Abstract: A medical device, system, and method are described for treating in utero a fetus with a lower urinary tract obstruction. An implantable medical device may have a flexible catheter and an anchor. The catheter may define a proximal port, a distal port, a longitudinal axis, and a lumen providing fluid communication between the ports. The anchor may be affixed to the catheter at a position between the ports, and may have a resilient proximal member and a resilient distal member spaced a longitudinal distance apart, the proximal member and distal member each extending radially outward with respect to the longitudinal axis. An elongate delivery member may be releasably affixed to the medical device, and the medical device may be delivered through a tubular sheath defining a sheath lumen.

Abstract: Methods and systems for determining patient specific treatment parameters for delivering vapor to the lung to treat lung tissue. In some embodiments vapor is delivered to the lung to cause coagulative necrosis, inducing fibrosis and thereby reducing the volume of at least one segment of the lung. The delivery parameters can be adjusted depending on the desired degree of injury to be induced in the lung tissue.

Abstract: In a gas supply system, a controller is electrically connected to a pressure regulator and an operation switch. The controller is operative to control the pressure regulator so that a predetermined gas is supplied to a first delivery member directing to a first body cavity with its pressure regulated to a first pressure suitable for the first body cavity. The controller is operative to control the pressure regulator depending on an instruction sent from the operation switch upon operation of the operator so that the predetermined gas is supplied to a second delivery member directing to a second body cavity with its pressure regulated to a second pressure suitable for the second body cavity.

Abstract: A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of a gas between an intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the at least one seal and caused to flow through a space on the blood-side face of the at least one seal. The system can further include a rotatable member. The space on the blood-side face of the at least one seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.

Abstract: Disclosed are systems, devices, and methods, including a system that includes a processor-based device implementing at least a residual insulin (RI) determination unit configured to determine a residual insulin in the patient's body at a particular time instance based on bolus doses previously delivered to the body of the patient, each bolus dose being associated with at least one dose value and a time representative of the time that dose value was delivered to the patient's body, and based on dose dependent RI time records that each includes at least a dose value and an associated duration value representative of dose-dependent duration of therapeutic effectiveness of the associated at least the dose value. The system also includes a pump to controllably dispense the insulin from a reservoir to the body of the patient based on the residual insulin determined by the RI determination unit.

Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.

Abstract: A manual breast pump, including a housing; a funnel connected to the housing and forming a passage for breast milk; a cup for receiving a breast; a lid connected to an upper portion of the housing; a handle assembly connected to the lid; a substantially semi-circular finger grip connected to the housing; a piston movably connected to the handle assembly and reciprocally movable within the housing to create a negative pressure for the expression of breast milk from the breast; a flexible insert sealably secured to the cup and forming an isolated air volume between the cup and the flexible insert. A valve is removably connected to a lower portion of the housing; and a receptacle for receiving the breast milk, the receptacle being removably attached to a lower portion of the housing. The isolated air volume expands and contracts as the piston moves reciprocally within the housing, causing the flexible insert to move.

Abstract: A breast milk pump having an electric motor, a pump driven by the motor, a suction cup, an electrically activated first three-way valve in a suction line, an electrically activated second three-way valve in a pressure line, an electronic control system, which sets the electric motor into an operating mode or an idle mode depending on an activation of a switch; in the operating mode, it operates the electric motor and the electrically activated first and second three-way valves in cycles, which comprise a suction phase, in which the electric motor is switched on, the inlet of the pump is connected to the suction cup via the first three-way valve and a floater valve, the pump outlet is connected via the second three-way valve.

Abstract: An expansion device includes an inflatable balloon moveable from an unexpanded configuration to an expanded configuration configured to pass through soft tissue between two adjacent teeth of a patient when in the unexpanded configuration. The an expansion device also includes an inflation tube having one end connected to the inflatable balloon and another end serving as an entry port for an inflation fluid. The inflatable balloon has a triangular shape when in the expanded configuration.

Abstract: An assembly of a pulmonary venting catheter and a pacing wire disposed therethrough whereby the pacing wire is extended from the distal end of the catheter tube during pacing mode, eliminating the need for exchanging the venting catheter with a pacing catheter to begin pacing after venting. The pacing wire includes a flexible distal end for a first conductor to conductively engage heart tissue after the pacing wire is extended from the catheter distal end; a second conductor, also exposed outside the catheter distal end, completes the circuit. The pacing wire is lockable in unextended and extended positions at the proximal end portion of the assembly. A method for venting and pacing a patient's heart during cardiac surgery is described, which includes retracting the catheter distal end from the pulmonary artery after venting mode, into the right ventricle during pacing mode, whereafter the pacing wire is extended for pacing.

Abstract: A non-compliant medical balloon, where the non-compliant medical balloon may be changed from a deflated state to an inflated state by increasing pressure within the balloon, is made with a first fiber layer, a second fiber layer over said first fiber layer such that the fibers of the first fiber layer and the fibers of the second fiber layer form an angle and a binding layer coating the first fiber layer and said second fiber layer. The interior surface area of the non-compliant medical balloon remains unchanged when the balloon changes from a deflated state to an inflated state.

Abstract: An injection aid is a tool used by being attached to an injection device having an injection needle and a syringe, and includes an aid main body and a tapered guide. The aid main body includes; an engagement part to be engaged with the syringe; a hollow part through which the injection needle penetrates; and a needle-protruding surface from which a needle tip part of the injection needle protrudes and which is brought into contact with skin when sticking the injection needle into a living body. The tapered guide is arranged in the hollow part of the aid main body and includes an inner surface that becomes continuously reduced in diameter toward the needle-protruding surface.

Abstract: Systems, methods and devices are described herein for adjusting the insertion depth of a cannula associated with a portable therapeutic device within the body of a patient. The systems may include a mounting unit securable to the skin of the patient and having a mounting base and a well defining a passageway through the mounting base and a cannula unit including a cannula subcutaneously insertable through the well of the mounting unit. The well may have an adjustable height and/or adjustable anchoring mechanisms that allow for varying and customized insertion depths of the cannula within the body of the patient.

Abstract: A dosing device having a pumping device delivering at least one medium into a pumping channel running along a pumping axis, as well as an applicator having at least one application opening is known. According to the invention, the applicator has at least one flow channel linking the pumping channel with the application opening and which is oriented transversely to the pumping axis, while the application opening is positioned laterally on the applicator. Use for pharmaceutical applications.

Abstract: An injection device comprising an outer housing adapted to receive a syringe for holding a volume of a medicament, said syringe comprising a barrel, a needle at one end of the barrel, and a plunger, axially moveable within the barrel, the needle and barrel being such that at least part of the needle is axially moveable in and out of said outer housing but is biased to be normally wholly inside said housing. The injection device further comprises an inner housing intermediate the outer housing and at least part of the barrel and/or plunger, an energy source in communication with the inner housing, and blocking means capable of preventing said inner housing moving axially under the influence of said energy source.

Abstract: An automatic injection apparatus including a delay mechanism for properly delivering medication prior to the needled syringe of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (170) for the syringe, a follower (250), a locking member, a damping compound between the follower and a supporting surface (308) to dampen rotation of the follower relative to the shuttle, and a dual functioning biasing member (290) acting between the shuttle and the follower. When the locking member moves to a release position during an injection, the dual functioning biasing member first provides a torsional force to force the follower to rotate relative to the shuttle from a latching position to an unlatching position, and then the dual functioning biasing member provides an axial force to force the shuttle axially relative to the follower to move the shuttle for retracting the syringe needle into the housing of the apparatus after injection.

Abstract: A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.

Abstract: Devices for the automatic release of liquid medicaments are disclosed. In particular, a flexible container for storing a liquid medicament, a port for such a flexible container, and a device for the automated release of a liquid medicament are disclosed. A flexible container for storing a medicament comprises sealed top and bottom flexible sheets and at least one port mounted to a wall of the flexible container. The at least one port comprises a flange attached to the wall and an inner conduit connecting the inner storage volume and the exterior of the flexible container. The port comprises an adapter protruding through a hole in the top flexible sheet and a base plate having at least one drain channel connected to the inner conduit via an inner opening on the base plate. A device for the automated release of a medicament comprises at least one flexible container.

Abstract: An improved system and method for placing implantable medical devices (IMDs) such as leads within the coronary sinus and branch veins is disclosed. In one embodiment, a slittable delivery sheath and a method of using the sheath are provided. The sheath includes a slittable hub, and a substantially straight body defining an inner lumen. The body comprises a shaft section and a distal section that is distal to, and softer than, the shaft section. A slittable braid extends adjacent to at least a portion of one of the shaft section and the distal section. In one embodiment of the invention, the sheath further includes a transition section that is distal to the shaft section, and proximal to the distal section. The transition section is softer than the shaft section, but stiffer than the distal section.

Abstract: A seal member for assembly within, or a seal zone portion of, a lumen of a medical instrument/device includes a slit segment and a bore, wherein the slit segment intersects with a funnel-like segment of the bore.

Abstract: An improved catheter is provided for insertion into a trachea, blood vessel, bladder or urinary tract of a patient. The self cleaning catheter can be easily inserted and removed from the patient without retained, solid components falling into a patient's trachea, blood vessels, bladder, or urinary tract when the catheter is removed from the patient. The self cleaning catheter has a flexible cylindrical sleeve on the exterior of a cylindrical member that can be withdrawn to the interior of the catheter prior to removal from the patient's body. Alternatively, the catheter has a design allowing an end of the catheter to fold inward on itself prior to removal from the patient's body.

Abstract: A catheter securement device 100 holds a medical article such as a catheter in position upon the body of a patient and at least inhibits longitudinal movement of the medical article. The securement device 100 includes a retainer 102 and a clamp 104. The retainer 102 and clamp 104 include interengaging structure. The interengaging structure may be a ratchet mechanism by which a medical provider tightens the clamp against the retainer. The ratchet mechanism allows a single securement system to be used with medical articles that have different longitudinal lengths as well as medical articles that have distally located contact surfaces. The retainer forms a channel 106 into which at least a portion of the medical article is inserted. Each of the retainer 102 and the clamp 104 include at least one abutment surface that can abut against a contact point or surface on the medical article.

Abstract: A securement device for securing a catheter to a patient comprises a pad having adhesive on at least a portion of the bottom surface. A fixed plate and a rotatabie adjustable plate are affixed to the pad. The adjustable plate is rotated with respect to the fixed plate to secure a catheter. Posts are on the fixed plate and the adjustable plate to secure a winged catheter. A bracket can be affixed to a fixed plate or an adjustable plate and a cooperating tab can be affixed to the other plate for securing a catheter there between. In a further modification, a base is secured to a pad and a pair of plates is pivotally mounted on the base for rotation with respect to one another. Complementary pawl and ratchet members enable limited rotation of plates with respect to one another and to fix plates in selected adjustment position.

Abstract: An injection device including a syringe having a needle, a barrel and a plunger. The device is configured to provide an automatic injection cycle and includes a drive coupling arrangement between a driving spring and the syringe. In operation, a drive force can be selectively transmitted between the respective first and second parts of the drive coupling arrangement depending upon their relative rotational positions such that, when the first and second parts are in a first relative rotational position during the dispensing stage, a driving force is transmitted to the plunger to drive the plunger into the barrel, and, when the first and second parts are in a second relative rotational position during the retraction stage, no force is transmitted to the plunger to allow the plunger and the syringe to retract.

Abstract: A lock for a dosing mechanism of an injection device, the lock including at least one holding element that interacts with the dosing mechanism, or with a dosing element of the dosing mechanism, whereby an adjustment movement of the dosing mechanism or the dosing element is prevented in a starting position of the lock and is possible only after a movement or displacement of the lock or the holding element. An injection device used in conjunction with a two-chamber ampoule is encompassed, as is a method for preparing the injection device for dispensing a substance wherein the ampoule is introduced into the injection device and a lock is released when the ampoule has been introduced far enough to appropriately mix the substances in the two chambers, whereupon the mixed substances can be dispensed from the ampoule.

Abstract: Lay flat tubing is used as a fluid conductor for transferring fluid to and from the body of a patient. The lay flat tubing lies flat or collapsed when not in use, utilizing minimal space during transportation and storage, but which expands to form a passage when used to conduct fluid. A plurality of lumens may be formed in the lay flat tubing. At least one lumen transports infused fluid end-to-end from a source to an entry site on a patient, or in the alternative from an entry site on or in a patient. All lumens are isolated with respect to each other in order to prevent crossover of fluid from one lumen to the other.

Abstract: Lay flat tubing is used as a fluid conductor for transferring fluid to and from the body of a patient. The lay flat tubing lies flat or collapsed when not in use, utilizing minimal space during transportation and storage, but which expands to form a passage when used to conduct fluid. A plurality of lumens may be formed in the lay flat tubing. At least one lumen transports infused fluid end-to-end from a source to an entry site on a patient, or in the alternative from an entry site on or in a patient. All lumens are isolated with respect to each other in order to prevent crossover of fluid from one lumen to the other.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: A nozzle for a nasal rinse device including a collar that forms a conduit. The collar is configured to attach the nozzle to the nasal rinse device. An outlet aperture defined by the collar is on a top portion of the nozzle. The nozzle also includes a skirt extending outwards and downwards from the collar, and an outer surface of the skirt is faceted.

Abstract: An eye drop bottle holder with resilient legs includes an inverted U-shaped member made from resilient injection molded plastic. The top portion of the inverted U-shaped member includes an eye drop bottle holder. The right and left leg of the U-shape each terminate in an outwardly disposed J-shape covered by a soft rubber-like pad. The user can attach an eye drop bottle to the inverted U-shaped member so that the dispensing tip of the bottle is in close proximity the user's eye. The user can cause his or her eye lid to remain open by squeezing the right and left legs together, then placing the pads on the upper and lower eye orbit, then releasing the legs causing the flesh of the user's eyelids to be spread apart. In a preferred embodiment, an electro-mechanical assembly can automatically press on the side wall of the bottle to cause a predetermined amount of solution to be dispensed. An LED light flashes (is either activated or deactivated) to show the user that a dispensing event has taken place.

Abstract: Provided is an apparatus that includes a scaffold with a gel or liquid composition deposed on at least a portion of a luminal surface, the gel or liquid composition adapted to include microbubbles. Also provided is a system that includes a source of reduced pressure, the above scaffold, a manifold adjacent the scaffold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above scaffold at the tissue site and disrupting a substantial portion of the microbubbles to induce fluid flow to the scaffold. Further provided is an apparatus that includes a scaffold that comprises a slowly degradable material and a quickly degradable material. Additionally provided is a system for coupling nerve tissue and a microchip assembly.

Abstract: Apparatus and a method for the provision of TNP therapy to a wound are described, the apparatus comprising: a sealing membrane (504) for covering a wound to form a wound cavity (500); one end of an aspirant conduit (522) operably associated with the wound cavity, vacuum means (524) provided at a distal end of the aspirant conduit for applying a vacuum to the wound cavity; and, air bleed means (510) in fluid communication with the wound cavity. Various embodiments of air bleed port members are also described.

Abstract: A multi-layer odor barrier catheter tube for a fecal drainage catheter. The external surface has a low coefficient of friction, as does the internal surface. The layers of the catheter tube may be co-extruded, or formed as a heat-laminated film rolled into a cylindrical shape and heat-welded. A flexible scrim may be included intermediate the first and third layers. One or more tie layers may be included between at least one of the first and second layers, or the second and third layers. A combination of a multi-layer odor barrier catheter tube with an odor barrier collection bag is also described.

Abstract: A stoma protection apparatus is disclosed, comprising a stoma collection bag having an elastomeric protector secured on its exterior surface directly opposite the opening in the interior surface of the bag for connection to the stoma. The structure and placement of the protector in relation to the opening prevent accidental closure of the bag opening to the stoma or compression of the bag when a user connects a belt to his or her waist area, so as to provide an adequate drainage area within the bag. Additionally, elastomeric protectors can be user affixed to a variety of available stoma bags for assured stoma pressure relief protection in an acceptably comfortable manner for the user.

Abstract: A packaged feminine care absorbent article has an absorbent article with an absorbent structure and a shell. The absorbent structure is configured for disposition adjacent a female wearer's vaginal region. The shell is configured for supporting the absorbent structure at the vaginal region. The shell has a body-facing surface and a garment-facing surface. The body-facing surface has an adhesive thereon for adhering the shell directly to the wearer. At least a portion of the shell extends outward beyond the periphery of the absorbent structure. The absorbent article is configurable between a packaged configuration and a use configuration. At least part of the outward extending portion of the shell is arranged in direct overlapping relationship with a portion of the absorbent structure in the packaged configuration. The outward extending portion of the shell is free from overlapping relationship with the absorbent structure in the use configuration.

Abstract: A pull-activated applicator includes a barrel, a pledget, a finger grip, and a deployment element. The pledget includes a withdrawal string and is located within the barrel. The barrel, the pledget, and the deployment element are configured such that application of a force to the deployment element in a first direction deploys the pledget and withdrawal string from the barrel in a second direction generally opposite the first direction.

Abstract: A feminine care absorbent article includes an absorbent structure and a shell for supporting the absorbent structure at a vaginal region of a wearer. The absorbent structure has a body-facing surface and a garment-facing surface. The shell has a body-facing surface and a garment-facing surface. The body-facing surface has an adhesive thereon for adhering the shell directly to the wearer. The article has a longitudinal axis, a transverse axis, an anterior region, a posterior region, and a central region extending longitudinally between and interconnecting the anterior and posterior regions. At least a portion of the absorbent structure is releasably attachable to the shell for configuring the absorbent structure between an operative configuration in which the releasably attachable portion of the absorbent structure is attached to the shell and an inoperative position in which at least part of the releasably attachable portion of the absorbent structure is detached from the shell.

Abstract: An absorbent article having a longitudinal direction, a transverse direction, a front portion, a rear portion, and a crotch portion located between the front portion and the rear portion. The article includes an absorption member having an upper side intended to face a wearer during use of the article and a lower side intended to face away from the wearer during use of the article, and a stiffening element that, at least during use of the article, provides the article with a predetermined shape that enhances the fit of the article to the wearer's body. The stiffening element is secured to the lower side of the absorption member such that an outer side of the stiffening element faces away from the absorption member. The stiffening element includes a material exhibiting mechanical fastening properties at least on a part of the outer side of the stiffening element.

Abstract: A simple disposable pant-like garment includes a chassis and an absorbent assembly. The chassis, which can be extensible, includes a water-impermeable sheet folded laterally inward at both of its side edges to form opposing side flaps. Each side flap is attached to the interior surface of the chassis adjacent to its end edges. Each side flap has a longitudinally extending elastic gathering member attached adjacent to its proximal edge. The absorbent assembly is smaller in width and in length than the chassis. The side edges and end edges of the absorbent assembly can be disposed proximally relative to the respective side edges and end edges of the chassis. The absorbent assembly includes an absorbent core that can contain superabsorbent particles contained inside pockets. The absorbent assembly may be attached in a cruciform pattern to the chassis to allow portions of the chassis to extend laterally.

Abstract: A pant-type wearing article configured so that fasteners used to connect front and rear waist regions with each other can be engaged with and disengaged from each other in a repetitive manner. Of the front and rear waist regions, at least one waist region, for example, the front waist region is formed in its transversely opposite lateral zones with inelastic regions being neither elastically stretchable nor elastically contractible in a waistline direction. These inelastic regions are provided with first fastener members selected from the first fastener members and second fastener members. The front waist region is further formed inside the respective inelastic regions as viewed in the waistline direction with a plurality of film-like joints defined by integrated sheet members forming the lateral zones.

Abstract: A cloth training diaper comprising an outer layer coupled to an inner layer, a front portion and a rear portion, a plurality of snaps arranged longitudinally along the right side of the front portion, the left side of the front portion, the right side of the rear portion, and the left side of the rear portion, the snaps extending through the outer and inner layers, and two side panels, each side panel comprised of a smocked material coupled to a non-smocked material, each side panel having a right side and a left side and a plurality of snaps arranged along the right and left sides of the smocked material. The snaps on the side panels engage with the snaps on the front and rear portions.

Abstract: A package assembly for a drug reconstitution assembly includes a body, a drug reconstitution assembly and a removable lid. The body includes a plurality of protrusions configured to mate with a plurality of corresponding features of the drug reconstitution assembly to inhibit axial and rotational translation of the drug reconstitution assembly and its constituent parts during shipping and handling. By preventing axial and rotational shifting during shipment, premature and accidental puncture or contamination of the medication or the spikes within the drug reconstitution assembly is minimized.

Abstract: The present invention features a method of treating pores on the skin by applying to skin in need of such treatment a device including a housing having a skin contacting surface, a first conductive electrode, a second conductive electrode, and a carrier; wherein the first conductive electrode is in electric communication with the second conductive electrode, wherein the first conductive electrode is in ionic communication with the carrier, wherein the carrier is in communication with the skin contacting surface, and wherein the skin contacting surface is placed in contact with the skin.

Abstract: Methods, system and devices for monitoring control parameters in a closed loop control operation including continuously monitoring glucose level and automatic administration of a medication, detecting a condition associated with hypoglycemia, determining whether a probability of the detected condition associated with hypoglycemia exceeding a threshold level, and outputting a notification based upon the determination are provided.

Abstract: Methods and apparatuses include applying a biting force to a bite-piece, the biting force is applied by a user's teeth, wherein the bite-piece is held inside of the user's mouth. Closing the mouth and the biting force suppress the user's gag reflex and the user's tonsils and adjacent Throat structures can be treated by spraying fluid onto the tonsil or manipulating the surface of the tonsil and related structures. The tonsils can be cleaned thereby.

Abstract: A catheter includes a proximal shaft, a distal shaft including a proximal end portion having an inner cavity into which a distal end portion of the proximal shaft is fitted, and a core wire extending through the inner cavity of the distal shaft. The core wire has a proximal end portion that is joined to a cutout portion formed in the distal end portion of the proximal shaft. Joining means are formed along a joint surface between the proximal end portion of the core wire and the cutout portion. When the joining means are divided into first joining means and second joining means along a longitudinal axis of the catheter, a length of one of the first joining means and the second joining means is larger than a length of the other of the first joining means and the second joining means.

Abstract: Methods and apparatuses are disclosed for applying negative pressure to a wound site. In some embodiments, the apparatus comprises a source of negative pressure, a processing element, and a memory comprising instructions configured to, when executed on the processing element, cause the apparatus to attempt to generate, via the source of negative pressure, a desired negative pressure at the wound site. If the desired negative pressure has not been generated after a first predetermined period of time, the instructions cause the apparatus to: deactivate the source of negative pressure for a second predetermined period of time, and subsequently attempt to generate the desired negative pressure at the wound site.

Abstract: A drainage catheter includes an elongated tubular member, a locking assembly engaged with a proximal end of the tubular member, and a tension member for drawing a distal end of the tubular member into a desired configuration. The locking assembly includes a connector, a locking arm, and a locking mechanism. The connector has an exterior surface profile that corresponds with an interior surface profile of the locking arm. The locking arm is pivotably attached to the connector to enable pivoting movement of the locking arm between an unlocked position and a locked position whereby the tension member is secured between the locking arm and the connector when the arm is in the locked position. The locking assembly may alternatively comprise a connector and a sliding sleeve or a connector having a clamping element disposed therein.

Abstract: A catheter comprising a tube part, a tip part and at least one through-going opening, where the through-going opening is positioned distally to the proximal end of the tube part, wherein the outer surface of the tube part has at its proximal end a first outer diameter that is smaller than a second outer diameter at the tube part's distal end, and the diameter of the outer surface of the tube part increases constantly along the entire length of the tube part from its proximal first outer diameter end to its distal second outer diameter.

Abstract: Methods of estimating human insulin absorption for use in an insulin pump are disclosed. A method includes prompting a user to select between a first insulin absorption model and a second insulin absorption model. The method also includes prompting a user to provide at least one model parameter. The method further includes forming an applied insulin absorption model from the selected insulin absorption model and the at least one model parameter.