Abstract: In some examples, a processor is configured determine whether efficacy of therapy delivered by a medical device to the patient may have changed and generate a notification based on the determination. For example, a processor may be configured to determine whether a bioelectrical brain signal indicative of activity of a brain of a patient includes a biomarker that indicates efficacy of therapy delivered by a medical device to the patient may have changed, and generate notification based on determining the bioelectrical brain signal includes the biomarker. In some examples, the processor modifies the therapy delivered to the patient prior to generating the notification.

Abstract: Embodiments of the present invention are directed to a temperature sensing device that can comprise an elastic ring structure. The temperature sensing device can further comprise a transducer device, such as a temperature sensor, and a microprocessor, memory and wireless transmitter. Such an arrangement can incorporate a passive (battery free), battery assisted or active battery powered transponder circuit with temperature measurement capability. The elastic ring, structure can be forced in a spring loaded state when elastically deformed thus becoming retained when disposed in a vaginal vault. In one embodiment, an active RF receiver or an RFID reader is brought in proximity to the temperature sensing and transmitting device arrangement, such as near a woman's pelvis from the outside to read the temperature and record it in a Central Processing Unit, CPU, associated with the receiver or RFID reader, such as a portable, handheld computer or wireless device.

Abstract: In a first embodiment, a portable, battery-operated, minimally invasive small fiber neuropathy testing and diagnostic device, microcontrolled and interfacing with wireless powering to a wireless communications device is being disclosed. Said device is constructed out of an intra-epidermal thermal stimulus consisting of an electronically heated temperature-controlled polymer covered semiconductor material 101 lowered inside the skin through a probe 108 configured with three miniaturized electrodes 109 while a nerve impulse response measurement system records and identifies nerve action potential pulses through a proprietary algorithm. The invention also discloses a detection and characterization method of action potential pulses from neuron cells with respect to their timing such as pulse repetition statistics and rates from a single-point of measurement as diagnostically relevant for determining neuropathies.

Abstract: A sleeve is provided for determining the location and severity of joint pain in a patient. The sleeve includes sensors in communication with a display device that allow for areas of pain to be quickly and accurately determined. Methods of utilizing the sleeve are also disclosed.

Abstract: Method, system and device for assisting diagnosis of autism which enable assistance of early detection and early definite diagnosis of autism (especially in infants) based on objective evaluation, using a conventionally suggested “eye-gaze detection technique”. The method for assisting diagnosis of autism of a subject uses an eye-gaze detecting unit, the unit having at least an imaging camera portion. The method includes displaying, at the position in front of the subject along the direction of the eye gaze of the subject, an illusionary image contained in a plane of an illusion-causing image on a displaying device. The eye-gaze position information of the subject looking at the plane is detected, and the eye-gaze position information of the subject is input into an eye-gaze position information storage portion The eye-gaze positions of the subject can be evaluated using a algorithm for assisting diagnosis of autism.

Abstract: The current invention presents a tissue sampling apparatus and methods to reliably obtain solid and liquid bone marrow samples in sequence in a single insertion of the apparatus to a target area. The apparatus comprises a proximal handle assembly, a distal cutting assembly and a shaft assembly connecting both assemblies. The handle assembly comprises an upper handle connected to an inner cutting tube and a lower handle connected to an outer cannula. The lower handle transmits axial rotation of the upper handle to longitudinal movement of the inner cutting tube. Axial rotation of an engaged upper handle longitudinally pulls out from the outer cannula the inner cutting tube that spirally holds fast a solid marrow sample inside a distal end of said inner cutting tube. Following acquisition of the solid marrow sample, a liquid marrow sample is aspirated through the outer cannula.

Abstract: A biopsy device includes coaxially disposed inner and outer needles in which the outer needle tip is configured for obtaining a tissue sample. The inner surface of the outer needle includes a tissue retention feature which may include a countersink and/or a feature formed in the inner surface. The device may be introduced to a biopsy site through an introducer in which the introducer is vented and/or a certain ratio of introducer inner diameter and biopsy device outer diameter is maintained. The full core devices also permit a tighter tolerance between the I.D. and O.D. of the outer cannula and stylet, respectively, which further permits the use of a smaller gage introducer. Full devices also include a sample trap assembly operable to enlarge the sample cavity after the full core sample has been obtained.

Abstract: The invention concerns a device for the laparoscopic removal of a superficial cylindrical sample of a human or animal body tissue, comprising:—a tube (1) whose inner diameter determines the diameter of the sample to be removed, and having a cutting edge (12) at its distal end (10),—a grip handle (2), fixed to the tube (1) in the region of a proximal end (11) of said tube(1),—a knife (3) arranged inside the tube (1) and having a cutting edge (31),—a device to actuate the knife (3), comprising an actuating element (22, 41) connected to the grip handle (2) in such a way as to give the knife (3) a helical movement in the direction of a distal end of the tube (1), followed by a rotational movement to detach the sample from the tissue.

Abstract: A specimen collection container having a separation chamber includes a first chamber, a second chamber, and a valve located between the first chamber and the second chamber. In an open position, the valve permits fluid communication between the first chamber and the second chamber. In a closed position, the valve maintains fluid isolation between the first chamber and the second chamber. A fluid stream passes from the first chamber to the second chamber through the valve permitting a predetermined volume of fluid to pass from the first chamber to the second chamber. When the predetermined volume of fluid passes to the second chamber, the valve transitions from the open position to the closed position so that additional fluid of the fluid stream received by the first chamber is maintained in the first chamber in fluid isolation from the predetermined volume of fluid contained in the second chamber.

Abstract: A biological testing device includes a housing body having a meter storage compartment, and a testing meter that is disposed in the meter storage compartment and that operates with a biosensor strip which is disposed after being used. The housing body further has a waste storage compartment that is separated from the meter storage compartment and that has s a waste take-out opening, and an insertion hole for inserting the used biosensor strip into the waste storage compartment. The waste take-out opening is larger than the insertion hole. The waste take-out opening is normally closed and is openable for permitting taking out of the used biosensor strip from the waste storage compartment.

Abstract: Devices, systems, and methods for tissue measurement are provided. In general, the devices, systems, and methods can allow a size of a target tissue, e.g., a wound, of a patient to be determined by tracing a perimeter of the target tissue using a handheld device. Examples of the size of the target tissue include a length of a perimeter of the target tissue, a surface area of the target tissue, a depth of the target tissue, and a volume of the target tissue.

Abstract: Systems and methods detect respiration of a subject, process respiration data, and based on the processed respiration data, perform extended monitoring. A monitoring system is configured with sensors that can be worn by the subject to provide the respiration data. The respiration data is processes to create a stability index. The stability index is used to, for example, determine sleep stages.

Abstract: The methods and systems described herein may involve determining at least one lifeotype of at least one individual, analyzing the at least one lifeotype, and delivering content to at least one individual based on the analysis. The methods and systems described herein may involve providing a game, determining at least one lifeotype of at least one player of the game, analyzing the at least one lifeotype, and affecting the game play based on the analysis. The methods and systems described herein may involve providing an interactive space, determining at least one lifeotype of at least one individual in the space, analyzing the at least one lifeotype, and modifying at least one attribute of the space based on the analysis.

Abstract: A treatment apparatus for external application to a mammal body, comprising a housing, a transducer element, adapted to provide an output towards and/or into the mammal body, a switch element, adapted to activate the transducer element in accordance with a first predetermined condition and deactivate the transducer element in accordance with a second predetermined condition, a feedback element, adapted to provide at least one first feedback signal in response at least a third predetermined condition, and a resilient coupling element, adapted to operatively couple the transducer element to said housing.

Abstract: Systems configured to apply pressure to a foot and electrically stimulate muscles to contract in order to increase circulation and facilitate removal of metabolic waste, and related methods, are disclosed. One exemplary embodiment comprises an actuator that repeatedly compresses the bottom of a foot and an electrical muscle stimulator that repeatedly sends electrical pulses to a muscle to facilitate a muscle contraction. The system may also include a compression garment, such as a compression sock to be worn while undergoing both the repeated compression cycles and the repeated electrical pulses. The system may also include an item of footwear, wherein the actuator portion is partially or completely contained within the item of footwear. Additionally and/or alternatively, the electrical muscle stimulator may be partially or completely contained within the item of footwear.

Abstract: Systems and methods related to the field of cardiac resuscitation, and in particular to devices for assisting rescuers in performing cardio-pulmonary resuscitation (CPR) are described herein.

Abstract: A manual cardiopulmonary resuscitation device for delivering chest compressions to a patient needing CPR. The device includes a handle, a deformable housing having a first end and a second end, an aperture positioned near the first end of the deformable housing, and a gasket or cover connected to the second end of the deformable housing. The deformable housing is configured to deform when pressure is applied to the handle to thereby apply compressive pressure to the patient's chest.

Abstract: A therapy vibration device, for use in increasing blood flow, relaxing muscles and the like in patients, including a support structure, at least one vibration plate coupled to the support structure, and at least one motor coupled to the at least one vibration plate. At least one power source is coupled to the at least one motor and at least one ramp coupled to the vibration plate. At least one railing may also be coupled to the support structure. Additional embodiments include a control system, including at least one payment system, coupled to the therapy vibration device. Alternative embodiments also include an additional therapy device in vibrational communication with the at least one vibration plate.

Abstract: A hand-held massage device and methods for applying pressure therapies to various parts of the anatomy using the device are provided. The device is an elongated, rigid, substantially planar member, configured with a series of alternating concave and convex shapes, and a knob-like projecting member at an end thereof.

Abstract: A hand-held massage device and methods for applying pressure therapies to various parts of the anatomy using the device are provided. The device is an elongated, rigid, substantially planar member, configured with a series of alternating concave and convex shapes, and a knob-like projecting member at an end thereof.

Abstract: A removable medical support mechanism can be used to protect a body member from injury. The mechanism includes a layer of flexible material providing a constrictive force upon the body member and a mesh layer comprising a plurality of interconnected mesh links. The mesh layer is configured to distribute a force of an impact upon the mechanism, thereby protecting the body member from receiving the force of the impact.

Abstract: A progressive strap assembly includes an elongate, inelastic body having first and second ends, and an elastic body having first and second ends, the first end of the elastic body anchored to the second end of the inelastic body. The elastic body is arranged to stretch a plurality of lengths and has a maximum stretchable length. A tension limiter is connected to the first and second ends of the elastic body and is arranged to inhibit a predetermined stretchable length of the elastic body short of the maximum stretchable length.

Abstract: An orthopedic device is arranged to apply a dynamic load on a leg of a user. The orthopedic device has a rigid or semi-rigid frame including lower and upper frames, and a hinge assembly connecting the lower and upper frames. A dynamic loading component is used to urge the load on the user's leg on the basis of flexion of the hinge assembly on the basis of tension in an elongate element connecting the dynamic loading component and at least one of the lower and upper frames. A peak load is generated at a flexion angle between extension and maximum flexion of the hinge assembly.

Abstract: The flexible, sloping paddle members of an orthopedic brace reduce brace migration. The flexible, sloping paddle members comprise males and/or relief cuts in the paddle members to reduce brace migration and contribute to a better fitting brace. Each paddle member is centrally connected to a connector member and can be flexed around a patient's limb. The face of the paddle member slopes so that when the paddle member is flexed to surround a patient's limb, the face forms a cavity in the shape of a conical section, which is complementary to a patients limb.

Abstract: Disclosed herein is a belt for relieving back pain. The belt includes a belt part which is wrapped around a waist of a user, snap buttons which are provided on an inner circumferential surface of the belt part at positions spaced apart, and a support rod coupled to at least one selected from among the snap buttons in such a way that the support rod is oriented perpendicular to the belt part. The support rod includes a cylindrical body that has on an outer circumferential surface thereof snap buttons, and a filler charged into the cylindrical body. The snap buttons of the support rod include snap buttons which are arranged in a longitudinal direction on the cylindrical body so that the support rod can also be horizontally fastened to the belt part.

Abstract: A robotic gait rehabilitation (RGR) training system is provided to address secondary gait deviations such as hip-hiking. An actuation assembly follows the natural motions of a user's pelvis, while applying corrective moments to pelvic obliquity. A human-robot interface (HRI), in the form of a lower body exoskeleton, is provided to improve the transfer of corrective moments to the pelvis. The system includes an impedance control system incorporating backdrivability that is able to modulate the forces applied onto the body depending on the patient's efforts. Various protocols for use of the system are provided.

Abstract: The magnetorheological (MAR) medical brace includes a flexible outer shell that fits around the anatomical area to be braced and a plurality of adjustable straps for securing the shell onto the anatomical area. The shell encases a MAR pack filled with magnetorheological fluid or gel. A plurality of magnets is attached to or encased in the shell to provide magnetic field acting on the MAR pack. The interaction of the magnetic field with the MAR pack adjustably increases or decreases the stiffness of the shell depending on the strength of the magnetic field. A control mechanism is provided for selective adjustment of the magnetic field and other functions.

Abstract: The present disclosure provides a custom or pre-fabricated ankle foot orthosis providing tri-planar control of the ankle foot structure. The ankle foot orthosis comprises a brace body composed of reinforcement strips and a closure mechanism.

Abstract: Toe cushioning device for protecting a patient's toes. A toe cushion device includes two tubular cushions positioned in a transverse plane on the plantar side of a patient's toes during use. The toe cushion relieves foot or toe pain and conforms to the changing contour of the patient's foot and toes during use.

Abstract: A pressure sensitive adhesive composition includes 4-15 w/w % styrene-isoprene-styrene copolymer, 20-35 w/w % styrene-isoprene diblock copolymer, 4-15 w/w % tackifier, 6-18 w/w % paraffin oil, and 30-45 w/w % hydrocolloid. The size of the hydrocolloid is below 40 ?m.

Abstract: The invention provides an adhesive support article for supporting a body part of a user. A single-sided stretchable adhesive tape blank is precut into a sheet having a central anchoring portion and a plurality of outwardly extending fingers. The sheet is marked with visual indicators to guide the user of the support article for applying the central anchoring portion onto a first exterior surface of the body part and for stretching the fingers before adhering them at a predetermined distance away from the central anchoring portion. The adhesive support article can also be provided in a support system with at least one corresponding body landmark article, providing further guidance for applying the support article to the desired body part.

Abstract: The invention relates to an extracorporeal blood treatment device for operation with a single patient connection, which is connected by an arterial and a venous blood line to an extracorporeal blood circuit. The invention further relates to a method for operating a blood treatment device with a single patient connection. The blood treatment device in accordance with the invention has two apparatuses 6, 7 for conveying blood in the arterial and venous blood lines 8, 9. The second apparatus 8 for conveying blood comprises means 11 for collecting blood and means 20 for establishing a pressure in the means for collecting blood 8, so that blood collected in the means for collecting blood flows to the patient connection.

Abstract: This disclosure relates generally to methods and devices for an ocular implant which can be positioned in the Schlemm's canal of a patient's eye for improving fluid flow, such as aqueous fluid, through the eye. The ocular implant can have a variety of shapes and sizes which can allow the ocular implant to be implanted in the Schlemm's canal for applying a force, including a predetermined force, along a part of the Schlemm's canal. The force applied by the ocular implant can change the shape of the Schlemm's canal which can increase the flow volume within and through the Schlemm's canal.

Abstract: A device for regulating blood pressure in a heart chamber is provided. The device includes a shunt positionable within a septum of the heart. The shunt is designed for enabling blood flow between a left heart chamber and a right heart chamber, wherein the flow rate capacity of the device is mostly a function of pressure in the left heart chamber.

Abstract: A system for therapy within a gastrointestinal system includes anchoring or attachment functionality embodied in a low-profile implant technology and removable therapy components, which can be reversibly attached to these low-profile implants to accomplish various therapies. This design allows the physician to tailor the therapy to the patient's needs. The system has the potential to create conduits for diversion and/or restriction of food and organ secretions and to facilitate the treatment of metabolic disorders such as obesity and T2DM.

Abstract: A system and method for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to treat mood and/or anxiety disorders uses an implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with one or more electrodes in the case of electrical stimulation, and an implantable pump with one or more catheters in the case of drug infusion. In cases requiring both electrical and drug stimulation, one or more SCUs are used. Alternatively and preferably, when needed, an SCU provides both electrical stimulation and one or more stimulating drugs. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters.

Abstract: A medical device comprising a socket unit for connecting a plug unit of a device for providing medical fluids, wherein the medical device is in particular an extra-corporal blood treatment device. The medical device provides an automated connection of the plug unit to the socket unit by means of a connecting mechanism for establishing a connection between the at least one connecting piece and the at least one connector. The connecting mechanism has a drive unit that has at least one movable drive body that carries out a translational and/or rotational movement. The connecting mechanism comprises a position detection mechanism for detecting the linear position and/or the angular position of the drive body.

Abstract: A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component.

Abstract: A breast pump adapter including a body, hooks, and wings. The body includes a top end that is configured to attach to a nozzle of a breast pump. The hooks extend outwardly from the body. Each hook is configured to be received in an aperture of a bag. The wings extend outwardly from the body. Each wing tapers from the body to a respective distal end.

Abstract: Single or multiple jointed bit (1) with at least two mouthpieces (10), characterized by the fact that at least one mouthpiece (10) comprises at least one channel (100) which extends longitudinally with or without slope through this mouthpiece from one end to the other end, to enable the sending of a viscous and/or liquid substance (72) directly into the middle of the mouth of an animal (2) without changing the feeling in the animal's mouth or on its tongue (2).

Abstract: A medical device includes an elongated body including an outer surface having a plurality of barbs extending therefrom and an inner surface defining a lumen therethrough. The elongated body includes at least one channel extending through the inner surface and the outer surface, the channel defined between an inner surface of one of the plurality of barbs and a cut outer surface of the elongated body. A wound treatment material is disposed within the lumen of the elongated body. The barb is configured to move between a first position to close the channel and retain the wound treatment material within the lumen and a second position to open the channel and permit the release of the wound treatment material therethrough.

Abstract: Balloon catheter comprises an elongated shaft having a proximal end and a distal end, the elongated shaft including a biaxially oriented nonporous thermoplastic polymer tubular member having a Shore durometer hardness of less than about 75D with an inflation lumen defined therein. The balloon catheter also comprises a balloon sealing secured proximate the distal end of the shaft and having an interior in fluid communication with the inflation lumen.

Abstract: An inflation device useful for inflating a balloon provided with a surgical instrument, such as a balloon sinus dilation instrument. The inflation device includes a syringe, a connector, and mechanical pressure indicator. The syringe includes a plunger slidably disposed within a barrel. The connector is configured to fluidly connect an outlet of the syringe with a surgical instrument balloon in establishing a closed inflation system between the syringe and an interior of the balloon. The pressure indicator is associated with the syringe and is configured to transition from a non-alert state to an alert state when a pressure of the inflation system has reached a predetermined level. In some embodiments, the inflation device is characterized by the absence of a pressure gauge.

Abstract: A flexible expandable inter vivos tube includes at least one arched segmented portion, a corresponding movable element and at least one positioning mechanism. The at least one arched segmented portion and corresponding movable element forming a flexible closed longitudinally expandable tube. The at least one arched segment includes an H-shaped connector having at least one cavity that allows variable slidable movement of a free end portion of the corresponding movable element. To move one or more of the movable elements of the expandable tube, which are within a cavity of the “H”-shaped connector, a fluid or air is introduced into the H-shaped connector running along the longitudinal axis of the flexible expandable inter vivos tube, so that the hydraulic or air pressure within an inner rib of the H-shaped connector expands the movable elements and, thus, the circumference and diameter of the flexible inter vivos tube are increased.

Abstract: A process for forming a catheter balloon includes subjecting a tubular parison in a mold to molding fluid pressure. The resulting catheter balloon includes a balloon portion having two ends and tubular leg portions extending from either end. The ends of the balloon portion are tapered to the tubular leg portions. The tapered ends have alternating elongate areas of greater and lesser resistance to deformation displaced circumferentially about the tapered ends. The elongate areas of greater and lesser resistance to deformation can include ridges which are either longitudinal or spiraled or rods imbedded in the body of the balloon. While in the mold, the tubular legs are drawn axially sufficiently to form permanent creases in the tapered ends. This drawing may be sufficient to cause the material of the tapered ends to exceed the yield strength, particularly with the balloon material in a malleable state.

Abstract: Neuromodulation assemblies (200) include an extravascular prosthesis (202) disposed around and contacting at least a portion of an exterior surface (204) of a vessel (V) and a radially expandable intravascular prosthesis (206) contacting an interior surface (208) of the vessel. The neuromodulation assemblies are configured to compress, pinch, or squeeze a target nerve within the adventitia of the vessel between the extravascular and intravascular prostheses in order to impinge and disrupt the target nerve, thereby blocking or stopping nerve signal transduction. Neuromodulation assemblies configured in accordance with the present technology may also utilize radio-frequency energy, a drug, and/or magnetic attraction to block nerve signal transduction for neuromodulation thereof.

Abstract: A barrel adapter mountable to a syringe barrel includes a barrel tip, a biasing member, a locking mechanism, and a needle assembly. A safety syringe includes a barrel, a plunger assembly, and a barrel adapter. The needle assembly includes a needle, a needle hub, and a needle seal. The needle is configured to pass-through the needle assembly, locking mechanism, biasing member, and barrel tip such that, at one end the needle is within the barrel and at another end the needle passes through an aperture in the barrel tip. The barrel may be substantially cylindrical, having along its longitudinal axis a distal end for drug injection, a proximal end for injection control, and at least a portion of the barrel interior for drug containment. The barrel adapter provides needle retraction mechanisms to the barrel to form a safety syringe. Methods of assembling, manufacturing, and using such syringes are also provided.

Abstract: A system for contactless transmission of energy and control signals between a primary device and a secondary device. The primary device has a primary set with at least one primary coil and an electronic supply driver for supplying primary signals to the primary set of primary coils. A secondary device has a secondary set with at least one secondary coil, at least one piezoelectric actuator, and electronic components including a resonant circuit powered by the secondary set. The piezoelectric actuator is powered and controlled through the secondary set of secondary coils and the electronic components.

Abstract: A core, rotatably fitted within a body of a manifold assembly, includes a flow channel configured so that, when the core is rotated 360 degrees, fluid communication between ports of the body is only established by the channel at a first position, between first and second ports, and at a second position, between third and fourth ports. The channel may define an angle greater than 90 degrees and less than 180 degrees, preferably 120 degrees; and, the rotation, between first and second positions, may be approximately 180 degrees. In a medical injection system, the first and second ports are fill ports of the assembly, the first being coupled to a reservoir, and the second being coupled to a pump; and the third and fourth ports are injection ports of the assembly, the third being coupled to the pump, and the fourth being coupled to an injection line.

Abstract: A fluid pathway connection includes a piercing member, a connection hub, and a sliding pierceable seal, wherein the sliding pierceable seal is configured to move from a first position, where the piercing member is initially retained within a sterile cavity between the connection hub and the sliding pierceable seal, to a second position, where the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. The fluid pathway connection may further be configured to move to a third position where one or more interconnects and/or one or more corresponding contacts are permitted to transmit a signal to the user. Such fluid pathway connections may be integrated into a drug container having a barrel and a plunger seal. A drug delivery pump includes such integrated fluid pathway connections and drug containers.