the present invention provides double-stranded molecules targeting the STC2 gene, which are suggested to be useful in the treatment of cancer. The compositions and methods of the present invention find particular applicability to prostate cancer, more specifically, castration-resistant prostate cancer and aggressive prostate cancer.

Abstract: Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.

Abstract: The present disclosure includes a method of determining the presence of a target in a sample comprising an allosteric DNAzyme; rolling circle amplification dependent on the activity of the allosteric DNAzyme in the presence of target and a detection system. The methods further comprise quantifying the amount of target in the sample by comparing the detection with a control. Also included herein are kits for practicing the methods described herein and methods of designing biosensor systems.

Abstract: The invention relates to kits and methods for assessing the susceptibility of a human to oxidative stress or damage. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated with oxidative stress and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kit for performing the methods.

Abstract: Tools are provided which allow rapid and unequivocal identification elite event A207-12 in biological samples.

Abstract: The present invention relates to a method for isolating microorganisms and/or microorganisms nucleic acids from a bodily fluid that may comprise or may be suspected to comprise microorganisms and/or host cells and/or host cells debris. Microorganisms nucleic acids may further be isolated by lysing the isolated microorganisms. The present invention also relates to a method for detecting microorganisms in a bodily fluid. The present invention further relates to a saponin formulation and its use.

Abstract: A method of amplification and/or of detection for removing contaminants in a liquid biological sample containing nucleic acids of interest to amplify, which includes treating the biological sample chemically or enzymatically to convert one type of base of the nucleic acids of interest to another type of base; adding amplification primers, intended for specifically amplifying said converted nucleic acids of interest, each primer being constituted of three different types of bases; adding to the biological sample, after these treatments, amplification reagents the primers previously synthesized; and placing the solution and the reagents in conditions permitting amplification and/or detection of the converted nucleic acids.

Abstract: The present invention relates to a method for screening an anticancer agent using ROR?, the method comprising the steps of: culturing cells; bringing a potential substance into contact with the cells; determining whether the phosphorylation level of ROR? in the cells increases as compared to that in control cells (not brought into contact with the potential substance); and selecting the potential substance as an anticancer agent if the phosphorylation level of ROR? in the cells increases.

Abstract: The present invention has an object to provide an automatic analyzer using a disc, which treats samples with different pretreatment times or samples with different measurement times requested at random with high throughput. The present invention relates to performing adjustment rotation, rotation returning to origin, and measurement rotation in specimen analysis using a disc having a plurality of sample positions on a circumference. The adjustment rotation is an operation for placing a desired sample position in a particular position for introducing a sample into the disc or discarding the sample. The rotation returning to origin is an operation for placing an origin of the disc in a particular position. The measurement rotation is an operation for rotating the disc at a predetermined speed for measuring a plurality of samples held by the disc.

Abstract: The present method provides methods, libraries, and kits related to the archiving and clonal expansion of sequences related to target polynucleotide sequences. The method allow for the attachment of polynucleotides with defined 3? and or 5? sequences to solid surfaces. The polynucleotides attached to the solid substrates can be stored or archived as libraries and can subsequently be retrieved for analysis, for example by clonal expansion. In some embodiments, nucleotides attached to solid surfaces can be used for sequencing of nucleotide sequences related to target RNA or target RNA. The methods are applicable to total RNA and/or total DNA analysis.

Abstract: This invention relates to transgenic winter oilseed rape (WOSR) plants, plant material and seeds, harboring a specific transformation event. It pertains to winter oilseed rape plants, more particularly to a pair of winter oilseed rape plants, which is particularly suited for the production of hybrid seed. More specifically, one plant is characterized by being male-sterile, due to the presence in its genome of a male sterility gene, while the other is characterized by carrying a fertility-restorer gene, capable of preventing the activity of the male-sterility gene. The invention further provides a method for producing hybrid seed, a process for producing a transgenic WOSR plant oil or plant, and a method to identify a transgenic plant, cell or tissue. A kit for identifying the transgenic plants comparing the elite event of the present invention is also described.

Abstract: Methods and kits for (i) determining a risk of a subject to develop cancer; (ii) evaluating an effectiveness and dosage of cancer therapy administered to a cancer patient; and (iii) determining a presence of correlation or non-correlation between an activity of at least one DNA repair enzyme and at least one cancer, are disclosed.

Abstract: The present invention relates to methods and compositions useful for the detection and quantitation of analytes. The present invention has particular applicability to the detection and quantitation of analytes in samples of biological origin or that interact with biological systems.

Abstract: The invention relates to a method for diagnosing pancreatic cancer (PaCa) or the precursor diseases and/or concomitant diseases thereof, in particular pancreatic ductal adenocarcinoma (PDAC), pancreatic intraepithelial neoplasia (PanIN), pancreatic lesions, chronic pancreatitis (CP), including endocrine pancreatic tumors. In said method, the diagnosis is performed using selected biomarkers. The invention further relates to biomarker combinations suitable for carrying out said method, particularly for in vitro diagnosis.

Abstract: The invention relates to an ADP binding molecule comprising a polypeptide, said polypeptide comprising amino acid sequence corresponding to at least amino acids 11 to 310 of SEQ ID NO:1, wherein said polypeptide comprises a substitution relative to SEQ ID NO:1 at amino acid C287, and wherein said polypeptide comprises a further cysteine residue for attachment of at least one reporter moiety, and wherein said polypeptide has at least 68% sequence identity to SEQ ID NO:1 at the amino acid residues corresponding to those shown in column III of table A.

Abstract: The present invention encompasses methods for the simultaneous measurement of the in vivo metabolism of two or more isoforms of a biomolecule. The biomolecule is typically produced in the central nervous system.

Abstract: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.

Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins. Other aspects of the invention include related immunoassays and test kits.

Abstract: A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. An object of the present invention can be solved by being brought into contact a lectin having an affinity for ?-N-acetylgalactosamine residues and/or a lectin having an affinity for fucose ?(1, 2) galactose residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can be provided by this method.