Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state.

Abstract: Described herein are systems and methods for operation of a prosthetic valve support structure (32) having additional reinforcement coupled with panels (36). Multiple support members (620) are distributed across the inner surface of the valve support structure (32) at regular intervals. Each support member (620) can include a looped portion (621) to act as a hinge (52). Each looped portion (621) is in a location coincidental with the interlace between adjacent panels (36).

Abstract: Apparatus for use with at least one leaflet-engaging element, the apparatus including a delivery tool which includes an inner shaft, a surrounding shaft, and at least one leaflet-engaging element holder coupled to a portion of the surrounding shaft, the leaflet-engaging-element holder being shaped to define at least one coupling site for reversibly coupling the leaflet-engaging element to the tool. The surrounding shaft surrounds a portion of the inner shaft and is slidable along the inner shaft so as to position the leaflet-engaging holder in a vicinity of at least one leaflet of an atrioventricular valve of a patient. A distal end of the inner shaft is advanceable between leaflets of the atrioventricular valve and toward a tissue site of a ventricle of the patient. Other applications are also described.

Abstract: A single piece stent construction having a plurality of commissure posts, each of which extends upwardly from a solid ring along a bend line and generally along a central longitudinal axis of the stent.

Abstract: A prosthetic heart valve assembly includes a gasket member and a valve member including a plurality of fasteners and a plurality of engagement members corresponding to the fasteners. The fasteners and/or engagement members may be configured to guide the engagement members into engagement with the fasteners. For example, the fasteners may include U-shaped spring-biased clips, e.g., attached to a core or other portion of a sewing cuff of the gasket member, and the engagement members may include latches or barbed protrusions that engage one or more holes in the fasteners. During use, the gasket member is introduced into a tissue annulus, and secured to the annulus, e.g., using a plurality of clips directed through the sewing cuff. The valve member is then introduced into the annulus and the engagement members are snapped or otherwise guided into engagement with the fasteners to secure the valve member relative to the gasket member.

Abstract: An ocular implant including a hydrophobic pseudo-endothelial implant and a binding agent applied thereto, the binding agent capable of bonding the implant to a posterior portion of a cornea such that the implant serves as a water barrier enabling dehydration of the cornea.

Abstract: An apparatus for sizing an intraocular lens and/or an ocular region of the eye of a subject, such as the anterior chamber, contains a sizing device and a measurement device. In one embodiment, the sizing device comprises a first leg having a first contact portion for operably engaging the ocular portion and a second leg having a second contact portion for operably engaging the ocular portion. The sizing device has a test geometry when placed within the ocular portion. The measurement device is adapted for determining a dimension of the sizing device based at least in part on the test geometry. The sizing device may also have a reference geometry when the sizing device in a reference condition. In certain embodiments, the difference between the reference geometry and the test geometry may be used for sizing the intraocular lens and/or the ocular portion.

Abstract: A method of manufacturing an aphakic intraocular lens that is capable of ensuring every multi-focusing effect more securely, while reducing the impact of aperture changes and lens eccentricity. At least two reliefs whose first order diffracted lights give respective focal distances different from one another are set to overlap with each other in at least a part of an area in a radial direction of the lens, and with respect to every grating pitches of one relief having a maximum grating pitch among the reliefs set up in overlap, grating pitches of another relief are overlapped periodically in order to obtain a relief pattern, so that the resulting relief pattern is formed on a lens surface.

Abstract: An intraocular lens has a polymeric optic defined by a harder posterior layer and a softer anterior layer. Haptics having a fulcrum attached to the posterior layer and a resistance arm attached to the anterior layer are provided. A bias is provided to the haptic to rotate the haptics about the fulcrum and cause the resistance arm to deform the softer anterior layer about the harder posterior layer to increase the optical power of the lens. As the haptic rotates, it axially displaces the optic anteriorly to additionally increase the optical power. The optical power is adjustable in response to stresses induced by the eye. The haptics are subject to a pre-bias that urges the haptics to rotate or bend about the fulcrum. Temporary restraints are provided to the haptics to retain a stressed shape of the lens against the bias during a post-implantation healing period.

Abstract: The invention relates to an intraocular lens comprising at least one pharmaceutically-acceptable photochromic polymer that enables all or part of the intraocular lens to change colour reversibly when exposed to light.

Abstract: Provided is an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.

Abstract: Described herein are methods and devices for use in repair of a patient's anterior cruciate ligament (ACL). These methods (and devices for performing them) allow the repair, rather than merely replacement, of the ACL. For example, described herein are anchoring devices that may be inserted into a bone and may anchor a scaffolding/support (e.g., graft) material within the bone so that the torn or damaged end of the ACL may be secured to the scaffolding/support material within the femoral notch. These anchoring devices and method of using them are particularly well suited for use with the continuous suture passers described herein, since these suture passers may allow access to previously inaccessible regions of the knee (or other body regions).

Abstract: Height-adjustable devices suitable for insertion between posterior spinal processes that allow the surgeon to post-operatively adjust the height of the implant.

Abstract: An orthopedic coupling device is used for simultaneous attachment of multiple heterogeneous orthopedic components, such as a spacer and plate, for implantation in the body. The device coupler includes a coupling base, at least one coupling member configured to attach to one an orthopedic spacer while also trapping or clamping an orthopedic fixation plate between the coupling base and the orthopedic spacer. The orthopedic coupler device may have a detachable handle to facilitate access and visibility of the spacer and plate after initial implantation.

Abstract: Disclosed in this specification are device and method that provides for adjustable, constrained motion of a spinal motion segment that is affected by degenerative disease, microinstability and the like. The device has first and second diagonal connectors, the leading ends of which are disposed within first and second fluid chambers of a housing unit. A liner is provided in the fluid chambers which are accessible through access ports into the housing unit.

Abstract: Systems are provided for reducing the complexity and invasiveness of spinal stabilization procedures and provide an expandable device deliverable to a spinal implantation location. The expandable device can be delivered through a minimally invasive access portal and expanded at the implantation location to manipulate one or more bony structures or maintain a configuration of one or more bony structures.

Abstract: A bone prosthesis device is comprised of an upper and lower abutment surfaces and an intervening malleable member. The device is sufficiently small so that implantation into an inter-vertebral disc space can be performed from a substantially posterior approach without significant impingement upon the neural elements.

Abstract: An insert (1) designed for insertion into a central cavity (10) within the upper part of the prosthetic stem (13) of a shoulder prosthesis. The insert (1) is provided with at least one transverse hole (6) that is threaded or provided with an inner retaining rib or any other screw-locking means. The insert (1) is designed for locking of transverse tuberosity bone screws (4) in the same way as a cross-dowel-nut. The outer surface of the prosthetic stem (13) is provided with at least one transverse unthreaded hole (7) communicating with the central cavity (10) in order to allow a sliding passage for the bone screw (4).The insert for a prosthetic humeral head implant of an anatomical shoulder prosthesis is interchangeable with an insert for the cup-shaped humeral implant (18) of a reverse shoulder prosthesis. The insert (1) is provided with a fixation site (8) for a targeting arm.

Abstract: Implants, and processes for installing them, which replace the medial condyle and portions of the patellofemoral channel but preferably not portions of the lateral condyle that articulate relative to the tibia. Processes are provided which allow proper location and orientation of an anterior resection and a distal resection on the femur, which make use of a transition point which can be designated on the bone, for navigating proper positioning of such implants. Proper positioning of the implant relative to the femur for insuring a smooth transition between lateral portions of the implant and the lateral condyle is thus reduced to determining proper medial/lateral location of the implant on the anterior and distal resections.

Abstract: A knee joint prosthesis which comprises a tibial component (4, 6) and a femoral component (2). The femoral component has condyles (14, 16) which act against the tibial component, directly or indirectly, during flexing of the knee. A cam (20) on the femoral component acts against a post (26) on the tibial component at high flex angles. The surface of the post which is contacted by the cam at high flex angles is convex when the post viewed generally perpendicular to the tibial bone contact and bearing surfaces, and the femoral bearing surface which is provided by the cam, where it contacts the convex surface of the post at high flex angles, is locally concave (32) when viewed along the surface of the post which contacts the cam so that the area of contact between the post and the cam is greater at high flex angles than at lower flex angles.

Abstract: A prosthetic knee joint assembly includes a femoral component and a bearing that supports articulation of the femoral component. The assembly further includes a tibial tray. Furthermore, the assembly includes a ligament link operably coupled to the tibial tray or the femoral component via a coupling component. The ligament link extending through the other of the tibial tray or the femoral component to couple to the respective one of the femur or tibia. The ligament link extends between first and second ends and includes an outer wall defining an interior longitudinal passage portion. First and second apertures extend through the wall. The first end extends through the first and second apertures and the longitudinal passage portion to define a first adjustable loop, and the second end extends through the first and second apertures and the longitudinal passage portion to define a second adjustable loop.

Abstract: A drug delivery and diagnostic system can include an orthopedic implant having an outer attachment surface. A conduit can be coupled to the outer attachment surface. The conduit can have an inlet and a plurality of perforations formed along a length thereof. The conduit can be adapted to pass fluid between the inlet and the perforations. A subcutaneous port can be fluidly coupled to the inlet and be adapted to communicate fluid through the inlet, along the conduit and out of the perforations around and along the outer attachment surface of the orthopedic implant.

Abstract: A bone cement collector includes a body having a structure that is permeable to bone cement and has opening for trapping bone cement. The body is releasably attached to an orthopaedic implant component at a location on the implant at which bone cement is likely to escape during positioning of the orthopaedic implant.

Abstract: A luminal valve for placing in a body lumen comprises at least four valve leaflets. The valve has a normally closed configuration in which the leaflets are engaged and an open configuration in which the leaflets are open. The valve may be mounted to an esophageal support.

Abstract: An object of the present invention is to provide an artificial tissue construct that has means for transporting nutrients, oxygen, waste products, or the like and is viable in vivo. The present invention relates to a tissue construct formed in vitro, which comprises a vascular layer, a basal membrane layer, and a tissue-forming cell layer.

Abstract: A knee prosthesis comprises an agonist-antagonist arrangement of two series-elastic actuators in parallel, including a knee joint, flexion and extension actuators connected to the joint in parallel with a leg member, and a controller for independently energizing the actuators to control the movement of the knee joint and leg. The flexion actuator comprises the series combination of a flexion motor and a flexion elastic element and the extension actuator comprises the series combination of an extension motor and an extension elastic element. Sensors provide feedback to the controller. The flexion actuator and the extension actuator may be unidirectional, with the flexion and extension elastic elements being series springs. The extension actuator may alternatively be bidirectional, with the extension elastic element being a set of pre-compressed series springs. Alternatively, the flexion elastic element may be a non-linear softening spring and the extension elastic element may be a non-linear hardening spring.

Abstract: The disclosure relates to a technology of a manual lock mechanism for manually switching over the oscillating motion of an upper member and a lower member at a knee joint between a locked condition and an unlocked condition. More particularly, the disclosure aims at a simple structure of the manual lock mechanism and a size reduction of the knee joint or an artificial leg including the manual lock mechanism. For these purposes, one of oscillating shafts for swingingly coupling the upper and lower members is regulated. Therefore, the manual lock mechanism includes an oscillating shaft including an irregular part and a lock member for regulating the movement of the oscillating shaft. The lock member can be switched over between a locked condition where the lock member is in contact with the irregular part of the oscillating shaft and the unlocked condition where it is separate from the irregular part.

Abstract: A prosthetic foot device has an elongate forefoot spring carried by a fastener and suspended between upper and lower bumpers. A heel spring is suspended between an end of the fastener and the lower bumper.

Abstract: Lipid-based wax compositions and their methods of making are provided for compositions substantially free of fat bloom. The compositions comprise approximately 7-80 percent by weight triacylglycerides and approximately 20-93 percent by weight monoacylglycerides and diacylglycerides combined. The methods comprise blending the monoacylglycerides, diacylglycerides, and triacylglycerides in the lipid-based wax composition by heating the lipid-based wax composition at a sufficiently high temperature to destroy substantially all crystal structure within the lipid-based wax composition. The methods further comprise pouring the lipid-based wax composition into a mold or a container having a surface and a core, wherein the pouring is conducted at a temperature at least 15° C. greater than the congeal point of the lipid-based wax composition. The methods further comprise cooling the lipid-based wax composition under conditions sufficient to cool the core to at least 5° C.

Abstract: Colloidal coal-in-water slurries having nano-particles of coal creating a pseudo-fluid. The colloidal coal-in-water slurry generally includes from about fifty to about seventy two weight percent of coal, with about 20 to about 80 percent of the coal having a particle size of about one micron or less with a mode particle size of about 250 nanometers. The coal-in-water slurry can also include a surfactant system containing one surfactant or mixtures of two or more surfactants, or mixtures of one or more surfactants and an inorganic or organic salt. The coal-in-water slurry can be used in low NOx burner applications as the main fuel and/or the reburn fuel, in gasification processes as the input fuel either alone, or in combination with organic materials, in gas turbine applications, and in diesel engine applications.

Abstract: The present invention relates to a process for preparing a bio-diesel, comprising the steps of, in the presence of an additional free fatty acid source, reacting a raw oil-fat with C1-C6 monohydric alcohol in a reactor, and separating fatty acid esters from the reacted materials, so as to produce the bio-diesel, wherein the amount of the free fatty acid in the free fatty acid source ranges from 2-100 wt % and is higher than the amount of the free fatty acid in the raw fat-oil. The present process can increase the fatty acid ester yield and purity of raw oil-fats having a low reaction activity, and has a high adaptability to raw materials.

Abstract: A pyrolysis oil derived from a lignocellulosic biomass material is converted into precursors for liquid hydrocarbon transportation fuels by contacting the oil with water and carbon monoxide at elevated temperature, typically from 280 to 350° C., an elevated pressure, typically a total system pressure of 12 to 30 MPa and a CO partial pressure from 5 to 10 MPa and a weight ratio of water:biomass oil from 0.5:1 to 5.0:1, to dissolve the oil into the reaction mixture and depolymerize, deoxygenate and hydrogenate the oil, so converting it into liquid transportation fuel precursors.

Abstract: A hydrogen generating apparatus and a fuel cell using the same is provided. The hydrogen generating apparatus is adapted to a fuel cell, and includes a main body, an electromagnet, a magnetic element, a containing tank and a sliding element. The electromagnet is fixed on the main body. The magnetic element is movably disposed on the main body. The containing tank is fixed on the main body and is used for containing liquid water. The sliding element is slidably disposed on the main body, wherein a solid fuel is fixed on the sliding element. When the electromagnet is electrified to generate magnetic force to drive a motion of the magnetic element, the magnetic element drives the sliding element to slide towards the containing tank, so that the solid fuel reacts with the liquid water in the containing tank to generate hydrogen.

Abstract: A device for continuously conditioning fed-out natural gas prior to feeding the same to supply lines leading to consumers has a mixing station for producing a burnable gas from natural gas and oxygen, a reactor container for a catalytic combustion of an introduced mixture of burnable gas and natural gas, at least one drying station that is connected downstream of an outlet of the reactor container, at least one separator, particularly for water, and at least one expansion fitting for reducing the pressure. The reactor container and separator chamber of the separator are disposed in an enclosed housing. The mixing chamber, into which a first feed line for fed-out cold natural gas opens, is disposed in the housing between the reactor container and the separator chamber.

Abstract: Provided is a fuel reforming device, which can produce and supply a reformed gas in quick response to a demand for the reformed gas and which is so inexpensive as can be suitably mounted on a vehicle. The fuel reforming device feeds a material to a reforming catalyst and produces the reformed gas under a pressure higher than the atmospheric pressure. The fuel reforming device comprises a material supply means for supplying the material to the reforming catalyst, a reforming means having the reforming catalyst, for reforming the material supplied from the material supply means, to produce the reformed gas, and a run control means for controlling the run of the fuel reforming device.

Abstract: An abrasive article including a material including an abrasive material and a filler material having an average negative coefficient of thermal expansion (CTE) within a range of temperatures between about 70 K to about 1500 K.

Abstract: A sintered cubic boron nitride (cBN) compact for use in a tool is obtained by sintering a mixture of (i) cubic boron nitride, (ii) aluminum oxide, (iii) one or more refractory metal compounds, and (iv) aluminum and/or one or more non-oxide aluminum compounds. The sintered bodies may have sufficient strength and toughness to be used as a tool material in solid, i.e. not carbide supported, form, and may be useful in heavy machining of cast irons.

Abstract: A hollow body for capturing particles includes at least one at least partially permeable wall extending between two at least partially oppositely disposed openings and along a first longitudinal direction. The hollow body has a primary cross-sectional shape defining a first cross-sectional area. At least one of the openings defines a second cross-sectional area. The second cross-sectional area is greater than the first cross-sectional area. An exhaust-gas treatment device having an exhaust line and a motor vehicle having an exhaust-gas treatment device are also provided.

Abstract: A centrifugal separator for separating liquid droplets from a gas flow can be used for scrubbing gases to be emitted into the atmosphere, as well as for separating water, oil and gas condensate droplets from a gas flow in any industry. The separator comprises a cylindrical body with axial gas flow inlet and outlet pipes and separated liquid removal sections located on the end surfaces of the body. A swirler and a central perforated pipe are installed in series and in axial alignment in the body from the gas inlet side. A conical displacer is installed in the perforated central pipe. Separation stage vanes are located between the central pipe and the conical displacer along the entire length of the displacer, and hydraulic seal vanes are placed at the same level between the central pipe and the body. The separator design provides a more efficient separation of liquid droplets from a high-velocity gas flow and can operate in any position.

Abstract: An enhanced vane bundle design that provides additional inlet chord area. An enhanced vane bundle for use in separator vessels includes top and bottom convexly-curved outlet baffles that extend horizontally from the outlet-side of the vane pack, the outlet baffles including a plurality of corresponding holes. The enhanced vane bundle further includes curved plates affixed to the convexly-curved outlet baffles, the curved plates and the convexly-curved outlet baffles define vertical pockets that extend vertically through an entirety of an outlet chord area on an outlet side of the enhanced vane bundle. The enhanced vane bundle further includes a plurality of tubes connecting the corresponding holes of the outlet baffles and extending vertically through the entirety of the outlet chord area.

Abstract: A method of using a modular International Organization for Standardization (ISO) filter house for filtering process fluids is provided. The filter house includes a self-contained rectangular cuboid enclosure having the outside dimension of a standard, transportable ISO shipping container. The filter house has apertures for fluid flow inlet and fluid flow outlet, and a filter element for removing impurities from the fluid flow. The method includes creating one standard filter house design to be used in any multiple to meet various flow requirements. The method further includes creating a common fluid connection between the filter houses and process equipment so that the filter houses operate in parallel. A kit of modular components for filtration of a fluid is also provided. The kit includes an external structure of an ISO shipping container, vanes to direct fluid flow, and a filter element.

Abstract: A panel filter including a pleated filter media, a frame and a screen is provided. The pleated filter media is supported by the frame which is a one-piece die cut frame or a two-piece die cut frame with integrally formed webbing and border. The pleated filter media is further supported by the screen on one or both sides.

Abstract: A cordierite-based ceramic honeycomb filter comprising a honeycomb structure having a large number of flow paths partitioned by porous cell walls, and plugs alternately formed in said flow paths on the exhaust-gas-inlet side or the exhaust-gas-outlet side for permitting an exhaust gas to pass through said porous cell walls to remove particulate matter from the exhaust gas, said porous cell walls having porosity of 45-58%, an average pore size of 15-30 ?m, the volume of pores having pore sizes exceeding 50 ?m being more than 10% and 25% or less of the total pore volume, the volume of pores having pore sizes of 100 ?m or more being 1-8% of the total pore volume, the volume of pores having pore sizes of less than 10 ?m being 3-10% of the total pore volume, and said pores having a pore size distribution deviation ? [=log(D20)?log(D80)] of 0.

Abstract: A method of preparing a fertilizer by feather processing inserts a weighed feather into a reaction container, and then adds caustic potash. Water is then added, and feather disintegration occurs. Phosphoric acid is poured into the mixture, and then the pH is measured—and if necessary improved with phosphoric acid or caustic potash. Epsom salt, vitriol of iron, boric acid, manganic sulphate, zinc sulphate, cuprous sulphate, ammonium molybdate and calcium nitrate are mixed in, and the mixture is partitioned into transportation containers depending on the weight of caustic potash included in the mixture using a drain pump through appropriate filter under constant stirring. The mixture is diluted with water, and the whole mass is perfectly mixed. Humic acids are then mixed into the diluted mixture to form a final keratin fertilizer with humic acid additive in colloid form.

Abstract: A cermet anode structure obtainable by a process comprising the steps of: (a) providing a slurry by dispersing a powder of an electronically conductive phase and by adding a binder to the dispersion, in which said electronically conductive phase comprises a FeCrMx alloy, wherein Mx is selected from the group consisting of Ni, Ti, Nb, Ce, Mn, Mo, W, Co, La, Y, Al, and mixtures thereof, (b) forming a metallic support of said slurry of the electronically conductive phase, (c) providing a precursor solution of ceria, said solution containing a solvent and a surfactant, (d) impregnating the structure of step (b) with the precursor solution of step (c), (e) subjecting the resulting structure of step (d) to calcination, and (f) conducting steps (d)-(e) at least once.

Abstract: An article of controlled porosity. The porosity of the article may be controlled by display of a particular pore character with respect to pore size, morphology and distribution through a metal, including a uniform distribution. The uniform distribution of porosity within the metal may be provided by a way of a coated pore former including a homogenizing agent thereat to maintain a uniform distribution of pore former throughout a mixture of the coated pore former and a powdered metal. A metal article may be formed of varying layers of porous metals each formed from an independent mixture of coated pore former and metal as indicated.

Abstract: A method of producing a powder of crystalline germanium.

Abstract: A unique pyrometallurgical lead refining process includes adding a Lewis acid component and an Arrhenius base compound to a molten lead bullion. The Lewis acid component and Arrhenius base compound are added in stoichiometric amounts that preferentially remove lighter amphoteric elements from the molten lead bullion, and promote reactions with amphoteric p-block elements in the lead bullion to form over the lead a slag of Lewis bases, thereby forming a slag layer incorporating the metal salts of the amphoteric p-block elements.

Abstract: The present invention is to provide a novel rare metal extractant containing a cyclic phenol sulfide derivative of the formula (1) and a method for extractive separation of rare metal(s) using the rare metal extractant with high efficiency.

Abstract: A gold thiosulfate leaching process uses carbon to remove gold from the leach liquor. The activated carbon is pretreated with copper cyanide. A copper (on the carbon) to gold (in solution) ratio of at least 1.5 optimizes gold recovery from solution. To recover the gold from the carbon, conventional elution technology works but is dependent on the copper to gold ratio on the carbon.