Patents Issued in March 4, 2014
  • Patent number: 8664441
    Abstract: The compound of formula (I) is a water-stable, long acting ?2-selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible obstructive airways diseases and the like. Processes for making the compound of formula (I), as well as related intermediates, are disclosed.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: March 4, 2014
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: Craig R. Abolin, H. Scott Wilkinson, Paul McGlynn, William K. McVicar
  • Patent number: 8664442
    Abstract: A dialkylanilino-cyclohexane compound useful as an antioxidant has the following formula I or formula II: wherein Ar1 and Ar2 can be the same or different and each is an alkylaromatic group; each of R1, R2, R3, and R4 is independently selected from hydrogen or CR7R8; each of R5, R6, and R7 is independently selected from hydrogen and a substituted or unsubstituted C1 to C32 hydrocarbyl group; and each R8 is independently selected from hydrogen and a C1 to C2 alkyl group, provided that when, each of R1 and R2 is CR7R8 and each such R8 is other than hydrogen, R1 and R2 may be joined to form a five or six-membered ring, and provided further that when, each of R3 and R4 is an adjacent CR7R8 and each such R8 is other than hydrogen, R3 and R4 may be joined to form a five or six-membered ring.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: March 4, 2014
    Assignee: Chemtura Corporation
    Inventor: Theodore E. Nalesnik
  • Patent number: 8664443
    Abstract: The present invention relates to an improved process for the preparation of (1S,3S,5S)-2-[2(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and its intermediates.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: March 4, 2014
    Assignee: Divi's Laboratories Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Gopinarayana Bodala
  • Patent number: 8664444
    Abstract: A continuous process for producing primary aliphatic amines having 9 to 18 carbon atoms by reaction of corresponding aliphatic aldehydes with ammonia and hydrogen in the presence of a hydrogenation catalyst in the liquid phase, characterized in that the reaction is carried out solventlessly at a molar ratio of aliphatic aldehyde:ammonia of at least 1:30, at a temperature of 100 to 200° C. and at a pressure of 6 to 11 MPa.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: March 4, 2014
    Assignee: Oxea GmbH
    Inventors: Kurt Schalapski, Norman Nowotny, Matthias Eisenacher, Dirk Bermann, Thorsten Kreickmann, Peter Heymanns, Heinz Strutz
  • Patent number: 8664445
    Abstract: A method for providing a secondary or tertiary amine with formula (R1R2NR3)2NR4 is provided, wherein each of R1 and R2 are chosen from the group consisting of a methyl group, an ethyl group, an iso-propyl group and an n-propyl group; R3 being an alkoxyalkyl group chosen from the group consisting of —CH2CH2OCH2CH2-, —CH2CH2OCH2CH2CH2- and —CH2CH2CH2OCH2CH2CH2-; R4 is chosen from the group consisting of a hydrogen, a methyl group, an ethyl group, an iso-propyl group, an n-propyl group and a group with formula R1R2NR3. The method comprises the steps: (?)reacting R1R2NR3(OH) with ammonia, thereby providing a mixture comprising (R1R2NR3)2NR4; (?) separating (R1R2NR3)2NR4 from said mixture.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: March 4, 2014
    Assignees: Huntsman International LLC, Huntsman Corporation Hungary ZRT
    Inventors: Zsolt Gaspar, Heiko H. Humbert, Gabor Felber, Attila Gaspar, Robert A. Grigsby, Jr., Imre Kordas, Petra Emma Vanderstraeten
  • Patent number: 8664446
    Abstract: Methods of purifying NMe3 by removing N2, NH2Me, NH3, and H2O are disclosed.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: March 4, 2014
    Assignee: American Air Liquide, Inc.
    Inventors: Brian Besancon, Christian Dussarrat, Nathan Stafford, Paul Jantzen
  • Patent number: 8664447
    Abstract: Provided is a process for effectively and efficiently oxidizing alkyl-containing molecules with the use of an oxygen-containing gas. An iridium metal catalyst complex with the iridium being coordinated with the nitrogen atoms of a benzimidazolyl-containing ligand is used as the catalyst. The process generates alcohols, ketones and aldehydes directly from alkyl-containing molecules and/or aromatic molecules.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: March 4, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Alan Stuart Goldman, Robert Timothy Stibrany
  • Patent number: 8664448
    Abstract: The present invention relates to a process for producing an odorless and colorless industrial grade propylene glycol from glycerol obtained during the manufacturing of biodiesel. The process includes hydrogenating the glycerol to form a hydrogenated product, distilling the hydrogenated product to form a glycol product, and contacting the glycol product with a treatment bed. The propylene glycol may be used in various industrial and consumer applications and products such as personal care products.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: March 4, 2014
    Assignee: Huntsman Petrochemical LLC
    Inventors: Srinivasa Godavarthy, Wei-Yang Su, Ralph M. DiGuilio, Stan Harville, Matthew W. Forkner
  • Patent number: 8664449
    Abstract: The invention relates to a method for continuously producing 2-butanone from 2,3-butanediol in hot pressurized water having an added electrolyte, characterized in that a compound selected from among the group comprising Ce(SO4)2, Fe2(SO4)3, Al2(SO4) is used as the added electrolyte.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: March 4, 2014
    Assignee: Wacker Chemie AG
    Inventors: Christoph Ruedinger, Hans-Juergen Eberle, Andrea Soler, Herbert Vogel
  • Patent number: 8664450
    Abstract: A process for the manufacture of gamma-delta-unsaturated ketones of formula (R1)(R2)C?CH—CH2—CH2—CO—R3 (I), wherein R1 is methyl or ethyl; R2 is a saturated or unsaturated linear or cyclic hydrocarbon residue and R3 is methyl or ethyl, by reacting a tertiary vinyl carbinol of formula (R1)(R2)C(OH)—CH?CH2 (II) with an isopropenyl methyl or ethyl ether of formula H3C—C(OR3)?CH2 (III) in the pre-sence of an ammonium salt as catalyst.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: March 4, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Fabrice Aquino, Werner Bonrath, Rolf Kuenzi
  • Patent number: 8664451
    Abstract: Control of an in-series, multiple, e.g., two, reaction zone, hydroformylation process for producing normal (N) and iso (I) aldehydes at a N:I ratio, the process comprising contacting an olefinically unsaturated compound, e.g., propylene, with carbon monoxide, hydrogen and a catalyst comprising (A) a transition metal, e.g., rhodium, (B) an organobisphosphite, and (C) an organomonophosphite ligand, the contacting conducted in first and subsequent reaction zones and at hydroformylation conditions comprising an olefinically unsaturated compound partial pressure in each zone, the control exercised by decreasing the olefinically unsaturated compound partial pressure in the first reaction zone to decrease the N:I ratio or increasing the olefinically unsaturated compound partial pressure in the first reaction zone to increase the N:I ratio.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: March 4, 2014
    Assignee: Dow Technology Investments LLC
    Inventors: Thomas C. Eisenschmid, Glenn A. Miller, Jeffrey S. Sawrey, Michael A. Brammer
  • Patent number: 8664452
    Abstract: Disclosed herein is a process for the preparation of highly pure 2,6-diisopropyl phenol (Formula I), which comprises reacting p-hydroxy benzoic acid (Formula II) with an alkylating agent in presence of aq. mineral acid followed by basification and subsequent washings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) free of dimer impurity, 4,4?-oxydibenzoic acid of Formula IV, ether impurity 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid of Formula V and the monoalkylated impurity 4-hydroxy-3-(propan-2-yl)benzoic acid of Formula VI; and decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) in presence of high boiling solvent and sodium hydroxide as a catalyst at high temperature to yield 2,6-diisopropyl phenol substantially free of ether impurity 1,3-di(propan-2-yl)-2-(propan-2-yloxy)benzene of Formula VII and monoalkylated phenol impurity 2-(propan-2-yl) phenol of Formula VIII. Propofol prepared by the process of the present invention is suitable for pharmaceutical use.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: March 4, 2014
    Assignee: Harman Finochem Limited
    Inventors: Kirti Prakash Jain, Dhananjay Uddhavrao Edaki, Harpreet Singh Minhas, Gurpreet Singh Minhas
  • Patent number: 8664453
    Abstract: A process and apparatus for recovering dichlorohydrins from a mixture comprising dichlorohydrins, one or more compounds selected from esters of dichlorohydrins, monochlorohydrins and/or esters thereof, and multihydroxylated-aliphatic hydrocarbon compounds and/or esters thereof, and optionally one or more substances comprising water, chlorinating agents, catalysts and/or esters of catalysts is disclosed. The mixture is distilled or fractionated to separate a lower boiling fraction comprising dichlorohydrin(s) from the mixture to form a higher boiling fraction comprising the residue of the distillation or fractionation. The higher boiling fraction is stripped to recover remaining dichlorohydrins. Advantages include more efficient recovery of dichlorohydrins for a given distillation column, less waste due to avoiding the conditions conducive to the formation of heavy byproducts, and reduced capital investment in recovery equipment.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: March 4, 2014
    Assignee: Dow Global Technologies Inc.
    Inventors: Danil Tirtowidjojo, Andrei S. Merenov, Christian D. Kneupper, Bruce D. Hook, Anil I. Mehta
  • Patent number: 8664454
    Abstract: The present invention produces ethanol in a reactor that comprises a catalyst comprising from 40 to 70 wt. % copper and 15 to 40 wt. % zinc and a support material. The crude ethanol product may be separated and ethanol recovered.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: March 4, 2014
    Assignee: Celanese International Corporation
    Inventors: Heiko Weiner, Zhenhua Zhou, Radmila Jevtic, Victor J. Johnston
  • Patent number: 8664455
    Abstract: The invention provides an improved process to manufacture 2-chloro-1,1,1,2-tetrafluoropropane (HCFC-244bb) by reacting 2-chloro-3,3,3,-trifluoropropene (HCFO-1233xf) with hydrogen fluoride, in a liquid phase reaction in the presence of hydrogen chloride and a liquid phase fluorination catalyst. The hydrogen chloride is added into the reaction from an external source at a pressure of about 100 psig or more. The HCFC-244bb is an intermediate in the production of 2,3,3,3-tetrafluoropropene-1 (HFO-1234yf).
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: March 4, 2014
    Assignee: Honeywell International Inc.
    Inventors: Daniel C. Merkel, Stephen A. Cottrell, Robert C. Johnson
  • Patent number: 8664456
    Abstract: Disclosed is an integrated process to co-produce trans-1-chloro-3,3,3-trifluoro-propene (1233zd (E)), trans-1,3,3,3-tetrafluoropropene (1234ze (E)), and 1,1,1,3,3-pentafluoropropane (245fa). Overall the co-production is a three-step process. The chemistry involves the steps of: (1) the reaction of 1,1,1,3-tetrachloropropene and/or 1,1,3,3-tetrachloropropene with anhydrous HF in excess in a liquid-phase catalyzed reactor in such a way as to co-produce primarily 1233zd (E) and 244fa (plus by-product HCl); an optionally (2) the 244fa stream can then be used to directly produce any (or all) of the following desired products; (a) the 244fa stream can be dehydrochlorinated to produce the desired second product 1234ze (E); and/or (b) the 244fa stream can be dehydrofluorinated to produce 1233zd (E) if more of that product is desired; and/or (c) the 244fa stream can be further fluorinated to form 245fa.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: March 4, 2014
    Assignee: Honeywell International Inc.
    Inventors: Daniel C. Merkel, Konstantin A. Pokrovski, Hsueh Sung Tung
  • Patent number: 8664457
    Abstract: A production method of 3,3,3-trifluoropropene includes the step of hydrogenating 1-chloro-3,3,3-trifluoropropene with hydrogen (H2) in a gas phase in the presence of either of: (A) a catalyst having carried on a carrier at least one kind of transition metal selected from the group consisting of ruthenium, nickel, rhodium, iridium, iron, osmium and cobalt, or an oxide of said transition metal; (B) an oxide catalyst of copper and manganese; and (C) a catalyst having carried on a carrier palladium and at least one kind of element selected from the group consisting of bismuth, zinc, copper, silver, lanthanum, lead, zirconium, niobium, hafnium, magnesium, tin and arsenic.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: March 4, 2014
    Assignee: Central Glass Company, Limited
    Inventors: Fuyuhiko Sakyu, Yasuo Hibino
  • Patent number: 8664458
    Abstract: In a process for converting mixed polyethylene waste to make waxes and grease base stocks through catalytic depolymerization, the mixed polyethylene waste is preheated to form a molten mixed polyethylene waste. Then, depolymerization reaction of the molten mixed polyethylene waste is started. The depolymerization reaction uses a catalyst in a high pressure reactor at a desired temperature using heaters in the high pressure reactor. The catalyst is disposed on a stirring blade. Progression of depolymerization reaction of the molten mixed polyethylene waste is allowed to continue until a pressure in the high pressure reactor reaches a desired value. The heaters are turned off and depolymerization reaction of the molten mixed polyethylene waste is stopped upon the pressure in the reactor reaching desired value. The mixed polyethylene waste is converted to wax or grease base stock.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: March 4, 2014
    Assignee: Greenmantra Recycling Technologies Ltd.
    Inventors: Anil Kumar, Pushkar Kumar
  • Patent number: 8664459
    Abstract: A process for hydrogenating olefins is disclosed. The olefins are present in a feed gas which includes H2 and one or more sulfur compounds. The sulfur compounds may include H2S and organic sulfur compounds. The feed gas is passed through a reactor at an inlet temperature from 100° C. to 250° C. The reactor contains a catalyst which is active at the inlet temperature. The reactor may be adiabatic. Saturated hydrocarbons are formed from the olefins. A temperature gradient may be formed in the reactor due to the exothermic nature of the hydrogenation reaction, causing the temperature to increase downstream in the reactor. At temperatures higher than the inlet temperature, H2S may be formed from organic sulfur compounds. A gas mixture including saturated hydrocarbons, H2S and H2 exits the reactor and may be brought into contact with a chemical adsorbent which removes the H2S. The gas stream may then be passed to a steam methane reformer.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: March 4, 2014
    Assignees: Air Products and Chemicals, Inc., Johnson Matthey PLC
    Inventors: Ruth A. Davis, Norman Macleod, Gordon Edward Wilson
  • Patent number: 8664460
    Abstract: The application discloses novel processes for the oligomerization of unsaturated hydrocarbons, and more specifically the use of selected ionic liquids containing Indium (III) Chloride in the oligomerization of unsaturated hydrocarbons, which allows for selection of the oligomers formed.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: March 4, 2014
    Assignee: The Queen's University of Belfast
    Inventors: Martyn John Earle, Johanna Kärkkäinen, Natalia V. Plechkova, Alina Tomaszowska, Kenneth Richard Seddon
  • Patent number: 8664461
    Abstract: This invention is directed to new mono-cyclopentadienyl (“mono-Cp”) metallocene catalyst compounds useful for producing high viscosity PAOs with narrow molecular weight distribution and good shear stability. Specifically, this invention relates to a group of bridged mono-Cp catalysts wherein, in an embodiment of the invention, the aromatic ring structure is substituted with: 1) at least one phenyl group, 2) at least one alkyl group, and 3) at least one other group, such as a hydrocarbyl group, a heteroatom, or a heteroatom-containing group.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: March 4, 2014
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Bruce A. Harrington, Abhimanyu O. Patil, Donna J. Crowther, Phillip T. Matsunaga, Kevin B. Stavens, Catalina L. Coker
  • Patent number: 8664462
    Abstract: A method of processing feed streams high in hydrogen sulfide is provided. The method includes providing a feed gas stream that includes hydrocarbons and at least 5 vol % hydrogen sulfide. At least a portion of the feed gas stream is separated into a hydrogen sulfide stream and a hydrocarbon stream. The hydrocarbon gas stream is processed to produce natural gas. At least 34 mol. % of the hydrogen sulfide in the hydrogen sulfide stream is combusted with an oxidant to generate thermal power. Thermal power generated by the combustion is utilized in one or more of the steps of separating the feed gas stream into the hydrogen sulfide stream and the hydrocarbon gas stream, and processing the hydrocarbon gas stream to produce natural gas, compressed natural gas, or liquefied natural gas.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: March 4, 2014
    Assignee: Shell Oil Company
    Inventors: Stanley Nemec Milam, Ann Marie Lauritzen, Michael Anthony Reynolds, Eswarachandra Kumar Paruchuri, Scott Lee Wellington
  • Patent number: 8664463
    Abstract: This disclosure relates generally to adhesives and particularly to reversible adhesives. This disclosure further relates to generally adhesive articles and particularly to wound dressings comprising such adhesives. The adhesive comprises a core and a shell comprising at least two components. One of the components of the shell comprises a polymer formed by reacting a monomer of a thermally reversible polymer and the other component comprises a polymer formed by reacting a monomer of a polymer of a pressure sensitive adhesive. The wound dressing comprises a substrate and the reversible adhesive, forming a reversible wound dressing. Such wound dressings are particularly suitable for treatment of damaged sensitive tissue, for example wounds formed on a fragile skin.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: March 4, 2014
    Assignee: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
    Inventors: Changhong Zhang, Manuel Martin Orosco, Xiang Yu, Fikret Nuri Kirkbir, Mark Edward Thompson
  • Patent number: 8664464
    Abstract: The invention provides wound dressings comprising an absorbent (porous) hydrogel composition comprising a foam portion which comprises a flexible plasticized hydrophilic polymer matrix having an internal cellular structure, and a continuous portion which comprises a flexible plasticized hydrophilic polymer matrix having relatively continuous internal structure. The continuous portion of the hydrogel composition includes apertures providing fluid flow communication through the continuous portion between an external surface of the continuous portion and the foam portion whereby the foam portion can take up external water or other fluid into the cellular structure through the apertures of the continuous portion. The continuous portion of the hydrogel composition may be tacky to the skin, allowing its use as a bioadhesive.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: March 4, 2014
    Assignee: Systagenix Wound Management (US), Inc.
    Inventors: Hugh S. Munro, Derek Silcock, Simon W. Bayliff, Richard Hoskins, Susana S. Garcia, Helen Burgess, Justin Barnes
  • Patent number: 8664465
    Abstract: A pad of elastomeric material having a softness of no more than about durometer 50 Shore 00. The pad may carry adhesive and/or a housing for adhering the pad to a surface, either directly or indirectly through an envelope which surrounds the pad and carries the adhesive. Such a pad exhibits hemostatic and leak prevention properties against needle puncture holes in the skin or the wall of a hollow medical device. Particularly, hemostasis may be prevented with low pressure application of the pad to the skin. The pad may be previously applied to the skin of the patient or a wall of a medical device such as tubing or a solution bag, and the needle may then penetrate both the pad and the skin or medical device wall, to make a resealable puncture with leakage reduction and hemostasis when the needle is withdrawn.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: March 4, 2014
    Assignee: Lifestream Medical Corporation
    Inventors: David S. Utterberg, William J. Schnell, David Bell
  • Patent number: 8664466
    Abstract: A bandage for a hoof, including a sheet material having a central body portion and a plurality of palmate lobes radiating outwardly from a central body portion. Straps extend from opposed sides of a lobe adjacent the back side of the hoof and are secured to an exterior portion of the bandage adjacent the toe of the hoof when the bandage is installed on the hoof.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: March 4, 2014
    Inventor: Bryan K. Tilghman
  • Patent number: 8664467
    Abstract: Absorbent articles incorporating sensory element members are disclosed. The absorbent articles may be disposable pant like garments designed to assist urinary toilet training such as of young children. Upon urination by the wearer, the article produces a feedback response which is transmitted to the wearer by the sensory element member. Wetness based, temperature based and other feedback responses are disclosed. The feedback response should be immediate and unmistakable to the wearer and also be temporary and harmless.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: March 4, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Donald Carroll Roe, Jennifer Joan Nandrea, Masaharu Nishikawa
  • Patent number: 8664468
    Abstract: Disposable absorbent article comprising an interior design signal indicating absorbency and an absorbent core including first and second absorbent layers, the first absorbent layer including a first substrate and the second absorbent layer including a second substrate, the first and second absorbent layers further including absorbent particulate polymer material deposited on the first and second substrates and thermoplastic material covering the absorbent particulate polymer material on the respective first and second substrates, the first and second absorbent layers combined together such that at least a portion of the thermoplastic material of the first absorbent layer contacts at least a portion of the thermoplastic material of the second absorbent layer, the absorbent particulate polymer material is disposed between the first and second substrates in an absorbent particulate polymer material area, and the absorbent particulate polymer material is substantially continuously distributed across the absorbent
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: March 4, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Kathleen Marie Lawson, Mark John Ciesko, Christofer Fuchs, Alizha Victoria Rice, Harald Hermann Hundorf, Horst Blessing, Peter Dziezok, Mattias Schmidt, Holger Beruda, Bruno Johannes Ehrnsperger
  • Patent number: 8664469
    Abstract: A disposable absorbent article has front and back panels, each having an elastic film layer and each having first and second zones. The first zone of each panel is extensible and retractable and the second zone of each panel is non-extensible and non-retractable. Each of the front and back panels has first and second side edges. An absorbent assembly is secured to the front and back panels. The absorbent assembly has a first end secured to the second zone of the front panel and a second end secured to the second zone of the back panel. A pair of seams join the front and back panels together at the first and second side edges to form a disposable absorbent article having a waist opening and a pair of leg openings.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 4, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Jerome Steven Veith, Paul VanGompel
  • Patent number: 8664470
    Abstract: The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals produced by the methods described herein. Methods of identifying an agent for use in inhibiting one or more pathological characteristics of retinal degeneration and/or AMD is also encompassed by the invention. Also provided is a method of treating AMD in an individual in need thereof comprising, administering to the individual an agent identified herein.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: March 4, 2014
    Assignees: The Cleveland Clinic Foundation, Case Western Reserve University
    Inventors: Victor L. Perez, Joe G. Hollyfield, Robert G. Salomon
  • Patent number: 8664471
    Abstract: Nucleic acid compositions encoding rapidly maturing fluorescent proteins, as well as non-aggregating versions thereof (and mutants thereof) as well as the proteins encoding the same, are provided. The proteins of interest are proteins that are fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins are further characterized in that, in certain embodiments, they are mutants of wild type proteins that are obtained either from non-bioluminescent Cnidarian, e.g., Anthozoan, species or are obtained from Anthozoan non-Pennatulacean (sea pen) species. In certain embodiments, the subject proteins are mutants of wild type Discosoma sp. “red” fluorescent protein. Also of interest are proteins that are substantially similar to, or mutants of, the above specific proteins. Also provided are fragments of the nucleic acids and the peptides encoded thereby, as well as antibodies to the subject proteins and transgenic cells and organisms.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: March 4, 2014
    Assignees: The University of Chicago, The University of Washington
    Inventors: Brooke Bevis, Benjamin Glick
  • Patent number: 8664472
    Abstract: Pygmy sesame plants having the py/py recessive gene and a character selected from non-dehiscence or improved non-dehiscence and a method for breeding the same are disclosed. Methods for improved sesame agriculture comprising growing a pygmy sesame line having py/py gene and a character selected from non-dehiscence or improved non-dehiscence are disclosed.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: March 4, 2014
    Assignee: Sesaco Corporation
    Inventor: Derald Ray Langham
  • Patent number: 8664473
    Abstract: The invention relates to alfalfa plants and lines having aluminum tolerance. The invention also relates to parts of alfalfa plants from lines having aluminum tolerance, including seeds capable of growing aluminum tolerant alfalfa plants. Methods for the use and breeding of aluminum tolerant alfalfa plants are also provided.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: March 4, 2014
    Assignee: The Samuel Roberts Noble Foundation, Inc.
    Inventors: Dong-Man Khu, Rafael Reyno, E. Charles Bummer, Joseph H. Bouton, Maria J. Monteros
  • Patent number: 8664474
    Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH982859. The invention thus relates to the plants, seeds and tissue cultures of the variety CH982859, and to methods for producing a corn plant produced by crossing a corn plant of variety CH982859 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH982859.
    Type: Grant
    Filed: April 21, 2012
    Date of Patent: March 4, 2014
    Assignee: Monsanto Technology LLC
    Inventors: Scott A. Bergemann, Fufa H. Birru, Chris Eichhorn, L. John Frederickson, Peter Guzman, Christopher L. Souder, Richard G. Stelpflug
  • Patent number: 8664475
    Abstract: This invention relates generally to a plant cell with enhanced nitrogen use efficiency and/or increased biomass production as compared to a corresponding non-transformed wild type plant cell by increasing or generating one or more activities of polypeptides associated with enhanced nitrogen use efficiency in plants.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: March 4, 2014
    Assignee: BASF Plant Science GmbH
    Inventors: Piotr Puzio, Oliver Bläsing, Oliver Thimm, Gerhard Ritte, Hardy Schön
  • Patent number: 8664476
    Abstract: Transgenic plants that express CIVPS or intein modified proteins, compositions of matter comprising them, products of diverse applications made from the transgenic plants, methods to construct the transgenic plants containing CIVPS or intein modified genes, methods to express CIVPS or intein modified proteins in plants, and methods of using the transgenic plants.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: March 4, 2014
    Assignee: Agrivida, Inc.
    Inventor: R. Michael Raab
  • Patent number: 8664477
    Abstract: The present invention relates to a new and distinctive canola, designated G152936H. Also included are seeds of canola G152936H, to the plants, or plant parts, of canola G152936H and to methods for producing a canola plant produced by crossing the canola G152936H with itself or another canola genotype, and the creation of variants by mutagenesis or transformation of canola G152936H.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: March 4, 2014
    Assignee: Agrigenetics, Inc.
    Inventors: Gregory R. Gingera, Donna C. Knievel, Thomas J. Kubik
  • Patent number: 8664478
    Abstract: A novel soybean variety, designated XB05Y12 is provided. Also provided are the seeds of soybean variety XB05Y12, cells from soybean variety XB05Y12, plants of soybean XB05Y12, and plant parts of soybean variety XB05Y12. Methods provided include producing a soybean plant by crossing soybean variety XB05Y12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB05Y12, methods for producing other soybean varieties or plant parts derived from soybean variety XB05Y12, and methods of characterizing soybean variety XB05Y12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB05Y12 are further provided.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi-Bred International Inc
    Inventors: Nadejda N. Krasheninnik, Martin A. Fabrizius, Michael T. Roach
  • Patent number: 8664479
    Abstract: A novel soybean variety, designated XBP19006 is provided. Also provided are the seeds of soybean variety XBP19006, cells from soybean variety XBP19006, plants of soybean XBP19006, and plant parts of soybean variety XBP19006. Methods provided include producing a soybean plant by crossing soybean variety XBP19006 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP19006, methods for producing other soybean varieties or plant parts derived from soybean variety XBP19006, and methods of characterizing soybean variety XBP19006. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP19006 are further provided.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi-Bred International Inc
    Inventors: Martin A. Fabrizius, Michael T. Roach, Paul A. Stephens
  • Patent number: 8664480
    Abstract: A novel soybean variety, designated XBP20001 is provided. Also provided are the seeds of soybean variety XBP20001, cells from soybean variety XBP20001, plants of soybean XBP20001, and plant parts of soybean variety XBP20001. Methods provided include producing a soybean plant by crossing soybean variety XBP20001 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP20001, methods for producing other soybean varieties or plant parts derived from soybean variety XBP20001, and methods of characterizing soybean variety XBP20001. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP20001 are further provided.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi-Bred International Inc
    Inventors: Martin A. Fabrizius, Michael T. Roach
  • Patent number: 8664481
    Abstract: A novel soybean variety, designated XB13R12 is provided. Also provided are the seeds of soybean variety XB13R12, cells from soybean variety XB13R12, plants of soybean XB13R12, and plant parts of soybean variety XB13R12. Methods provided include producing a soybean plant by crossing soybean variety XB13R12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB13R12, methods for producing other soybean varieties or plant parts derived from soybean variety XB13R12, and methods of characterizing soybean variety XB13R12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB13R12 are further provided.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi-Bred International Inc
    Inventors: Martin A. Fabrizius, Michael T. Roach
  • Patent number: 8664482
    Abstract: A novel soybean variety, designated XB37K12 is provided. Also provided are the seeds of soybean variety XB37K12, cells from soybean variety XB37K12, plants of soybean XB37K12, and plant parts of soybean variety XB37K12. Methods provided include producing a soybean plant by crossing soybean variety XB37K12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB37K12, methods for producing other soybean varieties or plant parts derived from soybean variety XB37K12, and methods of characterizing soybean variety XB37K12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB37K12 are further provided.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi-Bred International Inc
    Inventors: Thomas C. Corbin, Jason David Neus
  • Patent number: 8664483
    Abstract: The invention provides seed and plants of the bean line designated RS 08061277. The invention thus relates to the plants, seeds and tissue cultures of bean line RS 08061277, and to methods for producing a bean plant produced by crossing a plant of bean line RS 08061277 with itself or with another bean plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of bean line RS 08061277, including the pods and gametes of such plants.
    Type: Grant
    Filed: January 1, 2012
    Date of Patent: March 4, 2014
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventor: Arie Oppelaar
  • Patent number: 8664484
    Abstract: A novel maize variety designated X05B914 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X05B914 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X05B914 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X05B914, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X05B914. This invention further relates to methods for producing maize varieties derived from maize variety X05B914.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Thomas Charles Barker, Matthew David Smalley, Travis J. Lee
  • Patent number: 8664485
    Abstract: A novel maize variety designated X7H283 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X7H283 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X7H283 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X7H283, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X7H283. This invention further relates to methods for producing maize varieties derived from maize variety X7H283.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventor: Charles Thomas Cunnyngham
  • Patent number: 8664486
    Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH332645. The invention thus relates to the plants, seeds and tissue cultures of the variety CH332645, and to methods for producing a corn plant produced by crossing a corn plant of variety CH332645 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH332645.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: March 4, 2014
    Assignee: Monsanto Technology LLC
    Inventors: Fufa H. Birru, Allen C. Faue, Richard G. Stelpflug
  • Patent number: 8664487
    Abstract: According to the invention, there is provided seed and plants of the corn variety designated CV084705. The invention thus relates to the plants, seeds and tissue cultures of the variety CV084705, and to methods for producing a corn plant produced by crossing a corn plant of variety CV084705 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV084705 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV084705.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: March 4, 2014
    Assignee: Monsanto Technology LLC
    Inventors: Michael S. Olsen, Bradley A. Sockness
  • Patent number: 8664488
    Abstract: A novel maize variety designated X85C455 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X85C455 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X85C455 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X85C455, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X85C455. This invention further relates to methods for producing maize varieties derived from maize variety X85C455.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Lori Karyn Scott, Lori Lisa Carrigan, Steven Paul King
  • Patent number: 8664489
    Abstract: A novel maize variety designated PH1DAY and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1DAY with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1DAY through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1DAY or a locus conversion of PH1DAY with another maize variety.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: March 4, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventor: Lori Karyn Scott
  • Patent number: 8664490
    Abstract: According to the invention, there is provided seed and plants of the corn variety designated CV355838. The invention thus relates to the plants, seeds and tissue cultures of the variety CV355838, and to methods for producing a corn plant produced by crossing a corn plant of variety CV355838 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV355838 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV355838.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: March 4, 2014
    Assignee: Monsanto Technology LLC
    Inventor: Nathaniel J. Page