Patents Issued in March 11, 2014
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Patent number: 8669189Abstract: Disclosed is a method for treating semiconductor wafer including: providing a layer that contains lanthanum oxide or a lanthanide oxide (e.g. Dy2O3, Pr2O3, Ce2O3) applying an aqueous solution, wherein the aqueous solution is carbonated water, whereby the layer that contains lanthanum oxide or a lanthanide oxide is removed at specific areas, so that the surface, on which the layer that contains lanthanum oxide or a lanthanide oxide has been deposited, is exposed.Type: GrantFiled: June 14, 2010Date of Patent: March 11, 2014Assignee: Lam Research AGInventor: Kei Kinoshita
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Patent number: 8669190Abstract: In a method for manufacturing a semiconductor device, a process of providing a semiconductor wafer having a wiring layer having conductive patterns and a plurality of insulation films containing a first insulation film surrounding side surfaces of the conductive patterns are provided. After the process of providing the semiconductor wafer, a process of removing some regions of the plurality of insulation films to form openings is provided. Herein, the first insulation film is disposed to a position closer to the circumference of the semiconductor wafer than a position closest to the outermost circumference of the wafer among the arrangement positions of the conductive patterns.Type: GrantFiled: February 6, 2012Date of Patent: March 11, 2014Assignee: Canon Kabushiki KaishaInventors: Kenji Togo, Hiroaki Sano
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Patent number: 8669191Abstract: A method for the formation of an Ni film is herein disclosed, which comprises the steps of maintaining the temperature of an Si substrate at a desired level in a vacuum chamber; introducing, into the vacuum chamber, a nickel alkylamidinate (in this organometal compound, the alkyl group is a member selected from the group consisting of a methyl group, an ethyl group, a butyl group and a propyl group), H2 gas and NH3 gas; and then forming an Ni film according to the CVD technique, wherein the film-forming temperature is set at a level between higher than 280° C. and not higher than 350° C.Type: GrantFiled: April 12, 2012Date of Patent: March 11, 2014Assignee: Ulvac, Inc.Inventors: Toshimitsu Uehigashi, Yasushi Higuchi, Michio Ishikawa, Harunori Ushikawa, Naoki Hanada
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Patent number: 8669192Abstract: First and second vapor deposition particles (91a, 91b) discharged from first and second vapor deposition source openings (61a, 61b) pass through first and second limiting openings (82a, 82b) of a limiting plate unit (80), pass through mask opening (71) of a vapor deposition mask (70) and adhere to a substrate (10) so as to form a coating film. If regions on the substrate to which the first vapor deposition particles and the second vapor deposition particles adhere if the vapor deposition mask is assumed not to exist are respectively denoted by a first region (92a) and a second region (92b), the limiting plate unit limits the directionalities of the first vapor deposition particles and the second vapor deposition particles in a first direction (10a) that travel to the substrate such that the second region is contained within the first region. Accordingly, it is possible to form a light emitting layer with a doping method by using vapor deposition by color.Type: GrantFiled: January 4, 2012Date of Patent: March 11, 2014Assignee: Sharp Kabushiki KaishaInventors: Shinichi Kawato, Satoshi Inoue, Tohru Sonoda
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Patent number: 8669193Abstract: The subject of this invention is a sheet of material for the manufacture of a folding wall of a transition between two articulated vehicle units, as well as the folding wall of a passenger boarding bridge or passenger stairs, wherein the sheet material has at least one reinforcement element, with the reinforcement element is coated on both sides with a plastic layer, wherein the at least one reinforcement element has on one side a coating based on a silicone rubber and on the other side a coating based on an organic rubber.Type: GrantFiled: July 5, 2011Date of Patent: March 11, 2014Assignee: Hübner GmbH & Co., KGInventors: Reinhard Hübner, Volker Jünke, Kirsten Schmaler, Uwe Werner
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Patent number: 8669194Abstract: An air bag formed from a one piece woven air bag material having warp threads (10) and weft threads (20) composed of different polymeric fibers. The air bag in accordance with this invention is inexpensive to fabricate without compromises on strength by providing the weft threads (20) and the warp threads (10) have the same thread linear density.Type: GrantFiled: July 6, 2011Date of Patent: March 11, 2014Assignee: Autoliv Development ABInventors: Altay Kismir, Denis Jimmy Bray
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Patent number: 8669195Abstract: Electrical components are formed in a fabric during the weaving process by a series of crossing conductors in the warp and weft fibers of the fabric. Some of the crossing points provide permanent Separation of the crossing conductors, others permanent connection of the crossing conductors and others connection upon the application of pressure to the fabric. The structure provides the possibility of forming a greater range of components and more reliable component characteristics than heretofore possible.Type: GrantFiled: September 27, 2012Date of Patent: March 11, 2014Assignee: Intelligent Textiles LimitedInventors: Stanley Shigezo Swallow, Asha Peta-Thompson
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Patent number: 8669196Abstract: An impact resistant membrane and methods of preparing and utilizing the membrane are disclosed. The membrane comprises a loft layer, a first polymeric layer bonded to a first surface of the loft layer, and a second polymeric layer bonded to a second surface of the loft layer. The membrane can be fabricated by providing a loft layer and applying a polymeric layer on a first surface and on a second surface of the loft layer. The membrane has a higher resistance to failure due to impact and thus protects the underlying structure membrane for a longer time. A method of facilitating protecting a structure comprises providing a single ply membrane having a loft layer and a polymeric layer disposed on at least two surfaces of the loft layer.Type: GrantFiled: May 23, 2008Date of Patent: March 11, 2014Assignee: Cooley Group Holdings, Inc.Inventors: Naresh R. Mehta, Jeffrey Charles Flath, David Allen Pettey
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Patent number: 8669197Abstract: A grey glass composition employing in its colorant portion at least iron (Fe2O3/FeO), cobalt and selenium is provided. The glass allows high visible transmission, and good IR absorption, while at the same time achieving desired grey color. In certain example embodiments, the colorant portion includes, or may consist essentially of: total iron (expressed as Fe2O3) 0.20 to 0.35% selenium 0.0002 to 0.0020% cobalt oxide 0.0025 to 0.0060% titanium oxide 0 to 1.0% glass redox: <=.27; or 0.10 to 0.25.Type: GrantFiled: December 7, 2010Date of Patent: March 11, 2014Assignee: Guardian Industries Corp.Inventors: Anna Broughton, Richard Hulme, Scott V. Thomsen
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Patent number: 8669198Abstract: The present invention relates to a basic-refractory composition containing magnesium orthotitanate (Mg2TiO4) and calcium titanate (CaTiO3) suitable for use in rotating kilns for the production of Portland cement or lime.Type: GrantFiled: October 31, 2007Date of Patent: March 11, 2014Assignee: Elfusa Geral de Electgrofusao LtdaInventor: Luís Leonardo Horne Curimbaba Ferreira
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Patent number: 8669199Abstract: The present disclosure relates to cordierite-forming batch materials and methods of using the same, and in particular batch materials for forming porous cordierite bodies suitable for treating engine emissions. The batch materials include sources of magnesium, alumina, silica, and high BET specific surface area raw kaolin clay. In some embodiments, the BET specific surface area of the raw kaolin clay is greater than 22 m2/g. In other embodiments, the BET specific surface area of the raw kaolin clay is greater than 13 m2/g, and the source of magnesium oxide and the source of non-kaolin clay source of silica both have relatively coarse particle size.Type: GrantFiled: June 5, 2009Date of Patent: March 11, 2014Assignee: Corning IncorporatedInventors: Chris Maxwell, Martin Joseph Murtagh
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Patent number: 8669200Abstract: A hollow fibre containing one or more layers having a mean pore size in one or more of said layers of less than 100?m. The invention also extends to a method for preparing porous hollow fibres and to the apparatus for preparing said fibres.Type: GrantFiled: July 7, 2006Date of Patent: March 11, 2014Assignee: The University of BathInventors: Semali Priyanthi Perera, Chin-Chih Tai
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Patent number: 8669201Abstract: The invention is to a process for producing an acrylate product. The process includes the steps of contacting an alkanoic acid and an alkylenating agent over a catalyst composition under conditions effective to produce the acrylate product. The catalyst composition comprises vanadium, titanium and tungsten. Preferably, the catalyst comprises vanadium to tungsten at a molar ratio of at least 0.02:1, in an active phase.Type: GrantFiled: October 31, 2012Date of Patent: March 11, 2014Assignee: Celanese International CorporationInventors: Dick Nagaki, Tianshu Pan, Craig J. Peterson, Heiko Weiner, Elizabeth Bowden, Josefina T. Chapman, Sean Mueller
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Patent number: 8669202Abstract: A nano-particle comprising: an interior region comprising a mixed-metal oxide; and an exterior surface comprising a pure metal. In some embodiments, the mixed-metal oxide comprises aluminum oxide and a metallic pinning agent, such as palladium, copper, molybdenum, or cobalt. In some embodiments, the pure metal at the exterior surface is the same as the metallic pinning agent in the mixed-metal oxide in the interior region. In some embodiments, a catalytic nano-particle is bonded to the pure metal at the exterior surface. In some embodiments, the interior region and the exterior surface are formed using a plasma gun. In some embodiments, the interior region and the exterior surface are formed using a wet chemistry process. In some embodiments, the catalytic nano-particle is bonded to the pure metal using a plasma gun. In some embodiments, the catalytic nano-particle is bonded to the pure metal using a wet chemistry process.Type: GrantFiled: February 23, 2011Date of Patent: March 11, 2014Assignee: SDCmaterials, Inc.Inventors: Wilbert van den Hoek, Maximilian A. Biberger
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Patent number: 8669203Abstract: Compositions and methods for producing a manufactured product, a method for making a liquid absorbent, and processes for disposal of flammable liquids with a flue gas desulfurization by-product. The compositions for the manufactured products combine a binder and the by-product. The composition contains a greater percentage by weight of the by-product than the binder. The methods for producing manufactured products include dewatering the gypsum-depleted waste stream to reduce a water content, and forming the manufactured product. The method for making a liquid absorbent includes dewatering, granulating, drying, heating, and packaging a granulated gypsum-depleted composition as the liquid absorbent. The processes for disposal of flammable liquids include distributing a by-product into contact with flammable liquid, absorbing the liquid, transporting, and igniting the flammable liquid. The artificial soils are a combination of by-product and animal waste.Type: GrantFiled: March 4, 2013Date of Patent: March 11, 2014Assignee: Utter Technology LLCInventor: Terry D. Utter
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Patent number: 8669204Abstract: A composition for a protection layer for a thermal transfer ribbon which is free of solvents and which contains an acrylate oligomer or polymer having a functionality lower than or equal to 3, a di- or triacrylate monomer and a slip agent which are UV-crosslinkable in the presence of a photoinitiator, capable of forming, after coating on a backing film and after UV crosslinking, a protection layer having a thickness lower than 1 ?m. The layer has a good adhesiveness and a low friction coefficient. The composition can particularly be used for the back (5) of a thermal transfer ribbon (1) applied on a surface of the backing film (2), the other surface of the film receiving at least one ink layer (3), while imparting flexibility and thermal and mechanical resistance to the ribbon (1).Type: GrantFiled: February 2, 2010Date of Patent: March 11, 2014Assignee: ArmorInventors: Christophe Derennes, Pierre Guichard
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Patent number: 8669205Abstract: The present invention provides: a composition for controlling plant diseases comprising, as active ingredients, 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and tolclofos-methyl; a method for controlling plant diseases which comprises applying effective amounts of 4-oxo-4-[(2-phenylethyl) amino]-butyric acid and tolclofos-methyl to a plant or soil for growing plant; and so on.Type: GrantFiled: May 21, 2010Date of Patent: March 11, 2014Assignee: Sumitomo Chemical Company, LimitedInventor: Makoto Kurahashi
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Patent number: 8669206Abstract: The present invention provides an arthropod pests control composition comprising, as active ingredients, 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and a compound of formula (A); a method of controlling arthropod pests, which comprises applying effective amounts of 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and a compound of formula (A) to a plant or growing site of plant; and so on.Type: GrantFiled: November 18, 2010Date of Patent: March 11, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Miki Murakami, Shigeru Saito
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Patent number: 8669207Abstract: This invention is related to compounds and/or compositions useful against pathogens affecting meats, plants, or plant parts. In one embodiment, the provided compounds are products of certain oxaborole moieties. In a further embodiment, the compound comprises a di-oxaborole compound. Delivery systems are also provided to take advantage of the volatile nature of these compounds and/or compositions.Type: GrantFiled: July 18, 2013Date of Patent: March 11, 2014Assignee: Dow AgroSciences, LLC.Inventors: Richard Martin Jacobson, Daniel Maclean, Esther Gachango
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Patent number: 8669208Abstract: The present invention provides benzoxazinones of formula I wherein R1 is hydrogen or halogen; R2 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-alkenyl, C3-C6-haloalkenyl, C3-C6-alkynyl, C3-C6-haloalkynyl, C1-C6-alkoxy or C3-C6-cycloalkyl-C1-C6-alkyl; R3 is halogen; R4 is halogen; X is O or S; and Y is a substituted or unsubstituted heterocycle; Benzoxazinones of formula I are useful as herbicides.Type: GrantFiled: September 26, 2011Date of Patent: March 11, 2014Assignee: BASF SEInventors: Trevor William Newton, Thomas Seitz, Matthias Witschel, Anja Simon, Helmut Walter, Richard Roger Evans
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Patent number: 8669209Abstract: Soluble granule formulations of amine salts of pyridine containing carboxylic acids with improved handling properties are provided by an improved process in which the pyridine containing carboxylic acid is partially neutralized with an amine.Type: GrantFiled: November 22, 2010Date of Patent: March 11, 2014Assignee: Dow AgroSciences, LLC.Inventors: Franklin N. Keeney, Neil A. Foster, Martin C. Logan, Maria G. Perry
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Patent number: 8669210Abstract: This invention relates to a high-strength, aqueous herbicidal concentrate containing the clopyralid dimethylamine salt. The formulation is stable to storage and exhibits lower viscosity than other clopyralid amine salt formulations.Type: GrantFiled: March 21, 2011Date of Patent: March 11, 2014Assignee: Dow AgroSciences, LLC.Inventor: Robert M. Buttimor
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Patent number: 8669211Abstract: A method to measure enhancement in the quality of life of an animal fed a super senior pet food composition comprising quantitating the gene expression levels of one or more genes in said animal and comparing said levels in the animal to levels in the animal prior to administration of said super senior pet food composition. A method to enhance the quality of life of an animal by modulating the expression level of one or more genes in said animal in order to mimic the pattern of expression seen in vivo after administration of a super senior pet food composition.Type: GrantFiled: July 24, 2012Date of Patent: March 11, 2014Assignee: Hill's Pet Nutrition, Inc.Inventors: Ryan Michael Yamka, Kim Gene Friesen
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Patent number: 8669212Abstract: The present invention relates to fluids useful for subterranean operations, and more particularly, to fluorosurfactants useful for the reduction of water blocks, gas blocks, and/or gas condensates and their associated treatment fluids and methods. Provided is a method of treating a subterranean formation. The method may comprise contacting the subterranean formation with a fluorosurfactant. The fluorosurfactant may comprise an amine group, wherein the amine group comprises at least one substituent selected from the group consisting of a fluoroalkyl group, a fluoroalkenyl group, and combinations thereof, wherein the at least one substituent comprises about 3 carbons to about 22 carbons. Also provided are polymeric surfactants and treatment fluids that comprise fluorosurfactants.Type: GrantFiled: September 3, 2009Date of Patent: March 11, 2014Assignee: Halliburton Energy Services, Inc.Inventors: Lewis R. Norman, Rajesh K. Saini
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Patent number: 8669213Abstract: A well servicing fluid formulated with components comprising a friction reducer having at least one polymer unit chosen from acrylamide groups, acrylate groups, sulfo groups, and maleic acid groups; and an anionic surfactant, a cationic surfactant and an aqueous base capable of forming a viscoelastic gel. Methods of making the well servicing fluid and methods of employing the well servicing fluid in a well are also disclosed.Type: GrantFiled: March 31, 2010Date of Patent: March 11, 2014Assignee: Baker Hughes IncorporatedInventors: D. V. Satyanarayana Gupta, Justyna Ferraro, Kay Cawiezel
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Patent number: 8669214Abstract: The invention is directed to stable crosslinked water-soluble swellable polymers and methods for making same. More particularly, the invention relates to a composition comprising expandable polymeric particles having anionic sites and labile crosslinkers and stable crosslinkers, said particle mixed with a fluid and a cationic crosslinker that is capable of further crosslinking the particle on degradation of the labile crosslinker and exposure of the anionic sites so as to form a gel. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into target zone and when the heat and/or suitable pH of the target zone cause degradation of the labile crosslinker and the particle expands, the cationic crosslinker crosslinks the polymer to form a gel, thus diverting water to lower permeability regions and improving oil recovery.Type: GrantFiled: June 9, 2010Date of Patent: March 11, 2014Assignees: ConocoPhillips Company, University of KansasInventors: Ahmad Moradi-Araghi, James H. Hedges, David R. Zornes, Riley B. Needham, Huili Guan, Jenn-Tai Liang, Cory Berkland, James P. Johnson, Min Cheng, Faye L. Scully
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Patent number: 8669215Abstract: Gear oil formulations comprising a gear oil and a film forming agent are disclosed. The film forming agent comprises a polymeric ester which is the reaction product of at least one polyfunctional alcohol, a dimer fatty acid, an optional aliphatic dicarboxylic acid having 5 to 18 carbon atoms and one or more ingredients to reduce the acid value of the polymeric ester to below 5 mgKOH/g with the resultant polymeric ester having a kinematic viscosity at 100° C. ranging from 400 to 5000 mm2/s and a weight average molecular weight ranging from 5000 to 20000. When used as an automotive gear oil formulation the specifications for API GL-4 gear oils are at least satisfied. Use of the gear oil formulation in manual transmissions, transfer cases and differentials and use of the gear oil formulation in an industrial gear suitable for lubricating spur, helical, bevel, worm and hypoid gears are disclosed. Methods of lubrication are also disclosed.Type: GrantFiled: November 27, 2009Date of Patent: March 11, 2014Assignee: Croda International PLCInventors: Stephen James Randles, Stephen Boyde, Josephine Anne Lefevre
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Patent number: 8669216Abstract: The present invention relates to concentrated hard surface treatment compositions which are primarily intended to be dispersed in a larger volume or quantity of water prior to use by a consumer, in order to produce a ready to use type composition.Type: GrantFiled: September 8, 2009Date of Patent: March 11, 2014Assignee: Reckitt Benckiser LLCInventor: Yun-Peng Zhu
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Patent number: 8669217Abstract: A cleaning method is provided that includes a step of preparing a cleaning composition containing 57 to 95 wt % of (component a) water, 1 to 40 wt % of (component b) a secondary hydroxy group- and/or tertiary hydroxy group-containing hydroxy compound, (component c) an organic acid, and (component d) a quaternary ammonium compound, the composition having a pH of 5 to 10, and a step of removing plasma etching residue formed above a semiconductor substrate by means of the cleaning composition.Type: GrantFiled: March 17, 2011Date of Patent: March 11, 2014Assignee: FUJIFILM CorporationInventors: Atsushi Mizutani, Hideo Fushimi, Tomonori Takahashi, Kazutaka Takahashi
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Patent number: 8669218Abstract: An adherent gelled or pasty composition for cleaning and/or scenting a toilet, wherein the composition is applied internally onto the toilet ceramic and is rinsed off only after several flushing operations, the composition comprising: a surfactant selected from the group consisting of alkylpolyglycosides, amphoacetates, amphodiacetates, betaines, fatty alcohol ethercarboxylic acids, fatty acid sarcosinates, cocamidopropylamine oxide, aminopropionates, and biosurfactants; perfume; and water; wherein the composition comprises, as an adhesion promoter, an ester of polyisobutene succinic acid, and wherein the composition is free of further adhesion promoters and surfactants.Type: GrantFiled: August 23, 2013Date of Patent: March 11, 2014Assignee: Henkel AG & Co. KGaAInventors: Marc-Steffen Schiedel, Brigitte Giesen, Petra Plantikow, Luca Bellomi, Karl-Heinz Scheffler
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Patent number: 8669219Abstract: This invention concerns dosage elements for a ware washing machine and a method of manufacturing such dosage elements. In embodiments of the invention a dosage element comprises first (10) and second (20) joined parts, wherein the first part (10) is a part which, prior to joining with the second part (20), comprised an open receptacle and wherein the second part (20) comprises a substrate carrying a plurality of mutually separated substances A, B, C arranged in side by side relation. The second part (20) is joined to said first part (10) so as to close said receptacle and enclose said substances within it. Dosage elements produced in the inventive method are pleasant to handle, while being surprisingly resistant to damage in handling or transit.Type: GrantFiled: January 17, 2008Date of Patent: March 11, 2014Assignee: Reckitt Benckiser N.V.Inventors: Ralf Wiedemann, Pavlinka Roy, Frederic Moreux
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Patent number: 8669220Abstract: A method of forming a water soluble container, comprising an injection moulded water soluble polymer, in which is present a fabric care, surface care or dishwashing composition, by injection moulding a thermoplastic material into a mould, wherein before or during the injection moulding process the mould is actively heated, the mould being at an elevated temperature, below the melting point of the thermoplastic material, throughout the injection moulding process.Type: GrantFiled: April 1, 2009Date of Patent: March 11, 2014Assignee: Reckitt Benckiser N.V.Inventors: Andreas Huber, Markus Huber, Simone Huber, Jacobus Simon Petrus Van Diepen, Ralf Wiedemann
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Patent number: 8669221Abstract: Cleaning compositions comprising amphiphilic water-soluble alkoxylated polyalkylenimines having an inner polyethylene oxide block and an outer polypropylene oxide block.Type: GrantFiled: April 12, 2006Date of Patent: March 11, 2014Assignee: The Procter & Gamble CompanyInventors: Dieter Boeckh, Christian Bittner, Andrea Margret Misske, Arturo Luis Casado Dominguez
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Patent number: 8669222Abstract: Compositions and methods for release of adherent deposits from nonporous surfaces and substrates are provided. The compositions are low volatile organic compound (low VOC) compositions, solutions or mixtures that can be applied in a form that clings to the underlying surface while it is working. Adherent deposits removed using the compositions include grease and oil, and printers ink. The compositions may be used on any nonporous surface or substrate including metals, ceramics and plastics, without harming the surface or substrate. The composition may contain a thixotropic agent to act as an anti-shearing agent.Type: GrantFiled: April 12, 2012Date of Patent: March 11, 2014Inventor: Gregg Motsenbocker
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Patent number: 8669223Abstract: A stability enhancement agent for use in a solid detergent and solid detergent compositions is described. Stability enhancement is provided by a hydratable salt, water and a polyepoxysuccinic acid or polyepoxysuccinic acid metal salt binding agent forming a dimensionally stable composition. Preferred polyepoxysuccinic acid or polyepoxysuccinic acid metal salts have a molecular weight of between about 400 and about 1,500 g/mol. The stability enhancement composition for use in a solid detergent and solid detergent compositions are preferably biodegradable and substantially free of phosphorus and NTA.Type: GrantFiled: December 19, 2012Date of Patent: March 11, 2014Assignee: Ecolab USA Inc.Inventors: Carter M. Silvernail, Kerrie Walters
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Patent number: 8669224Abstract: The present invention relates to compositions including threshold agents, and methods of use thereof. The threshold agents can include hydroxycarboxylate compounds present at an amount sufficient to control water hardness. The threshold agents are present in the wash solution at a molar amount less than the molar amount of water hardness ions present.Type: GrantFiled: September 16, 2009Date of Patent: March 11, 2014Assignee: Ecolab USA IncInventors: Altony J. Miralles, Carter M. Silvernail
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Patent number: 8669225Abstract: Methods are described for producing non-immunogenic nanoparticles from protein sources by controlling the pH in a nanoprecipitation process. The nanoparticles that are produced by the disclosed methods range in diameter size from about 100 ran to about 400 nm, with a preferred diameter size of from approximately 100 nm to approximately 300 nm, thereby rendering them non-immunogenic. The invention further discloses methods for producing nanoconjugates that are suitable for a variety of therapeutic, diagnostic and other uses.Type: GrantFiled: May 11, 2009Date of Patent: March 11, 2014Assignee: South Dakota State UniversityInventors: Omathanu P. Perumal, Satheesh K. Podaralla, Radhey S. Kaushik
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Patent number: 8669226Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.Type: GrantFiled: October 7, 2011Date of Patent: March 11, 2014Assignee: Morehouse School of MedicineInventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Martin Neville Shelton
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Patent number: 8669227Abstract: The invention relates to a complex between an insulin and a polysaccharide comprising carboxyl functional groups, said polysaccharide being chosen from polysaccharides functionalized with at least one phenylalanine derivative, noted Phe, said phenylalanine derivative being chosen from the group consisting of phenylalanine and its alkali metal cation salts, phenylalaninol, phenylalaninamide and ethylbenzylamine or from phenylalanine esters, and said insulin being either a human insulin or an insulin analog. The invention also relates to a pharmaceutical composition comprising at least one complex according to the invention, especially in the form of an injectable solution.Type: GrantFiled: March 29, 2010Date of Patent: March 11, 2014Assignee: AdociaInventors: Olivier Soula, Remi Soula, Gerard Soula
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Patent number: 8669228Abstract: Modified glucagon peptides are disclosed having improved solubility while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.Type: GrantFiled: January 3, 2008Date of Patent: March 11, 2014Assignee: Indiana University Research and Technology CorporationInventors: Richard D. Dimarchi, Maria Dimarchi, Joseph Chabenne
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Patent number: 8669229Abstract: The present invention provides a benzazepine compound that can maintain for a long period of time the blood level of tolvaptan enabling to provide the desired pharmaceutical effects. The benzazepine compound of the present invention is represented by general formula (1) wherein R1 represents a —CO—(CH2)n—COR2 group (wherein n is an integer of 1 to 4, and R2 is (2-1) a hydroxy group; (2-2) a lower alkoxy group optionally substituted with a hydroxy group, a lower alkanoyl group, a lower alkanoyloxy group, a lower alkoxycarbonyloxy group, a cycloalkyloxycarbonyloxy group, or 5-methyl-2-oxo-1,3-dioxo-4-yl; or (2-3) an amino group optionally substituted with a hydroxy-lower alkyl group), or the like.Type: GrantFiled: June 26, 2008Date of Patent: March 11, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kazumi Kondo, Yasuhiro Menjo, Takahiro Tomoyasu, Shin Miyamura, Yuso Tomohira, Takakuni Matsuda, Keigo Yamada, Yusuke Kato
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Patent number: 8669230Abstract: The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. The present invention relates to novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells which can be used in vaccine compositions for eliciting anti-tumor immune responses.Type: GrantFiled: October 29, 2010Date of Patent: March 11, 2014Assignee: Immatics Biotechnologies GmbHInventors: Harpreet Singh, Steffen Walter, Toni Weinschenk, Norbert Hilf, Oliver Schoor, Claudia Lemmel
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Patent number: 8669231Abstract: The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodrug by hK2, the therapeutic drugs are activated and exert their toxicity. Methods for treating cell proliferative disorders are also featured in the invention.Type: GrantFiled: January 10, 2011Date of Patent: March 11, 2014Assignee: GenSpera, Inc.Inventors: Samuel R. Denmeade, John Tod Isaacs, Hans Lilja
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Patent number: 8669232Abstract: The present invention provides a flavonol compound and a bioactive extract/fraction from Ulmus wallichiana useful for the management or prevention or treatment of bone disorders. Said extract/fraction comprising marker compounds of general formula 2, K058: R1?R2?OH K012: R1?R2?OH, 2,3 double bond K068: R1?R2?H KIOOi R1?OH, R2?H mula 2 Wherein the marker compounds K012, K058, K068, K1OO ranges 6.7-12%, 1.7-4.5%, 0.6-1.2%, 1.7-4.5% respectively in alcoholic extract and a process of extraction thereof. According to another aspect of the invention provides a pharmaceutical composition comprising the said compound. The present invention further provides a method of treating bone disorders by administering the pharmaceutical composition by oral, intravenous, subcutaneous, intra-peritoneal or intramuscular route.Type: GrantFiled: March 3, 2009Date of Patent: March 11, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Rakesh Maurya, Preeti Rawat, Kunal Sharan, Jawed Akhtar Siddiqui, Gaurav Swarnkar, Geetanjali Mishra, Lakshmi Manickavasagam, Girish Kumar Jain, Kamal Ram Arya, Naibedya Chattopadhyay
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Patent number: 8669233Abstract: A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay is described.Type: GrantFiled: February 16, 2010Date of Patent: March 11, 2014Assignee: Galderma Research & DevelopmentInventors: André Jomard, Laurent Fredon, Olivier Roye
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Patent number: 8669234Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: GrantFiled: June 7, 2012Date of Patent: March 11, 2014Assignee: Gilead Sciences, Inc.Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Evan S. Krygowski, John O. Link, Michael L. Mitchell, Jay P. Parrish, James Taylor
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Patent number: 8669235Abstract: The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.Type: GrantFiled: March 22, 2007Date of Patent: March 11, 2014Assignee: California Institute of TechnologyInventors: David Baltimore, Mark Boldin, Konstantin Taganov
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Patent number: 8669236Abstract: Novel biotinylated composition comprising a nucleic acid, e.g. siRNA, that are useful for targeting therapeutic and imaging agents to sites of infection and tumors are disclosed.Type: GrantFiled: May 12, 2006Date of Patent: March 11, 2014Assignees: The General Hospital Corporation, Children's Medical Center CorporationInventors: David R. Elmaleh, Bruce R. Zetter, Earl Weinstein, Jacqueline Banyard Bhisitkul
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Patent number: 8669237Abstract: The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.Type: GrantFiled: January 25, 2012Date of Patent: March 11, 2014Assignee: Dynavax Technologies CorporationInventors: Gary Van Nest, Stephen Tuck, Karen L. Fearon, Dino Dina
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Patent number: 8669238Abstract: The present invention relates to novel pharmaceutical or cosmetic compositions comprising at least one inhibitor of a sub-unit of AP-1 adaptor complex, of a kinesin interacting with AP-1, in particular Kif13A, or of the interaction between a sub-unit of AP-1 adaptor complex and said kinesin, as well as the use of same to manufacture a drug intended for the treatment of pigmentary disorders and as a depigmentation agent.Type: GrantFiled: August 8, 2012Date of Patent: March 11, 2014Assignees: Institut Curie, Centre National de la Recherche Scientifique (CNRS)Inventors: Graca Raposo, Cédric Delevoye, Danièle Tenza, Ilse Hurbain