Patents Issued in July 1, 2014
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Patent number: 8765873Abstract: The invention provides a compression blow formed article formed from a composition comprising at least the following: 1) a polypropylene homopolymer and 2) a propylene-based polymer.Type: GrantFiled: December 29, 2011Date of Patent: July 1, 2014Assignee: Braskem America, Inc.Inventors: Rennan A. Mendoza, Rodolfo Salmang, Roberto Rigobello
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Patent number: 8765874Abstract: Provided are ethylene-based polymer compositions, articles made therefrom, and methods of making the same. Ethylene-based polymer compositions include blends of a linear low density polyethylene prepared with metallocene catalyst and a low density polyethylene. The linear low density polyethylene may optionally have about five mole percent or less of monomer units derived from an alpha-olefin comonomer. Articles composed of such ethylene-based polymer compositions, such as blown films, exhibit favorable physical properties, including excellent optical properties and retained strength i.e., mitigation of expected decline in physical strength due to LDPE addition.Type: GrantFiled: January 28, 2008Date of Patent: July 1, 2014Assignee: ExxonMobil Chemical Patents Inc.Inventors: Alan M. Malakoff, Danny Van Hoyweghen, Hitesh A. Fruitwala
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Patent number: 8765875Abstract: Fluoroelastomer compositions comprising fluoroelastomers having copolymerized units of a nitrile-containing cure site monomer are cured with certain hydrazide curatives. The hydrazide is of the general formula R1C(O)NHNHR2, wherein R1 is alkyl, aryl, benzyl, heterocycle, fluoroalkyl, or H; R2 is H, alkyl, aryl, heterocycle, CO2R3, C(O)H, or CH2R4; R3 is alkyl, CH2R4, aryl, benzyl, or heterocycle; and R4 is a fluoroalkyl group.Type: GrantFiled: March 15, 2012Date of Patent: July 1, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Christopher J Bish, Peter A Morken
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Patent number: 8765876Abstract: Fluoroelastomer compositions comprising fluoroelastomers having copolymerized units of a nitrile-containing cure site monomer are cured with certain hydrazide curatives. The hydrazide is of the general formula R1(C(O))nNHNHR2, wherein n is 1 or 2; R1 is NH2, NHNH2, NHR3, NR32, NHNHC(O)NH2, NHNHC(O)NHNH2, NHNHR2, or NHC(O)NHNH2; R2 is H, alkyl, aryl, heterocycle, CO2R3, C(O)R3, CH2R4, or C(O)R4; R3 is alkyl, aryl, heterocycle, or CH2R4; and R4 is a fluoroalkyl group.Type: GrantFiled: March 15, 2012Date of Patent: July 1, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Christopher J Bish, Peter A Morken, Robert Clayton Wheland
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Patent number: 8765877Abstract: The invention generally relates to chain shuttling agents (CSAs), a process of preparing the CSAs, a composition comprising a CSA and a catalyst, a process of preparing the composition, a processes of preparing polyolefins, end functional polyolefins, and telechelic polyolefins with the composition, and the polyolefins, end functional polyolefins, and telechelic polyolefins prepared by the processes.Type: GrantFiled: November 2, 2012Date of Patent: July 1, 2014Assignee: Dow Global Technologies LLCInventors: Thomas P. Clark, Nahrain E. Kamber, Sara B. Klamo, Phillip D. Hustad, David R. Wilson
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Patent number: 8765878Abstract: Provided is a resin composition including a compound in which a vinyl group in a side chain of a phosphazene compound is bonded to an ? carbon in an aliphatic polyester resin.Type: GrantFiled: May 23, 2013Date of Patent: July 1, 2014Assignee: Fuji Xerox Co., Ltd.Inventor: Akira Imada
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Patent number: 8765879Abstract: To provide a modified recycled polyester resin that has stable moldability, is capable of producing as a by-product only a small amount of gel-like material during the process of modification to allow stable cross-linking reaction, and can prevent the possibility of recleavage, and to provide a molded article using the same. The modified recycled polyester resin contains a recycled PET resin having a carboxyl group, and a modifying agent having an epoxy group and an oxazoline group, ends of the carboxyl group of the recycled PET resin being modified with the modifying agent, wherein a mole ratio between the oxazoline group and the epoxy group is within a range of 100:90 to 100:0.01, and an additive amount of the modifying agent is 0.001 to 15 parts by mass with respect to 100 parts by mass of the recycled PET resin.Type: GrantFiled: October 13, 2010Date of Patent: July 1, 2014Assignees: Autonetworks Technologies, Ltd., Sumitomo Wiring Systems, Ltd., Sumitomo Electric Industries, Ltd., Kyushu UniversityInventors: Tatsuya Hase, Makoto Mizoguchi
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Patent number: 8765880Abstract: Disclosed are terminal-modified difunctional sulfur-containing polymers that are the reaction products of a sulfur-containing diol, an aldehyde or a ketone, and a compound containing a functional group. Compositions comprising the terminal-modified difunctional sulfur-containing polymers useful as sealants are also disclosed.Type: GrantFiled: December 19, 2013Date of Patent: July 1, 2014Assignee: PRC DeSoto International, Inc.Inventors: Stephen J. Hobbs, Gregory J. McCollum, Lawrence G. Anderson, Renhe Lin
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Patent number: 8765881Abstract: A method of preparing polydiorganosiloxane polyoxamide copolymers is described. These copolymers have at least one polydiorganosiloxane segment and at least two aminooxalylamino groups. The method can be used in the presence or absence of a solvent. Intermediates involved in the preparation of the copolymers are also described.Type: GrantFiled: December 22, 2010Date of Patent: July 1, 2014Assignee: 3M Innovative Properties CompanyInventors: David S. Hays, Richard G. Hansen
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Patent number: 8765882Abstract: New monomers, polymers, and blends of polymers with an electron acceptor are provided, e.g., for use in a photovoltaic device. The electron acceptor can be a fullerene derivative and the polymer can comprise monomer units according to the formula: wherein L? is L-C(O)O-J, L-C(O)NR?-J, L-OCO-J?, L-NR?CO-J?, L-SCO-J?, L-O-J, L-S-J, L-Se-J, L-NR?-J or L-CN; L is a linear or branched alkylene group having from 1 to 10 carbon atoms; J is a hydrogen atom or a linear or branched alkyl group having from 1 to 4 carbon atoms; J? is a group having from 1 to 10 carbon atoms, being saturated or unsaturated, linear or branched, optionally comprising a phenyl unit; and R? is a hydrogen atom or a linear or branched alkyl group having from 1 to 4 carbon atoms.Type: GrantFiled: June 8, 2012Date of Patent: July 1, 2014Assignees: IMEC, Universiteit HasseltInventors: Laurence Lutsen, Dirk Vanderzande, Bert Campo
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Patent number: 8765883Abstract: Disclosed are water soluble polymeric conjugates comprising the structure POLY-[Y—S—S-A]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 2, S—S is a disulfide group attached to an sp3 hybridized carbon of Y; and A is a covalently linked residue of a pharmacologically active molecule. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are polymeric reagents useful to prepare such conjugates, and methods of their formation and use.Type: GrantFiled: June 19, 2013Date of Patent: July 1, 2014Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Samuel P. McManus
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Patent number: 8765884Abstract: A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.Type: GrantFiled: September 20, 2013Date of Patent: July 1, 2014Assignee: Chevron Phillips Chemical Company LPInventors: Robert R. McElvain, John D. Hottovy, Ralph W. Romig, Donald W. Verser, David H. Burns, John H. Tait, Richard Peacock, James E. Hein, Scott E. Kufeld, Carl W. Fenderson, Anurag Gupta, Dale A. Zellers
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Patent number: 8765885Abstract: Apparatus and process for gas phase polymerisation of olefins. The apparatus includes (a) a reaction zone having a grid at its base, (b) an inlet located in the lower half of the reaction zone for introducing a reaction gas to the reaction zone, (c) an outlet located in the upper half of the reaction zone for removing the reaction gas from the reaction zone, and (d) a solids separation unit having an inlet fluidly connected to the outlet for removing the reaction gas from the reaction zone. The inlet of the solids separation unit is located at a vertical height lower than the outlet for removal of reaction gas from the reaction zone and such that the angle to the horizontal of a straight line drawn between the inlet of the solids separation unit and the outlet for removal of reaction gas from the reaction zone is greater than 20°.Type: GrantFiled: November 29, 2011Date of Patent: July 1, 2014Assignee: Ineos Sales (UK) LimitedInventors: Andrew David Bell, Kevin Peter Ramsay
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Patent number: 8765886Abstract: The invention generally relates to chain shuttling agents (CSAs), a process of preparing the CSAs, a composition comprising a CSA and a catalyst, a process of preparing the composition, a processes of preparing polyolefins, end functional polyolefins, and telechelic polyolefins with the composition, and the polyolefins, end functional polyolefins, and telechelic polyolefins prepared by the processes.Type: GrantFiled: November 2, 2012Date of Patent: July 1, 2014Assignee: Dow Global Technologies LLCInventors: Thomas P. Clark, Nahrain E. Kamber, Sara B. Klamo, Phillip D. Hustad, David R. Wilson
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Patent number: 8765887Abstract: A process for preparing a polydiene, the process comprising the step of polymerizing conjugated diene monomer with a lanthanide-based catalyst system in the presence of a vinylsilane, an allylsilane, or an allylvinylsilane.Type: GrantFiled: August 24, 2010Date of Patent: July 1, 2014Assignee: Bridgestone CorporationInventor: Steven Luo
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Patent number: 8765888Abstract: Vulcanizates with desirable properties can be obtained from compounds incorporating polymers that include hydroxyl group-containing diphenylethylene-type functionalities. The functionalities can be incorporated by using any or all of appropriate initiators, monomers and optional terminating compounds. Such polymers exhibit excellent interactivity with both conventional and non-conventional fillers.Type: GrantFiled: June 30, 2010Date of Patent: July 1, 2014Assignee: Bridgestone CorporationInventors: Zengquan Qin, Yuan-Yong Yan, Xiao-Dong Pan
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Patent number: 8765889Abstract: The invention relates to a method for producing hybrid-particles containing polymer and SiO2-particles, wherein a) in a first polymerization step in aqueous medium a water-insoluble phase containing one or more monomeric and colloidal SiO2-particles having an average particle diameter of 1 to 150 nm are polymerized, and b) in a second polymerization step in aqueous medium one or more monomers are polymerized in the presence of the polymer obtained in the first polymerization step.Type: GrantFiled: October 18, 2010Date of Patent: July 1, 2014Assignee: Evonik Nanoresins GmbHInventors: Werner Siol, Klaus Langerbeins, Uwe Dietrich Kühner
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Patent number: 8765890Abstract: A novel aqueous polymerization process for making fluoropolymer dispersions is disclosed in which non-ionic non-fluorinated emulsifier is used to produce fluoropolymer emulsions. The emulsifiers contain blocks of polyethylene glycol, polypropylene glycol and/or polytetramethylene glycol. The process and fluoropolymer produced contain no fluorinated surfactant. The fluoropolymers have excellent resistance to discoloration.Type: GrantFiled: November 16, 2011Date of Patent: July 1, 2014Assignee: Arkema Inc.Inventors: Ramin Amin-Sanayei, Mehdi Durali, Patrick Kappler, Greylan Burch
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Patent number: 8765891Abstract: It is an object of the present invention to provide a laminate having excellent weatherability and abrasion resistance as well as adhesion. The present invention relates to a laminate comprising a base, a first layer formed by thermally curing an acrylic resin composition and a second layer formed by thermally curing an organosiloxane resin composition, all of which are formed in the mentioned order, wherein the acrylic resin composition comprises: (A) an acrylic copolymer which contains at least 70 mol % of a recurring unit represented by the following formula (A): wherein X is a hydrogen atom or methyl group, and Y is a methyl group, ethyl group, cycloalkyl group, hydroxyalkyl group having 2 to 5 carbon atoms or triazine-based ultraviolet absorber residue; (B) a blocked polyisocyanate compound; (C) a curing catalyst; and (D) a triazine-based ultraviolet absorber, and the organosiloxane resin composition comprises: (E) colloidal silica and (F) a hydrolysis condensate of an alkoxysilane.Type: GrantFiled: February 8, 2013Date of Patent: July 1, 2014Assignee: Teijin Chemicals, Ltd.Inventors: Toshio Kita, Shunsuke Kajiwara, Ryou Niimi, Takehiro Suga, Tatsuya Ekinaka, Nobuaki Takaoka
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Patent number: 8765892Abstract: The present invention relates to a conjugated diene polymer that can give a polymer composition having excellent fuel economy, a polymer composition formed by combining the conjugated diene polymer and a filler such as silica, and a method for producing the conjugated diene polymer.Type: GrantFiled: August 21, 2009Date of Patent: July 1, 2014Assignee: Sumitomo Chemical Company, LimitedInventor: Mayumi Oshima
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Patent number: 8765893Abstract: Embodiments of the present disclosure encompass vinyl addition and ROMP polymers having at least one type of repeating unit that encompasses a comprise N+(CH3)3OH? moiety. Other embodiments in accordance with the disclosure include alkali anion-exchange membranes (AAEMs) made from one of such polymers, anion fuel cells (AFCs) that encompass such AAEMs and components of such AFCs, other than the AAEM, that encompass one of such polymers.Type: GrantFiled: December 13, 2010Date of Patent: July 1, 2014Assignee: Promerus, LLCInventors: Andrew Bell, Edmund Elce, Keitaro Seto
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Patent number: 8765894Abstract: Embodiments of the present disclosure encompass vinyl addition and ROMP polymers having at least one type of repeating unit that encompasses a comprise N+(CH3)3OH? moiety. Other embodiments in accordance with the disclosure include alkali anion-exchange membranes (AAEMs) made from one of such polymers, anion fuel cells (AFCs) that encompass such AAEMs and components of such AFCs, other than the AAEM, that encompass one of such polymers.Type: GrantFiled: June 10, 2011Date of Patent: July 1, 2014Assignee: Promerus, LLCInventors: Andrew Bell, Edmund Elce, Keitaro Seto
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Patent number: 8765895Abstract: The invention relates to a polymer composition that includes a branched alkene which is cationically polymerizable as well as a glass-forming comonomer and/or a vinyl comonomer containing benzocyclobutene as the pendant group. The structure of the polymer composition can take various forms: linear random copolymer, linear block copolymer, star random copolymer, star block copolymer, and other hyperbranched polymers. The copolymer composition can undergoes crosslinking at elevated temperatures (preferably above 180° C.).Type: GrantFiled: June 25, 2008Date of Patent: July 1, 2014Assignee: Innolene LLCInventors: Yonghua Zhou, Leonard Pinchuk
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Patent number: 8765896Abstract: The present invention relates to an acrylic copolymer having high heat resistance and high strength, and an optical film comprising the same, and more particularly, to an acrylic copolymer for optical films in which alkyl (meth)acrylate monomers; (meth)acrylate monomers comprising aromatic rings and/or aliphatic rings; and (meth)acrylamide monomers are included and polymerized. An acrylic copolymer according to the present invention is excellent in heat resistance while maintaining transparency. Further, an optical film comprising a compound resin including the acrylic copolymer has superior transparency and heat resistance and is excellent in formability, adhesion, retardation properties, and durability.Type: GrantFiled: June 8, 2011Date of Patent: July 1, 2014Assignee: LG Chem, Ltd.Inventors: Su-Kyung Kim, Da-Eun Sung, Chang-Hun Han, Byung-Il Kang, Jae-Bum Seo, Eun-Jung Choi, Byoung-Kue Chun, Yu-Taek Sung
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Patent number: 8765897Abstract: The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerization from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.Type: GrantFiled: November 17, 2010Date of Patent: July 1, 2014Assignee: Merck Patent GmbHInventors: Matthias Joehnck, Eckhard Sabrowskii
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Patent number: 8765898Abstract: The invention relates to a process for producing water-absorbing polymer particles, comprising handling water-absorbing polymer particles in intermediate silos, storage silos and/or big bag filing stations that are connected with vent lines having a mitered joint.Type: GrantFiled: August 23, 2013Date of Patent: July 1, 2014Assignee: BASF SEInventors: Monte Peterson, Ronny De Kaey, Leo Van Miert, Oskar Stephan, Rüdiger Funk, Matthias Weismantel, Dominicus van Esbroeck, Frans van Dyck
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Patent number: 8765899Abstract: A silicon polymer material, which has a silicon polymer backbone with chromophore groups attached directly to at least a part of the silicon atoms, the polymer further exhibiting carbosilane bonds. The film forming composition and resulting coating properties can be tailored to suit the specific exposure wavelength and device fabrication and design requirements. By using two different chromophores the refractive index and the absorption co-efficient can be efficiently tuned. By varying the proportion of carbosilane bonds, and a desired Si-content of the anti-reflective coating composition can be obtained.Type: GrantFiled: November 6, 2008Date of Patent: July 1, 2014Assignee: Braggone OyInventor: Ari Kärkkäinen
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Patent number: 8765900Abstract: The present disclosure is directed to an aliphatic isocyanate-based moisture-curable resin. The disclosed resin may include an aliphatic isocyanate functional material and an cycloaliphatic isocyanate functional material. The resin may be used to formulate a coating composition that may exhibit no substantial sag when applied at a wet film thickness of at least 6 mils, and no substantial blistering when cured to a dry film thickness of at least 6 mils.Type: GrantFiled: August 27, 2009Date of Patent: July 1, 2014Assignee: Bayer MaterialScience LLCInventors: Kurt E. Best, Michael K. Jeffries, Ahren Olson, Carl Angeloff
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Patent number: 8765901Abstract: A spandex comprising a polyurethane or polyurethaneurea reaction product of at least one diisocyanate compound and a poly(tetramethylene-co-ethyleneether) glycol comprising constituent units derived by copolymerizing tetrahydrofuran and ethylene oxide wherein the percentage of ethylene ether moieties is from about 16 to about 70 mole percent with at least one chain extender selected from the group consisting of diamines and diols and at least one chain terminator wherein the spandex is spun at a speed in excess of about 750 meters per minute.Type: GrantFiled: May 8, 2006Date of Patent: July 1, 2014Assignee: Invista North America S.ár.l.Inventors: Charles F. Palmer, Jr., Gary A. Lodoen
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Patent number: 8765902Abstract: In a process for preparing a polyamide based on dicarboxylic acids and diamines in an extruder, a solid mixture comprising a monomer mixture composed of 50 mol % of dicarboxylic acid mixture composed of from 60 to 88 % by weight of terephthalic acid and from 12 to 40% by weight of isophthalic acid, in which up to 20% by weight of the dicarboxylic acid mixture may also be replaced by other dicarboxylic acids, and 50 mol % of hexamethylenediamine which may be up to 20% by weight replaced by other C2-30-diamines, in a corotatory twin-screw extruder for a residence time of from 10 seconds to 30 minutes, is heated to a temperature in the range from 150 to 400° C. while removing steam and if appropriate diamines through venting orifices.Type: GrantFiled: June 11, 2008Date of Patent: July 1, 2014Assignee: BASF SEInventors: Philippe Desbois, Michael Kopietz, Ralf Neuhaus, Hagen Stawitzki, Hans-Joachim Weis, Jochen Engelmann
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Patent number: 8765903Abstract: A carbazole polymer containing a repeating unit represented by a chemical structure 1: where R represents an aliphatic or alicyclic bifunctional group, Ar represents an aromatic hydrocarbon or heterocyclic ring bifunctional group, and Ar1 represents an aromatic hydrocarbon or heterocyclic ring monofunctional group.Type: GrantFiled: September 7, 2011Date of Patent: July 1, 2014Assignee: Ricoh Company, Ltd.Inventors: Masaomi Sasaki, Shigeyuki Harada, Takashi Okada, Toshiya Sagisaka
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Patent number: 8765904Abstract: Embodiments of the present disclosure include polyetheramines, methods of making polyetheramine, methods of using polyetheramine, and the like.Type: GrantFiled: September 12, 2011Date of Patent: July 1, 2014Assignee: INVISTA North America S.à r.l.Inventor: Ronald L. Amey
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Patent number: 8765905Abstract: The present invention relates to a novel proton-conducting polymer membrane based on polyazoles which can, owing to its excellent chemical and thermal properties, be used for a variety of purposes and is particularly suitable as a polymer-electrolyte membrane (PEM) for the production of membrane electrode units for so-called PEM fuel cells.Type: GrantFiled: December 30, 2004Date of Patent: July 1, 2014Assignee: BASF Fuel Cell GmbHInventors: Oemer Uensal, Ursula Leister, Melanie Schlegel
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Patent number: 8765906Abstract: A water absorbent resin having less fine powder or powdery dust and a controlled particle size is provided, and the water absorption rate of the water absorbent resin is increased by a simple method at low cost, while maintaining or improving other physical properties such as liquid permeability.Type: GrantFiled: April 27, 2011Date of Patent: July 1, 2014Assignee: Nippon Shokubai, Co., Ltd.Inventors: Yusuke Watanabe, Kazushi Torii, Kozo Nogi, Kunihiko Ishizaki, Reiko Nakatsuru, Shigeru Sakamoto
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Patent number: 8765907Abstract: The invention relates to a compound of the general structure (I), where R is a hydrogen atom (II) or an unsubstituted, monosubstituted or polysubstituted C1-C20-alkyl, wherein the alkyl is straight, branched, cyclic and/or partially unsaturated, or an unsubstituted, monosubstituted or polysubstituted phenyl group.Type: GrantFiled: April 30, 2010Date of Patent: July 1, 2014Assignee: Geomar Helmholtz-Zentrum fur Ozeanforschung KielInventors: Johannes Imhoff, Inga Knopf-Kajahn, Gerhard Lang, Jutta Wiese, Arne Peters
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Patent number: 8765908Abstract: The present invention provides a therapeutic composition, and method of use thereof, for improving bone mass, rigidity, or strength, or preventing and treating bone loss via modulation of the RANK signaling pathway. The therapeutic composition of the present invention comprises a RYBP peptide, or fragments thereof, that specifically interact with a motif of RANK to regulate osteoclastogenesis. The present invention further provides a composition, and method of use thereof, comprising a modulator that is capable of modulating the RYBP-RANK interaction, or modulating an effector in the RANK signaling pathway through the RYBP-RANK interaction.Type: GrantFiled: August 10, 2012Date of Patent: July 1, 2014Assignee: The UAB Research FoundationInventors: Xu Feng, Shunqing Wang
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Patent number: 8765909Abstract: The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.). By substituting the constituent amino acids of metastin with specific amino acids, the metastin derivatives of the present invention achieve more improved blood stability, solubility, etc., reduced gelation tendency, improved pharmacokinetics, as well as exhibit an excellent cancer metastasis suppressing activity or a cancer growth suppressing activity. The metastin derivatives of the present invention also have a gonadotropic hormone secretion suppressing activity, sex hormone secretion suppressing activity, etc.Type: GrantFiled: October 24, 2007Date of Patent: July 1, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Taiji Asami, Naoki Nishizawa
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Patent number: 8765910Abstract: The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.Type: GrantFiled: September 13, 2006Date of Patent: July 1, 2014Assignee: Sanofi-Aventis Deutschland GmbHInventors: Sebastian Rissom, Paul Habermann, Christophe Salagnad, Frank Zocher, Laure Landric-Burtin
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Patent number: 8765911Abstract: Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.Type: GrantFiled: December 3, 2012Date of Patent: July 1, 2014Assignee: Momenta Pharmaceuticals, Inc.Inventors: Cuihua Liu, Shiming Dong, Xiao-Jin Xu, Jonathan C. Lansing, Yanjie Jiang
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Patent number: 8765912Abstract: The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the polypeptides. The present invention also relates to methods for screening for compounds that modify the genes' function or activity, the compounds identified by such screens, and mimetics of the identified compounds. The invention further provides methods for modifying the taste preferences, ingestive responses, or general behavior of a mammal such as a dog by administering compounds that affect the function or activity of the gene or the polypeptide encoded thereby.Type: GrantFiled: March 28, 2012Date of Patent: July 1, 2014Assignee: Monell Chemical Senses CenterInventors: Xia Li, Weihua Li, Joseph G. Brand
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Patent number: 8765913Abstract: The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells. The present invention still further provides a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor and said soluble receptor is capable of inhibiting tumor growth. The present invention still further provides a method of treating cancer comprising administering a soluble FZD receptor comprising for example, either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth.Type: GrantFiled: November 2, 2012Date of Patent: July 1, 2014Assignee: OncoMed Pharmaceuticals, Inc.Inventors: Austin L. Gurney, John Lewicki, Sanjeev Satyal, Timothy Hoey
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Patent number: 8765914Abstract: Purified genes encoding a cytokine referred to as interleukin-B30 (IL-B30) from a mammal, and reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.Type: GrantFiled: July 22, 2013Date of Patent: July 1, 2014Assignee: Merck Sharp & Dohme Corp.Inventor: J. Fernando Bazan
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Patent number: 8765915Abstract: The present invention relates to the fields of Factor VII (FVII) and Factor VIIa (FVIIa) albumin linked polypeptides. More specifically, the invention relates to cDNA sequences coding for human Factor VII and Factor VIIa and derivatives genetically fused to a cDNA coding for human serum albumin which may be linked by oligonucleotides which code for intervening peptidic linkers such encoded derivatives exhibiting improved stability and extended functional plasma half-life, recombinant expression vectors containing such cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and prolonged shelf-life and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences.Type: GrantFiled: February 3, 2007Date of Patent: July 1, 2014Assignee: CSL Behring GmbHInventors: Thomas Weimer, Stefan Schulte, Ulrich Kronthaler, Wiegand Lang, Uwe Liebing, Wilfried Wormsbächer
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Patent number: 8765916Abstract: Monoclonal antibodies, or antigen-binding fragments thereof, that bind to ERG, and more specifically, to an epitope formed by amino acids 42-66 of ERG3 are disclosed. The monoclonal antibodies can be non-human antibodies (e.g., rabbit or mouse) or humanized monoclonal antibodies having the CDR regions derived from those non-human antibodies. In other embodiments, the monoclonal antibodies are chimeric, having the light and heavy chain variable regions of a non-human ERG antibody. Methods of using the antibodies to detect ERG, or fusion proteins comprising all or part of an ERG polypeptide, such as an ERG polypeptide encoded by a TMPRSS2/ERG, SLC45A3/ERG, or NDRG1/ERG fusion transcript, are also provided, including methods of detecting ERG or ERG fusion events in a clinical setting.Type: GrantFiled: April 28, 2010Date of Patent: July 1, 2014Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Shiv Srivastava, Shyh-Han Tan, Albert Dobi
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Patent number: 8765917Abstract: Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to CD37 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.Type: GrantFiled: March 11, 2011Date of Patent: July 1, 2014Assignee: ImmunoGen, Inc.Inventors: Jutta Deckert, Peter Park, Daniel Tavares, Lingyun Rui
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Patent number: 8765918Abstract: Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.Type: GrantFiled: March 23, 2012Date of Patent: July 1, 2014Assignee: Abbott GmbH & Co., KGInventors: Jochen G. Salfeld, Michael Roguska, Michael Paskind, Subhashis Banerjee, Daniel Edward Tracey, Michael White, Zehra Kaymakcalan, Boris Labkovsky, Paul Sakorafas, Geertruida M. Veldman, Amy Venturini, Angela Widom, Stuart Friedrich, Nicholas W. Warne, Angela Myles, John Gawain Elvin, Alexander Robert Duncan, Elaine Joy Derbyshire, Sara Carmen, Stephen Smith, Thor Las Holtet, Sarah Leila Du Fou
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Patent number: 8765919Abstract: The invention provides compositions and methods for detecting and/or modulating TOX3 gene expression and/or biological activity. Such compositions and methods find utility in the detection and/or treatment of certain subsets of cancers, e.g. breast cancer. In particular, the inventive compositions and methods are drawn to production and use of anti-TOX3 antibodies and TOX3 nucleic acids for both detection and modulation of TOX3. The invention also provides for pharmaceutical compositions and methods for the modulation of TOX3 in a subject in need thereof. Further aspects of the invention relate to transgenic mice that either over-express or inducibly express TOX3.Type: GrantFiled: June 4, 2012Date of Patent: July 1, 2014Assignee: Cedars-Sinai Medical CenterInventor: Jonathan Kaye
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Patent number: 8765920Abstract: A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.Type: GrantFiled: December 23, 2010Date of Patent: July 1, 2014Assignee: The Scripps Research InstituteInventors: Carlos F. Barbas, III, Hitoshi Ban, Julia Gavrilyuk
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Patent number: 8765921Abstract: There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).Type: GrantFiled: August 22, 2013Date of Patent: July 1, 2014Assignees: JNC Corporation, Tokyo Institute of TechnologyInventors: Satoshi Inouye, Yuiko Sahara, Rie Iimori, Takamitsu Hosoya
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Patent number: 8765922Abstract: A method and associated device for enrichment of Neél-magnetic particles from a dispersion of Brown-magnetic particles and Neél-magnetic particles. The device and method use ferromagnetic separation particles having a mean diameter of 100 to 250 ?m located in a alternating magnetic field. The ferromagnetic separation particles have a magnetically and chemically inert coating.Type: GrantFiled: October 19, 2011Date of Patent: July 1, 2014Assignee: Miltenyi Biotec GmbHInventors: Jürgen Schulz, Daniel Michalek, Dirk Merkel, Stefan Miltenyi