Patents Issued in April 9, 2013
  • Patent number: 8414851
    Abstract: The apparatus converts ethylene in a dilute ethylene stream and dilute benzene in an aromatic containing stream via alkylation to heavier hydrocarbons. The catalyst may be a zeolite such as UZM-8. The catalyst is resistant to feed impurities such as hydrogen sulfide, carbon oxides, and hydrogen and selectively converts benzene. At least 40 wt-% of the ethylene in the dilute ethylene stream and at least 20 wt-% of the benzene in the dilute benzene stream can be converted to heavier hydrocarbons.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: April 9, 2013
    Assignee: UOP LLC
    Inventors: Christopher P. Nicholas, Alakananda Bhattacharyya
  • Patent number: 8414852
    Abstract: Plants and method of treating a combustion gas are presented in which NOx compounds are removed from the combustion gas to a predetermined level to thereby create a pre-cleaned combustion gas from which CO2 is removed in an absorber using an amine solvent. Preferably, the predetermined level of NOx compounds reduces nitro-amines, especially nitrosamine emission from the absorber to quantities of equal or less than 100 ppb.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: April 9, 2013
    Assignee: Fluor Technologies Corporation
    Inventors: Dennis W. Johnson, Satish Reddy
  • Patent number: 8414853
    Abstract: A solvent based flue gas processing system for removing CO2 from a flue gas stream is described. A catalyst is provided to increase the efficiency of the solvent in capturing CO2 from the flue gas stream or in regenerating the solvent.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: April 9, 2013
    Assignee: ALSTOM Technology Ltd
    Inventors: Zheng Liu, Naresh B. Handagama
  • Patent number: 8414854
    Abstract: This invention relates to crystalline boehmitic aluminas the crystallites of which exhibit unusual dimensional differences in the space directions 020 and 120. This invention further relates to a method for preparing such aluminas and the follow-up products obtained therefrom by calcination.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: April 9, 2013
    Assignee: Sasol Germany GmbH
    Inventors: Klaus Noweck, Jürgen Schimanski, Jens Juhl, Frank Michael Bohnen, Reiner Glöckler, Arnold Meyer
  • Patent number: 8414855
    Abstract: Spherical boron nitride nanoparticles having an average particle diameter of less than 50 nm is obtained by a method of synthesizing spherical boron nitride nanoparticles including the following steps; heating a mixture of boric acid ester and nitrogen gas in ammonia gas and argon gas to form reaction product; crystallizing reaction product to form precursor of spherical boron nitride nanoparticles; and, heating the precursor in inert gas.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: April 9, 2013
    Assignee: National Institute for Materials Science
    Inventors: Chengchun Tang, Yashio Bando, Yang Huang, Chunyi Zhi, Dmitri Golberg
  • Patent number: 8414856
    Abstract: A unit for use within a furnace chamber having a gaseous environment of air, for carrying out a synthesizing process for synthesizing precursors to form a synthesized product at elevated temperatures. The materials of the synthesizing process are separated from the air of the furnace chamber by the vessel or the reductive material.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: April 9, 2013
    Inventors: Chun-Chieh Chang, Tsun-Yu Chang
  • Patent number: 8414857
    Abstract: The invention concerns calcium phosphates in granular form having an x-ray diffraction pattern characteristic of hydroxyapatite and good compressibility and flow properties in direct compression applications. The invention also concerns the method for preparing said granules characterized in that it comprises processing a suspension of brushite dicalcium phosphate having a certain particle-size distribution using a basic solution, and maintaining the pH at not less than 7.0 for a sufficient time interval to enable the transformation of the brushite calcium phosphate into hydroxyapatite calcium phosphate.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: April 9, 2013
    Assignee: Innophos, Inc.
    Inventors: John Godber, Lorraine Leite
  • Patent number: 8414858
    Abstract: A novel method for high quality crystal growth of intermetallic clathrates is presented. The synthesis of high quality pure phase crystals has been complicated by the simultaneous formation of both clathrate type-I and clathrate type-II structures. It was found that selective, phase pure, single-crystal growth of type-I and type-II clathrates can be achieved by maintaining sufficient partial pressure of a chemical constituent during slow, controlled deprivation of the chemical constituent from the primary reactant. The chemical constituent is slowly removed from the primary reactant by the reaction of the chemical constituent vapor with a secondary reactant, spatially separated from the primary reactant, in a closed volume under uniaxial pressure and heat to form the single phase pure crystals.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: April 9, 2013
    Assignee: University of South Florida
    Inventors: George S. Nolas, Matthew K. Beekman
  • Patent number: 8414859
    Abstract: The present disclosure relates to a method for making a carbon nanotube carbon nanotube structure. The method includes steps of providing a tubular carbon nanotube array; and drawing out a carbon nanotube structure from the tubular carbon nanotube array by using a drawing tool. The carbon nanotube structure is a carbon nanotube film or a carbon nanotube wire.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: April 9, 2013
    Assignee: Beijing FUNATE Innovation Technology Co., Ltd.
    Inventors: Chen Feng, Liang Liu
  • Patent number: 8414860
    Abstract: Methods and apparatus for controlling a catalytic layer deposition process are provided. A feed stream comprising a carbon source is provided to a catalyst layer. An asymmetrical alternating current is applied to the catalyst layer. A polarization impedance of the catalyst layer is monitored. The polarization impedance can be controlled by varying the asymmetrical alternating current. The controlling of the polarization impedance provides control over the structure and amount of carbon particles deposited on the catalyst layer. The carbon particles may be in the form of nanotubes, fullerenes, and/or nanoparticles.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: April 9, 2013
    Assignee: Catelectric Corp.
    Inventor: Victor Stancovski
  • Patent number: 8414861
    Abstract: Disclosed herein is a carbonized cellulose material having a graphite nanosized surface layer directly carbonized from a cellulose fiber, and a method of synthesizing a carbonized cellulose material having a graphite nanolayer on a surface thereof, including: i) heating a cellulose fiber in a reactor; ii) forming a primary carbonized cellulose while maintaining temperature of the reactor; iii) cooling the formed primary carbonized cellulose; iv) heating the cooled primary carbonized cellulose; v) forming a secondary carbonized cellulose while maintaining temperature of the reactor; vi) cooling the formed secondary carbonized cellulose.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 9, 2013
    Assignee: Korea Institute of Energy Research
    Inventors: Nam Jo Jeong, Seong Ok Han, Hong Soo Kim, Hee Yeon Kim
  • Patent number: 8414862
    Abstract: The present invention relates to synthesis of copper zinc tin sulfide, Cu2ZnSnS4, and its corresponding selenide and telluride analogs in ionic liquids. Cu2ZnSnS4 and related compounds are useful as absorber materials in thin film solar cells.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: April 9, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventor: Alex Sergey Ionkin
  • Patent number: 8414863
    Abstract: The invention relates to a process for preparing hydrogen. According to the invention, monosilane or polysilane is converted to hydrogen at an elevated temperature with steam or oxygen.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: April 9, 2013
    Assignee: SPAWNT Private S.A.R.L.
    Inventors: Julius Pretterebner, Norbert Auner
  • Patent number: 8414864
    Abstract: New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: April 9, 2013
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf E. Swenson, Michael Tweedle
  • Patent number: 8414865
    Abstract: Use of Mycobacterium bovis BCG killed by Extended Freeze Drying (EFD) for preventing or treating atherosclerosis.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: April 9, 2013
    Assignees: Institut Pasteur, Institut National de la Recherche Agronomique
    Inventors: Gilles Marchal, Micheline Lagranderie, Isabelle Schwartz-Cornil
  • Patent number: 8414866
    Abstract: The present invention relates to a magnetic resonance imaging (MRI) method, in particular to a MRI method enabling early detection of myocardial ischemia.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: April 9, 2013
    Assignee: GE Healthcare AS
    Inventors: Morten Eriksen, Geir Torheim
  • Patent number: 8414867
    Abstract: A dry powder suitable for inhalation in a dry powder inhaler, the powder comprising a carrier, an active agent and at least 0.5% by weight of magnesium stearate, the powder being further characterized in that the less than 10% of the surface of the carrier material is covered with particles of magnesium stearate. The invention is also directed to a method of making dry powders by blending together the ingredients mentioned in a diffusion blender for a period of time that is less than 60 minutes.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: April 9, 2013
    Assignee: Jagotec AG
    Inventors: Rudi Mueller-Walz, Roland Steiner
  • Patent number: 8414868
    Abstract: In situ foamable dental bleaching compositions include a dental bleaching agent, thickening agent, polyol, and in situ foaming agent. The foamable dental bleaching compositions are initially dispensed as a dental bleaching gel. Upon placement of the dental bleaching gel onto a person's tooth surfaces, the in situ foaming agent causes the bleaching gel to foam. Dental bleaching systems include an in situ foamable dental bleaching composition within a pressurized container (e.g., bag-on valve container) having a nozzle that, when actuated, expels the in situ dental bleaching composition as a gel. Dental bleaching methods include dispensing the in situ foamable dental bleaching composition as a gel, contacting a person's tooth surfaces with the dental bleaching gel, and allowing the gel to expand and foam in order to dynamically distribute and replenish the dental bleaching agent to the tooth surfaces and into the interproximal spaces between teeth.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: April 9, 2013
    Assignee: Ultradent Products, Inc.
    Inventor: Scot N. Andersen
  • Patent number: 8414869
    Abstract: The invention provides sunless tanning compositions for application to skin comprising an effective amount of at least one dopamine precursor, an effective amount of curcumin and a dermatologically acceptable carrier. Methods for preparation of said compositions are disclosed. When applied to the skin, the compositions may be used darken skin.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: April 9, 2013
    Assignee: N.V. Perricone LLC
    Inventor: Nicholas V. Perricone
  • Patent number: 8414870
    Abstract: Substituted benzylidene 2,4-pentanediones are found to provide stabilization to otherwise photosensitive compounds and compositions.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: April 9, 2013
    Assignee: Sytheon, Ltd.
    Inventor: Ratan K. Chaudhuri
  • Patent number: 8414871
    Abstract: Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C—R—C— or —C—; Z is between 2 and about 100, inclusive; R1 is CH?CH or (CH2), wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: April 9, 2013
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Joachim Kohn, Bozena Michniak, David Devore, Larisa Sheihet, Prafulla Chandra, Priya Batheja
  • Patent number: 8414872
    Abstract: The present invention includes a hair straightening formulation consisting of a hair fixative that will straighten the hair for at least 2-3 months after one application despite frequent washings of the hair as well as methods for obtaining said formulation. The formulation comprises as active ingredients one or more keratin hydrolysates and an aldehyde. Hair straightening system comprising shampoo and one or more conditioners are also provided. The invention is further directed to a method for straightening hair using said formulation.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: April 9, 2013
    Assignee: Liquid Keratin, Inc.
    Inventors: Lionel Resnick, Irwin Grams, Angela Goodfellow, David Allice
  • Patent number: 8414873
    Abstract: A blood vessel metal stent coating of amidoglucosan polysaccharide loaded with antibody comprises carrier material composed of chitosan and inartificial degradable acidic amidoglucosan polysaccharide and the effective dose of CD133 antibody loaded in the carrier material. The blood vessel metal stent coating is manufactured with self-assemble method to fix the CD133 antibody in the carrier material of the coating. The coating has good biocompatibility, water retention property, flexibility, flush resistance and bio-stability, and can specifically capture the vascular endothelial progenitor cells in human peripheral blood, and differentiate into vascular endothelial cells. The process would accelerate endothelialization to repair injured vessel caused and prevent restenosis and thrombosis efficiently.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: April 9, 2013
    Inventors: Shixuan Zhang, Jinghan Sui, Hong Zhao, Dazhi Yang
  • Patent number: 8414874
    Abstract: This invention deals with a carboxyl-bearing, amphiphilic, solid copolyester stent coating composition for multifaceted prevention of vascular restenosis through a plurality of physicopharmacological modes. The composition includes one or more bioactive compounds and a copolymerization product of polyalkylene glycol, end-grafted with one or more cyclic monomer and treated further to introduce carboxyl-bearing end- or side-groups. The invention also deals with bioactive agents in an ionically conjugated form. The present coating may be applied to a metallic or an absorbable polymeric stent for use in preventing vascular restenosis.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: April 9, 2013
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • Patent number: 8414875
    Abstract: The present invention is related to bait which is water resistance, especially for fire ants. Its water resistance, anti-oxidation and the use of fire ants favorite eating formula which can mix with different toxic substances, and the production is easy and low cost, suitable for use in Taiwan or other humid areas to control fire ants.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: April 9, 2013
    Assignee: National Taiwan University
    Inventors: Cheng-Jen Shih, Lekhnath Kafle
  • Patent number: 8414876
    Abstract: Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL-1 antagonist is a molecule capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), or systemic onset juvenile idiopathic arthritis (Still's Disease).
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: April 9, 2013
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Scott Mellis, Margaret Karow, George D. Yancopoulos, Joanne Papadopoulos
  • Patent number: 8414877
    Abstract: The present application discloses a method of treating a disease that is treatable by therapeutic angiogenesis comprising administering to a needy subject an effective amount of a chimeric coiled coil molecule comprising a coiled-coil domain linked to a receptor binding domain of a ligand.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: April 9, 2013
    Assignee: Aprogen, Inc.
    Inventors: Gou Young Koh, Chung-Hyun Cho
  • Patent number: 8414878
    Abstract: A bioengineering, in particular to develop novel probiotic preparations based on Bacillus-strain bacteria, which can be used for preventing and treating infectious diseases and disbiosis of a human being, farm animals and birds. The novel strains of B. subtilis 07 (VKPM No. B-8611) and B. licheniformis 09 (VKPM No. B-8610) exhibit a broad spectrum of antagonistic activity, high proteolytic and amylase activity and a distinct ability in terms of a lysozim production. Such strains do not compete with each other but enter into synergistic relations in the form of an increased antagonistic action of the biopreparation. The inventive biopreparation comprises the B. subtilis 07 VKPM No. B-8611 and B. licheniformis 09 VKPM No. B-8610 strains and a protective medium. Such biopreparation can also contain a solvent and/or filler and exhibits an increased antagonistic activity with respect to a wide range of pathogenic and opportunistic pathogenic microorganisms and a resistance to quite a number of antibiotics.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: April 9, 2013
    Inventors: Irina Grigorievna Osipova, Irina Borisovna Sorokulova, Elena Aleksandrovna Vasilieva, Sergei Gennadievich Trofimov, Vera Franzevna Evlashkina, Elena Yurievna Haritonova, Sergei Eduardovich Sarkisov, Natalia Vasilievna Tereshkina, Yurii Igorevich Ostroumov, Aleksandr Nikolaevich Doronin, Marina Aleksandrovna Kulichizkaya, Aleksandr Aleksandrovich Matveev
  • Patent number: 8414879
    Abstract: The present invention is a superporous hydrogel with cells encapsulated within the hydrogel matrix, and a method for producing the same.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: April 9, 2013
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Richard A. Gemeinhart
  • Patent number: 8414880
    Abstract: Photosensitizer mixtures and method of treating cellulites by light illumination are presented. Photosensitizer is combined with cellular products, e.g. adipose cells, collagen, previously removed by liposuction. Concentrations used depend on treatment area, cellulite stage and whether cellulites are in depressed or elevated skin areas. The cosmetic treatment reduces/removes localized lipodystrophies, flaccidity, cellulite using localized laser, LED, etc emissions. Applied light energy destroys “fat” cells by a combination of chemical reactions primarily, and temperature, wherein cell walls break releasing cell fluid. Transmission devices guide radiation to the treatment site. One or more light sources like laser diodes or LEDs may be coupled into one or more optical fibers to increase the covered area and increase the amount of radiation in that area. Optical fibers can be introduced percutaneously or interstitially. Cell fluid in the treatment area is removed by a combination of techniques.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: April 9, 2013
    Assignee: Bioliter Pharme Marketing Ltd
    Inventors: Danilo Castro, Wolfgang Neuberger
  • Patent number: 8414881
    Abstract: Consumption of blue-green algae, or extracts thereof, enhances trafficking or homing of stem cells in animals by inducing a transient increase in the population of stem cells present in the animal's circulatory system. The animal may be healthy or suffering some disease or physiological condition.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: April 9, 2013
    Assignee: Desert Lake Technologies, LLC
    Inventors: Gitte S. Jensen, Christian Drapeau
  • Patent number: 8414882
    Abstract: The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several steps, including ensuring canines are naïve to Leishmania, infecting the canines using bites of Leishmania-infected sand fly bites, and evaluating successful transmission of the Leishmania parasites.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: April 9, 2013
    Assignee: Merial Limited
    Inventors: Laurent Bernard Fischer, Shaden Kamahwi, Jesus Valenzuela, Hamide Aslan Suau
  • Patent number: 8414883
    Abstract: Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: April 9, 2013
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Jean Rommelaere, Zahari Raykov, Joerg Schlehofer, Irina Kiprijanova, Tanja Heimberger, Assia Angelova, Karsten Geletneky, Marc Aprahamian
  • Patent number: 8414884
    Abstract: Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type I interferon response allows improved expression of the encoded transgene.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: April 9, 2013
    Assignee: Aeras Global TB Vaccine Foundation
    Inventors: Jerald C. Sadoff, Mohamad F. Jamiluddin, Ravi P. Anantha, John F. Fulkerson, Jr.
  • Patent number: 8414885
    Abstract: The invention relates to a method of treating cancer, comprising administering to a subject in need thereof an effective amount of a HSV-2 virus, wherein the virus lacks protein kinase activity of ICP10. The invention further relates to pharmaceutical compositions comprising HSV-2 virus, wherein the virus lacks protein kinase activity of ICP10.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: April 9, 2013
    Assignee: University of Maryland, Baltimore
    Inventors: Laure Aurelian, Aric Colunga, Jennifer Laing
  • Patent number: 8414886
    Abstract: This invention relates to compositions comprising a bacterium of the genus Dietzia that is useful for treating paratuberculosis in ruminants and to a method for culturing the bacterium. The invention further relates to methods of treating Johne's disease by administering to a mammal a composition of the invention.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: April 9, 2013
    Assignee: ParaLab LLC
    Inventor: Robert E. Click
  • Patent number: 8414887
    Abstract: The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression Toll-like Receptor 4 mediated activation of the immune system. The invention further provides screening assays to identify compounds which have utility in the foregoing compositions and methods.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: April 9, 2013
    Assignee: Opsona Therapeutics Limited
    Inventors: Luke O'Neill, Susan Carpenter, Aisling Dunne
  • Patent number: 8414888
    Abstract: The present invention relates to compositions containing IgG and methods for the promotion of nerve regeneration or prevention or inhibition of neuronal degeneration by IgG to ameliorate the effects of injury, disorder or disease of the nervous system.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: April 9, 2013
    Assignee: University Health Network
    Inventors: Michael Fehlings, Sherri Robins
  • Patent number: 8414889
    Abstract: Anti-?-1,3-glucan antibodies have been found to be protective against systemic fungal infection with Candida albicans. The present invention provides monoclonal antibodies that bind to ?-1,3-glucan, hybridoma cell lines producing the antibodies, compositions comprising the antibodies and methods of using such antibodies for treatment of microbial infections, particularly against Candida albicans and Aspergillus fumigatis infections. The antibodies of the present invention are not specific for ?-1,6-glucan.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: April 9, 2013
    Inventors: Antonio Cassone, Antonella Torosantucci
  • Patent number: 8414890
    Abstract: Isolated human antibodies or antigen-binding fragments thereof, which specifically bind to human RANKL and block hRANKL binding to a RANK receptor, are provided. The antibodies are useful in preventing or treating disorders and/or diseases, which are associated with RANKL/RANK interactions, including bone disorders or cancer.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: April 9, 2013
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Joel H. Martin, Aris N. Economides, Regina Raz
  • Patent number: 8414891
    Abstract: We found that FIZZ1/RELM? is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELM? was located in the pulmonary vasculature, bronchial epithelial cells, and type II pneumocytes. Recombinant FIZZ1/RELM? protein stimulates rat pulmonary microvascular smooth muscle cell (RPSM) proliferation dose-dependently. Therefore, we renamed this gene as hypoxia-induced mitogenic factor (HIMF). HIMF strongly activated Akt phosphorylation. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 inhibits HIMF-activated Akt phosphorylation. It also inhibits HIMF-stimulated RPSM proliferation. Thus, the PI3K/Akt pathway, at least in part, mediates the proliferative effect of HIMF. HIMF also has angiogenic and vasoconstrictive activity. Notably, HIMF increases pulmonary arterial pressure and vascular resistance more potently than either endothelin-1 or angiotensin II.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: April 9, 2013
    Assignee: The Johns Hopkins University
    Inventors: Roger Johns, Xingwu Teng, Dechun Li
  • Patent number: 8414892
    Abstract: This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: April 9, 2013
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventor: Nai-Kong V. Cheung
  • Patent number: 8414893
    Abstract: Compositions for treating neurodegenerative or amyloidogenic disorders such as Alzheimer's disease (AD) are provided. More particularly, anti-amyloid-beta antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: April 9, 2013
    Assignee: Amgen Inc.
    Inventors: Anja Leona Biere-Citron, Frederick W. Jacobsen, Stephen J. Wood
  • Patent number: 8414894
    Abstract: Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor ? (hTNF?) are disclosed. These antibodies have high affinity for hTNF? (e.g., Kd=10?8 M or less), a slow off rate for hTNF? dissociation (e.g., Koff=10?3 sec?1 or less) and neutralize hTNF? activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNF? and for inhibiting hTNF? activity, e.g., in a human subject suffering from a disorder in which hTNF? activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: April 9, 2013
    Assignee: Abbott Biotechnology Ltd.
    Inventors: Jochen G. Salfeld, John A. Mankovich, Deborah J. Allen, Hendricus R.J.M. Hoogenboom, Boris Labkovsky, Brian T. McGuinness, Paul Sakorafas, Michael White, Alison J. Wilton, Zehra Kaymakcalan, Andrew J. Roberts, David Schoenhaut, Tristan J. Vaughan
  • Patent number: 8414895
    Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: April 9, 2013
    Assignee: Immunex Corporation
    Inventors: Kristine M. Kim, Steven R. Wiley, Randal R. Ketchem, William C. Fanslow, III
  • Patent number: 8414896
    Abstract: The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies showed synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: April 9, 2013
    Assignee: Symphogen A/S
    Inventors: Mikkel Wandahl Pedersen, Lucilla Steinaa, Allan Jensen, Klaus Koefoed, Per-Johan Meijer, Robert Carlsson, Charles Pyke, Lars Sogaard Nielsen
  • Patent number: 8414897
    Abstract: The present disclosure demonstrates for the first time that Th-17 cells are the product of a distinct CD4+ T cell lineage with unique developmental and functional characteristics. The developmental signals required for Th-17 commitment and development are also described. As a result, the teachings of the present disclosure provide a basis for understanding the developmental pathway of Th-17 cells and offer novel avenues to modulate (stimulate or inhibit) this developmental program and offer new methods for the treatment and prevention of disease states and conditions related to aberrant activity of Th-17 cells.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: April 9, 2013
    Assignee: The UAB Research Foundation
    Inventors: Casey T. Weaver, Paul R. Mangan, Laurie E. Harrington
  • Patent number: 8414898
    Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: April 9, 2013
    Assignee: Genentech, Inc.
    Inventors: Daniel E. Afar, Rene S. Hubert, Kahan Leong, Arthur B. Raitano, Douglas C. Saffran, Stephen Chappell Mitchell
  • Patent number: 8414899
    Abstract: The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing peptide carriers derived from heat shock protein 60 (HSP60). The known synthetic peptide carrier, p458, provides significantly improved immunogenicity when provided as a multimeric conjugate comprising a plurality of peptide carrier units conjugated to each antigen. Cell vaccine compositions comprising antigen presenting cells loaded with multimeric p458 conjugates are also provided.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: April 9, 2013
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Irun R. Cohen, Hila Amir-Kroll, Noam Cohen, Gabriel Nussbaum
  • Patent number: 8414900
    Abstract: The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA sequence inserted into the new insertion site as medicine or vaccine.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: April 9, 2013
    Assignee: Bavarian Nordic A/S
    Inventors: Paul Howley, Sonja Leyrer