Patents Issued in April 1, 2014
-
Patent number: 8685854Abstract: A process for burying a tungsten member into a blind hole formed in a wafer, in which blind hole a through via is to be made. Film-formation (for forming the tungsten member) is carried out to position, at the periphery of the wafer, the outer circumference of the tungsten member inside the outer circumference of a barrier metal beneath the tungsten film. This process makes it possible to bury the tungsten member, which may be relatively thin, into the blind hole, which may be relatively large, so as to decrease a warp of the wafer and further prevent an underlying layer beneath the tungsten member from being peeled at the periphery of the wafer.Type: GrantFiled: March 11, 2011Date of Patent: April 1, 2014Assignee: Renesas Electronics CorporationInventors: Kazuhito Ichinose, Kotaro Kihara, Tatsunori Murata
-
Patent number: 8685855Abstract: A tray for film formation by a CVD method includes a tray main body (2) and a supporting member (3) mounted on the tray main body (2) for supporting a silicon wafer (5). The supporting member (3) has a holding portion (3c), on which the silicon wafer (5) is directly placed. The holding portion (3c) has its lower surface (3d) apart from a surface (2a) of the tray main body that is opposed to and apart from the supported silicon wafer (5), whereby the thickness distribution of an oxide film formed on the silicon wafer can be made uniform. The tray has a structure for reducing a contact area between the supporting member (3) and the tray main body (2), with the holding portion (3c) having a tilted surface with its inner circumferential side closer to the tray main body surface (2a) that is opposed to the silicon wafer.Type: GrantFiled: November 29, 2010Date of Patent: April 1, 2014Assignee: Sumco CorporationInventors: Takashi Nakayama, Tomoyuki Kabasawa, Takayuki Kihara
-
Patent number: 8685856Abstract: A fabrication method of an anti-reflection structure includes the steps of: forming a resin film having micro-particles dispersed therein on a surface of a substrate; forming a protrusion dummy pattern on the resin film by etching the resin film using the micro-particles in the resin film as a mask while gradually etching the micro-particles; and forming a protrusion pattern on the surface of the substrate by etching back the surface of the substrate together with the resin film having the protrusion dummy pattern formed thereon, and transferring a surface shape of the protrusion dummy pattern formed on a surface of the resin film to the surface of the substrate.Type: GrantFiled: March 22, 2010Date of Patent: April 1, 2014Assignee: Sony CorporationInventors: Kensaku Maeda, Kaoru Koike, Tohru Sasaki, Tetsuya Tatsumi
-
Patent number: 8685857Abstract: There is disclosed a chemical mechanical polishing method of an organic film comprising forming the organic film above a semiconductor substrate, contacting the organic film formed above the semiconductor substrate with a polishing pad attached to a turntable, and dropping a slurry onto the polishing pad to polish the organic film, the slurry being selected from the group consisting of a first slurry and a second slurry, the first slurry comprising a resin particle having a functional group selected from the group consisting of an anionic functional group, a cationic functional group, an amphoteric functional group and a nonionic functional group, and having a primary particle diameter ranging from 0.05 to 5 ?m, the first slurry having a pH ranging from 2 to 8, and the second slurry comprising a resin particle having a primary particle diameter ranging from 0.05 to 5 ?m, and a surfactant having a hydrophilic moiety.Type: GrantFiled: October 24, 2008Date of Patent: April 1, 2014Assignee: Kabushiki Kaisha ToshibaInventors: Yukiteru Matsui, Gaku Minamihaba, Yoshikuni Tateyama, Hiroyuki Yano, Atsushi Shigeta
-
Patent number: 8685858Abstract: Hemispheres and spheres are formed and employed for a plurality of applications. Hemispheres are employed to form a substrate having an upper surface and a lower surface. The upper surface includes peaks of pillars which have a base attached to the lower surface. The peaks have a density defined at the upper surface by an array of hemispherical metal structures that act as a mask during an etch to remove substrate material down to the lower surface during formation of the pillars. The pillars are dense and uniform and include a microscale average diameter. The spheres are formed as independent metal spheres or nanoparticles for other applications.Type: GrantFiled: August 30, 2011Date of Patent: April 1, 2014Assignee: International Business Machines CorporationInventors: Augustin J. Hong, Woo-Shik Jung, Jeehwan Kim, Jae-Woong Nah, Devendra K. Sadana
-
Patent number: 8685859Abstract: Methods for forming a semiconductor device include forming self-aligned trenches, in which a first set of trenches is used to align a second set of trenches. Methods taught herein can be used as a pitch doubling technique, and may therefore enhance device integration. Further, employing a very thin CMP stop layer, and recessing surrounding materials by about an equal amount to the thickness of the CMP stop layer, provides improved planarity at the surface of the device.Type: GrantFiled: September 26, 2013Date of Patent: April 1, 2014Assignee: Micron Technology, Inc.Inventors: Juengling Werner, Richard Lane
-
Patent number: 8685860Abstract: A semiconductor structure and a manufacturing method thereof are provided. The method includes the following steps. Firstly, a semiconductor substrate having an active surface and a back surface is provided. The active surface is opposite to the back surface, and the semiconductor substrate includes at least one grounding pad disposed on the active surface. Secondly, at least one through silicon via is formed through the semiconductor substrate from the back surface to the active surface thus exposing the grounding pad. Then, a conductive layer is formed on the back surface of the semiconductor substrate and filled into the through silicon via to electrically connect to the grounding pad and the semiconductor substrate.Type: GrantFiled: October 18, 2012Date of Patent: April 1, 2014Assignee: Ineffable Cellular Limited Liability CompanyInventor: Wen-Hsiung Chang
-
Patent number: 8685861Abstract: A integrated circuit system including providing an integrated circuit device, forming an undoped insulating layer over the integrated circuit device, forming a thin insulating layer over the undoped insulating layer, forming a doped insulating layer over the thin insulating layer, and forming a contact in the undoped insulating layer, thin insulating layer and the doped insulating layer.Type: GrantFiled: August 2, 2006Date of Patent: April 1, 2014Assignee: GLOBALFOUNDRIES Singapore Pte. Ltd.Inventors: Chih Ping Yong, Peter Chew, Chuin Boon Yeap, Hoon Lian Yap, Ranbir Singh, Nace Rossi, Jovin Lim
-
Patent number: 8685862Abstract: A micropattern is joined to a substrate (W1) by: a first group of covering step and micropattern forming step by etching in a transfer step; and a second group of covering step and micropattern forming step by etching in the transfer step.Type: GrantFiled: July 23, 2012Date of Patent: April 1, 2014Assignee: Toshiba Kikai Kabushiki KaishaInventors: Hiroshi Goto, Hiroshi Okuyama, Mitsunori Kokubo, Kentaro Ishibashi
-
Patent number: 8685863Abstract: The present invention relates to a semiconductor process, a semiconductor element and a package having a semiconductor element. The semiconductor element includes a base material and at least one through via structure. The base material has a first surface, a second surface, at least one groove and at least one foundation. The groove opens at the first surface, and the foundation is disposed on the first surface. The through via structure is disposed in the groove of the base material, and protrudes from the first surface of the base material. The foundation surrounds the through via structure. Whereby, the foundation increases the strength of the through via structure, and prevents the through via structure from cracking.Type: GrantFiled: December 20, 2012Date of Patent: April 1, 2014Assignee: Advanced Semiconductor Engineering, Inc.Inventor: Bin-Hong Cheng
-
Patent number: 8685864Abstract: In a method for the treatment of a substrate surface of a flat substrate with a process medium at the substrate underside, the process medium has a removing or etching effect on the substrate surface. The substrates are wetted with the process medium from below in a manner lying horizontally. The upwardly facing substrate top side is wetted or covered with water or a corresponding protective liquid over a large area or over the whole area as protection against the process medium acting on the substrate top side.Type: GrantFiled: July 28, 2010Date of Patent: April 1, 2014Assignee: Gebr. Schmid GmbHInventor: Christian Schmid
-
Patent number: 8685865Abstract: A method of forming patterns of a semiconductor device may include forming a photoresist layer that includes a photo acid generator (PAG) and a photo base generator (PBG), generating an acid from the PAG in a first exposed portion of the photoresist layer by first-exposing the photoresist layer, and generating a base from the PBG in a second exposed portion of the photoresist layer by second-exposing a part of the first exposed portion and neutralizing the acid. The method may also include baking the photoresist layer after the first and second-exposing and deblocking the photoresist layer of the first exposed portion in which the acid is generated to form a deblocked photoresist layer, and forming a photoresist pattern by removing the deblocked photoresist layer by using a developer.Type: GrantFiled: September 10, 2012Date of Patent: April 1, 2014Assignee: Samsung Electronics Co., Ltd.Inventors: Jeong-ju Park, Kyoung-mi Kim, Min-jung Kim, Dong-jun Lee, Boo-deuk Kim
-
Patent number: 8685866Abstract: A method of manufacturing a semiconductor device including alternately repeating a process of forming a first metal oxide film including a first metal element and a process of forming a second metal oxide film including a second metal element on a substrate accommodated in a processing chamber, so as to form a third metal oxide film including the first and second metal elements with a predetermined composition ratio on the substrate. One of the first and second metal elements of the third metal oxide film has a concentration higher than a concentration of the other, and one of the first and second metal oxide films including the higher-concentration metal element is formed in a chemical vapor deposition (CVD) mode or an atomic layer deposition (ALD) saturation mode, and the other of the first and second metal oxide films is formed in an ALD unsaturation mode.Type: GrantFiled: June 24, 2010Date of Patent: April 1, 2014Assignees: Hitachi Kokusai Electric, Inc., Renesas Electronics Corp.Inventors: Sadayoshi Horii, Atsushi Sano, Masahito Kitamura, Yoshitake Kato
-
Patent number: 8685867Abstract: Provided herein are novel pre-metal dielectric (PMD) integration schemes. According to various embodiments, the methods involve depositing flowable dielectric material to fill trenches or other gaps between gate structures in a front end of line (FEOL) fabrication process. The flowable dielectric material may be partially densified to form dual density filled gaps having a low density region capped by a high density region. In certain embodiments, the methods include further treating at least a portion of the gap fill material after subsequent process operations such as chemical mechanical planarization (CMP) or contact etching.Type: GrantFiled: December 8, 2011Date of Patent: April 1, 2014Assignee: Novellus Systems, Inc.Inventors: Michal Danek, Bart van Schravendijk, Nerissa Draeger, Lakshminarayana Nittala
-
Patent number: 8685868Abstract: A reinforcing fiber structure woven as a single piece for fabricating a composite material part, the fiber structure having an internal portion or core (72), and a portion adjacent to an outside surface of the structure, or skin (74, 76), and the fiber structure being formed by a three-dimensional weaving in its core using at least one weave selected from an interlock weave and a multilayer weave, and by weaving at its skin with a weave of satin type that is different from the weave in the core the weaving at the skin being of the multilayer type or of the two-dimensional type.Type: GrantFiled: June 21, 2006Date of Patent: April 1, 2014Assignees: SNECMA, SNECMA Propulsion SolideInventors: Eric Bouillon, Francois Charleux, Dominique Coupe, Bruno Dambrine, Jean Noel Mahieu
-
Patent number: 8685869Abstract: A knitted textile fabric for use in safety apparel, comprising a first yarn containing modacrylic fibers and a second yarn containing apparel, preferably cellulosic, fibers. The first and second yarns are interknitted with one another, e.g., in plated or bi-ply, relationship with the modacrylic yarn disposed predominantly at an outer face of the fabric for imparting flame resistant properties and an affinity for high visibility dyes and with the cellulosic yarn disposed predominantly at the opposite face of the fabric for imparting a hand suitable for comfortable body contact with a user's skin.Type: GrantFiled: June 26, 2009Date of Patent: April 1, 2014Assignee: Innovative Textiles, Inc.Inventors: Michael N. Byles, John N. Wasylyk
-
Patent number: 8685870Abstract: Absorbent sheet materials are produced from a coformed blend of absorbent fibers and extensible meltblown polymer fibers. Laminates of these extensible coforms are prepared with layers of extensible polymeric fibers or filaments. The absorbent sheet materials are incrementally stretched to improve softness and drape.Type: GrantFiled: February 20, 2007Date of Patent: April 1, 2014Assignee: Fitesa Nonwoven, Inc.Inventors: Jared A. Austin, Samuel C. Baer
-
Patent number: 8685871Abstract: A toughening agent for use in making composites comprises an epoxy curing agent and a thermoplastic. Compositions, composites that comprise the toughening agent and associated methods of making and using the toughening agent are also disclosed.Type: GrantFiled: December 17, 2010Date of Patent: April 1, 2014Assignee: Cytec Technology Corp.Inventors: Paul Mark Cross, Richard Thomas Price, Dominique Ponsolle, Patrick Terence McGrail
-
Patent number: 8685872Abstract: A low softening point glass composition, which is substantially free from lead, bismuth and antimony and comprises oxides of vanadium, phosphorous, tellurium and iron, a softening point of the composition being 380° C. or lower.Type: GrantFiled: May 22, 2013Date of Patent: April 1, 2014Assignee: Hitachi Chemical Co., Ltd.Inventors: Takashi Naito, Shinichi Tachizono, Kei Yoshimura, Yuji Hashiba, Keiichi Kanazawa, Shinji Yamada, Satoru Amou, Hiroki Yamamoto, Takuya Aoyagi
-
Patent number: 8685873Abstract: A lithium-aluminosilicate glass or a corresponding glass ceramic that has a content of 0-0.4SnO2, 1.3-2.7% by weight of ?SnO2+TiO2, 1.3-2.5% by weight of ZrO2, 3.65-4.3% by weight of ?ZrO2+0.87 (TiO2+SnO2), ?0.04% by weight of Fe2O3, 50-4000 ppm of Nd2O3 and 0-50 ppm of CoO is described. The glass or the glass ceramic is color-neutral, has a turbidity of less than 1% HAZE and a high light transmission. The glazing time for conversion of the glass into glass ceramic is especially short with less than 2.5 hours.Type: GrantFiled: August 6, 2012Date of Patent: April 1, 2014Assignee: Schott AGInventors: Friedrich Siebers, Ulrich Schiffner, Wolfgang Schmidbauer, Klaus Schonberger
-
Patent number: 8685874Abstract: A ceramic material having a high toughness can include carbon and a transition metal. The transition metal can have an elemental body centered cubic structure at room temperature. A substantial amount of the ceramic can be of a rhombohedral ? phase of the transition metal and carbon. These materials can have a high thermal shock resistance, high fracture toughness, and good high temperature performance. A particulate mixture of a carbon source and a transition metal source can be assembled (12) and reacted (14) under high pressure and high temperature. The transition metal source can include a transition metal of a metal which has an elemental BCC structure at room temperature. The particulate mixture carbon to transition metal ratio is chosen so as to achieve a zeta phase carbide and processing is affected in order to retain the zeta phase at a substantial weight percent of the material (i.e. greater than about 5 wt %).Type: GrantFiled: June 23, 2009Date of Patent: April 1, 2014Assignee: University of Utah Research FoundationInventors: Dinesh K. Shetty, Raymond A. Cutler, Kenneth Hackett, Shane Verhoef
-
Patent number: 8685875Abstract: Methods for enhancing the mesoporosity of a zeolite-containing material. Such methods may comprise contacting a composite shaped article containing at least one zeolite and at least one non-zeolitic material with at least one pH controlling agent and at least one surfactant. Such methods may be performed under conditions sufficient to increase the pore volume of at least one 10 angstrom subset of mesoporosity.Type: GrantFiled: October 19, 2010Date of Patent: April 1, 2014Assignee: Rive Technology, Inc.Inventors: Javier Garcia-Martinez, Lawrence B. Dight, Barry K. Speronello
-
Patent number: 8685876Abstract: A supported platinum catalyst comprising an open-pored support material and platinum of oxidation state 0, wherein an XRD spectrum of the catalyst is free of signals of elemental platinum.Type: GrantFiled: June 10, 2013Date of Patent: April 1, 2014Assignee: Sud-Chemie IP GmbH & Co. KGInventors: Hans-Christoph Schwarzer, Arno Tissler, Markus Hutt
-
Patent number: 8685877Abstract: A catalyst particle for use in growth of elongated nanostructures, such as e.g. nanowires, is provided. The catalyst particle comprises a catalyst compound for catalyzing growth of an elongated nanostructure comprising a nanostructure material without substantially dissolving in the nanostructure material and at least one dopant element for doping the elongated nanostructure during growth by substantially completely dissolving in the nanostructure material. A method for forming an elongated nanostructure, e.g. nanowire, on a substrate using the catalyst particle is also provided. The method allows controlling dopant concentration in the elongated nanostructures, e.g. nanowires, and allows elongated nanostructures with a low dopant concentration of lower than 1017 atoms/cm3 to be obtained.Type: GrantFiled: December 19, 2007Date of Patent: April 1, 2014Assignee: IMECInventors: Francesca Iacopi, Philippe M. Vereecken
-
Patent number: 8685878Abstract: A multimetallic nanoscale catalyst having a core portion enveloped by a shell portion and exhibiting high catalytic activity and improved catalytic durability. In various embodiments, the core/shell nanoparticles comprise a gold particle coated with a catalytically active platinum bimetallic material. The shape of the nanoparticles is substantially defined by the particle shape of the core portion. The nanoparticles may be dispersed on a high surface area substrate for use as a catalyst and is characterized by no significant loss in surface area and specific activity following extended potential cycling.Type: GrantFiled: April 23, 2012Date of Patent: April 1, 2014Assignee: UChicago Argonne, LLCInventors: Vojislav Stamenkovic, Nenad M. Markovic, Chao Wang, Hideo Daimon, Shouheng Sun
-
Patent number: 8685879Abstract: Disclosed are spherical magnesium-based catalyst supports and methods of using the same in a Ziegler-Natta catalyst system for the polymerization of an olefin. The spherical magnesium-based catalyst supports are made by reacting a magnesium halide, a haloalkylepoxide, and a phosphate acid ester in an organic solvent that does not have to contain substantial amounts of toluene.Type: GrantFiled: April 29, 2011Date of Patent: April 1, 2014Assignee: BASF CorporationInventors: Michael Donald Spencer, Neil O'Reilly
-
Patent number: 8685880Abstract: Methods for amending the composition of catalyst inventory of ionic liquid catalyzed processes, whereby the catalytic activity of the catalyst inventory may be adjusted and maintained for the steady state operation of such processes by contacting the catalyst inventory with a liquid phase, catalyst make-up material comprising an anhydrous salt and/or a mixture of the ionic liquid with the salt, wherein the salt comprises a precursor of the ionic liquid.Type: GrantFiled: June 23, 2011Date of Patent: April 1, 2014Assignee: Chevron U.S.A. Inc.Inventor: Sven Ivar Hommeltoft
-
Patent number: 8685881Abstract: The present invention relates to a method for producing esters from triglycerides by using solid heterogeneous catalysts comprised of calcined calcium carbonate, particularly for obtaining biodiesel.Type: GrantFiled: November 20, 2009Date of Patent: April 1, 2014Assignee: Rohm and Haas CompanyInventors: Rajiv Banavali, Jose Trejo
-
Patent number: 8685882Abstract: Disclosed is a vanadium/titania-based catalyst including natural manganese ore for removing nitrogen oxides and dioxin in a wide operating temperature range and a method of using the same. Specifically, this invention pertains to a vanadium/titania (V/TiO2)-based catalyst, including natural manganese ore, and a method for removing nitrogen oxides and dioxin over a wide operating temperature range, in which the WTiO2 catalyst for selective catalytic reduction of nitrogen oxides and removal of dioxin contained in flue gas includes 5-30 wt % of natural manganese ore.Type: GrantFiled: April 12, 2013Date of Patent: April 1, 2014Assignee: Korea Power Engineering Company, Inc.Inventors: Sung Ho Hong, Jun Yub Lee, Seok Joo Hong, Sung Pill Cho, Sung Chang Hong, Do Gyong Lee, Sang Hyun Choi
-
Patent number: 8685883Abstract: The present invention provides porous body precursors and shaped porous bodies. Also included are catalysts and other end-use products based upon the shaped porous bodies and thus the porous body precursors. Finally, processes for making these are provided. The porous body precursors comprise a precursor alumina blend capable of enhancing one or more properties of a shaped porous body based thereupon. The need to employ modifiers to achieve a similar result may thus be substantially reduced, or even avoided, and cost savings are thus provided, as well as savings in time and equipment costs.Type: GrantFiled: April 29, 2009Date of Patent: April 1, 2014Assignee: Dow Technology Investments LLCInventors: Todd R. Bryden, Kevin E. Howard, Peter C. LeBaron, Sten A. Wallin
-
Patent number: 8685884Abstract: A process for the production of low-temperature activated or partially activated partially decomposed organic matter for use as an ion-exchange medium comprising the steps of granulating partially decomposed moisture-bearing organic matter, drying the granules and activating the granules at a temperature of about 175-520° C., wherein the granule has a hardness and cation-exchange capacity suitable for a particular application desired.Type: GrantFiled: June 26, 2012Date of Patent: April 1, 2014Assignee: American Peat Technology, LLCInventors: Douglas A. Green, Eric Ingwer Paulson
-
Patent number: 8685885Abstract: A honeycomb structure includes a ceramic block including honeycomb fired bodies. The honeycomb fired bodies include an assembly including a plurality of substantially quadrangular-cross-section units which are combined with one another with an adhesive layer interposed between the plurality of substantially quadrangular-cross-section units. A peripheral face of the assembly of substantially quadrangular-cross-section units has a concave portion and a convex portion formed in a substantially step-shaped pattern. At least one substantially triangular-cross-section unit has an outer wall on a periphery portion of the at least one substantially triangular-cross-section unit. The at least one substantially triangular-cross-section unit is fit in the concave portion with the adhesive layer interposed between the at least one substantially triangular-cross-section unit and the concave portion. A sealing material layer is provided on a peripheral face of the ceramic block.Type: GrantFiled: April 20, 2011Date of Patent: April 1, 2014Assignee: Ibiden Co., Ltd.Inventors: Seiji Tamura, Masaya Sato, Shigeaki Goto
-
Patent number: 8685886Abstract: The invention is directed to a seed coating composition, to a seed coating cocktail, to a method for preparing a coated seed, to a coated seed, and to the use of specific inorganic particles. The seed coating composition for a seed comprises water and at least 35 wt. % by weight of the coating composition of inorganic particles, wherein the mean particle size (D50) of said inorganic particles as measured by laser obscuration time technology is 250 ?m or less.Type: GrantFiled: March 17, 2010Date of Patent: April 1, 2014Assignee: Incotec Europe B.V.Inventors: Henricus A. M. Reus, Jantien Glas
-
Patent number: 8685887Abstract: The present application relates to surfactant compositions comprising a) at least one phosphated arylphenol alkoxylate surfactant having an average degree of alkoxylation of from 4-8; and b) at least one alkylamine alkoxylate surfactant having an average degree of alkoxylation of from 2-12 and to the use of these compositions in pesticide formulations comprising solid or encapsulated pesticidally active ingredients or formulation aids and methods for improving the re-suspension properties of pesticide suspensions.Type: GrantFiled: March 23, 2009Date of Patent: April 1, 2014Assignee: Syngenta Crop Protection LLCInventors: Randall Charles Cush, Sarah Beth Cush, Michael James Hopkinson, Jason Keiper
-
Patent number: 8685888Abstract: In one embodiment, a remediation agent and method of remediation of an algae bloom are disclosed. The remediation agent contains light absorbing compounds in a buoyant water semi-insoluble and biodegradable casein product. The remediation agent may be distributed by boat or seeded by airplane to remediate or prevent algae blooms.Type: GrantFiled: January 17, 2012Date of Patent: April 1, 2014Inventor: John P. Fuhrer
-
Patent number: 8685889Abstract: The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe.Type: GrantFiled: April 18, 2012Date of Patent: April 1, 2014Assignee: Keygene N.V.Inventors: Michael Josephus Theresia van Eijk, Henricus Johannes Adam van der Poel
-
Patent number: 8685890Abstract: The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.Type: GrantFiled: February 4, 2010Date of Patent: April 1, 2014Assignee: Bicycle Therapeutics LimitedInventors: Gregory Paul Winter, Christian Heinis, Elise Bernard, David Loakes, John Tite, Marina Vaysburd, Daniel Paul Teufel, Lutz Riechmann
-
Patent number: 8685891Abstract: Methods and immunoassays for the determination of fatty acid synthase (FAS) expression in patients having or suspected of having a proliferative disorder, especially prostate cancer, are disclosed. The sensitive method and assay detect the level of expression of FAS in a biological sample using antibodies that are highly specific for FAS. The method and assay can be used to monitor the progression of cancer, and/or to predict the efficacy of certain treatments or the likelihood of recurrence of the cancer.Type: GrantFiled: August 26, 2010Date of Patent: April 1, 2014Assignee: Nuclea Biotechnologies, Inc.Inventor: Patrick J. Muraca
-
Patent number: 8685892Abstract: The present invention relates to methods, compositions and systems for detecting perchlorate in a sample. Compositions useful for detecting perchlorate in a sample include those comprising a perchlorate reductase, a reductant and an electron shuttle. In an exemplary embodiment, the composition comprises perchlorate reductase from Dechloromonas agitata, reduced nicotinamide adenine dinucleotide and N-methylphenazinium methylsulfate. The present invention also provides for methods of using the compositions disclosed herein, as well as systems thereof. In some exemplary embodiments, the methods comprise a concentration step, in which, for example, the sample is contacted with a cationic solid phase extraction column. Employing this step provides certain advantages such as a lowered detection limit and the removal of contaminants.Type: GrantFiled: September 1, 2009Date of Patent: April 1, 2014Assignee: The Regents of the University of CaliforniaInventors: John D. Coates, Mark L. Heinnickel
-
Patent number: 8685893Abstract: The transformation yield of electroporation is increased by using higher DNA concentrations and DNA affinity purification. Fusion proteins of a viral coat protein variant and a heterologous polypeptide are useful in phage display systems.Type: GrantFiled: July 28, 2008Date of Patent: April 1, 2014Assignee: Genentech, Inc.Inventors: Sachdev S. Sidhu, Gregory A. Weiss, James A. Wells
-
Patent number: 8685894Abstract: The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use.Type: GrantFiled: May 23, 2007Date of Patent: April 1, 2014Assignee: Arizona Board of Regents, A body Corporate of the State of Arizona Acting for and on behalf of Arizona State UniversityInventors: John Chaput, Stuart Lindsay, Hao Yan, Peiming Zhang
-
Patent number: 8685895Abstract: The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans.Type: GrantFiled: December 4, 2009Date of Patent: April 1, 2014Inventors: Carolyn Enever, Laurent Jespers, Malgorzata Pupecka, Ian M Tomlinson
-
Patent number: 8685896Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.Type: GrantFiled: May 29, 2010Date of Patent: April 1, 2014Assignee: MorphoSys AGInventors: Markus Enzelberger, Stefanie Urlnger, Thomas Tiller, Josef Prassler, Tanja Herrmann
-
Patent number: 8685897Abstract: This invention relates to methods for the generation of humanized antibodies, particularly a humanized antibody heavy chain protein and a humanized antibody light chain protein. The method comprises using cells that express or can be induced to express Activation Induced Cytidine Deaminase (AID).Type: GrantFiled: May 17, 2011Date of Patent: April 1, 2014Assignee: Anaptysbio, Inc.Inventors: Peter M. Bowers, Andrew B. Cubitt, Robert A. Horlick
-
Patent number: 8685898Abstract: Methods are provided for producing monoclonal antibody candidates using adaptive immunity profiling. In some aspects, the method provides for the use of massively parallel signature sequencing.Type: GrantFiled: January 15, 2010Date of Patent: April 1, 2014Assignee: Imdaptive, Inc.Inventor: Steven R. Wiley
-
Patent number: 8685899Abstract: Methods, reagents and kits are provided for the production and use in detection assays of labeled nucleic acid molecules wherein a labeling molecule is attached directly to the 3? end of the nucleic acid molecules.Type: GrantFiled: February 14, 2008Date of Patent: April 1, 2014Assignee: Genisphere Inc.Inventors: Robert C. Getts, James Kadushin, Jessica Bowers
-
Patent number: 8685900Abstract: Methods and fluids are provided that include, but are not limited to, a drilling fluid comprising an aqueous base fluid and a fluid loss control additive that comprises at least one polymeric micro gel and a method comprising: providing an aqueous based treatment fluid comprising a fluid loss control additive that comprises at least one polymeric micro gel; placing the aqueous based treatment fluid in a subterranean formation via a well bore penetrating the subterranean formation; allowing the fluid loss control additive to become incorporated into a filter cake located on a surface within the subterranean formation; allowing the filter cake to be degraded; and producing hydrocarbons from the formation. Additional methods are also provided.Type: GrantFiled: April 3, 2009Date of Patent: April 1, 2014Assignee: Halliburton Energy Services, Inc.Inventors: Ryan G. Ezell, Jun Jim Wu
-
Patent number: 8685901Abstract: A method of servicing a wellbore in contact with a subterranean formation, comprising placing into a wellbore a composition comprising a calcium aluminate cement and a polyvalent cation-containing compound, and allowing the composition to set. A method of increasing the thickening time of a calcium aluminate cement comprising contacting the calcium aluminate cement with a polyvalent cation-containing compound. A method of adjusting the thickening time of a calcium aluminate cement comprising contacting the calcium aluminate cement with a polyvalent cation-containing compound and at least one other set modifier.Type: GrantFiled: January 30, 2007Date of Patent: April 1, 2014Assignee: Halliburton Energy Services, Inc.Inventors: Ying Xu, B. R. Reddy, Rickey Morgan, Lance Brothers
-
Patent number: 8685902Abstract: The invention relates to the area of oil and gas production (especially, to the production in which the propping technique is used for the stimulation of a well) and can be used in the development of a composition and a method of production of propping agents (proppant), as well as a method of application of these propping agents. A new type of proppant, proppant production method and use of the proppant are based on allowing the production of proppant having an apparent density of 2.5 to 4.0 g/cm3, as well as a high mechanical strength and a high chemical durability. A proppant contains granules made of the sintered feedstock, wherein the charge mixture containing at least one of the following materials—silicon carbide, boron carbide, titanium carbide, silicon nitride, titanium nitride, boron nitride, silicon oxynitrides, SIALON-type compounds, was used as the feedstock.Type: GrantFiled: November 30, 2007Date of Patent: April 1, 2014Assignee: Schlumberger Technology CorporationInventors: Elena Mikhailovna Pershikova, Eamonn O'Neill
-
Patent number: 8685903Abstract: An embodiment includes a method of servicing a well bore. The method may comprise introducing a lost circulation composition into a lost circulation zone, the lost circulation composition comprising hydraulic cement, nano-particles, amorphous silica, clay, and water. The method further may comprise allowing the lost circulation composition to set in the lost circulation zone. Another embodiment includes a lost circulation composition. The lost circulation may comprise hydraulic cement, nano-particles, amorphous silica, clay, and water.Type: GrantFiled: March 21, 2011Date of Patent: April 1, 2014Assignee: Halliburton Energy Services, Inc.Inventors: Krishna Ravi, Rahul Chandrakant Patil, Sandip Prabhakar Patil, Sairam KS Pindiprolu, Craig W. Roddy, Jiten Chatterji, D. Chad Brenneis, Ricky Covington